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Review

Human L‑asparaginase: Acquiring knowledge of its activation (Review)

  • Authors:
    • Stephanie Bath De Morais
    • Tatiana De Arruda Campos Brasil De Souza
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    Affiliations: Structural and Computational Proteomics Laboratory, Carlos Chagas Institute, FIOCRUZ‑PR, Curitiba, Parana 80320‑290, Brazil
  • Article Number: 11
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    Published online on: February 24, 2021
       https://doi.org/10.3892/ijo.2021.5191
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Abstract

L‑asparaginase enzymes have been a vital component of acute lymphoblastic leukemia therapy for >40 years. L‑asparaginase acts by depleting plasma L‑asparagine, which is essential to the survival of leukemia cells. In contrast to normal cells, tumor cells cannot synthesize L‑asparagine and thus depend on its external uptake for growth. Currently, three bacterial L‑asparaginases are used in therapy; however, they are associated with severe side‑effects related to high toxicity and immunogenicity. The introduction of human L‑asparaginase‑like protein 1 in acute lymphoblastic leukemia treatment would avoid the problems caused by the bacterial enzymes; however, a major difficulty in the therapeutic use of the human enzyme comes from the fact that human L‑asparaginase must be activated through an autoprocessing step, which is a low‑efficiency process in vitro that results in reduced enzymatic activity. The present review article aimed to contribute to the understanding of the enzyme self‑activation process and focuses on the efforts made for the development of a therapeutic variant of human L‑asparaginase.
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1 

Lang S: Über desamidierung im Tierkörper. Beitr hem Physiol Pathol. 5:321–345. 1904.

2 

Fürth O and Friedmann M: Über die Verbreitung asparaginspaltender Organfermente. Biochem Z. 26:435–440. 1910.

3 

Clementi A: La Désamidation Enzymatique De L'asparagine Chez Les Différentes Espéces Animales Et La Signification Physio Logique De Sa Presence Dans L'organisme. Arch Int de Physiol. 19:369–398. 1922.

4 

Kidd JG: Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. I Course of transplanted cancers of various kinds in mice and rats given guinea pig serum, horse serum, or rabbit serum. J Exp Med. 98:565–582. 1953. View Article : Google Scholar : PubMed/NCBI

5 

Broome JD: Evidence that the L-Asparaginase activity of guinea pig serum is responsible for its Antilymphoma Effects. Nature. 191:1114–1115. 1961. View Article : Google Scholar

6 

Broome JD: Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. I Properties of the L-asparaginase of guinea pig serum in relation to those of the antilymphoma substance. J Exp Med. 118:99–120. 1963. View Article : Google Scholar : PubMed/NCBI

7 

Mashburn LT and Wriston JC: Tumor inhibitory effect of L-asparaginase from Escherichia coli. Arch Biochem Biophys. 105:450–452. 1964. View Article : Google Scholar : PubMed/NCBI

8 

Broome JD: Antilymphoma activity of L-asparaginase in vivo: Clearance rates of enzyme preparations from guinea pig serum and yeast in relation to their effect on tumor growth. J Natl Cancer Inst. 35:967–974. 1965.PubMed/NCBI

9 

Dolowy WC, Henson D, Cornet J and Sellin H: Toxic and antineoplastic effects of L-asparaginase. Study of mice with lymphoma and normal monkeys and report on a child with leukemia. Cancer. 19:1813–1819. 1966. View Article : Google Scholar : PubMed/NCBI

10 

Oettgen HF, Stephenson PA, Schwartz MK, Leeper RD, Tallai L, Tan CC, Clarkson BD, Golbey RB, Krakoff IH, Karnofsky DA, et al: Toxicity of E. coli L-asparaginase in man. Cancer. 25:253–278. 1970. View Article : Google Scholar : PubMed/NCBI

11 

Hill JM, Roberts J, Loeb E, Khan A, MacLellan A and Hill RW: L-asparaginase therapy for leukemia and other malignant neoplasms. JAMA. 202:882–888. 1967. View Article : Google Scholar : PubMed/NCBI

12 

Salzer WL, Asselin BL, Plourde PV, Corn T and Hunger SP: Development of asparaginase Erwinia chrysanthemi for the treatment of acute lymphoblastic leukemia. Ann N Y Acad Sci. 1329:81–92. 2014. View Article : Google Scholar : PubMed/NCBI

