|
1
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Herbst RS, Morgensztern D and Boshoff C:
The biology and management of non-small cell lung cancer. Nature.
553:446–454. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Allemani C, Matsuda T, Di Carlo V,
Harewood R, Matz M, Nikšić M, Bonaventure A, Valkov M, Johnson CJ,
Estève J, et al: Global surveillance of trends in cancer survival
2000-14 (CONCORD-3): Analysis of individual records for 37513025
patients diagnosed with one of 18 cancers from 322 population-based
registries in 71 countries. Lancet. 391:1023–1075. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Sharifi-Rad J, Ozleyen A, Boyunegmez TT,
Tumer T, Oluwaseun Adetunji C, El Omari N, Balahbib A, Taheri Y,
Bouyahya A, Martorell M, et al: Natural products and synthetic
analogs as a source of antitumor drugs. Biomolecules. 9:6792019.
View Article : Google Scholar :
|
|
5
|
Qian YY, Zhang H, Hou Y, Yuan L, Li GQ,
Guo SY, Hisamits T and Liu YQ: Celastrus orbiculatus extract
inhibits tumor angiogenesis by targeting vascular endothelial
growth factor signaling pathway and shows potent antitumor activity
in hepatocarcinomas in vitro and in vivo. Chin J Integr Med.
18:752–760. 2012. View Article : Google Scholar
|
|
6
|
Zhou GB, Kang H, Wang L, Gao L, Liu P, Xie
J, Zhang FX, Weng XQ, Shen ZX, Chen J, et al: Oridonin, a
diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion
protein and shows potent antitumor activity with low adverse
effects on t(8;21) leukemia in vitro and in vivo. Blood.
109:3441–3450. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Jang M, Cai L, Udeani GO, Slowing KV,
Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta
RG, et al: Cancer chemopreventive activity of resveratrol, a
natural product derived from grapes. Science. 275:218–220. 1997.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Hu YQ, Wang J and Wu JH: Administration of
resveratrol enhances cell-cycle arrest followed by apoptosis in
DMBA-induced skin carcinogenesis in male Wistar rats. Eur Rev Med
Pharmacol Sci. 20:2935–2946. 2016.PubMed/NCBI
|
|
9
|
Sun L, Chen B, Jiang R, Li J and Wang B:
Resveratrol inhibits lung cancer growth by suppressing M2-like
polarization of tumor associated macrophages. Cell Immunol.
311:86–93. 2017. View Article : Google Scholar
|
|
10
|
Hu C, Liu Y, Teng M, Jiao K, Zhen J, Wu M
and Li Z: Resveratrol inhibits the proliferation of estrogen
receptor-positive breast cancer cells by suppressing EZH2 through
the modulation of ERK1/2 signaling. Cell Biol Toxicol. 35:445–456.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
El-Readi MZ, Eid S, Abdelghany AA,
Al-Amoudi HS, Efferth T and Wink M: Resveratrol mediated cancer
cell apoptosis, and modulation of multidrug resistance proteins and
metabolic enzymes. Phytomedicine. 55:269–281. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Pistritto G, Trisciuoglio D, Ceci C,
Garufi A and D'Orazi G: Apoptosis as anticancer mechanism: Function
and dysfunction of its modulators and targeted therapeutic
strategies. Aging (Albany NY). 8:603–619. 2016. View Article : Google Scholar
|
|
13
|
Liu G, Pei F, Yang F, Li L, Amin AD, Liu
S, Buchan JR and Cho WC: Role of autophagy and apoptosis in
non-small-cell lung cancer. Int J Mol Sci. 18:3672017. View Article : Google Scholar :
|
|
14
|
Yen CM, Tsai CW, Chang WS, Yang YC, Hung
YW, Lee HT, Shen CC, Sheu ML, Wang JY, Gong CL, et al: Novel
combi-nation of arsenic trioxide (As2O3) plus resveratrol in
inducing programmed cell death of human Neuroblastoma SK-N-SH
cells. Cancer Genomics Proteomics. 15:453–460. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Zhang W, Wang X and Chen T: Resveratrol
induces apoptosis via a Bak-mediated intrinsic pathway in human
lung adenocarcinoma cells. Cell Signal. 24:1037–1046. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Liu Y, Tong L, Luo Y, Li X, Chen G and
Wang Y: Resveratrol inhibits the proliferation and induces the
apoptosis in ovarian cancer cells via inhibiting glycolysis and
targeting AMPK/mTOR signaling pathway. J Cell Biochem.
