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Review Open Access

Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review)

  • Authors:
    • Xuezhi Wei
    • Yaxing Shi
    • Zhijun Dai
    • Pei Wang
    • Xin Meng
    • Bo Yin
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Sheng Jing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Surgery, People's Hospital of Nong An Country, Changchun, Jilin 130200, P.R. China, Department of Orthopedics, Chengde Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, P.R. China, Department of Biochemistry and Molecular Biology, School of Life Sciences, China Medical University, Shenyang, Liaoning 110122, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 289-297
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    Published online on: January 28, 2021
       https://doi.org/10.3892/ijo.2021.5179
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Abstract

Circular RNA (circRNA) is a long non‑coding RNA molecule with a closed loop structure lacking a 5'cap and 3'tail. circRNA is stable, difficult to cleave and resistant to RNA exonuclease or RNase R degradation. circRNA molecules have several clinical applications, especially in tumors. For instance, circRNA may be used for non‑invasive diagnosis, therapy and prognosis. Exosomes play a crucial role in the development of tumors. Exosomal circRNA in particular has led to increased research interest into tumorigenesis and tumor progression. Additionally, exosomal circRNA plays a role in cell‑cell communication. Exosomal circRNA facilitates tumor metastasis by altering the tumor microenvironment and the pre‑metastatic niche. Additionally, studies have revealed the mechanism by which exosomal circRNA affects malignant progression through signal transduction. Moreover, exosomal circRNA promotes tumor metastasis by regulating gene expression, RNA transcription and protein translation. In this review, the biological features and clinical application of exosomal circRNA are described, highlighting the underlying mechanisms through which they regulate tumor metastasis. The application of circRNA as clinical diagnostic biomarkers and in the development of novel therapeutic strategies is also discussed.
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1 

Kristensen LS, Hansen TB, Venø MT and Kjems J: Circular RNAs in cancer: Opportunities and challenges in the field. Oncogene. 37:555–565. 2018. View Article : Google Scholar :

2 

Lin J, Zhang Y, Zeng X, Xue C and Lin X: CircRNA CircRIMS Acts as a MicroRNA sponge to promote gastric cancer metastasis. ACS Omega. 5:23237–23246. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Wang Y, Mo Y, Gong Z, Yang X, Yang M, Zhang S, Xiong F, Xiang B, Zhou M, Liao Q, et al: Circular RNAs in human cancer. Mol Cancer. 16:252017. View Article : Google Scholar : PubMed/NCBI

4 

Martins VR, Dias MS and Hainaut P: Tumor-cell-derived microvesicles as carriers of molecular information in cancer. Curr Opin Oncol. 25:66–75. 2013. View Article : Google Scholar

5 

Whiteside TL: Tumor-derived exosomes and their role in cancer progression. Adv Clin Chem. 74:103–141. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF and Sharpless NE: Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 19:141–157. 2013. View Article : Google Scholar :

7 

Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X and Huang S: Circular RNA is enriched and stable in exosomes: A promising biomarker for cancer diagnosis. Cell Res. 25:981–984. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Funes SC, Rios M, Escobar-Vera J and Kalergis AM: Implications of macrophage polarization in autoimmunity. Immunology. 154:186–195. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Mantovani A, Sozzani S, Locati M, Allavena P and Sica A: Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23:549–555. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Wang JJ, Lei KF and Han F: Tumor microenvironment: Recent advances in various cancer treatments. Eur Rev Med Pharmacol Sci. 22:3855–3864. 2018.PubMed/NCBI

11 

Sun Y: Tumor microenvironment and cancer therapy resistance. Cancer Lett. 380:205–215. 2016. View Article : Google Scholar

12 

Xie F, Zhou X, Fang M, Li H, Su P, Tu Y, Zhang L and Zhou F: Extracellular vesicles in cancer immune microenvironment and cancer immunotherapy. Adv Sci (Weinh). 6:19017792019. View Article : Google Scholar

13 

Sanger HL, Klotz G, Riesner D, Gross HJ and Kleinschmidt AK: Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci USA. 73:3852–3856. 1976. View Article : Google Scholar : PubMed/NCBI

