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Article Open Access

Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4

  • Authors:
    • Zhongmin Jiang
    • Chunyan Zhang
    • Xiaozhi Liu
    • Xiaofang Ma
    • Xiyun  Bian
    • Xiaolin Xiao
    • Rui Gao
    • Yajing Sun
    • Wenhan Wu
    • Po Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Chinese People's Liberation Army (PLA) General Hospital, Beijing 100853, P.R. China, Department of Pharmacy, Binhai New Area Hospital of Traditional Chinese Medicine, Tianjin 300450, P.R. China, Tianjin Key Laboratory of Epigenetics for Organ Development in Preterm Infants, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China, Department of Pathology, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China, Department of Pathology, Chinese People's Liberation Army (PLA) General Hospital, Beijing 100853, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 780-790
    |
    Published online on: July 8, 2020
       https://doi.org/10.3892/ijo.2020.5097
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Abstract

It has been controversial whether patients with hepatocellular carcinoma (HCC) should receive glucocorticoid therapy during chemotherapy. Recent studies have demonstrated that glucocorticoids increase the therapeutic sensitivity of tumors to some chemotherapeutic drugs, but the specific mechanism remains unclear. In the present study, dexamethasone (Dex) was used to treat HCC stem cells. The results demonstrated that Dex reduced stemness maintenance and self‑renewal of HCC stem cells, promoted epithelial‑to‑mesenchymal transition, inhibited migration and angiogenesis and, more importantly, increased cell sensitivity to the herpes simplex virus thymidine kinase/ganciclovir drug system in vitro and in vivo. Further mechanistic analyses demonstrated that Dex inhibited small ubiquitin‑like modifier (SUMO) modification of several proteins in HCC stem cells, including hypoxia‑inducible factor (HIF)‑1α, an important hypoxia tolerance protein, and octamer‑binding transcription factor 4 (Oct4), a crucial stemness maintenance protein. Inducing deSUMOylation of HIF‑1α and Oct4 reduced their accumulation in the nucleus, thereby inhibiting tumor angiogenesis and stemness maintenance. These findings provide a new perspective to the study of the mechanism underlying the anti‑hepatocarcinogenesis effects of Dex. Due to the few side effects of glucocorticoids at low doses and their anti‑inflammatory effects, the appropriate combination of glucocorticoids and chemotherapeutic drugs is expected to improve the survival of HCC patients and their prognosis.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

2 

El-Karaksy HM, Mogahed E, El-Sayed R, El-Raziky M, Sheba M, Besheer M, Elkiki H and Ghita H: Focal hepatic lesions in Egyptian infants and children: The pediatric hepatologist perspective. Minerva Pediatr. 70:35–45. 2018.

3 

Hartke J, Johnson M and Ghabril M: The diagnosis and treatment of hepatocellular carcinoma. Semin Diagn Pathol. 34:153–159. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Li Y, Ruan DY, Jia CC, Zhao H, Wang GY, Yang Y and Jiang N: Surgical resection versus liver transplantation for hepatocellular carcinoma within the Hangzhou criteria: A preoperative nomogram-guided treatment strategy. Hepatobiliary Pancreat Dis Int. 16:480–486. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Gnutzmann D, Kortes N, Sumkauskaite M, Schmitz A, Weiss KH and Radeleff B: Transvascular therapy of hepatocellular carcinoma (HCC), status and developments. Minim Invasive Ther Allied Technol. 27:69–80. 2018. View Article : Google Scholar : PubMed/NCBI

6 

da Motta Girardi D, Correa TS, Crosara Teixeira M and Dos Santos Fernandes G: Hepatocellular carcinoma: Review of targeted and immune therapies. J Gastrointest Cancer. 49:227–236. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Lui WY, P'eng FK, Chang YF, Chang TJ, Tsai TF, Hsu ML, Su TS, Tsay SH, Wu CW, Liu TY, et al: Analysis of glucocorticoid receptors in human hepatocellular carcinoma and HepG2 cells. Hepatology. 18:1167–1174. 1993. View Article : Google Scholar : PubMed/NCBI

8 

Ray K: Hepatocellular carcinoma: restoring gluconeogenesis: steroids could treat liver cancer. Nat Rev Gastroenterol Hepatol. 10:6932013. View Article : Google Scholar : PubMed/NCBI

9 

Woods CP, Hazlehurst JM and Tomlinson JW: Glucocorticoids and non-alcoholic fatty liver disease. J Steroid Biochem Mol Biol. 154:94–103. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Lee DH, Cheul Oh S, Giles AJ, Jung J, Gilbert MR and Park DM: Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1α in human glioma stem cells. Oncotarget. 8:40233–40245. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Xiang L, Gilkes DM, Chaturvedi P, Luo W, Hu H, Takano N, Liang H and Semenza GL: Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J Mol Med (Berl). 92:151–164. 2014. View Article : Google Scholar

