Role of extracellular vesicles in the progression, diagnosis and treatment of thyroid cancer (Review)

  • Authors:
    • Ying Lu
    • Ning Lan
    • Yigan Zhang
    • Xin Nie
    • Shuangshuang Pu
    • Wenzhen Yuan
  • View Affiliations

  • Published online on: August 14, 2020     https://doi.org/10.3892/ijo.2020.5111
  • Pages: 881-889
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Abstract

Extracellular vesicles (EVs) enclose a myriad of proteins and nucleic acids that are released in the extracellular milieu of cells through EVs. These secreted molecules serve as signaling factors that can alter the biological characteristics of tumor cells. Several studies have suggested that EVs are associated with tumor proliferation, metastasis and microenvironmental regulation in thyroid carcinoma (TC). The biomolecules in EVs can serve as differential diagnostic biomarkers for TC. Moreover, EVs derived from natural killer (NK) cells can be developed as potential immunotherapeutic agents, since they can actively target and kill tumor cells in TC. Recent years have witnessed a steep rise in the number of TC cases, and thus, accurate diagnosis and novel TC treatment strategies are being actively explored. The present review discusses the recent research investigations on EVs as far as the biological, clinical diagnosis and treatment of primary TC tumors are concerned. In addition, the new opportunities and challenges encountered in the practical applications of EVs in thyroid carcinoma are outlined.
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October-2020
Volume 57 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Lu Y, Lan N, Zhang Y, Nie X, Pu S and Yuan W: Role of extracellular vesicles in the progression, diagnosis and treatment of thyroid cancer (Review). Int J Oncol 57: 881-889, 2020
APA
Lu, Y., Lan, N., Zhang, Y., Nie, X., Pu, S., & Yuan, W. (2020). Role of extracellular vesicles in the progression, diagnosis and treatment of thyroid cancer (Review). International Journal of Oncology, 57, 881-889. https://doi.org/10.3892/ijo.2020.5111
MLA
Lu, Y., Lan, N., Zhang, Y., Nie, X., Pu, S., Yuan, W."Role of extracellular vesicles in the progression, diagnosis and treatment of thyroid cancer (Review)". International Journal of Oncology 57.4 (2020): 881-889.
Chicago
Lu, Y., Lan, N., Zhang, Y., Nie, X., Pu, S., Yuan, W."Role of extracellular vesicles in the progression, diagnosis and treatment of thyroid cancer (Review)". International Journal of Oncology 57, no. 4 (2020): 881-889. https://doi.org/10.3892/ijo.2020.5111