14 

Li J, Mohammed-Elsabagh M, Paczkowski F and Li Y: Circular nucleic acids: Discovery, functions and applications. Chembiochem. 21:1547–1566. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Jeck WR and Sharpless NE: Detecting and characterizing circular RNAs. Nat Biotechnol. 32:453–461. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, Zhong G, Yu B, Hu W, Dai L, et al: Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 22:256–264. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Patop IL, Wüst S and Kadener S: Past, present, and future of circRNAs. EMBO J. 38:e1008362019. View Article : Google Scholar : PubMed/NCBI

18 

Meng X, Chen Q, Zhang P and Chen M: CircPro: An integrated tool for the identification of circRNAs with protein-coding potential. Bioinformatics. 33:3314–3316. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Zhao X, Cai Y and Xu J: Circular RNAs: Biogenesis, mechanism, and function in human cancers. Int J Mol Sci. 20:39262019. View Article : Google Scholar :

20 

Wilusz JE: A 360° view of circular RNAs: From biogenesis to functions. Wiley interdisciplinary reviews. RNA. 9:e14782018.

21 

Chen X, Yang T, Wang W, Xi W, Zhang T, Li Q, Yang A and Wang T: Circular RNAs in immune responses and immune diseases. Theranostics. 9:588–607. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Liang D and Wilusz JE: Short intronic repeat sequences facilitate circular RNA production. Genes Dev. 28:2233–2247. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Das A, Rout PK, Gorospe M and Panda AC: Rolling Circle cDNA synthesis uncovers circular RNA splice variants. Int J Mol Sci. 20:39882019. View Article : Google Scholar :

24 

Chan JJ and Tay Y: Noncoding RNA:RNA Regulatory networks in cancer. Int J Mol Sci. 19:13102018. View Article : Google Scholar :

25 

Pardini B, Sabo AA, Birolo G and Calin GA: Noncoding RNAs in extracellular fluids as cancer biomarkers: The New Frontier of Liquid Biopsies. Cancers. 11:11702019. View Article : Google Scholar :

26 

Liu K, Zhang Q, Pan F, Wang XD, Wenjing H and Tong H: Expression of circular RNAs in gynecological tumors: A systematic review. Medicine. 98:e157362019. View Article : Google Scholar : PubMed/NCBI

27 

Zheng X, Chen L, Zhou Y, Wang Q, Zheng Z, Xu B, Wu C, Zhou Q, Hu W, Wu C and Jiang J: A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling. Mol Cancer. 18:472019. View Article : Google Scholar : PubMed/NCBI

28 

Correia de Sousa M, Gjorgjieva M, Dolicka D, Sobolewski C and Foti M: Deciphering miRNAs' Action through miRNA Editing. Int J Mol Sci. 20:62492019. View Article : Google Scholar

29 

O'Brien J, Hayder H, Zayed Y and Peng C: Overview of MicroRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol. 9:4022018. View Article : Google Scholar

30 

Tan W, Liu B, Qu S, Liang G, Luo W and Gong C: MicroRNAs and cancer: Key paradigms in molecular therapy. Oncol Lett. 15:2735–2742. 2018.PubMed/NCBI

31 

Xue D, Wang H, Chen Y, Shen D, Lu J, Wang M, Zebibula A, Xu L, Wu H, Li G and Xia L: Circ-AKT3 inhibits clear cell renal cell carcinoma metastasis via altering miR-296-3p/E-cadherin signals. Mol Cancer. 18:1512019. View Article : Google Scholar : PubMed/NCBI

32 

Li R, Wu B, Xia J, Ye L and Yang X: Circular RNA hsa_ circRNA_102958 promotes tumorigenesis of colorectal cancer via miR-585/CDC25B axis. Cancer Manag Res. 11:6887–6893. 2019. View Article : Google Scholar :

33 

Xu H, Guo S, Li W and Yu P: The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells. Sci Rep. 5:124532015. View Article : Google Scholar : PubMed/NCBI

34 

Zhu W, Wang Y, Zhang D, Yu X and Leng X: MiR-75p functions as a tumor suppressor by targeting SOX18 in pancreatic ductal adenocarcinoma. Biochem Biophys Res Commun. 497:963–970. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Lin J, Liu Z, Liao S, Li E, Wu X and Zeng W: Elevated microRNA-7 inhibits proliferation and tumor angiogenesis and promotes apoptosis of gastric cancer cells via repression of Raf-1. Cell Cycle. 19:2496–2508. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Shen B, Wang Z, Li Z, Song H and Ding X: Circular RNAs: An emerging landscape in tumor metastasis. Am J Cancer Res. 9:630–643. 2019.PubMed/NCBI

