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Probiotic‑derived ferrichrome inhibits the growth of refractory pancreatic cancer cells

  • Authors:
    • Akemi Kita
    • Mikihiro Fujiya
    • Hiroaki Konishi
    • Hiroki Tanaka
    • Shin Kashima
    • Takuya Iwama
    • Masami Ijiri
    • Yuki Murakami
    • Shuhei Takauji
    • Takuma Goto
    • Aki Sakatani
    • Katsuyoshi Ando
    • Nobuhiro Ueno
    • Naoki Ogawa
    • Toshikatsu Okumura
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa 078‑8510, Japan, Department of Gastroenterology and Advanced Medical Sciences, Asahikawa Medical University, Asahikawa 078‑8510, Japan, Division of Tumor Pathology, Department of Pathology, Asahikawa Medical University, Asahikawa 078‑8510, Japan, Asahikawa Medical University Hospital Emergency Unit, Asahikawa 078‑8510, Japan, Center for Advanced Research and Education, Department of Medicine, Asahikawa Medical University, Asahikawa 078‑8510, Japan
    Copyright: © Kita et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 721-732
    |
    Published online on: July 8, 2020
       https://doi.org/10.3892/ijo.2020.5096
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Abstract

Pancreatic cancer is associated with a poor prognosis due to challenges in early detection, severe progression of the primary tumor, metastatic lesions, and resistance to antitumor agents. However, previous studies have indicated a relationship between the microbiome and pancreatic cancer outcomes. Our previous study demonstrated that ferrichrome derived from Lactobacillus casei, a probiotic bacteria, exhibited tumor‑suppressive effects in colorectal and gastric cancer, and that the suppressive effects were stronger than conventional antitumor agents, such as 5‑fluorouracil (5‑FU) and cisplatin, suggesting that certain probiotics exert antitumorigenic effects. However, whether or not probiotic‑derived molecules, including ferrichrome, exert a tumor‑suppressive effect in other gastrointestinal tumors, such as pancreatic cancer, remains unclear. In the present study, it was demonstrated that probiotic‑derived ferrichrome inhibited the growth of pancreatic cancer cells, and its tumor‑suppressive effects were further revealed in 5‑FU‑resistant pancreatic cancer cells in vitro and in vivo in a mouse xenograft model. Ferrichrome inhibited the progression of cancer cells via dysregulation of the cell cycle by activating p53. DNA fragmentation and cleavage of poly (ADP‑ribose) polymerase were induced by ferrichrome treatment, suggesting that ferrichrome induced apoptosis in pancreatic cancer cells. A transcriptome analysis revealed that the expression p53‑associated mRNAs was significantly altered by ferrichrome treatment. Thus, the tumor‑suppressive effects of probiotics may mediated by probiotic‑derived molecules, such as ferrichrome, which may have applications as an antitumor drug, even in refractory and 5‑FU‑resistant pancreatic cancer.
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1 

Conroy T, Desseigne F, Ychou M, Bouché O, Guimbaud R, Bécouarn Y, Adenis A, Raoul JL, Gourgou-Bourgade S, de la Fouchardière C, et al Groupe Tumeurs Digestives of Unicancer; PRODIGE Intergroup: FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 364:1817–1825. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Heinemann V, Boeck S, Hinke A, Labianca R and Louvet C: Meta-analysis of randomized trials: Evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer. BMC Cancer. 8:822008. View Article : Google Scholar : PubMed/NCBI

3 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Chand S, O'Hayer K, Blanco FF, Winter JM and Brody JR: The landscape of pancreatic cancer therapeutic resistance mechanisms. Int J Biol Sci. 12:273–282. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Loehrer PJ Sr, Einhorn LH, Williams SD, Hui SL, Estes NC and Pennington K: Cisplatin plus 5-FU for the treatment of adeno-carcinoma of the colon. Cancer Treat Rep. 69:1359–1363. 1985.PubMed/NCBI

6 

Gaiser RA, Halimi A, Alkharaan H, Lu L, Davanian H, Healy K, Hugerth LW, Ateeb Z, Valente R, Fernández Moro C, et al: Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer. Gut. 68:2186–2194. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Half E, Keren N, Reshef L, Dorfman T, Lachter I, Kluger Y, Reshef N, Knobler H, Maor Y, Stein A, et al: Fecal microbiome signatures of pancreatic cancer patients. Sci Rep. 9:168012019. View Article : Google Scholar : PubMed/NCBI

8 

Food and Agriculture Organization of the United Nations; World Health Organization: Guidelines for the Evaluation of Probiotics in Food. Ontario, Canada: 2002