13 

American Cancer Society: Cancer Facts and Figures 2019. American Cancer Society; Atlanta, GA: 2019

14 

Terwilliger T and Abdul-Hay M: Acute lymphoblastic leukemia: A comprehensive review and 2017 update. Blood Cancer J. 7:e5772017. View Article : Google Scholar : PubMed/NCBI

15 

American Cancer Society: Leukemia-Acute Lymphocytic (Adults). American Cancer Society; Atlanta, GA: 2014

16 

Cooper SL and Brown PA: Treatment of pediatric acute lymphoblastic leukemia. Pediatr Clin North Am. 62:61–73. 2015. View Article : Google Scholar :

17 

Moghrabi A, Levy DE, Asselin B, Barr R, Clavell L, Hurwitz C, Samson Y, Schorin M, Dalton VK, Lipshultz SE, et al: Results of the Dana-Farber cancer institute ALL consortium protocol 95-01 for children with acute lymphoblastic leukemia. Blood. 109:896–905. 2007. View Article : Google Scholar

18 

Pui CH and Evans WE: Treatment of acute lymphoblastic leukemia. N Engl J Med. 354:166–178. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Pui CH and Evans WE: Acute lymphoblastic leukemia. N Engl J Med. 339:605–615. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Nachman JB, Sather HN, Sensel MG, Trigg ME, Cherlow JM, Lukens JN, Wolff L, Uckun FM and Gaynon PS: Augmented Post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy. N Engl J Med. 338:1663–1671. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Gaynon P, Trigg M, Heerema N, Sensel M, Sather H, Hammond G and Bleyer W: Children's cancer group trials in childhood acute lymphoblastic leukemia: 1983-1995. Leukemia. 14:2223–2233. 2000. View Article : Google Scholar

22 

Schrappe M, Reiter A, Ludwig WD, Harbott J, Zimmermann M, Hiddemann W, Niemeyer C, Henze G, Feldges A, Zintl F, et al: Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: Results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group. Blood. 95:3310–3322. 2000.PubMed/NCBI

23 

Lee EJ, Petroni GR, Schiffer CA, Freter CE, Johnson JL, Barcos M, Frizzera G, Bloomfield CD and Peterson BA: Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: Results of cancer and leukemia group B study 9251. J Clin Oncol. 19:4014–4022. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Patte C: The Societe Francaise d'Oncologie Pediatrique LMB89 protocol: Highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia. Blood. 97:3370–3379. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Silverman LB, Gelber RD, Dalton VK, Asselin BL, Barr RD, Clavell LA, Hurwitz CA, Moghrabi A, Samson Y, Schorin MA, et al: Improved outcome for children with acute lymphoblastic leukemia: Results of Dana-Farber consortium protocol 91-01. Blood. 97:1211–1218. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Pui CH: Improved outcome for children with acute lymphoblastic leukemia: Results of Total Therapy Study XIIIB at St Jude Children's Research Hospital. Blood. 104:2690–2696. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Rytting ME: Role of L-asparaginase in acute lymphoblastic leukemia: Focus on adult patients. Blood Lymphatic Cancer Targets Ther. 2:117–124. 2012. View Article : Google Scholar

28 

American Cancer Society: Chemotherapy for Childhood Leukemia. American Cancer Society; Atlanta, GA: 2019

29 

Pui CH, Campana D and Evans WE: Childhood acute lymphoblastic leukaemia-current status and future perspectives. Lancet Oncol. 2:597–607. 2001. View Article : Google Scholar

30 

Gleissner B, Gökbuget N, Bartram CR, Janssen B, Rieder H, Janssen JW, Fonatsch C, Heyll A, Voliotis D, Beck J, et al: Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: A prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis. Blood. 99:1536–1543. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Pui CH, Relling MV and Downing JR: Acute lymphoblastic leukemia. N Engl J Med. 350:1535–1548. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Armstrong SA and Look AT: Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol. 23:6306–6315. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Mancini M: A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): Analysis of the GIMEMA 0496 protocol. Blood. 105:3434–3441. 2005. View Article : Google Scholar : PubMed/NCBI

34 

National Cancer Institute (NIH): Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®)-Health Professional Version, NIH 2020.