119:6162–6172. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Park D, Jeong H, Lee MN, Koh A, Kwon O,
Yang YR, Noh J, Suh PG, Park H and Ryu SH: Resveratrol induces
autophagy by directly inhibiting mTOR through ATP competition. Sci
Rep. 6:217722016. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Chang CH, Lee CY, Lu CC, Tsai FJ, Hsu YM,
Tsao JW, Juan YN, Chiu HY, Yang JS and Wang CC: Resveratrol-induced
autophagy and apoptosis in cisplatin-resistant human oral cancer
CAR cells: A key role of AMPK and Akt/mTOR signaling. Int J Oncol.
50:873–882. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Wang J, Li J, Cao N, Li Z, Han J and Li L:
Resveratrol, an activator of SIRT1, induces protective autophagy in
non-small-cell lung cancer via inhibiting Akt/mTOR and activating
p38-MAPK. Onco Targets Ther. 11:7777–7786. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Dasari SK, Bialik S, Levin-Zaidman S,
Levin-Salomon V, Merrill AH Jr, Futerman AH and Kimchi A:
Signalome-wide RNAi screen identifies GBA1 as a positive mediator
of autophagic cell death. Cell Death Differ. 24:1288–1302. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Zhang B, Yin X and Sui S: Resveratrol
inhibited the progression of human hepatocellular carcinoma by
inducing autophagy via regulating p53 and the phosphoinositide
3kinase/protein kinase B pathway. Oncol Rep. 40:2758–2765.
2018.PubMed/NCBI
|
|
22
|
Lin YT, Wang HC, Hsu YC, Cho CL, Yang MY
and Chien CY: Capsaicin induces autophagy and apoptosis in human
nasopharyngeal carcinoma cells by downregulating the PI3K/AKT/mTOR
pathway. Int J Mol Sci. 18:13432017. View Article : Google Scholar :
|
|
23
|
Wen Z, Zhang J, Tang P, Tu N, Wang K and
Wu G: Overexpression of miR185 inhibits autophagy and apoptosis of
dopaminergic neurons by regulating the AMPK/mTOR signaling pathway
in Parkinson's disease. Mol Med Rep. 17:131–137. 2018.
|
|
24
|
Son Y, An Y, Jung J, Shin S, Park I, Gwak
J, Ju BG, Chung YH, Na M and Oh S: Protopine isolated from Nandina
domestica induces apoptosis and autophagy in colon cancer cells by
stabilizing p53. Phytother Res. 33:1689–1696. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Zhang J, Sun M, Hao M, Diao K, Wang J, Li
S, Cao Q and Mi X: FAM53A affects breast cancer cell proliferation,
migration, and invasion in a p53-dependent manner. Front Oncol.
9:12442019. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Wang P, Zhang SD, Jiao J, Wang W, Yu L,
Zhao XL, Wang LT, Meng D and Fu YJ: ROS-mediated p53 activation by
Juglone enhances apoptosis and autophagy in vivo and in vitro.
Toxicol Appl Pharmacol. 379:1146472019. View Article : Google Scholar
|
|
27
|
Meng J, Li Y, Zhang M, Li W, Zhou L, Wang
Q, Lin L, Jiang L and Zhu W: A combination of curcumin, vorinostat
and silibinin reverses Aβ-induced nerve cell toxicity via
activation of AKT-MDM2-p53 pathway. PeerJ. 7:e67162019. View Article : Google Scholar
|
|
28
|
Xu W, Gao L, Li T, Zheng J, Shao A and
Zhang J: Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF)
protects against neuronal apoptosis via activation of Akt/MDM2/p53
signaling pathway in a rat model of intracerebral hemorrhage. Front
Mol Neurosci. 11:1762018. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Ritchie ME, Phipson B, Wu D, Hu Y, Law CW,
Shi W and Smyth GK: Limma powers differential expression analyses
for RNA-sequencing and microarray studies. Nucleic Acids Res.
43:e472015. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
The Gene Ontology Consortium: The gene
ontology resource: 20 years and still Going strong. Nucleic Acids
Res. 47:D330–D338. 2019. View Article : Google Scholar :
|
|
31
|
Ashburner M, Ball CA, Blake JA, Botstein
D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT,
et al: Gene ontology: Tool for the unification of biology. The Gene
Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Kanehisa M: Post-genome informatics.
Oxford University Press; Oxford; 2000
|
|
33
|
Huang DW, Sherman BT and Lempicki RA:
Systematic and integrative analysis of large gene lists using DAVID
bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar
|
|
34
|
Huang DW, Sherman BT and Lempicki RA:
Bioinformatics enrichment tools: Paths toward the comprehensive
functional analysis of large gene lists. Nucleic Acids Res.