9 

Gerritsen J, Smidt H, Rijkers GT and de Vos WM: Intestinal microbiota in human health and disease: The impact of probiotics. Genes Nutr. 6:209–240. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Kalliomäki M, Salminen S, Arvilommi H, Kero P, Koskinen P and Isolauri E: Probiotics in primary prevention of atopic disease: A randomised placebo-controlled trial. Lancet. 357:1076–1079. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Gu Y-H, Choi H, Yamashita T, Kang KM, Iwasa M, Lee MJ, Lee KH and Kim CH: Pharmaceutical production of anti-tumor and immune-potentiating Enterococcus faecalis-2001 β-glucans: Enhanced activity of macrophage and lymphocytes in tumor-implanted mice. Curr Pharm Biotechnol. 18:653–661. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Rowland IR, Rumney CJ, Coutts JT and Lievense LC: Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis. 19:281–285. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Maroof H, Hassan ZM, Mobarez AM and Mohamadabadi MA: Lactobacillus acidophilus could modulate the immune response against breast cancer in murine model. J Clin Immunol. 32:1353–1359. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Singhal B, Mukherjee A and Srivastav S: Role of probiotics in pancreatic cancer prevention: The prospects and challenges. Adv Biosci Biotechnol. 07:468–500. 2016. View Article : Google Scholar

15 

Segawa S, Fujiya M, Konishi H, Ueno N, Kobayashi N, Shigyo T and Kohgo Y: Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway. PLoS One. 6:e232782011. View Article : Google Scholar : PubMed/NCBI

16 

Hemarajata P and Versalovic J: Effects of probiotics on gut microbiota: Mechanisms of intestinal immunomodulation and neuromodulation. Therap Adv Gastroenterol. 6:39–51. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Tsai TL, Li AC, Chen YC, Liao YS and Lin TH: Antimicrobial peptide m2163 or m2386 identified from Lactobacillus casei ATCC 334 can trigger apoptosis in the human colorectal cancer cell line SW480. Tumour Biol. 36:3775–3789. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Sakatani A, Fujiya M, Ueno N, Kashima S, Sasajima J, Moriichi K, Ikuta K, Tanabe H and Kohgo Y: Polyphosphate derived from lactobacillus brevis inhibits colon cancer progression through induction of cell apoptosis. Anticancer Res. 36:591–598. 2016.PubMed/NCBI

19 

Konishi H, Fujiya M, Tanaka H, Ueno N, Moriichi K, Sasajima J, Ikuta K, Akutsu H, Tanabe H and Kohgo Y: Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis. Nat Commun. 7:123652016. View Article : Google Scholar : PubMed/NCBI

20 

Ijiri M, Fujiya M, Konishi H, Tanaka H, Ueno N, Kashima S, Moriichi K, Sasajima J, Ikuta K and Okumura T: Ferrichrome identified from Lactobacillus casei ATCC334 induces apoptosis through its iron-binding site in gastric cancer cells. Tumour Biol. 39:10104283177113112017. View Article : Google Scholar : PubMed/NCBI

21 

Ecker DJ, Passavant CW and Emery T: Role of two siderophores in Ustilago sphaerogena. Regulation of biosynthesis and uptake mechanisms. Biochim Biophys Acta. 720:242–249. 1982. View Article : Google Scholar : PubMed/NCBI

22 

Kato H, Ishikura H, Kawarada Y, Furuya M, Kondo S, Kato H and Yoshiki T: Anti-angiogenic treatment for peritoneal dissemination of pancreas adenocarcinoma: A study using TNP-470. Jpn J Cancer Res. 92:67–73. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Li Z, Wang N, Huang C, Bao Y, Jiang Y and Zhu G: Downregulation of caveolin-1 increases the sensitivity of drug-resistant colorectal cancer HCT116 cells to 5-fluorouracil. Oncol Lett. 13:483–487. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Moore JD: In the wrong place at the wrong time: Does cyclin mislocalization drive oncogenic transformation? Nat Rev Cancer. 13:201–208. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Leu JIJ, Pimkina J, Frank A, Murphy ME and George DL: A small molecule inhibitor of inducible heat shock protein 70. Mol Cell. 36:15–27. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Michaud DS, Izard J, Wilhelm-Benartzi CS, You DH, Grote VA, Tjønneland A, Dahm CC, Overvad K, Jenab M, Fedirko V, et al: Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. Gut. 62:1764–1770. 2013. View Article : Google Scholar

27 

Fan X, Alekseyenko AV, Wu J, Peters BA, Jacobs EJ, Gapstur SM, Purdue MP, Abnet CC, Stolzenberg-Solomon R, Miller G, et al: Human oral microbiome and prospective risk for pancreatic cancer: A population-based nested case-control study. Gut. 67:120–127. 2018. View Article : Google Scholar

28 

Pushalkar S, Hundeyin M, Daley D, Zambirinis CP, Kurz E, Mishra A, Mohan N, Aykut B, Usyk M, Torres LE, et al: The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression. Cancer Discov. 8:403–416. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Li S, Fuhler GM, Bn N, Jose T, Bruno MJ, Peppelenbosch MP and Konstantinov SR: Pancreatic cyst fluid harbors a unique microbiome. Microbiome. 5:1472017. View Article : Google Scholar : PubMed/NCBI

