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Article

Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells

  • Authors:
    • Shin Kan
    • Tsuuse Bito
    • Masamori Shimabuku
    • Junichi Taguchi
    • Toshifumi  Ohkusa
    • Shigetaka Shimodaira
    • Haruo Sugiyama
    • Shigeo Koido
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Chiba 277‑8567, Japan, Tokyo Midtown Center for Advanced Medical Science and Technology, Tokyo 107‑6206, Japan, Department of Regenerative Medicine, Kanazawa Medical University, Ishikawa 920‑0293, Japan, Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan
  • Pages: 1047-1056
    |
    Published online on: August 14, 2020
       https://doi.org/10.3892/ijo.2020.5110
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Abstract

The proliferation and activation of CD4+ T helper 1 (Th1) cells and CD8+ cytotoxic T lymphocytes (CTLs) that produce interferon‑γ (IFN‑γ) is an essential action of effective cancer vaccines. Recently, a novel Wilms' tumor 1 (WT1) helper peptide (WT1 HP34‑51; amino acid sequence, WAPVLDFAPPGASAYGSL) applicable for various human leukocyte antigen (HLA) subtypes (HLA‑DR, HLA‑DP and HLA‑DQ) was reported to increase peptide immunogenicity; however, the function of WT1 HP34‑51 remains unclear. In the present study, mature dendritic cells (mDCs) pulsed with WT1 HP34‑51 (mDC/WT1 HP34‑51) activated not only WT1‑specific CD4+ T cells but also CD8+ T cells that produced IFN‑γ following stimulation with immature dendritic cells (imDCs) pulsed with WT1 killer peptide (imDC/WT1 KP37‑45) in an HLA‑A*02:01‑ or HLA‑A*02:06‑restricted manner. Furthermore, the activated WT1‑reactive CD4+ Th1 cells were predominantly effector memory (EM) T cells. In 5 of 12 (41.7%) patients with cancer carrying the HLA‑A*02:01 or HLA‑A*02:06 allele, WT1‑reactive CD8+ T cells stimulated with mDC/WT1 HP34‑51 enhanced their levels of WT1 KP37‑45‑specific IFN‑γ production, with an increase >10%. Simultaneous activation of CD4+ and CD8+ T cells occurred more often when stimulation with mDC/WT1 HP34‑51 was combined with imDC/WT1 KP37‑45 restimulation. These results indicated that the novel mDC/WT1 HP34‑51 combination induced responses by WT1‑specific EM CD4+ Th1 cells and HLA‑A*02:01‑ or HLA‑A*02:06‑restricted CD8+ CTLs, suggesting its potential as a WT1‑targeting cancer vaccine.
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1 

Steinman RM and Banchereau J: Taking dendritic cells into medicine. Nature. 449:419–426. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Baldin AV, Savvateeva LV, Bazhin AV and Zamyatnin AA Jr: Dendritic cells in anticancer vaccination: Rationale for ex vivo loading or in vivo targeting. Cancers (Basel). 12:5902020. View Article : Google Scholar

3 

Rosenberg SA, Yang JC and Restifo NP: Cancer immunotherapy: Moving beyond current vaccines. Nat Med. 10:909–915. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Koido S, Homma S, Okamoto M, Takakura K, Mori M, Yoshizaki S, Tsukinaga S, Odahara S, Koyama S, Imazu H, et al: Treatment with chemotherapy and dendritic cells pulsed with multiple Wilms' tumor 1 (WT1)-specific MHC class I/II-restricted epitopes for pancreatic cancer. Clin Cancer Res. 20:4228–4239. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Melseen M and Slingluff CL Jr: Vaccines targeting helper T cells for cancer immunotherapy. Curr Opin Immunol. 47:85–92. 2017. View Article : Google Scholar

6 

Taniuchi I: CD4 helper and CD8 cytotoxic T cell differentiation. Annu Rev Immunol. 36:579–601. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Fujiki F, Oka Y, Kawakatsu M, Tsuboi A, Nakajima H, Elisseeva OA, Harada Y, Li Z, Tatsumi N, Kamino E, et al: A WT1 protein-derived, naturally processed 16-mer peptide, WT1(332), is a promiscuous helper peptide for induction of WT1-specificTh1-type CD4(+) T cells. Microbiol Immunol. 52:591–600. 2008. View Article : Google Scholar

