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Article

Platelet adherence to cancer cells promotes escape from innate immune surveillance in cancer metastasis

  • Authors:
    • Mitsuyoshi Okazaki
    • Takahisa Yamaguchi
    • Hidehiro Tajima
    • Sachio Fushida
    • Tetsuo Ohta
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan
  • Pages: 980-988
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    Published online on: July 27, 2020
       https://doi.org/10.3892/ijo.2020.5102
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Abstract

The impacts of post‑operative abdominal infectious complications increase hematogenous distant metastasis and result in poor long‑term survival after curative resection. Even if curative resection can be performed, the presence of circulating tumor cells is affected. The liver, the most common site of metastases, is an important organ in innate immune surveillance. However, the molecular mechanisms of distant hematogenous metastasis are not yet fully known. Platelets are crucial components in the tumor microenvironment that function to promote tumor progression and metastasis. The purpose of this study was to identify the effect of platelets on escape from innate immune surveillance in post‑operative abdominal infectious complications. Platelet adherence was assessed by co‑culturing human pancreatic cancer cells including transforming growth factor (TGF‑β)‑treated BxPC‑3. CD44 isoform, transcription factors and epithelial‑mesenchymal transition markers were examined using western blotting. We also assessed whether cancer cells surrounded by activated platelets could escape from innate immune surveillance, using infectious and non‑infectious mouse models injected intraperitoneally with LPS. Platelets were found to preferentially adhere to mesenchymal cells rather than epithelial cells. BxPC‑3 epithelial cells showed upregulation of CD44‑variant and epithelial splicing regulatory protein 1 (ESRP‑1) expression. However, Panc‑1 mesenchymal cells and TGF‑β‑treated BxPC‑3 cells showed upregulation of CD44‑standard and zinc finger E‑box‑binding homeobox 1 (ZEB‑1) expression and a reduction in ESRP‑1. In the non‑infectious model, cancer cells were not found in the liver. In the infectious model, although epithelial cells without platelet adhesion were in an apoptotic state, mesenchymal cells showed many viable cancer cells surrounded by activated platelets. Cancer cells were suggested to have phenotypic plasticity through the switching of CD44 isoforms. Mesenchymal cells, which express CD44‑standard, could escape from immune surveillance by becoming surrounded by adhered activated platelets. Therefore, it may be necessary to administer antiplatelet agents to prevent distant hematogenous metastasis when post‑operative abdominal infectious complications occur.
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View References

1 

Pilleron S, Sarfati D, Janssen-Heijnen M, Vignat J, Ferlay J, Bray F and Soerjomataram I: Global cancer incidence in older adults, 2012 and 2035: A population-based study. Int J Cancer. 144:49–58. 2019. View Article : Google Scholar

2 

Carioli G, Malvezzi M, Bertuccio P, Hashim D, Waxman S, Negri E, Boffetta P and La Vecchia C: Cancer mortality in the elderly in 11 countries worldwide, 1970-2015. Ann Oncol. 30:1344–1355. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Farid SG, Aldouri A, Morris-Stiff G, Khan AZ, Toogood GJ, Lodge JP and Prasad KR: Correlation between postoperative infective complications and long-term outcomes after hepatic resection for colorectal liver metastasis. Ann Surg. 251:91–100. 2010. View Article : Google Scholar

4 

Ito H, Are C, Gonen M, D'Angelica M, Dematteo RP, Kemeny NE, Fong Y, Blumgart LH and Jarnagin WR: Effect of postoperative morbidity on long-term survival after hepatic resection for meta-static colorectal cancer. Ann Surg. 247:994–1002. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Kataoka K, Takeuchi H, Mizusawa J, Igaki H, Ozawa S, Abe T, Nakamura K, Kato K, Ando N and Kitagawa Y: Prognostic impact of postoperative morbidity after esophagectomy for esophageal cancer: Exploratory analysis of JCOG9907. Ann Surg. 265:1152–1157. 2017. View Article : Google Scholar

