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Review

Exosomal proteins: Key players mediating pre‑metastatic niche formation and clinical implications (Review)

  • Authors:
    • Mei Wang
    • Xinxin Zhao
    • Feng Huang
    • Lin Wang
    • Jiaying Huang
    • Zheng Gong
    • Wanjun Yu
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China, Department of Clinical Laboratory, The First People's Hospital of Kunshan Affiliated to Jiangsu University, Suzhou, Jiangsu 215300, P.R. China
  • Article Number: 4
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    Published online on: February 5, 2021
       https://doi.org/10.3892/ijo.2021.5184
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Abstract

Tumor metastasis is a destructive characteristic of malignant tumors and the fundamental reason why malignant tumors are difficult to cure. The concept of a pre‑metastatic niche (PMN) provides a novel way to elucidate the molecular mechanism of tumor metastasis. At present, the PMN has been considered as a critical determinant priming distal sites for metastasis. Accumulating evidence has suggested that exosomes are cellular communicators serving a pivotal role in mediating tumor cell metastasis by establishing the PMN. Among exosomal cargos, non‑coding RNAs and proteins are two commonly studied components; however, the latter has received less attention. The present review aimed to summarize the findings regarding cargo proteins selectively loaded in malignant tumor‑derived exosomes. Metastasis‑associated proteins have been demonstrated to be selectively enriched in malignant tumor‑derived exosomes. Exosomal proteins promote PMN formation to mediate the site‑specific metastasis of tumor cells by inducing lymphangiogenesis, angiogenesis and permeability, educating stromal cells, remodeling the extracellular matrix, and suppressing the antitumor immune response. These exosomal proteins have great potential in predicting organ‑directed metastasis and prognosis, as well as in cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Wang M, Zhao X, Huang F, Wang L, Huang J, Gong Z and Yu W: Exosomal proteins: Key players mediating pre‑metastatic niche formation and clinical implications (Review). Int J Oncol 58: 4, 2021.
APA
Wang, M., Zhao, X., Huang, F., Wang, L., Huang, J., Gong, Z., & Yu, W. (2021). Exosomal proteins: Key players mediating pre‑metastatic niche formation and clinical implications (Review). International Journal of Oncology, 58, 4. https://doi.org/10.3892/ijo.2021.5184
MLA
Wang, M., Zhao, X., Huang, F., Wang, L., Huang, J., Gong, Z., Yu, W."Exosomal proteins: Key players mediating pre‑metastatic niche formation and clinical implications (Review)". International Journal of Oncology 58.4 (2021): 4.
Chicago
Wang, M., Zhao, X., Huang, F., Wang, L., Huang, J., Gong, Z., Yu, W."Exosomal proteins: Key players mediating pre‑metastatic niche formation and clinical implications (Review)". International Journal of Oncology 58, no. 4 (2021): 4. https://doi.org/10.3892/ijo.2021.5184
Copy and paste a formatted citation
x
Spandidos Publications style
Wang M, Zhao X, Huang F, Wang L, Huang J, Gong Z and Yu W: Exosomal proteins: Key players mediating pre‑metastatic niche formation and clinical implications (Review). Int J Oncol 58: 4, 2021.
APA
Wang, M., Zhao, X., Huang, F., Wang, L., Huang, J., Gong, Z., & Yu, W. (2021). Exosomal proteins: Key players mediating pre‑metastatic niche formation and clinical implications (Review). International Journal of Oncology, 58, 4. https://doi.org/10.3892/ijo.2021.5184
MLA
Wang, M., Zhao, X., Huang, F., Wang, L., Huang, J., Gong, Z., Yu, W."Exosomal proteins: Key players mediating pre‑metastatic niche formation and clinical implications (Review)". International Journal of Oncology 58.4 (2021): 4.
Chicago
Wang, M., Zhao, X., Huang, F., Wang, L., Huang, J., Gong, Z., Yu, W."Exosomal proteins: Key players mediating pre‑metastatic niche formation and clinical implications (Review)". International Journal of Oncology 58, no. 4 (2021): 4. https://doi.org/10.3892/ijo.2021.5184
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