8 

Koski GK, Koldovsky U, Xu S, Mick R, Sharma A, Fitzpatrick E, Weinstein S, Nisenbaum H, Levine BL, Fox K, et al: A novel dendritic cell-based immunization approach for the induction of durable Th1-polarized anti-HER-2/neu responses in women with early breast cancer. J Immunother. 35:54–65. 2012. View Article : Google Scholar

9 

Sharma A, Koldovsky U, Xu S, Mick R, Roses R, Fitzpatrick E, Weinstein S, Nisenbaum H, Levine BL, Fox K, et al: HER-2 pulsed dendritic cell vaccine can eliminate HER-2 expression and impact ductal carcinoma in situ. Cancer. 118:4354–4362. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Aarntzen EH, De Vries IJ, Lesterhuis WJ, Schuurhuis D, Jacobs JF, Bol K, Schreibelt G, Mus R, De Wilt JH, Haanen JB, et al: Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination. Cancer Res. 73:19–29. 2013. View Article : Google Scholar

11 

Chever MA, Allison JP, Ferris AS, Finn OJ, Hastings BM, Hecht TT, Mellman I, Prindiville SA, Viner JL, Weiner LM, et al: The prioritization of cancer antigens: A national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res. 15:5323–5337. 2009. View Article : Google Scholar

12 

Huff V: Wilms' tumours: About tumour suppressor genes, an oncogene and a chameleon gene. Nat Rev Cancer. 11:111–121. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Oka Y, Tsuboi A, Taguchi T, Osaki T, Kyo T, Nakajima H, Elisseeva OA, Oji Y, Kawakami M, Ikegame K, et al: Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccinean the resultant cancer regression. Proc Natl Acad Sci USA. 101:13885–13890. 2004. View Article : Google Scholar

14 

Takahara A, Koido S, Ito M, Nagasaki E, Sagawa Y, Iwamoto T, Komita H, Ochi T, Fujiwara H, Yasukawa M, et al: Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response. Cancer Immunol Immunother. 60:1289–1297. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Krug LM, Dao T, Brown AB, Maslak P, Travis W, Bekele S, Korontsvit T, Zakhaleva V, Wolchok J, Yuan J, et al: WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesothelioma and non-small cell lung cancer. Cancer Immunol Immunother. 59:1467–1479. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Keilholz U, Menssen HD, Gaiger A, Menke A, Oji Y, Oka Y, Scheibenbogen C, Stauss H, Thiel E and Sugiyama H: Wilms' tumour gene 1 (WT1) in human neoplasia. Leukemia. 19:1318–1323. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Nakata J, Nakajima H, Hayashibara H, Imafuku K, Morimoto S, Fujiki F, Motooka D, Okuzaki D, Hasegawa K, Hosen N, et al: Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides. Oncotarget. 9:36029–36038. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Schmied S, Gostick E, Price DA, Abken H, Assenmacher M and Richter A: Analysis of the functional WT1-specific T cell repertoire in healthy donors reveals a discrepancy between CD4(+) and CD8(+) memory formation. Immunology. 145:558–569. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Hori S, Heike Y, Takei M, Maruyama M, Inoue Y, Lee JJ, Kim HJ, Harada Y, Kawai H, Shimosaka A, et al: Freeze-thawing procedures have no influence on the phenotypic and functional development of dendritic cells generated from peripheral blood CD14+ monocytes. J Immunother. 27:27–35. 2004. View Article : Google Scholar

20 

Goto M, Nakamura M, Suginobe N, Takasu H, Takanashi Y, Ban H and Li C: DSP-7888, a novel cocktail design of WT1 peptide vaccine, and its combinational immunotherapy with immune checkpoint-blocking antibody against PD-1. Blood. 128:4715. 2016. View Article : Google Scholar

21 

Miyakoshi S, Usuki K, Matsumura I, Ueda Y, Iwasaki H, Miyamoto T, Origuchi M, Tagashira S, Naoi I, Naoe T, et al: Preliminary results from a phase 1/2 study of DSP-7888, a novel WT1 peptide-based vaccine in patients with myelodysplastic syndrome (MDS). Blood. 128:4335. 2016. View Article : Google Scholar