6 

Lerut T, Moons J, Coosemans W, Van Raemdonck D, De Leyn P, Decaluwé H, Decker G and Nafteux P: Postoperative complications after transthoracic esophagectomy for cancer of the esophagus and gastroesophageal junction are correlated with early cancer recurrence: Role of systematic grading of complications using the modified Clavien classification. Ann Surg. 250:798–807. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Braunwarth E, Primavesi F, Göbel G, Cardini B, Oberhuber R, Margreiter C, Maglione M, Schneeberger S, Öfner D and Stättner S: Is bile leakage after hepatic resection associated with impaired long-term survival? Eur J Surg Oncol. 45:1077–1083. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Dranoff G: Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer. 4:11–22. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Ogura M, Takeuchi H, Kawakubo H, Nishi T, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, et al: Clinical significance of CXCL-8/CXCR-2 network in esophageal squamous cell carcinoma. Surgery. 154:512–520. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Okamura A, Takeuchi H, Matsuda S, Ogura M, Miyasho T, Nakamura R, Takahashi T, Wada N, Kawakubo H, Saikawa Y, et al: Factors affecting cytokine change after esopha-gectomy for esophageal cancer. Ann Surg Oncol. 22:3130–3135. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Pachot A, Cazalis MA, Venet F, Turrel F, Faudot C, Voirin N, Diasparra J, Bourgoin N, Poitevin F, Mougin B, et al: Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppression. J Immunol. 180:6421–6429. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Panis Y, Ribeiro J, Chrétien Y and Nordlinger B: Dormant liver metastases: An experimental study. Br J Surg. 79:221–223. 1992. View Article : Google Scholar : PubMed/NCBI

13 

Hackl C, Neumann P, Gerken M, Loss M, Klinkhammer-Schalke M and Schlitt HJ: Treatment of colorectal liver metastases in Germany: A ten-year population-based analysis of 5772 cases of primary colorectal adenocarcinoma. BMC Cancer. 14:8102014. View Article : Google Scholar : PubMed/NCBI

14 

Liu J and Chen L: Current status and progress in gastric cancer with liver metastasis. Chin Med J (Engl). 124:445–456. 2011.

15 

Murakami Y, Satoi S, Sho M, Motoi F, Matsumoto I, Kawai M, Honda G, Uemura K, Yanagimoto H, Shinzeki M, et al: National comprehensive cancer network resectability status for pancreatic carcinoma predicts overall survival. World J Surg. 39:2306–2314. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Krenkel O and Tacke F: Liver macrophages in tissue homeostasis and disease. Nat Rev Immunol. 17:306–321. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, et al: Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species. Immunity. 45:669–684. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Nolan JP: The role of intestinal endotoxin in liver injury: A long and evolving history. Hepatology. 52:1829–1835. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Crispe IN: The liver as a lymphoid organ. Annu Rev Immunol. 27:147–163. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Jenne CN and Kubes P: Immune surveillance by the liver. Nat Immunol. 14:996–1006. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Davies LC, Jenkins SJ, Allen JE and Taylor PR: Tissue-resident macrophages. Nat Immunol. 14:986–995. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y and Zychlinsky A: Neutrophil extracellular traps kill bacteria. Science. 303:1532–1535. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Brinkmann V and Zychlinsky A: Neutrophil extracellular traps: Is immunity the second function of chromatin? J Cell Biol. 198:773–783. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Erpenbeck L and Schön MP: Neutrophil extracellular traps: Protagonists of cancer progression? Oncogene. 36:2483–2490. 2017. View Article : Google Scholar

25 

Chen R, Kang R, Fan XG and Tang D: Release and activity of histone in diseases. Cell Death Dis. 5:e13702014. View Article : Google Scholar : PubMed/NCBI

26 

Sakurai K, Miyashita T, Okazaki M, Yamaguchi T, Ohbatake Y, Nakanuma S, Okamoto K, Sakai S, Kinoshita J, Makino I, et al: Role for neutrophil extracellular traps (NETs) and platelet aggregation in early sepsis-induced hepatic dysfunction. In Vivo. 31:1051–1058. 2017.PubMed/NCBI

27 

Miyashita T, Ahmed AK, Nakanuma S, Okamoto K, Sakai S, Kinoshita J, Makino I, Nakamura K, Hayashi H, Oyama K, et al: A three-phase approach for the early identification of acute lung injury induced by severe sepsis. In Vivo. 30:341–349. 2016.PubMed/NCBI

28 

Placke T, Örgel M, Schaller M, Jung G, Rammensee HG, Kopp HG and Salih HR: Platelet-derived MHC class I confers a pseudonormal phenotype to cancer cells that subverts the anti-tumor reactivity of natural killer immune cells. Cancer Res. 72:440–448. 2012. View Article : Google Scholar

29 

Miyashita T, Tajima H, Makino I, Nakagawara H, Kitagawa H, Fushida S, Harmon JW and Ohta T: Metastasis-promoting role of extravasated platelet activation in tumor. J Surg Res. 193:289–94. 2015. View Article : Google Scholar

30 

Ishikawa S, Miyashita T, Inokuchi M, Hayashi H, Oyama K, Tajima H, Takamura H, Ninomiya I, Ahmed AK, Harman JW, et al: Platelets surrounding primary tumor cells are related to chemoresistance. Oncol Rep. 36:787–774. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Zhao S, Chen C, Chang K, Karnad A, Jagirdar J, Kumar AP and Freeman JW: CD44 expression level and isoform contributes to pancreatic cancer cell plasticity, invasiveness, and response to therapy. Clin Cancer Res. 15:5592–5604. 2016. View Article : Google Scholar