12 

Yoon C, Chang KK, Lee JH, Tap WD, Hart CP, Simon MC and Yoon SS: Multimodal targeting of tumor vasculature and cancer stem like cells in sarcomas with VEGF A inhibition, HIF 1α inhibition, and hypoxia activated chemotherapy. Oncotarget. 7:42844–42858. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Cui CP, Wong CC, Kai AK, Ho DW, Lau EY, Tsui YM, Chan LK, Cheung TT, Chok KS, Chan ACY, et al: SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop. Gut. 66:2149–2159. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Han X, Wang XL, Li Q, Dong XX, Zhang JS and Yan QC: HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells. Graefes Arch Clin Exp Ophthalmol. 253:1279–1290. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Tahmasebi S, Ghorbani M, Savage P, Gocevski G and Yang XJ: The SUMO conjugating enzyme Ubc9 is required for inducing and maintaining stem cell pluripotency. Stem Cells. 32:1012–1020. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Wu Y, Guo Z, Wu H, Wang X, Yang L, Shi X, Du J, Tang B, Li W, Yang L, et al: SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2. PLoS One. 7:e396062012. View Article : Google Scholar : PubMed/NCBI

17 

Han ZJ, Feng YH, Gu BH, Li YM and Chen H: The post-translational modification, SUMOylation, and cancer (Review). Int J Oncol. 52:1081–1094. 2018.Review. PubMed/NCBI

18 

Gupta KJ, Kolbert Z, Durner J, Lindermayr C, Corpas FJ, Brouquisse R, Barroso JB, Umbreen S, Palma JM, Hancock JT, et al: Regulating the regulator: Nitric oxide control of post-translational modifications. New Phytol. Apr 27–2020.Epub ahead of print. View Article : Google Scholar

19 

Li R, Wei J, Jiang C, Liu D, Deng L, Zhang K and Wang P: Akt SUMOylation regulates cell proliferation and tumorigenesis. Cancer Res. 73:5742–5753. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Ni P, Xu H, Chen C, Wang J, Liu X, Hu Y, Fan Q, Hou Z and Lu Y: Serum starvation induces DRAM expression in liver cancer cells via histone modifications within its promoter locus. PLoS One. 7:e505022012. View Article : Google Scholar : PubMed/NCBI

21 

Polderman JA, Farhang-Razi V, Van Dieren S, Kranke P, DeVries JH, Hollmann MW, Preckel B and Hermanides J: Adverse side effects of dexamethasone in surgical patients. Cochrane Database Syst Rev. 8:CD0119402018.PubMed/NCBI

22 

Tang H, Jin Y, Jin S, Tan Z, Peng Z and Kuang Y: Arsenite inhibits the function of CD133+ CD13+ liver cancer stem cells by reducing PML and Oct4 protein expression. Tumour Biol. 37:14103–14115. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Luo T, Wang L, Wu P, Gong W, Chen W, Zhao H and Zheng Z: Downregulated vimentin and upregulated E-cadherin in T1 stage non-small-cell lung cancer: Does it suggest a mesenchymal-epithelial transition? Neoplasma. 64:693–699. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Zilio N, Eifler-Olivi K and Ulrich HD: Functions of SUMO in the Maintenance of Genome Stability. Adv Exp Med Biol. 963:51–87. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Zhao X: SUMO-mediated regulation of nuclear functions and signaling processes. Mol Cell. 71:409–418. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Pichler A, Fatouros C, Lee H and Eisenhardt N: SUMO conjugation - a mechanistic view. Biomol Concepts. 8:13–36. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Wang L, Zhang T, Fang M, Shen N, Wang D, Teng J, Fu B, Xie H, Hong Q and Lin H: Podocytes protect glomerular endothelial cells from hypoxic injury via deSUMOylation of HIF-1α signaling. Int J Biochem Cell Biol. 58:17–27. 2015. View Article : Google Scholar