37 

Tong H, Zhao K, Wang J, Xu H and Xiao J: CircZNF609/miR-134-5p/BTG-2 axis regulates proliferation and migration of glioma cell. J Pharm Pharmacol. 72:68–75. 2020. View Article : Google Scholar

38 

Yang P, Qiu Z, Jiang Y, Dong L, Yang W, Gu C, Li G and Zhu Y: Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/β-catenin signaling pathway. Oncotarget. 7:63449–63455. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, et al: Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol Cell. 58:870–885. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Li Z, Chen Z, Hu G and Jiang Y: Roles of circular RNA in breast cancer: Present and future. Am J Transl Res. 11:3945–3954. 2019.PubMed/NCBI

41 

Sun S, Wang W, Luo X, Li Y, Liu B and Li X, Zhang B, Han S and Li X: Circular RNA circ-ADD3 inhibits hepatocellular carcinoma metastasis through facilitating EZH2 degradation via CDK1-mediated ubiquitination. Am J Cancer Res. 9:1695–1707. 2019.PubMed/NCBI

42 

Liu Z, Yu Y, Huang Z, Kong Y, Hu X, Xiao W, Quan J and Fan X: CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression. Cell Death Dis. 10:9002019. View Article : Google Scholar : PubMed/NCBI

43 

Boriachek K, Islam MN, Möller A, Salomon C, Nguyen NT, Hossain MSA, Yamauchi Y and Shiddiky MJA: Biological functions and current advances in isolation and detection strategies for exosome nanovesicles. Small. 14:17021532018. View Article : Google Scholar

44 

Braicu C, Tomuleasa C, Monroig P, Cucuianu A, Berindan-Neagoe I and Calin GA: Exosomes as divine messengers: Are they the Hermes of modern molecular oncology? Cell Death Differ. 22:34–45. 2015. View Article : Google Scholar

45 

Pant S, Hilton H and Burczynski ME: The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities. Biochem Pharmacol. 83:1484–1494. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Ngalame NNO, Luz AL, Makia N and Tokar EJ: Arsenic alters exosome quantity and cargo to mediate stem cell recruitment into a cancer stem cell-like phenotype. Toxicol Sci. 165:40–49. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Shi X, Wang B, Feng X, Xu Y, Lu K and Sun M: circRNAs and exosomes: A mysterious frontier for human cancer. Mol Ther Nucleic Acids. 19:384–392. 2020. View Article : Google Scholar :

48 

Li S, Li Y, Chen B, Zhao J, Yu S, Tang Y, Zheng Q, Li Y, Wang P, He X and Huang S: exoRBase: A database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Res. 46:D106–D112. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Su Y, Lv X, Yin W, Zhou L, Hu Y, Zhou A and Qi F: CircRNA Cdr1as functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression. Aging (Albany NY). 11:8182–8203. 2019.

50 

Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, et al: Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med. 24:541–550. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Ridge SM, Sullivan FJ and Glynn SA: Mesenchymal stem cells: Key players in cancer progression. Mol Cancer. 16:312017. View Article : Google Scholar : PubMed/NCBI

52 

Kalluri R: The biology and function of fibroblasts in cancer. Nat Rev Cancer. 16:582–598. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Li K, Chen Y, Li A, Tan C and Liu X: Exosomes play roles in sequential processes of tumor metastasis. Int J Cancer. 144:1486–1495. 2019. View Article : Google Scholar

54 

Matei I, Kim HS and Lyden D: Unshielding exosomal RNA unleashes tumor growth and metastasis. Cell. 170:223–225. 2017. View Article : Google Scholar : PubMed/NCBI

55 

Wang L, Yang G, Zhao D, Wang J, Bai Y, Peng Q, Wang H, Fang R, Chen G, Wang Z, et al: CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: Role of remote MiR-19b-3p. Mol Cancer. 18:862019. View Article : Google Scholar : PubMed/NCBI

