Open Access

Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review)

  • Authors:
    • Xuezhi Wei
    • Yaxing Shi
    • Zhijun Dai
    • Pei Wang
    • Xin Meng
    • Bo Yin
  • View Affiliations

  • Published online on: January 28, 2021     https://doi.org/10.3892/ijo.2021.5179
  • Pages: 289-297
  • Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNA (circRNA) is a long non‑coding RNA molecule with a closed loop structure lacking a 5'cap and 3'tail. circRNA is stable, difficult to cleave and resistant to RNA exonuclease or RNase R degradation. circRNA molecules have several clinical applications, especially in tumors. For instance, circRNA may be used for non‑invasive diagnosis, therapy and prognosis. Exosomes play a crucial role in the development of tumors. Exosomal circRNA in particular has led to increased research interest into tumorigenesis and tumor progression. Additionally, exosomal circRNA plays a role in cell‑cell communication. Exosomal circRNA facilitates tumor metastasis by altering the tumor microenvironment and the pre‑metastatic niche. Additionally, studies have revealed the mechanism by which exosomal circRNA affects malignant progression through signal transduction. Moreover, exosomal circRNA promotes tumor metastasis by regulating gene expression, RNA transcription and protein translation. In this review, the biological features and clinical application of exosomal circRNA are described, highlighting the underlying mechanisms through which they regulate tumor metastasis. The application of circRNA as clinical diagnostic biomarkers and in the development of novel therapeutic strategies is also discussed.
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March-2021
Volume 58 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Wei X, Shi Y, Dai Z, Wang P, Meng X and Yin B: Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review). Int J Oncol 58: 289-297, 2021
APA
Wei, X., Shi, Y., Dai, Z., Wang, P., Meng, X., & Yin, B. (2021). Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review). International Journal of Oncology, 58, 289-297. https://doi.org/10.3892/ijo.2021.5179
MLA
Wei, X., Shi, Y., Dai, Z., Wang, P., Meng, X., Yin, B."Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review)". International Journal of Oncology 58.3 (2021): 289-297.
Chicago
Wei, X., Shi, Y., Dai, Z., Wang, P., Meng, X., Yin, B."Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review)". International Journal of Oncology 58, no. 3 (2021): 289-297. https://doi.org/10.3892/ijo.2021.5179