37:1–13. 2009. View Article : Google Scholar :
|
|
35
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
36
|
Whyte L, Huang YY, Torres K and Mehta RG:
Molecular mechanisms of resveratrol action in lung cancer cells
using dual protein and microarray analyses. Cancer Res.
67:12007–12017. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Liu F, Gao S, Yang Y, Zhao X, Fan Y, Ma W,
Yang D, Yang A and Yu Y: Curcumin induced autophagy anticancer
effects on human lung adenocarcinoma cell line A549. Oncol Lett.
14:2775–2782. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Liu F, Gao S, Yang Y, Zhao X, Fan Y, Ma W,
Yang D, Yang A and Yu Y: Antitumor activity of curcumin by
modulation of apoptosis and autophagy in human lung cancer A549
cells through inhibiting PI3K/Akt/mTOR pathway. Oncol Rep.
39:1523–1531. 2018.PubMed/NCBI
|
|
39
|
Eskelinen EL, Reggiori F, Baba M, Kovacs
AL and Seglen PO: Seeing is believing: The impact of electron
microscopy on autophagy research. Autophagy. 7:935–956. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Cristofani R, Montagnani Marelli M,
Cicardi ME, Fontana F, Marzagalli M, Limonta P, Poletti A and
Moretti RM: Dual role of autophagy on docetaxel-sensitivity in
prostate cancer cells. Cell Death Dis. 9:8892018. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Liu D, Yang Y, Liu Q and Wang J:
Inhibition of autophagy by 3-MA potentiates cisplatin-induced
apoptosis in esophageal squamous cell carcinoma cells. Med Oncol.
28:105–111. 2011. View Article : Google Scholar
|
|
42
|
Zhang J, Chiu J, Zhang H, Qi T, Tang Q, Ma
K, Lu H and Li G: Autophagic cell death induced by resveratrol
depends on the Ca(2+)/AMPK/mTOR pathway in A549 cells. Biochem
Pharmacol. 86:317–328. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Li X, Wang D, Zhao QC, Shi T and Chen J:
Resveratrol inhibited Non-small cell lung cancer through inhibiting
STAT-3 signaling. Am J Med Sci. 352:524–530. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Wang H, Zhang H, Tang L, Chen H, Wu C,
Zhao M, Yang Y, Chen X and Liu G: Resveratrol inhibits
TGF-β1-induced epithelial-to-mesenchymal transition and suppresses
lung cancer invasion and metastasis. Toxicology. 303:139–146. 2013.
View Article : Google Scholar
|
|
45
|
Czarnomysy R, Bielawska A and Bielawski K:
Effect of 2nd and 3rd generation PAMAM dendrimers on proliferation,
differentiation, and pro-inflammatory cytokines in human
keratinocytes and fibroblasts. Int J Nanomedicine. 14:7123–7139.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Yuan X, Nie W, He Z, Yang J, Shao B, Ma X,
Zhang X, Bi Z, Sun L, Liang X, et al: Carbon black nanoparticles
induce cell necrosis through lysosomal membrane permeabilization
and cause subsequent inflammatory response. Theranostics.
10:4589–4605. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Gao J, Zhao Y, Wang C, Ji H, Yu J, Liu C
and Liu A: A novel synthetic chitosan selenate (CS) induces
apoptosis in A549 lung cancer cells via the Fas/FasL pathway. Int J
Biol Macromol. 158:689–697. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Chen S, Cheng AC, Wang MS and Peng X:
Detection of apoptosis induced by new type gosling viral enteritis
virus in vitro through fluorescein Annexin V-FITC/PI double
labeling. World J Gastroenterol. 14:2174–2178. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Feng J, Feng T, Yang C, Wang W, Sa Y and
Feng Y: Feasibility study of stain-free classification of cell
apoptosis based on diffraction imaging flow cytometry and
supervised machine learning techniques. Apoptosis. 23:290–298.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Deng S, Shanmugam MK, Kumar AP, Yap CT,
Sethi G and Bishayee A: Targeting autophagy using natural compounds
for cancer prevention and therapy. Cancer Am Cancer Soc.
125:1228–1246. 2019.
|
|
51
|
Klionsky DJ and Emr SD: Autophagy as a
regulated pathway of cellular degradation. Science. 290:1717–1721.