32 

Ohta T, Nakagawara H, Arakawa H, Futagami F, Tsukioka Y, Kitagawa H, Kayahara M, Nagakawa T and Miyazaki I: A new strategy for the therapy of pancreatic cancer invasion and metastasis by protease inhibitor and protein pump inhibitor agents. Jpn J Gastroenterol Surg. 29:888–892. 1996. View Article : Google Scholar

33 

Cools-Lartigue J, Spicer J, McDonald B, Gowing S, Chow S, Giannias B, Bourdeau F, Kubes P and Ferri L: Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. J Clin Invest. 123:3446–3458. 2013. View Article : Google Scholar

34 

Qiao Y, Li J, Shi C, Wang W, Qu X, Xiong M, Sun Y, Li D, Zhao X and Zhang D: Prognostic value of circulating tumor cells in the peripheral blood of patients with esophageal squamous cell carcinoma. Onco Targets Ther. 10:1363–1373. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Cohen SJ, Punt CJ, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, Picus J, Morse M, Mitchell E, Miller MC, et al: Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol. 26:3213–3221. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Groot Koerkamp B, Rahbari NN, Büchler MW, Koch M and Weitz J: Circulating tumor cells and prognosis of patients with resectable colorectal liver metastases or widespread meta-static colorectal cancer: A meta-analysis. Ann Surg Oncol. 20:2156–2165. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Rahbari NN, Aigner M, Thorlund K, Mollberg N, Motschall E, Jensen K, Diener MK, Büchler MW, Koch M and Weitz J: Meta-analysis shows that detection of circulating tumor cells indicates poor prognosis in patients with colorectal cancer. Gastroenterology. 138:1714–1726. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Negin BP and Cohen SJ: Circulating tumor cells in colorectal cancer: Past, present, and future challenges. Curr Treat Options Oncol. 11:1–13. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Dotan E, Alpaugh RK, Ruth K, Negin BP, Denlinger CS, Hall MJ, Astsaturov I, McAleer C, Fittipaldi P, Thrash-Bingham C, et al: Prognostic significance of MUC-1 in circulating tumor cells in patients with metastatic pancreatic adenocarcinoma. Pancreas. 45:1131–1135. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Kurihara T, Itoi T, Sofuni A, Itokawa F, Tsuchiya T, Tsuji S, Ishii K, Ikeuchi N, Tsuchida A, Kasuya K, et al: Detection of circulating tumor cells in patients with pancreatic cancer: A preliminary result. J Hepatobiliary Pancreat Surg. 15:189–195. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Tien YW, Kuo HC, Ho BI, Chang MC, Chang YT, Cheng MF, Chen HL, Liang TY, Wang CF, Huang CY, et al: A high circulating tumor cell count in portal vein predicts liver metastasis from periampullary or pancreatic cancer: A high portal venous CTC count predicts liver metastases. Medicine (Baltimore). 95:e34072016. View Article : Google Scholar

42 

Richardson JJR, Hendrickse C, Gao-Smith F and Thickett DR: Neutrophil extracellular trap production in patients with colorectal cancer in vitro. Int J Inflam. 2017:49150622017. View Article : Google Scholar : PubMed/NCBI

43 

Engelmann B and Massberg S: Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol. 13:34–45. 2013. View Article : Google Scholar

44 

Nakanuma S, Miyashita T, Hayashi H, Tajima H, Takamura H, Tsukada T, Okamoto K, Sakai S, Makino I, Kinoshita J, et al: Extravasated platelet aggregation in liver zone 3 may correlate with the progression of sinusoidal obstruction syndrome following living donor liver transplantation: A case report. Exp Ther Med. 9:1119–1124. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Miyashita T, Nakanuma S, Ahmed AK, Makino I, Hayashi H, Oyama K, Nakagawara H, Tajima H, Takamura H, Ninomiya I, et al: Ischemia reperfusion-facilitated sinusoidal endothelial cell injury in liver transplantation and the resulting impact of extravasated platelet aggregation. Eur Surg. 48:92–98. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Keysar SB and Jimeno A: More than markers: Biological significance of cancer stem cell-defining molecules. Mol Cancer Ther. 9:2450–2457. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Zoller M: CD44: Can a cancer-initiating cell profit from an abundantly expressed molecule? Nat Rev Cancer. 11:254–267. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Brabletz T: EMT and MET in metastasis: Where are the cancer stem cells? Cancer Cell. 22:699–701. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Alix-Panabières C, Mader S and Pantel K: Epithelial-mesenchymal plasticity in circulating tumor cells. J Mol Med (Berl). 95:133–142. 2017. View Article : Google Scholar