56 

Hakulinen J, Sankkila L, Sugiyama N, Lehti K and Keski-Oja J: Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes. J Cell Biochem. 105:1211–1218. 2008. View Article : Google Scholar : PubMed/NCBI

57 

Turley SJ, Cremasco V and Astarita JL: Immunological hall-marks of stromal cells in the tumour microenvironment. Nat Rev Immunol. 15:669–682. 2015. View Article : Google Scholar : PubMed/NCBI

58 

Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA and Breakefield XO: Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters. Nat Commun. 6:70292015. View Article : Google Scholar : PubMed/NCBI

59 

Yoon YJ, Kim OY and Gho YS: Extracellular vesicles as emerging intercellular communicasomes. BMB Rep. 47:531–539. 2014. View Article : Google Scholar : PubMed/NCBI

60 

Lin Y, Xu J and Lan H: Tumor-associated macrophages in tumor metastasis: Biological roles and clinical therapeutic applications. J Hematol Oncol. 12:762019. View Article : Google Scholar : PubMed/NCBI

61 

Biswas SK and Mantovani A: Macrophage plasticity and inter-action with lymphocyte subsets: Cancer as a paradigm. Nat Immunol. 11:889–896. 2010. View Article : Google Scholar : PubMed/NCBI

62 

Najafi M, Hashemi Goradel N, Farhood B, Salehi E, Nashtaei MS, Khanlarkhani N, Khezri Z, Majidpoor J, Abouzaripour M, Habibi M, et al: Macrophage polarity in cancer: A review. J Cell Biochem. 120:2756–2765. 2019. View Article : Google Scholar

63 

Allavena P, Sica A, Garlanda C and Mantovani A: The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol Rev. 222:155–161. 2008. View Article : Google Scholar : PubMed/NCBI

64 

Preußer C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S and Bindereif A: Selective release of circRNAs in platelet-derived extracellular vesicles. J Extracell Vesicles. 7:14244732018. View Article : Google Scholar

65 

Hou J, Jiang W, Zhu L, Zhong S, Zhang H, Li J, Zhou S, Yang S, He Y, Wang D, et al: Circular RNAs and exosomes in cancer: A mysterious connection. Clin Transl Oncol. 20:1109–1116. 2018. View Article : Google Scholar : PubMed/NCBI

66 

Sekar S, Cuyugan L, Adkins J, Geiger P and Liang WS: Circular RNA expression and regulatory network prediction in posterior cingulate astrocytes in elderly subjects. BMC Genomics. 19:3402018. View Article : Google Scholar : PubMed/NCBI

67 

Zou Y, Zheng S, Deng X, Yang A and Xie X, Tang H and Xie X: The role of circular RNA CDR1as/ciRS-7 in regulating tumor micro-environment: A pan-cancer analysis. Biomolecules. 9:4292019. View Article : Google Scholar

68 

Pickup M, Novitskiy S and Moses HL: The roles of TGFβ in the tumour microenvironment. Nature Revi Cancer. 13:788–799. 2013. View Article : Google Scholar

69 

Yang J and Weinberg RA: Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev Cell. 14:818–829. 2008. View Article : Google Scholar : PubMed/NCBI

70 

Shang BQ, Li ML, Quan HY, Hou PF, Li ZW, Chu SF, Zheng JN and Bai J: Functional roles of circular RNAs during epithelial-to-mesenchymal transition. Mol Cancer. 18:1382019. View Article : Google Scholar : PubMed/NCBI

71 

Chen X, Chen RX, Wei WS, Li YH, Feng ZH, Tan L, Chen JW, Yuan GJ, Chen SL, Guo SJ, et al: PRMT5 circular RNA promotes metastasis of urothelial carcinoma of the bladder through sponging miR-30c to induce epithelial-mesenchymal transition. Clin Cancer Res. 24:6319–6330. 2018. View Article : Google Scholar : PubMed/NCBI

72 

Zhang X, Wang S, Wang H, Cao J, Huang X, Chen Z, Xu P, Sun G, Xu J, Lv J and Xu Z: Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. Mol Cancer. 18:202019. View Article : Google Scholar : PubMed/NCBI