22 

Rosalia RA, Quakkelaar ED, Redeker A, Khan S, Camps M, Drijfhout JW, Silva AL, Jiskoot W, van Hall T, van Veelen PA, et al: Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation. Eur J Immunol. 43:2554–2565. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Maiers M, Graget L and Klitz W: High-resolution HLA alleles and haplotypes in the United States population. Hum Immunol. 68:779–788. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Mintern JD, Davey GM, Belz GT, Carbone FR and Heath WR: Cutting edge: Precursor frequency affects the helper dependence of cytotoxic T cells. J Immunol. 168:977–980. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Lanzavecchia A and Sallusto F: Dynamics of T lymphocyte responses: Intermediates, effectors, and memory cells. Science. 290:92–97. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Wedén S, Klemp M, Gladhaug IP, Møller M, Eriksen JA, Gaudernack G and Buanes T: Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras. Int J Cancer. 128:1120–1128. 2011. View Article : Google Scholar

27 

Nishida S, Koido S, Takeda Y, Homma S, Komita H, Takahara A, Morita S, Ito T, Morimoto S, Hara K, et al: Wilms tumor gene (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer. J Immunother. 37:105–114. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Lesterhuis WJ, de Vries IJ, Schuurhuis DH, Boullart AC, Jacobs JF, de Boer AJ, Scharenborg NM, Brouwer HM, van de Rakt MW, Figdor CG, et al: Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: Antigen-specific T cell responses in DTH skin tests. Ann Oncol. 17:974–980. 2006. View Article : Google Scholar : PubMed/NCBI

29 

MacLeod MK, Clambey ET, Kappler JW and Marrack P: CD4 memory T cells: What are they and what can they do? Semin Immunol. 21:53–61. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Krawczyk CM, Shen H and Pearce EJ: Memory CD4 T cells enhance primary CD8 T-cell responses. Infect Immun. 75:3556–3560. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kan S, Bito T, Shimabuku M, Taguchi J, Ohkusa T, Shimodaira S, Sugiyama H and Koido S: Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells. Int J Oncol 57: 1047-1056, 2020.
APA
Kan, S., Bito, T., Shimabuku, M., Taguchi, J., Ohkusa, T., Shimodaira, S. ... Koido, S. (2020). Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells. International Journal of Oncology, 57, 1047-1056. https://doi.org/10.3892/ijo.2020.5110
MLA
Kan, S., Bito, T., Shimabuku, M., Taguchi, J., Ohkusa, T., Shimodaira, S., Sugiyama, H., Koido, S."Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells". International Journal of Oncology 57.4 (2020): 1047-1056.
Chicago
Kan, S., Bito, T., Shimabuku, M., Taguchi, J., Ohkusa, T., Shimodaira, S., Sugiyama, H., Koido, S."Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells". International Journal of Oncology 57, no. 4 (2020): 1047-1056. https://doi.org/10.3892/ijo.2020.5110
Copy and paste a formatted citation
x
Spandidos Publications style
Kan S, Bito T, Shimabuku M, Taguchi J, Ohkusa T, Shimodaira S, Sugiyama H and Koido S: Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells. Int J Oncol 57: 1047-1056, 2020.
APA
Kan, S., Bito, T., Shimabuku, M., Taguchi, J., Ohkusa, T., Shimodaira, S. ... Koido, S. (2020). Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells. International Journal of Oncology, 57, 1047-1056. https://doi.org/10.3892/ijo.2020.5110
MLA
Kan, S., Bito, T., Shimabuku, M., Taguchi, J., Ohkusa, T., Shimodaira, S., Sugiyama, H., Koido, S."Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells". International Journal of Oncology 57.4 (2020): 1047-1056.
Chicago
Kan, S., Bito, T., Shimabuku, M., Taguchi, J., Ohkusa, T., Shimodaira, S., Sugiyama, H., Koido, S."Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells". International Journal of Oncology 57, no. 4 (2020): 1047-1056. https://doi.org/10.3892/ijo.2020.5110
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