28 

Gupta P, Ho PC, Huq MM, Ha SG, Park SW, Khan AA, Tsai NP and Wei LN: Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression. Proc Natl Acad Sci USA. 105:11424–11429. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Parikh ND, Fu S, Rao H, Yang M, Li Y, Powell C, Wu E, Lin A, Xing B, Wei L, et al: Risk assessment of hepatocellular carcinoma in patients with hepatitis C in China and the USA. Dig Dis Sci. 62:3243–3253. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Mak LY, Cruz-Ramón V, Chinchilla-López P, Torres HA, LoConte NK, Rice JP, Foxhall LE, Sturgis EM, Merrill JK, Bailey HH, et al: Global epidemiology, prevention, and management of hepatocellular carcinoma. Am Soc Clin Oncol Educ Book. 38:262–279. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Pinna AD, Yang T, Mazzaferro V, De Carlis L, Zhou J, Roayaie S, Shen F, Sposito C, Cescon M, Di Sandro S, et al: Liver transplantation and hepatic resection can achieve cure for hepatocellular carcinoma. Ann Surg. 268:868–875. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Akoad ME and Pomfret EA: Surgical resection and liver transplantation for hepatocellular carcinoma. Clin Liver Dis. 19:381–399. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Fillat C, Carrió M, Cascante A and Sangro B: Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: Fifteen years of application. Curr Gene Ther. 3:13–26. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Zhang JH, Wan MX, Pan BR and Yu B: Cytotoxicity of HSVtk and hrTNF-alpha fusion genes with IRES in treatment of gastric cancer. Cancer Biol Ther. 3:1075–1080. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Parada C, Hernández Losa J, Guinea J, Sánchez-Arévalo V, Fernández Soria V, Alvarez-Vallina L, Sánchez-Prieto R and Ramón y Cajal S: Adenovirus E1a protein enhances the cytotoxic effects of the herpes thymidine kinase-ganciclovir system. Cancer Gene Ther. 10:152–160. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Shang F, Liu M, Li B, Zhang X, Sheng Y, Liu S, Han J, Li H and Xiu R: The anti-angiogenic effect of dexamethasone in a murine hepatocellular carcinoma model by augmentation of gluconeogenesis pathway in malignant cells. Cancer Chemother Pharmacol. 77:1087–1096. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Ogasawara S, Chiba T, Ooka Y, Kanogawa N, Motoyama T, Suzuki E, Tawada A, Nagai K, Nakagawa T, Sugawara T, et al: A randomized placebo-controlled trial of prophylactic dexa-methasone for transcatheter arterial chemoembolization. Hepatology. 67:575–585. 2018. View Article : Google Scholar

38 

Yang H, Seon J, Sung PS, Oh JS, Lee HL, Jang B, Chun HJ, Jang JW, Bae SH, Choi JY and Yoon SK: Dexamethasone Prophylaxis to Alleviate Postembolization Syndrome after Transarterial Chemoembolization for Hepatocellular Carcinoma: A Randomized, Double Blinded, Placebo Controlled Study. J Vasc Interv Radiol. 28:1503–1511.e2. 2017. View Article : Google Scholar

39 

Tang YA, Chen YF, Bao Y, Mahara S, Yatim SMJM, Oguz G, Lee PL, Feng M, Cai Y, Tan EY, et al: Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer. Proc Natl Acad Sci USA. 115:E5990–E5999. 2018. View Article : Google Scholar

40 

Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC and Keith B: HIF-2alpha regulates Oct-4: Effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 20:557–570. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Yuan L, Jiang ZM, Chen XH, Bian XY, Li YX, Ma XF and Liu XZ: Hypoxia inducible factor-1α deSUMOylation reduces the stemness maintenance ability of endometrial cancer stem cell and increases its chemosensitivity. Zhonghua Yi Xue Za Zhi. 97:3579–3582. 2017.In Chinese. PubMed/NCBI

42 

Liebelt F and Vertegaal AC: Ubiquitin-dependent and independent roles of SUMO in proteostasis. Am J Physiol Cell Physiol. 311:C284–C296. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang Z, Zhang C, Liu X, Ma X, Bian X, Xiao X, Gao R, Sun Y, Wu W, Zhao P, Zhao P, et al: Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4. Int J Oncol 57: 780-790, 2020.
APA
Jiang, Z., Zhang, C., Liu, X., Ma, X., Bian, X., Xiao, X. ... Zhao, P. (2020). Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4. International Journal of Oncology, 57, 780-790. https://doi.org/10.3892/ijo.2020.5097
MLA
Jiang, Z., Zhang, C., Liu, X., Ma, X., Bian, X., Xiao, X., Gao, R., Sun, Y., Wu, W., Zhao, P."Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4". International Journal of Oncology 57.3 (2020): 780-790.
Chicago
Jiang, Z., Zhang, C., Liu, X., Ma, X., Bian, X., Xiao, X., Gao, R., Sun, Y., Wu, W., Zhao, P."Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4". International Journal of Oncology 57, no. 3 (2020): 780-790. https://doi.org/10.3892/ijo.2020.5097
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Z, Zhang C, Liu X, Ma X, Bian X, Xiao X, Gao R, Sun Y, Wu W, Zhao P, Zhao P, et al: Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4. Int J Oncol 57: 780-790, 2020.
APA
Jiang, Z., Zhang, C., Liu, X., Ma, X., Bian, X., Xiao, X. ... Zhao, P. (2020). Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4. International Journal of Oncology, 57, 780-790. https://doi.org/10.3892/ijo.2020.5097
MLA
Jiang, Z., Zhang, C., Liu, X., Ma, X., Bian, X., Xiao, X., Gao, R., Sun, Y., Wu, W., Zhao, P."Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4". International Journal of Oncology 57.3 (2020): 780-790.
Chicago
Jiang, Z., Zhang, C., Liu, X., Ma, X., Bian, X., Xiao, X., Gao, R., Sun, Y., Wu, W., Zhao, P."Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4". International Journal of Oncology 57, no. 3 (2020): 780-790. https://doi.org/10.3892/ijo.2020.5097
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