Open Access

Polycomb repressor complex 2 function in breast cancer (Review)

  • Authors:
    • Courtney J. Martin
    • Roger A. Moorehead
  • View Affiliations

  • Published online on: September 17, 2020     https://doi.org/10.3892/ijo.2020.5122
  • Pages: 1085-1094
  • Copyright: © Martin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epigenetic modifications are important contributors to the regulation of genes within the chromatin. The polycomb repressive complex 2 (PRC2) is a multi‑subunit protein complex that is involved in silencing gene expression through the trimethylation of lysine 27 at histone 3 (H3K27me3). The dysregulation of this modification has been associated with tumorigenicity through the increased repression of tumour suppressor genes via condensing DNA to reduce access to the transcription start site (TSS) within tumor suppressor gene promoters. In the present review, the core proteins of PRC2, as well as key accessory proteins, will be described. In addition, mechanisms controlling the recruitment of the PRC2 complex to H3K27 will be outlined. Finally, literature identifying the role of PRC2 in breast cancer proliferation, apoptosis and migration, including the potential roles of long non‑coding RNAs and the miR‑200 family will be summarized as will the potential use of the PRC2 complex as a therapeutic target.
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November-2020
Volume 57 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Martin CJ and Martin CJ: Polycomb repressor complex 2 function in breast cancer (Review). Int J Oncol 57: 1085-1094, 2020
APA
Martin, C.J., & Martin, C.J. (2020). Polycomb repressor complex 2 function in breast cancer (Review). International Journal of Oncology, 57, 1085-1094. https://doi.org/10.3892/ijo.2020.5122
MLA
Martin, C. J., Moorehead, R. A."Polycomb repressor complex 2 function in breast cancer (Review)". International Journal of Oncology 57.5 (2020): 1085-1094.
Chicago
Martin, C. J., Moorehead, R. A."Polycomb repressor complex 2 function in breast cancer (Review)". International Journal of Oncology 57, no. 5 (2020): 1085-1094. https://doi.org/10.3892/ijo.2020.5122