35 

Li BS, Gu LJ, Luo CY, Li WS, Jiang LM, Shen SH, Jiang H, Shen SH, Zhang B, Chen J, et al: The downregulation of asparagine synthetase expression can increase the sensitivity of cells resistant to l-asparaginase. Leukemia. 20:2199–2201. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Song P, Ye L, Fan J, Li Y, Zeng X, Wang Z, Wang S, Zhang G, Yang P, Cao Z and Ju D: Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells. Oncotarget. 6:3861–3873. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Pieters R, Hunger SP, Boos J, Rizzari C, Silverman L, Baruchel A, Goekbuget N, Schrappe M and Pui CH: L-asparaginase treatment in acute lymphoblastic leukemia: A focus on Erwinia asparaginase. Cancer. 117:238–249. 2011. View Article : Google Scholar

38 

Avramis VI: Asparaginases: Biochemical pharmacology and modes of drug resistance. Anticancer Res. 32:2423–2437. 2012.PubMed/NCBI

39 

Ueno T, Ohtawa K, Mitsui K, Kodera Y, Hiroto M, Matsushima A, Inada Y and Nishimura H: Cell cycle arrest and apoptosis of leukemia cells induced by L-asparaginase. Leukemia. 11:1858–1861. 1997. View Article : Google Scholar : PubMed/NCBI

40 

Yu M, Henning R, Walker A, Kim G, Perroy A, Alessandro R, Virador V and Kohn EC: L-asparaginase inhibits invasive and angiogenic activity and induces autophagy in ovarian cancer. J Cell Mol Med. 16:2369–2378. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Willems L, Jacque N, Jacquel A, Neveux N, Maciel TT, Lambert M, Schmitt A, Poulain L, Green AS, Uzunov M, et al: Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia. Blood. 122:3521–3532. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Zhang B, Fan J, Zhang X, Shen W, Cao Z, Yang P, Xu Z and Ju D: Targeting asparagine and autophagy for pulmonary adenocarcinoma therapy. Appl Microbiol Biotechnol. 100:9145–9161. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Lorenzi PL, Claerhout S, Mills GB and Weinstein JN: A curated census of autophagy-modulating proteins and small molecules. Autophagy. 10:1316–1326. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Purwaha P, Lorenzi PL, Silva LP, Hawke DH and Weinstein JN: Targeted metabolomic analysis of amino acid response to L-asparaginase in adherent cells. Metabolomics. 10:909–919. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Panosyan EH, Wang Y, Xia P, Lee WN, Pak Y, Laks DR, Lin HJ, Moore TB, Cloughesy TF, Kornblum HI and Lasky JL III: Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors. Mol Cancer Res. 12:694–702. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Sircar K, Huang H, Hu L, Cogdell D, Dhillon J, Tzelepi V, Efstathiou E, Koumakpayi IH, Saad F, Luo D, et al: Integrative molecular profiling reveals asparagine synthetase is a target in castration-resistant prostate cancer. Am J Pathol. 180:895–903. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Kobrinsky NL, Sposto R, Shah NR, Anderson JR, DeLaat C, Morse M, Warkentin P, Gilchrist GS, Cohen MD, Shina D and Meadows AT: Outcomes of treatment of children and adolescents with recurrent non-Hodgkin's lymphoma and Hodgkin's disease with dexamethasone, etoposide, cisplatin, cytarabine, and l-asparaginase, maintenance chemotherapy, and transplantation: Children's Cancer Group Study CCG-5912. J Clin Oncol. 19:2390–2396. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Bansal S, Srivastava A, Mukherjee G, Pandey R, Verma AK, Mishra P and Kundu B: Hyperthermophilic asparaginase mutants with enhanced substrate affinity and antineoplastic activity: Structural insights on their mechanism of action. FASEB J. 26:1161–1171. 2012. View Article : Google Scholar

49 

Roth G, Nunes JES, Rosado LA, Bizarro CV, Volpato C, Nunes CP, Renard G, Basso LA, Santo DS and Chies JM: Recombinant Erwinia caratovora L-asparaginase II production in Escherichia coli Fed-batch cultures. Br J Chem Engineering. 30:245–256. 2013. View Article : Google Scholar