73 

Ma C, Shi T, Qu Z, Zhang A, Wu Z, Zhao H, Zhao H and Chen H: CircRNA_ACAP2 suppresses EMT in head and neck squamous cell carcinoma by targeting the miR-21-5p/STAT3 signaling axis. Front Oncol. 10:5836822020. View Article : Google Scholar : PubMed/NCBI

74 

Zhao X, Dou W, He L, Liang S, Tie J, Liu C, Li T, Lu Y, Mo P, Shi Y, et al: MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. Oncogene. 32:1363–1372. 2013. View Article : Google Scholar

75 

Ball SG, Shuttleworth CA and Kielty CM: Mesenchymal stem cells and neovascularization: Role of platelet-derived growth factor receptors. J Cell Mol Med. 11:1012–1030. 2007. View Article : Google Scholar : PubMed/NCBI

76 

Altaner C, Altanerova U and Jakubechova J: Intracellular acting tumor cell-targeted chemotherapy by MSC-suicide gene exosomes. Oncotarget. 10:5573–5575. 2019. View Article : Google Scholar : PubMed/NCBI

77 

Brossa A, Fonsato V and Bussolati B: Anti-tumor activity of stem cell-derived extracellular vesicles. Oncotarget. 10:1872–1873. 2019. View Article : Google Scholar : PubMed/NCBI

78 

Ferguson SW, Wang J, Lee CJ, Liu M, Neelamegham S, Canty JM and Nguyen J: The microRNA regulatory landscape of MSC-derived exosomes: A systems view. Sci Rep. 8:14192018. View Article : Google Scholar : PubMed/NCBI

79 

Shimbo K, Miyaki S, Ishitobi H, Kato Y, Kubo T, Shimose S and Ochi M: Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration. Biochem Biophys Res Commun. 445:381–387. 2014. View Article : Google Scholar : PubMed/NCBI

80 

Li X, Wang S, Zhu R, Li H, Han Q and Zhao RC: Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway. J Hematol Oncol. 9:422016. View Article : Google Scholar

81 

Menck K, Klemm F, Gross JC, Pukrop T, Wenzel D and Binder C: Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles. Oncotarget. 4:2057–2066. 2013. View Article : Google Scholar : PubMed/NCBI

82 

Cherubini A, Barilani M, Rossi RL, Jalal MMK, Rusconi F, Buono G, Ragni E, Cantarella G, Simpson HARW, Péault B and Lazzari L: FOXP1 circular RNA sustains mesenchymal stem cell identity via microRNA inhibition. Nucleic Acids Res. 47:5325–5340. 2019. View Article : Google Scholar : PubMed/NCBI

83 

Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, Thakur BK, Becker A, Hoshino A, Mark MT, Molina H, et al: Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nature Cell Biol. 17:816–826. 2015. View Article : Google Scholar : PubMed/NCBI

84 

Ahmed N, Escalona R, Leung D, Chan E and Kannourakis G: Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells. Semin Cancer Biol. 53:265–281. 2018. View Article : Google Scholar : PubMed/NCBI

85 

Steinbichler TB, Dudás J, Riechelmann H and Skvortsova II: The role of exosomes in cancer metastasis. Semin Cancer Biol. 44:170–181. 2017. View Article : Google Scholar : PubMed/NCBI

86 

Raposo G and Stoorvogel W: Extracellular vesicles: Exosomes, microvesicles, and friends. J Cell Biol. 200:373–383. 2013. View Article : Google Scholar : PubMed/NCBI

87 

Wortzel I, Dror S, Kenific CM and Lyden D: Exosome-mediated metastasis: Communication from a distance. Dev Cell. 49:347–360. 2019. View Article : Google Scholar : PubMed/NCBI

88 

Zhang H, Zhu L, Bai M, Liu Y, Zhan Y, Deng T, Yang H, Sun W, Wang X, Zhu K, et al: Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway. Int J Cancer. 144:2501–2515. 2019. View Article : Google Scholar

89 

Zong ZH, Du YP, Guan X, Chen S and Zhao Y: CircWHSC1 promotes ovarian cancer progression by regulating MUC1 and hTERT through sponging miR-145 and miR-1182. J Exp Clin Cancer Res. 38:4372019. View Article : Google Scholar : PubMed/NCBI