2000. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Ravikumar B, Moreau K, Jahreiss L, Puri C
and Rubinsztein DC: Plasma membrane contributes to the formation of
pre-autophagosomal structures. Nat Cell Biol. 12:747–757. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Puissant A and Auberger P: AMPK- and
p62/SQSTM1-dependent autophagy mediate resveratrol-induced cell
death in chronic myelogenous leukemia. Autophagy. 6:655–657. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Wang M, Yu T, Zhu C, Sun H, Qiu Y, Zhu X
and Li J: Resveratrol triggers protective autophagy through the
ceramide/Akt/mTOR pathway in melanoma B16 cells. Nutr Cancer.
66:435–440. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Puissant A, Robert G, Fenouille N, Luciano
F, Cassuto JP, Raynaud S and Auberger P: Resveratrol promotes
autophagic cell death in chronic myelogenous leukemia cells via
JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res.
70:1042–1052. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Zheng Y, Tu J, Wang X, Yu Y, Li J, Jin Y
and Wu J: The therapeutic effect of melatonin on GC by inducing
cell apoptosis and autophagy induced by endoplasmic reticulum
stress. Onco Targets Ther. 12:10187–10198. 2019. View Article : Google Scholar
|
|
57
|
Xiang M, Jiang HG, Shu Y, Chen YJ, Jin J,
Zhu YM, Li MY, Wu JN and Li J: Bisdemethoxycurcumin enhances the
sensitivity of Non-small cell lung cancer cells to Icotinib via
dual induction of autophagy and apoptosis. Int J Biol Sci.
16:1536–1550. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Shin D, Kim EH, Lee J and Roh JL: RITA
plus 3-MA overcomes chemoresistance of head and neck cancer cells
via dual inhibition of autophagy and antioxidant systems. Redox
Biol. 13:219–227. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Bao Y, Ding Z, Zhao P, Li J, Chen P, Zheng
J and Qian Z: Autophagy inhibition potentiates the anti-EMT effects
of alteronol through TGF-beta/Smad3 signaling in melanoma cells.
Cell Death Dis. 11:2232020. View Article : Google Scholar
|
|
60
|
Zeng R, He J, Peng J, Chen Y, Yi S, Zhao F
and Cui G: The time-dependent autophagy protects against apoptosis
with possible involvement of Sirt1 protein in multiple myeloma
under nutrient depletion. Ann Hematol. 91:407–417. 2012. View Article : Google Scholar
|
|
61
|
Zhi L, Song D, Ma L and Feng T:
Soyasapogenol B attenuates laryngeal carcinoma progression through
inducing apoptotic and autophagic cell death. Anat Rec (Hoboken).
303:1851–1858. 2020. View Article : Google Scholar
|
|
62
|
Park BS, Choi NE, Lee JH, Kang HM, Yu SB,
Kim HJ, Kang HK and Kim IR: Crosstalk between Fisetin-induced
apoptosis and autophagy in human oral squamous cell carcinoma. J
Cancer. 10:138–146. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Zhou J, An X, Dong J, Wang Y, Zhong H,
Duan L, Ling J, Ping F and Shang J: IL-17 induces cellular stress
microenvironment of melanocytes to promote autophagic cell
apoptosis in vitiligo. FASEB J. 32:4899–4916. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Tang ZH, Chen X, Wang ZY, Chai K, Wang YF,
Xu XH, Wang XW, Lu JH, Wang YT, Chen XP and Lu JJ: Induction of
C/EBP homologous protein-mediated apoptosis and autophagy by
licochalcone A in non-small cell lung cancer cells. Sci Rep.
6:262412016. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Liu S, Lin H, Wang D, Li Q, Luo H, Li G,
Chen X, Li Y, Chen P, Zhai B, et al: PCDH17 increases the
sensitivity of colorectal cancer to 5-fluorouracil treatment by
inducing apoptosis and autophagic cell death. Signal Transduct
Target Ther. 4:532019. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Ogawara Y, Kishishita S, Obata T, Isazawa
Y, Suzuki T, Tanaka K, Masuyama N and Gotoh Y: Akt enhances
Mdm2-mediated ubiquitination and degradation of p53. J Biol Chem.
277:21843–21850. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Zhu Y, He W, Gao X, Li B, Mei C, Xu R and
Chen H: Resveratrol overcomes gefitinib resistance by increasing
the intracellular gefitinib concentration and triggering apoptosis,
autophagy and senescence in PC9/G NSCLC cells. Sci Rep.
5:177302015. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Luo H, Yang A, Schulte BA, Wargovich MJ
and Wang GY: Resveratrol induces premature senescence in lung
cancer cells via ROS-mediated DNA damage. PLoS One. 8:e600652013.
View Article : Google Scholar : PubMed/NCBI
|