50 

Tong WH, van der Sluis IM, Alleman CJM, van Litsenburg RRL, Kaspers GJL, Pieters R and Uyl-de Groot CA: Cost-analysis of treatment of childhood acute lymphoblastic leukemia with asparaginase preparations: The impact of expensive chemotherapy. Haematologica. 98:753–759. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Müller HJ, Löning L, Horn A, Schwabe D, Gunkel M, Schrappe M, von Schütz V, Henze G, Casimiro da Palma J, Ritter J, et al: Pegylated asparaginase (Oncaspar) in children with ALL: Drug monitoring in reinduction according to the ALL/NHL-BFM 95 protocols. Br J Haematol. 110:379–384. 2000. View Article : Google Scholar : PubMed/NCBI

52 

Willer A, Gerss J, König T, Franke D, Kühnel HJ, Henze G, von Stackelberg A, Möricke A, Schrappe M, Boos J and Lanvers-Kaminsky C: Anti-Escherichia coli asparaginase anti-body levels determine the activity of second-line treatment with pegylated E coli asparaginase: A retrospective analysis within the ALL-BFM trials. Blood. 118:5774–5782. 2011. View Article : Google Scholar : PubMed/NCBI

53 

Højfeldt SG, Wolthers BO, Tulstrup M, Abrahamsson J, Gupta R, Harila-Saari A, Heyman M, Henriksen LT, Jónsson ÒG, Lähteenmäki PM, et al: Genetic predisposition to PEG-asparaginase hypersensitivity in children treated according to NOPHO ALL2008. Br J Haematol. 184:405–417. 2019. View Article : Google Scholar

54 

Fernandez CA, Smith C, Yang W, Mullighan CG, Qu C, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, et al: Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Blood. 126:69–75. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Chen SH, Pei D, Yang W, Cheng C, Jeha S, Cox NJ, Evans WE, Pui CH and Relling MV: Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity. Clin Pharmacol Ther. 88:191–196. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Hijiya N and van der Sluis IM: Asparaginase-associated toxicity in children with acute lymphoblastic leukemia. Leuk Lymphoma. 57:748–757. 2016. View Article : Google Scholar :

57 

van der Sluis IM, Vrooman LM, Pieters R, Baruchel A, Escherich G, Goulden N, Mondelaers V, Sanchez de Toledo J, Rizzari C, Silverman LB and Whitlock JA: Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation. Haematologica. 101:279–285. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Tong WH, Pieters R, Tissing WJE and van der Sluis IM: Desensitization protocol should not be used in acute lymphoblastic leukemia patients with silent inactivation of PEGasparaginase. Haematologica. 99:e102–e104. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Müller HJ and Boos J: Use of L-asparaginase in childhood ALL. Crit Rev Oncol Hematol. 28:97–113. 1998. View Article : Google Scholar : PubMed/NCBI

60 

Lee JK, Kang S, Wang X, Rosales JL, Gao X, Byun HG, Jin Y, Fu S, Wang J and Lee KY: HAP1 loss confers l-asparaginase resistance in ALL by downregulating the calpain-1-Bid-caspase-3/12 pathway. Blood. 133:2222–2232. 2019. View Article : Google Scholar : PubMed/NCBI

61 

Chen SH: Asparaginase therapy in pediatric acute lymphoblastic leukemia: A focus on the mode of drug resistance. Pediatr Neonatol. 56:287–293. 2015. View Article : Google Scholar : PubMed/NCBI

62 

Aslanian AM and Kilberg MS: Multiple adaptive mechanisms affect asparagine synthetase substrate availability in asparaginase-resistant MOLT-4 human leukaemia cells. Biochem J. 358:59–67. 2001. View Article : Google Scholar : PubMed/NCBI

63 

Su N, Pan YX, Zhou M, Harvey RC, Hunger SP and Kilberg MS: Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines. Pediatr Blood Cancer. 50:274–279. 2008. View Article : Google Scholar

64 

Kang SM, Rosales JL, Meier-Stephenson V, Kim S, Lee KY and Narendran A: Genome-wide loss-of-function genetic screening identifies opioid receptor µ1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia. Oncogene. 36:5910–5913. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Patel N, Krishnan S, Offman MN, Krol M, Moss CX, Leighton C, van Delft FW, Holland M, Liu J, Alexander S, et al: A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase. J Clin Invest. 119:1964–1973. 2009.PubMed/NCBI

66 

Avramis VI and Tiwari PN: Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia. Int J Nanomedicine. 1:241–254. 2006.