90 

Li Z, Yanfang W, Li J, Jiang P, Peng T, Chen K, Zhao X, Zhang Y, Zhen P, Zhu J and Li X: Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer. Cancer Lett. 432:237–250. 2018. View Article : Google Scholar : PubMed/NCBI

91 

Luna J, Boni J, Cuatrecasas M, Bofill-De Ros X, Núñez-Manchón E, Gironella M, Vaquero EC, Arbones ML, de la Luna S and Fillat C: DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumour growth. Gut. 68:1465–1476. 2019. View Article : Google Scholar

92 

Li J, Li Z, Jiang P, Peng M, Zhang X, Chen K, Liu H, Bi H, Liu X and Li X: Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis. J Exp Clin Cancer Res. 37:1772018. View Article : Google Scholar : PubMed/NCBI

93 

Wang G, Liu W, Zou Y, Wang G, Deng Y, Luo J, Zhang Y, Li H, Zhang Q, Yang Y and Chen G: Three isoforms of exosomal circPTGR1 promote hepatocellular carcinoma metastasis via the miR449a-MET pathway. EBioMedicine. 40:432–445. 2019. View Article : Google Scholar : PubMed/NCBI

94 

Yang X, Xiong Q, Wu Y, Li S and Ge F: Quantitative proteomics reveals the regulatory networks of circular RNA CDR1as in hepatocellular carcinoma cells. J Proteome Res. 16:3891–3902. 2017. View Article : Google Scholar : PubMed/NCBI

95 

Zhong Q, Huang J, Wei J and Wu R: Circular RNA CDR1as sponges miR-7-5p to enhance E2F3 stability and promote the growth of nasopharyngeal carcinoma. Cancer Cell Int. 19:2522019. View Article : Google Scholar : PubMed/NCBI

96 

Li T, Sun X and Chen L: Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker. J Cell Biochem. 121:2118–2126. 2020. View Article : Google Scholar

97 

Wang S, Hu Y, Lv X, Li B, Gu D, Li Y, Sun Y and Su Y: Circ-0000284 arouses malignant phenotype of cholangiocarcinoma cells and regulates the biological functions of peripheral cells through cellular communication. Clin Sci (Lond). 133:1935–1953. 2019. View Article : Google Scholar

98 

Li Y, Zheng F, Xiao X, Xie F, Tao D, Huang C, Liu D, Wang M, Wang L, Zeng F and Jiang G: CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells. EMBO Rep. 18:1646–1659. 2017. View Article : Google Scholar : PubMed/NCBI

99 

Ren GL, Zhu J, Li J and Meng XM: Noncoding RNAs in acute kidney injury. J Cell Physiol. 234:2266–2276. 2019. View Article : Google Scholar

100 

Xu Y, Ku X, Wu C, Cai C, Tang J and Yan W: Exosomal proteome analysis of human plasma to monitor sepsis progression. Biochem Biophys Res Commun. 499:856–861. 2018. View Article : Google Scholar : PubMed/NCBI

101 

Fanale D, Taverna S, Russo A and Bazan V: Circular RNA in Exosomes. Adv Exp Med Biol. 1087:109–117. 2018. View Article : Google Scholar : PubMed/NCBI

102 

Chen R, Xu X, Qian Z, Zhang C, Niu Y, Wang Z, Sun J, Zhang X and Yu Y: The biological functions and clinical applications of exosomes in lung cancer. Cell Mol Life Sci. 76:4613–4633. 2019. View Article : Google Scholar : PubMed/NCBI

103 

Lakhal S and Wood MJ: Exosome nanotechnology: An emerging paradigm shift in drug delivery: Exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers. Bioessays. 33:737–741. 2011. View Article : Google Scholar : PubMed/NCBI

104 

Ma H, Xu Y, Zhang R, Guo B, Zhang S and Zhang X: Differential expression study of circular RNAs in exosomes from serum and urine in patients with idiopathic membranous nephropathy. Arch Med Sci. 15:738–753. 2019. View Article : Google Scholar : PubMed/NCBI

105 

Liu S, Lin Z, Rao W, Zheng J, Xie Q, Lin Y, Lin X, Chen H, Chen Y and Hu Z: Upregulated expression of serum exosomal hsa_circ_0026611 is associated with lymph node metastasis and poor prognosis of esophageal squamous cell carcinoma. J Cancer. 12:918–926. 2021. View Article : Google Scholar : PubMed/NCBI