30 

Sethi V, Kurtom S, Tarique M, Lavania S, Malchiodi Z, Hellmund L, Zhang L, Sharma U, Giri B, Garg B, et al: Gut microbiota promotes tumor growth in mice by modulating immune response. Gastroenterology. 155:33–37.e6. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Kastan MB, Zhan Q, el-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B and Fornace AJ Jr: A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell. 71:587–597. 1992. View Article : Google Scholar : PubMed/NCBI

32 

Kuerbitz SJ, Plunkett BS, Walsh WV and Kastan MB: Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA. 89:7491–7495. 1992. View Article : Google Scholar : PubMed/NCBI

33 

Bourdon JC, Renzing J, Robertson PL, Fernandes KN and Lane DP: Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. J Cell Biol. 158:235–246. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Gu Z, Wang H, Xia J, Yang Y, Jin Z, Xu H, Shi J, De Domenico I, Tricot G and Zhan F: Decreased ferroportin promotes myeloma cell growth and osteoclast differentiation. Cancer Res. 75:2211–2221. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Markkanen E, Dorn J and Hübscher U: MUTYH DNA glyco-sylase: The rationale for removing undamaged bases from the DNA. Front Genet. 4:182013. View Article : Google Scholar

36 

Oka S, Leon J, Tsuchimoto D, Sakumi K and Nakabeppu Y: MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death. Oncogenesis. 3:e121. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Ali S, Zhang Y, Zhou M, Li H, Jin W, Zheng L, Yu X, Stark JM, Weitzel JN and Shen B: Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis. Oncogene. 39:1246–1259. 2020. View Article : Google Scholar

38 

Longley DB, Harkin DP and Johnston PG: 5-fluorouracil: Mechanisms of action and clinical strategies. Nat Rev Cancer. 3:330–338. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kita A, Fujiya M, Konishi H, Tanaka H, Kashima S, Iwama T, Ijiri M, Murakami Y, Takauji S, Goto T, Goto T, et al: Probiotic‑derived ferrichrome inhibits the growth of refractory pancreatic cancer cells. Int J Oncol 57: 721-732, 2020.
APA
Kita, A., Fujiya, M., Konishi, H., Tanaka, H., Kashima, S., Iwama, T. ... Okumura, T. (2020). Probiotic‑derived ferrichrome inhibits the growth of refractory pancreatic cancer cells. International Journal of Oncology, 57, 721-732. https://doi.org/10.3892/ijo.2020.5096
MLA
Kita, A., Fujiya, M., Konishi, H., Tanaka, H., Kashima, S., Iwama, T., Ijiri, M., Murakami, Y., Takauji, S., Goto, T., Sakatani, A., Ando, K., Ueno, N., Ogawa, N., Okumura, T."Probiotic‑derived ferrichrome inhibits the growth of refractory pancreatic cancer cells". International Journal of Oncology 57.3 (2020): 721-732.
Chicago
Kita, A., Fujiya, M., Konishi, H., Tanaka, H., Kashima, S., Iwama, T., Ijiri, M., Murakami, Y., Takauji, S., Goto, T., Sakatani, A., Ando, K., Ueno, N., Ogawa, N., Okumura, T."Probiotic‑derived ferrichrome inhibits the growth of refractory pancreatic cancer cells". International Journal of Oncology 57, no. 3 (2020): 721-732. https://doi.org/10.3892/ijo.2020.5096
Copy and paste a formatted citation
x
Spandidos Publications style
Kita A, Fujiya M, Konishi H, Tanaka H, Kashima S, Iwama T, Ijiri M, Murakami Y, Takauji S, Goto T, Goto T, et al: Probiotic‑derived ferrichrome inhibits the growth of refractory pancreatic cancer cells. Int J Oncol 57: 721-732, 2020.
APA
Kita, A., Fujiya, M., Konishi, H., Tanaka, H., Kashima, S., Iwama, T. ... Okumura, T. (2020). Probiotic‑derived ferrichrome inhibits the growth of refractory pancreatic cancer cells. International Journal of Oncology, 57, 721-732. https://doi.org/10.3892/ijo.2020.5096
MLA
Kita, A., Fujiya, M., Konishi, H., Tanaka, H., Kashima, S., Iwama, T., Ijiri, M., Murakami, Y., Takauji, S., Goto, T., Sakatani, A., Ando, K., Ueno, N., Ogawa, N., Okumura, T."Probiotic‑derived ferrichrome inhibits the growth of refractory pancreatic cancer cells". International Journal of Oncology 57.3 (2020): 721-732.
Chicago
Kita, A., Fujiya, M., Konishi, H., Tanaka, H., Kashima, S., Iwama, T., Ijiri, M., Murakami, Y., Takauji, S., Goto, T., Sakatani, A., Ando, K., Ueno, N., Ogawa, N., Okumura, T."Probiotic‑derived ferrichrome inhibits the growth of refractory pancreatic cancer cells". International Journal of Oncology 57, no. 3 (2020): 721-732. https://doi.org/10.3892/ijo.2020.5096
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