67 

Ghasemian A, Al-Marzoqi AH, Al-Abodi HR, Alghanimi YK, Kadhum SA, Shokouhi Mostafavi SK and Fattahi A: Bacterial l-asparaginases for cancer therapy: Current knowledge and future perspectives. J Cell Physiol. 234:19271–19279. 2019. View Article : Google Scholar : PubMed/NCBI

68 

Sokolov NN, Eldarov MA, Pokrovskaya MV, Aleksandrova SS, Abakumova OY, Podobed OV, Melik-Nubarov NS, Kudryashova EV, Grishin DV and Archakov AI: Bacterial recombinant L-asparaginases: Properties, structure and anti-proliferative activity. Biomed Khim. 61:312–324. 2015.In Russian. View Article : Google Scholar : PubMed/NCBI

69 

Krishnapura PR, Belur PD and Subramanya S: A critical review on properties and applications of microbial l-asparaginases. Crit Rev Microbiol. 42:720–737. 2016.

70 

Chiu M, Taurino G, Bianchi MG, Kilberg MS and Bussolati O: Asparagine synthetase in cancer: Beyond acute lymphoblastic leukemia. Front Oncol. 9:14802019. View Article : Google Scholar

71 

Egler RA, Ahuja SP and Matloub Y: L-asparaginase in the treatment of patients with acute lymphoblastic leukemia. J Pharmacol Pharmacother. 7:62–71. 2016. View Article : Google Scholar : PubMed/NCBI

72 

Lee MB and Bridges JM: L-Asparaginase activity in human and animal sera. Nature. 217:758–759. 1968. View Article : Google Scholar : PubMed/NCBI

73 

Oinonen C, Tikkanen R, Rouvinen J and Peltonen L: Three-dimensional structure of human lysosomal aspartylglucosaminidase. Nat Struct Biol. 2:1102–1108. 1995. View Article : Google Scholar : PubMed/NCBI

74 

Sugimoto H, Odani S and Yamashita S: Cloning and expression of cDNA encoding rat liver 60-kDa lysophospholipase containing an asparaginase-like region and ankyrin repeat. J Biol Chem. 273:12536–12542. 1998. View Article : Google Scholar : PubMed/NCBI

75 

Bush LA, Herr JC, Wolkowicz M, Sherman NE, Shore A and Flickinger CJ: A novel asparaginase-like protein is a sperm auto-antigen in rats. Mol Reprod Dev. 247:233–247. 2002. View Article : Google Scholar

76 

Evtimova V, Zeillinger R, Kaul S and Weidle UH: Identification of CRASH, a gene deregulated in gynecological tumors. Int J Oncol. 24:33–41. 2004.

77 

Nomme J, Su Y, Konrad M and Lavie A: Structures of Apo and product-bound human L-asparaginase: Insights into the mechanism of autoproteolysis and substrate hydrolysis. Biochemistry. 51:6816–6826. 2012. View Article : Google Scholar : PubMed/NCBI

78 

Böhme L, Bär JW, Hoffmann T, Manhart S, Ludwig HH, Rosche F and Demuth HU: Isoaspartate residues dramatically influence substrate recognition and turnover by proteases. Biol Chem. 389:1043–1053. 2008. View Article : Google Scholar : PubMed/NCBI

79 

Michalska K and Jaskólski M: Structural aspects of l-asparaginases, their friends and relations. Acta Biochimica Pol. 53:627–640. 2006. View Article : Google Scholar

80 

Dieterich DC, Landwehr M, Reissner C, Smalla KH, Richter K, Wolf G, Böckers TM, Gundelfinger ED and Kreutz MR: Gliap-A novel untypical L-asparaginase localized to rat brain astrocytes. J Neurochem. 85:1117–1125. 2003. View Article : Google Scholar : PubMed/NCBI

81 

Cantor JR, Stone EM, Chantranupong L and Georgiou G: The human asparaginase-like protein 1 hASRGL1 is an Ntn Hydrolase with β-aspartyl peptidase activity. Biochemistry. 48:11025–11031. 2009. View Article : Google Scholar

