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Article

Development and validation of a multivariable risk prediction model for head and neck cancer using the UK Biobank

  • Authors:
    • Caroline Elizabeth Mccarthy
    • Laura Jayne Bonnet
    • Michael Williams Marcus
    • John K. Field
  • View Affiliations / Copyright

    Affiliations: Department of Oral Medicine, Liverpool University Dental Hospital, Pembroke Place, Liverpool, Merseyside L3 5PS, UK, Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, Merseyside L69 3GL, UK, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, Merseyside L7 8TX, UK
  • Pages: 1192-1202
    |
    Published online on: September 22, 2020
       https://doi.org/10.3892/ijo.2020.5123
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Abstract

Head and neck cancer (HNC) is the eighth most common cancer in the UK, with over 12,000 new cases every year. The incidence of HNC is predicted to increase by 33% by 2035. Risk modelling produces personalised risk estimates for specific diseases, which can be used to inform education, screening programmes and recruitment to clinical trials. The present study describes the development and validation of the first risk prediction model for absolute risk of HNC, using a nested case‑control study within the UK Biobank dataset. The UK Biobank recruited 502,647 individuals aged 40‑69 years from around the UK. In total, 859 cases of HNC were identified, with 253 incident cases (individuals who developed HNC in the 7 years following recruitment to the UK Biobank study). Logistic regression was used to develop the model, then the model performance was validated using a cohort from the North West of England. Overall, increasing age, male sex, positive history of smoking and alcohol consumption and higher levels of material deprivation were significantly associated with a higher risk of HNC. Consuming at least five portions of fruit and vegetables per day, exercising at least once per week and higher BMI offered a protective effect against HNC. The C‑statistic was 0.69 [95% confidence interval (CI), 0.66‑0.71] and the model displayed good calibration. Upon external validation, the C‑statistic was 0.64 (95% CI, 0.60‑0.68) with reasonable calibration. The model developed and validated in the present study allows calculation of a personalised risk estimate for HNC. This could be used to guide clinicians when counselling individuals on risk behaviour, and there is potential for such models to inform recruitment to screening trials.
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Copy and paste a formatted citation
Spandidos Publications style
Mccarthy CE, Bonnet LJ, Marcus MW and Field JK: Development and validation of a multivariable risk prediction model for head and neck cancer using the UK Biobank. Int J Oncol 57: 1192-1202, 2020.
APA
Mccarthy, C.E., Bonnet, L.J., Marcus, M.W., & Field, J.K. (2020). Development and validation of a multivariable risk prediction model for head and neck cancer using the UK Biobank. International Journal of Oncology, 57, 1192-1202. https://doi.org/10.3892/ijo.2020.5123
MLA
Mccarthy, C. E., Bonnet, L. J., Marcus, M. W., Field, J. K."Development and validation of a multivariable risk prediction model for head and neck cancer using the UK Biobank". International Journal of Oncology 57.5 (2020): 1192-1202.
Chicago
Mccarthy, C. E., Bonnet, L. J., Marcus, M. W., Field, J. K."Development and validation of a multivariable risk prediction model for head and neck cancer using the UK Biobank". International Journal of Oncology 57, no. 5 (2020): 1192-1202. https://doi.org/10.3892/ijo.2020.5123
Copy and paste a formatted citation
x
Spandidos Publications style
Mccarthy CE, Bonnet LJ, Marcus MW and Field JK: Development and validation of a multivariable risk prediction model for head and neck cancer using the UK Biobank. Int J Oncol 57: 1192-1202, 2020.
APA
Mccarthy, C.E., Bonnet, L.J., Marcus, M.W., & Field, J.K. (2020). Development and validation of a multivariable risk prediction model for head and neck cancer using the UK Biobank. International Journal of Oncology, 57, 1192-1202. https://doi.org/10.3892/ijo.2020.5123
MLA
Mccarthy, C. E., Bonnet, L. J., Marcus, M. W., Field, J. K."Development and validation of a multivariable risk prediction model for head and neck cancer using the UK Biobank". International Journal of Oncology 57.5 (2020): 1192-1202.
Chicago
Mccarthy, C. E., Bonnet, L. J., Marcus, M. W., Field, J. K."Development and validation of a multivariable risk prediction model for head and neck cancer using the UK Biobank". International Journal of Oncology 57, no. 5 (2020): 1192-1202. https://doi.org/10.3892/ijo.2020.5123
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