[Corrigendum] Mutation of TGF‑β receptor II facilitates human bladder cancer progression through altered TGF‑β1 signaling pathway

Bian,Jing; Li,Bo; Zeng,Xiaoyong; Hu,Heyu; Hong,Yi; Ouyang,Hui; Zhang,Xiaoxue; Wang,Zhihua; Zhu,Huifen; Lei,Ping; Huang,Bo; Shen,Guanxin

doi:10.3892/ijo.2020.5161

February-2021 Volume 58 Issue 2

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February-2021 Volume 58 Issue 2

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[Corrigendum] Mutation of TGF‑β receptor II facilitates human bladder cancer progression through altered TGF‑β1 signaling pathway

Authors:
- Jing Bian
- Bo Li
- Xiaoyong Zeng
- Heyu Hu
- Yi Hong
- Hui Ouyang
- Xiaoxue Zhang
- Zhihua Wang
- Huifen Zhu
- Ping Lei
- Bo Huang
- Guanxin Shen
View Affiliations / Copyright

Affiliations: Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China

Copyright: © Bian et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Pages: 280-280
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Published online on: December 14, 2020

https://doi.org/10.3892/ijo.2020.5161
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Int J Oncol 43: [Related article:] 1549-1559, 2013; DOI: 10.3892/ijo.2013.2065

Subsequently to the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1B on p. 1552, the MCF-7 and T24, and the A549 and ScaBER data panels, respectively, appeared to be strikingly similar.

Figure 1

TGF-βRII is highly expressed in human bladder cancer cell line T24. (A) RT-qPCR showed expression of TGF-β1, TGF-βRI and TGF-βRII in different kinds of human cancer cell lines, **P<0.01 for each cancer cell line compared to embryo hepatocyte derived L02 cells. (B) Flow cytometry showed expression of cytoplasmic TGF-β1 and membraned TGF-βRII in human cancer cell lines. (C) Cell immunohistochemistry (a, c, e, g and i, isotype control; and b, d, f, h and j, experimental group) also showed strong staining of TGF-βRII in T24 cell membrane, *P<0.05, **P<0.01 compared to control group. Magnification, ×400. Similar results were obtained at least in three separate experiments.

After having re-examined the original data, the authors have realized that these pairings of data panels were indeed duplicates of each other. Essentially, errors were made in the labelling of the data panels pertaining to the separate experiments, and in the compilation of the published version of Fig. 1. The authors, however, were willing to repeat the affected experiments, and obtained results that were consistent with those of the experiments that had been originally performed.

Consequently, the revised version of Fig. 1 is shown below, showing the new data for Fig. 1B. The results from the flow cytometric analysis demonstrated the abnormally high expression level of TGF-β receptor II in T24 cells. The authors confirm that these data support the main conclusions presented in their paper, and are grateful to the Editor of International Journal of Oncology for allowing them this opportunity to publish a Corrigendum. They also apologise to the readership for any inconvenience caused.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Corrigendum] Mutation of TGF‑β receptor II facilitates human bladder cancer progression through altered TGF‑β1 signaling pathway

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