82 

Brannigan JA, Dodson G, Duggleby HJ, Moody PCE, Smith JL, Tomchick DR and Murzin AG: A protein catalytic framework with an N-terminal nucleophile is capable of self-activation. Nature. 378:416–419. 1995. View Article : Google Scholar : PubMed/NCBI

83 

Duggleby HJ, Tolley SP, Hill CP, Dodson EJ, Dodson G and Moody PCE: Penicillin acylase has a single-amino-acid catalytic Centre. Nature. 373:264–268. 1995. View Article : Google Scholar : PubMed/NCBI

84 

Khan JA, Dunn BM and Tong L: Crystal Structure of human Taspase1, a crucial protease regulating the function of MLL. Structure. 13:1443–1452. 2005. View Article : Google Scholar : PubMed/NCBI

85 

Lowe J, Stock D, Jap B, Zwickl P, Baumeister W and Huber R: Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A Resolution. Science. 268:533–539. 1995. View Article : Google Scholar : PubMed/NCBI

86 

Borek D, Michalska K, Brzezinski K, Kisiel A, Podkowinski J, Bonthron DT, Krowarsch D, Otlewski J and Jaskolski M: Expression, purification and catalytic activity of Lupinus luteus asparagine beta-amidohydrolase and its Escherichia coli homolog. Eur J Biochem. 271:3215–3226. 2004. View Article : Google Scholar : PubMed/NCBI

87 

Li W, Irani S, Crutchfield A, Hodge K, Matthews W, Patel P, Zhang YJ and Stone E: Intramolecular cleavage of the hASRGL1 Homodimer occurs in two stages. Biochemistry. 55:960–969. 2016. View Article : Google Scholar : PubMed/NCBI

88 

Nomme J, Su Y and Lavie A: Elucidation of the specific function of the conserved threonine triad responsible for human l-Asparaginase autocleavage and substrate hydrolysis. J Mol Biol. 426:2471–2485. 2014. View Article : Google Scholar : PubMed/NCBI

89 

Su Y, Karamitros CS, Nomme J, McSorley T, Konrad M and Lavie A: Free glycine accelerates the autoproteolytic activation of human asparaginase. Chem Biol. 20:533–540. 2013. View Article : Google Scholar : PubMed/NCBI

90 

Li W, Cantor JR, Yogesha SD, Yang S and Chantranupong L: Uncoupling Intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation. ACS Chem Biol. 7:1840–1847. 2012. View Article : Google Scholar : PubMed/NCBI

91 

Karamitros CS and Konrad M: Bacterial co-expression of the α and β protomers of human l-asparaginase-3: Achieving essential N-terminal exposure of a catalytically critical threonine located in the beta-subunit. Protein Expr Purif. 93:1–10. 2014. View Article : Google Scholar

92 

Karamitros CS and Konrad M: Fluorescence-activated cell sorting of Human l-asparaginase mutant libraries for detecting enzyme variants with enhanced activity. ACS Chem Biol. 11:2596–2607. 2016. View Article : Google Scholar : PubMed/NCBI

93 

Kelo E, Noronkoski T and Mononen I: Depletion of L-asparagine supply and apoptosis of leukemia cells induced by human glycosylasparaginase. Leukemia. 23:1167–1171. 2009. View Article : Google Scholar : PubMed/NCBI

94 

Leader B, Baca QJ and Golan DE: Protein therapeutics: A summary and pharmacological classification. Nat Rev Drug Discov. 7:21–39. 2008. View Article : Google Scholar

95 

Silverstein SM, Greenbaum S and Stern R: Hyaluronidase in ophthalmology. J App Res. 12:1–13. 2012.

96 

Grabowski GA: Enzyme therapy in type 1 Gaucher disease: Comparative efficacy of mannose-terminated glucocerebrosidase from natural and recombinant sources. Ann Intern Med. 122:33–39. 1995. View Article : Google Scholar : PubMed/NCBI

97 

Eng CM, Guffon N, Wilcox WR, Germain DP, Lee P, Waldek S, Caplan L, Linthorst GE and Desnick RJ; International Collaborative Fabry Disease Study Group: Safety and efficacy of recombinant Human α-Galactosidase A replacement therapy in Fabry's disease. N Engl J Med. 345:9–16. 2001. View Article : Google Scholar : PubMed/NCBI