50 

Bourcy M, Suarez-Carmona M, Lambert J, Francart ME, Schroeder H, Delierneux C, Skrypek N, Thompson EW, Jérusalem G, Berx G, et al: Tissue factor induced by epithelial-mesenchymal transition triggers a procoagulant state that drives metastasis of circulating tumor cells. Cancer Res. 76:4270–4282. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Cortés-Hernández LE, Eslami-S Z and Alix-Panabières C: Circulating tumor cells as the functional aspect of liquid biopsy to understand the metastatic cascade in solid cancer. Mol Aspects Med. 72:1008162020. View Article : Google Scholar

52 

Aceto N, Toner M, Maheswaran S and Haber DA: En route to metastasis: Circulating tumor cell clusters and epithelial-to-mesenchymal transition. Trends Cancer. 1:44–52. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells MN, Shah AM, et al: Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science. 339:580–584. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Yu H, Ni YN, Liang ZA, Liang BM and Wang Y: The effect of aspirin in preventing the acute respiratory distress syndrome/acute lung injury: A meta-analysis. Am J Emerg Med. 36:1486–1491. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Boyle AJ, Di Gangi S, Hamid UI, Mottram LJ, McNamee L, White G, Cross LJ, McNamee JJ, O'Kane CM and McAuley DF: Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: A prospective analysis. Crit Care. 19:1092015. View Article : Google Scholar : PubMed/NCBI

56 

Rothwell PM, Wilson M, Price JF, Belch JF, Meade TW and Mehta Z: Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials. Lancet. 379:1591–1601. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Liao X, Lochhead P, Nishihara R, Morikawa T, Kuchiba A, Yamauchi M, Imamura Y, Qian ZR, Baba Y, Shima K, et al: Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med. 367:1596–1606. 2012. View Article : Google Scholar : PubMed/NCBI

58 

Sahasrabuddhe VV, Gunja MZ, Graubard BI, Trabert B, Schwartz LM, Park Y, Hollenbeck AR, Freedman ND and McGlynn KA: Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma. J Natl Cancer Inst. 104:1808–1814. 2012. View Article : Google Scholar : PubMed/NCBI

59 

Takada S, Miyashita T, Yamamoto Y, Kanou S, Munesue S, Ohbatake Y, Nakanuma S, Okamoto K, Sakai S, Kinoshita J, et al: Soluble thrombomodulin attenuates endothelial cell damage in hepatic sinusoidal obstruction syndrome. In Vivo. 32:1409–1417. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Okazaki M, Yamaguchi T, Tajima H, Fushida S and Ohta T: Platelet adherence to cancer cells promotes escape from innate immune surveillance in cancer metastasis. Int J Oncol 57: 980-988, 2020.
APA
Okazaki, M., Yamaguchi, T., Tajima, H., Fushida, S., & Ohta, T. (2020). Platelet adherence to cancer cells promotes escape from innate immune surveillance in cancer metastasis. International Journal of Oncology, 57, 980-988. https://doi.org/10.3892/ijo.2020.5102
MLA
Okazaki, M., Yamaguchi, T., Tajima, H., Fushida, S., Ohta, T."Platelet adherence to cancer cells promotes escape from innate immune surveillance in cancer metastasis". International Journal of Oncology 57.4 (2020): 980-988.
Chicago
Okazaki, M., Yamaguchi, T., Tajima, H., Fushida, S., Ohta, T."Platelet adherence to cancer cells promotes escape from innate immune surveillance in cancer metastasis". International Journal of Oncology 57, no. 4 (2020): 980-988. https://doi.org/10.3892/ijo.2020.5102
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Spandidos Publications style
Okazaki M, Yamaguchi T, Tajima H, Fushida S and Ohta T: Platelet adherence to cancer cells promotes escape from innate immune surveillance in cancer metastasis. Int J Oncol 57: 980-988, 2020.
APA
Okazaki, M., Yamaguchi, T., Tajima, H., Fushida, S., & Ohta, T. (2020). Platelet adherence to cancer cells promotes escape from innate immune surveillance in cancer metastasis. International Journal of Oncology, 57, 980-988. https://doi.org/10.3892/ijo.2020.5102
MLA
Okazaki, M., Yamaguchi, T., Tajima, H., Fushida, S., Ohta, T."Platelet adherence to cancer cells promotes escape from innate immune surveillance in cancer metastasis". International Journal of Oncology 57.4 (2020): 980-988.
Chicago
Okazaki, M., Yamaguchi, T., Tajima, H., Fushida, S., Ohta, T."Platelet adherence to cancer cells promotes escape from innate immune surveillance in cancer metastasis". International Journal of Oncology 57, no. 4 (2020): 980-988. https://doi.org/10.3892/ijo.2020.5102
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