106 

Fan L, Cao Q, Liu J, Zhang J and Li B: Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis. Mol Cancer. 18:162019. View Article : Google Scholar : PubMed/NCBI

107 

Yang C, Wei Y, Yu L and Xiao Y: Identification of altered circular RNA expression in serum exosomes from patients with papillary thyroid carcinoma by high-throughput sequencing. Med Sci Monit. 25:2785–2791. 2019. View Article : Google Scholar : PubMed/NCBI

108 

Pan B, Qin J, Liu X, He B, Wang X, Pan Y, Sun H, Xu T, Xu M, Chen X, et al: Identification of serum exosomal hsa-circ-0004771 as a novel diagnostic biomarker of colorectal cancer. Front Genet. 10:10962019. View Article : Google Scholar : PubMed/NCBI

109 

Chen F, Huang C, Wu Q, Jiang L, Chen S and Chen L: Circular RNAs expression profiles in plasma exosomes from early-stage lung adenocarcinoma and the potential biomarkers. J Cell Biochem. 121:2525–2533. 2020. View Article : Google Scholar

110 

Feng Y, Hang W, Sang Z, Li S, Xu W, Miao Y, Xi X and Huang Q: Identification of exosomal and non-exosomal microRNAs associated with the drug resistance of ovarian cancer. Mol Med Rep. 19:3376–3392. 2019.PubMed/NCBI

111 

Sousa D, Lima RT and Vasconcelos MH: Intercellular transfer of cancer drug resistance traits by extracellular vesicles. Trends Mol Med. 21:595–608. 2015. View Article : Google Scholar : PubMed/NCBI

112 

Zhao Z, Ji M, Wang Q, He N and Li Y: Circular RNA Cdr1as upregulates SCAI to suppress cisplatin resistance in ovarian cancer via miR-1270 suppression. Mol Ther Nucleic Acids. 18:24–33. 2019. View Article : Google Scholar : PubMed/NCBI

113 

Tang W, Ji M, He G, Yang L, Niu Z, Jian M, Wei Y, Ren L and Xu J: Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7. OncoTargets Ther. 10:2045–2056. 2017. View Article : Google Scholar

114 

Sang M, Meng L, Sang Y, Liu S, Ding P, Ju Y, Liu F, Gu L, Lian Y, Li J, et al: Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression. Cancer Lett. 426:37–46. 2018. View Article : Google Scholar : PubMed/NCBI

115 

Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z and Sharpless NE: Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet. 6:e10012332010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wei X, Shi Y, Dai Z, Wang P, Meng X and Yin B: Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review). Int J Oncol 58: 289-297, 2021.
APA
Wei, X., Shi, Y., Dai, Z., Wang, P., Meng, X., & Yin, B. (2021). Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review). International Journal of Oncology, 58, 289-297. https://doi.org/10.3892/ijo.2021.5179
MLA
Wei, X., Shi, Y., Dai, Z., Wang, P., Meng, X., Yin, B."Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review)". International Journal of Oncology 58.3 (2021): 289-297.
Chicago
Wei, X., Shi, Y., Dai, Z., Wang, P., Meng, X., Yin, B."Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review)". International Journal of Oncology 58, no. 3 (2021): 289-297. https://doi.org/10.3892/ijo.2021.5179
Copy and paste a formatted citation
x
Spandidos Publications style
Wei X, Shi Y, Dai Z, Wang P, Meng X and Yin B: Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review). Int J Oncol 58: 289-297, 2021.
APA
Wei, X., Shi, Y., Dai, Z., Wang, P., Meng, X., & Yin, B. (2021). Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review). International Journal of Oncology, 58, 289-297. https://doi.org/10.3892/ijo.2021.5179
MLA
Wei, X., Shi, Y., Dai, Z., Wang, P., Meng, X., Yin, B."Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review)". International Journal of Oncology 58.3 (2021): 289-297.
Chicago
Wei, X., Shi, Y., Dai, Z., Wang, P., Meng, X., Yin, B."Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review)". International Journal of Oncology 58, no. 3 (2021): 289-297. https://doi.org/10.3892/ijo.2021.5179
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