98 

Klinge L, Straub V, Neudorf U, Schaper J, Bosbach T, Görlinger K, Wallot M, Richards S and Voit T: Safety and efficacy of recombinant acid alpha-glucosidase (rhGAA) in patients with classical infantile Pompe disease: Results of a phase II clinical trial. Neuromuscul Disord. 15:24–31. 2005. View Article : Google Scholar : PubMed/NCBI

99 

Schalk AM and Lavie A: Structural and kinetic characterization of guinea Pig. Biochemistry. 53:2318–2328. 2014. View Article : Google Scholar : PubMed/NCBI

100 

Wang Y and Guo HC: Two-step dimerization for autoproteolysis to activate glycosylasparaginase. J Biol Chem. 278:3210–3219. 2003. View Article : Google Scholar

101 

Marianayagam NJ, Sunde M and Matthews JM: The power of two: Protein dimerization in biology. Trends Biochem Sci. 29:618–625. 2004. View Article : Google Scholar : PubMed/NCBI

102 

Morais SB, Pirolla RAS, Frota NF, Lourenzoni MR, Gozzo FC and Souza TACB: The role of the quaternary structure in the activation of human L-asparaginase. J Proteomics. 224:1038182020. View Article : Google Scholar : PubMed/NCBI

103 

Morin A, Meiler J and Mizoue LS: Computational design of protein-ligand interfaces: Potential in therapeutic development. Trends Biotechnol. 29:159–66. 2011. View Article : Google Scholar : PubMed/NCBI

104 

Marshall SA, Lazar GA, Chirino AJ and Desjarlais JR: Rational design and engineering of therapeutic proteins. Drug Discovery Today. 8:212–221. 2003. View Article : Google Scholar : PubMed/NCBI

105 

Park S and Cochran J: Protein engineering and design. CRC Press; 2009, View Article : Google Scholar

106 

Dinndorf PA, Gootenberg J, Cohen MH, Keegan P and Pazdur R: FDA drug approval summary: Pegaspargase (Oncaspar) for the first-line treatment of Children with acute lymphoblastic leukemia (ALL). Oncologist. 12:991–998. 2007. View Article : Google Scholar : PubMed/NCBI

107 

Schalk AM, Nguyen H-A, Rigouin C and Lavie A: Identification and structural analysis of an l-asparaginase enzyme from guinea pig with putative tumor cell killing properties. J Biol Chem. 289:33175–33186. 2014. View Article : Google Scholar : PubMed/NCBI

108 

Nguyen HA, Su Y and Lavie A: Design and characterization of Erwinia chrysanthemi l-asparaginase variants with diminished l-Glutaminase activity. J Biol Chem. 291:17664–17676. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
De Morais SB and De Souza TD: Human L‑asparaginase: Acquiring knowledge of its activation (Review). Int J Oncol 58: 11, 2021.
APA
De Morais, S.B., & De Souza, T.D. (2021). Human L‑asparaginase: Acquiring knowledge of its activation (Review). International Journal of Oncology, 58, 11. https://doi.org/10.3892/ijo.2021.5191
MLA
De Morais, S. B., De Souza, T. D."Human L‑asparaginase: Acquiring knowledge of its activation (Review)". International Journal of Oncology 58.4 (2021): 11.
Chicago
De Morais, S. B., De Souza, T. D."Human L‑asparaginase: Acquiring knowledge of its activation (Review)". International Journal of Oncology 58, no. 4 (2021): 11. https://doi.org/10.3892/ijo.2021.5191
Copy and paste a formatted citation
x
Spandidos Publications style
De Morais SB and De Souza TD: Human L‑asparaginase: Acquiring knowledge of its activation (Review). Int J Oncol 58: 11, 2021.
APA
De Morais, S.B., & De Souza, T.D. (2021). Human L‑asparaginase: Acquiring knowledge of its activation (Review). International Journal of Oncology, 58, 11. https://doi.org/10.3892/ijo.2021.5191
MLA
De Morais, S. B., De Souza, T. D."Human L‑asparaginase: Acquiring knowledge of its activation (Review)". International Journal of Oncology 58.4 (2021): 11.
Chicago
De Morais, S. B., De Souza, T. D."Human L‑asparaginase: Acquiring knowledge of its activation (Review)". International Journal of Oncology 58, no. 4 (2021): 11. https://doi.org/10.3892/ijo.2021.5191
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