Three‑dimensional models to study breast cancer (Review)

  • Authors:
    • Maira Huerta‑Reyes
    • Arturo Aguilar‑Rojas
  • View Affiliations

  • Published online on: January 25, 2021     https://doi.org/10.3892/ijo.2021.5176
  • Pages: 331-343
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Abstract

Breast cancer (BC) is the most commonly occurring cancer and primary cause of cancer‑related mortality in women worldwide. Investigations into BC have been conducted in in vitro and in vivo models. Of these models, the cultivation of tumor cell lines in two‑dimensional models is the most widely employed in vitro model to study tumor physiology. However, this approach does not accurately model all aspects observed in tumors. To address these limitations, three‑dimensional (3D) in vitro models have been developed. In these, it is possible to reproduce the interaction between tumor cells and the extracellular matrix, as well as the interrelationship between tumor cells and stromal cells, in order to replicate the interactions observed within the 3D environment of in vivo tumors. The present review summarizes the most common 3D in vitro models used to study BC, including spheroid models, organ‑on‑a‑chip models, hydrogel models and bio‑printed models, with a discussion of their particular advantages and limitations.
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March-2021
Volume 58 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Huerta‑Reyes M and Huerta‑Reyes M: Three‑dimensional models to study breast cancer (Review). Int J Oncol 58: 331-343, 2021
APA
Huerta‑Reyes, M., & Huerta‑Reyes, M. (2021). Three‑dimensional models to study breast cancer (Review). International Journal of Oncology, 58, 331-343. https://doi.org/10.3892/ijo.2021.5176
MLA
Huerta‑Reyes, M., Aguilar‑Rojas, A."Three‑dimensional models to study breast cancer (Review)". International Journal of Oncology 58.3 (2021): 331-343.
Chicago
Huerta‑Reyes, M., Aguilar‑Rojas, A."Three‑dimensional models to study breast cancer (Review)". International Journal of Oncology 58, no. 3 (2021): 331-343. https://doi.org/10.3892/ijo.2021.5176