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Review Open Access

Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review)

  • Authors:
    • Mark A. Baxter
    • Russell D. Petty
    • Daniel Swinson
    • Peter S. Hall
    • Shane O'Hanlon
  • View Affiliations / Copyright

    Affiliations: Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD2 1SY, Scotland, UK, Department of Oncology, St. James's Hospital, Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK, Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh EH4 2XR, Scotland, UK, Department of Geriatric Medicine, St. Vincent's University Hospital, Dublin 4, D04 N2E0, Republic of Ireland
    Copyright: © Baxter et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 22
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    Published online on: March 17, 2021
       https://doi.org/10.3892/ijo.2021.5202
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Abstract

Gastroesophageal adenocarcinoma (GOA) is a disease of older people. Incidence is rising in the developed world and the majority of patients present with advanced disease. Based on clinical trial data, systemic chemotherapy in the advanced setting is associated with improvements in quality of life and survival. However, there is a recognised mismatch between trial populations and the patients encountered in clinical practice in terms of age, comorbidity and fitness. Appropriate patient selection is essential to safely deliver effective treatment. In this narrative review, we discuss the challenges faced by clinicians when assessing real‑world patients with advanced GOA for systemic therapy. We also highlight the importance of frailty screening and the current available evidence we can use to guide our management.
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Copy and paste a formatted citation
Spandidos Publications style
Baxter MA, Petty RD, Swinson D, Hall PS and O'Hanlon S: Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review). Int J Oncol 58: 22, 2021.
APA
Baxter, M.A., Petty, R.D., Swinson, D., Hall, P.S., & O'Hanlon, S. (2021). Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review). International Journal of Oncology, 58, 22. https://doi.org/10.3892/ijo.2021.5202
MLA
Baxter, M. A., Petty, R. D., Swinson, D., Hall, P. S., O'Hanlon, S."Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review)". International Journal of Oncology 58.5 (2021): 22.
Chicago
Baxter, M. A., Petty, R. D., Swinson, D., Hall, P. S., O'Hanlon, S."Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review)". International Journal of Oncology 58, no. 5 (2021): 22. https://doi.org/10.3892/ijo.2021.5202
Copy and paste a formatted citation
x
Spandidos Publications style
Baxter MA, Petty RD, Swinson D, Hall PS and O'Hanlon S: Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review). Int J Oncol 58: 22, 2021.
APA
Baxter, M.A., Petty, R.D., Swinson, D., Hall, P.S., & O'Hanlon, S. (2021). Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review). International Journal of Oncology, 58, 22. https://doi.org/10.3892/ijo.2021.5202
MLA
Baxter, M. A., Petty, R. D., Swinson, D., Hall, P. S., O'Hanlon, S."Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review)". International Journal of Oncology 58.5 (2021): 22.
Chicago
Baxter, M. A., Petty, R. D., Swinson, D., Hall, P. S., O'Hanlon, S."Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review)". International Journal of Oncology 58, no. 5 (2021): 22. https://doi.org/10.3892/ijo.2021.5202
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