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Oncogenic role of abnormal spindle‑like microcephaly‑associated protein in lung adenocarcinoma

  • Authors:
    • Jiang Wang
    • Jinghui Liang
    • Haixia Li
    • Jingyi Han
    • Jin Jiang
    • Yongmeng Li
    • Zitong Feng
    • Renchang Zhao
    • Hui Tian
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Physiology and Pathophysiology, School of Basic Medical Sciences of Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 23
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    Published online on: March 29, 2021
       https://doi.org/10.3892/ijo.2021.5203
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Abstract

Lung adenocarcinoma (LUAD) is a common malignant cancer worldwide. It is urgent to explore its underlying molecular mechanism and identify novel diagnostic biomarkers. Abnormal spindle‑like microcephaly (ASPM) has recently received considerable attention due to its function in tumor progression. However, its role in LUAD is unclear. The present study aimed to explore the clinical role of ASPM in LUAD. Seven pairs of LUAD and adjacent normal tissues were collected to identify potential LUAD biomarkers using transcriptome sequencing. The association between ASPM expression and LUAD progression was evaluated using bioinformatics analysis and data obtained from clinical specimens. Using small interfering RNA technology, the function of ASPM was analyzed in the LUAD H1299 and A549 cell lines. Transcriptional profiling of ASPM‑deficient H1299 cells was then performed to determine the downstream targets of ASPM. Using databases and clinical specimens, it was revealed that ASPM expression was frequently elevated in LUAD tissues, and this upregulation was highly associated with LUAD progression. ASPM served as an oncogenic regulator of LUAD cell proliferation and metastasis. Mechanistically, ASPM facilitated epithelial‑mesenchymal transition (EMT) via the PI3K/AKT signaling pathway and 740 Y‑P, an activator of this pathway, restored the migratory ability of ASPM‑knockdown LUAD cells. The current study identified ASPM as an independent prognostic biomarker of LUAD that served an important oncogenic role in regulating LUAD cell metastasis by promoting EMT via the PI3K/AKT signaling pathway. Targeting ASPM may therefore be a therapeutic strategy for treating LUAD.
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Cancer Genome Atlas and Research Network: Comprehensive molecular profiling of lung adenocarcinoma. Nature. 511:543–550. 2014. View Article : Google Scholar

3 

Hirsch FR, Scagliotti GV, Mulshine JL, Kwon R, Curran WJ Jr, Wu YL and Paz-Ares L: Lung cancer: Current therapies and new targeted treatments. Lancet. 389:299–311. 2017. View Article : Google Scholar

4 

Borczuk AC: Prognostic considerations of the new world health organization classification of lung adenocarcinoma. Eur Respir Rev. 25:364–371. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Zhong X, Liu L, Zhao A, Pfeifer GP and Xu X: The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein. Cell Cycle. 4:1227–1229. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Kouprina N, Pavlicek A, Mochida GH, Solomon G, Gersch W, Yoon YH, Collura R, Ruvolo M, Barrett JC, Woods CG, et al: Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion. PLoS Biol. 2:E1262004. View Article : Google Scholar : PubMed/NCBI

7 

Passemard S, Titomanlio L, Elmaleh M, Afenjar A, Alessandri JL, Andria G, Billette de Villemeur T, Boespflug-Tanguy O, Burglen L, Del Giudice E, et al: Expanding the clinical and neuroradiologic phenotype of primary microcephaly due to ASPM mutations. Neurology. 73:962–969. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Capecchi MR and Pozner A: ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. Nat Commun. 6:87632015. View Article : Google Scholar : PubMed/NCBI

9 

Gai M, Bianchi FT, Vagnoni C, Verni F, Bonaccorsi S, Pasquero S, Berto GE, Sgrò F, Chiotto AA, Annaratone L, et al: ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules. EMBO Rep. 18:18702017. View Article : Google Scholar : PubMed/NCBI

10 

Jiang K, Rezabkova L, Hua S, Liu Q, Capitani G, Altelaar AFM, Heck AJR, Kammerer RA, Steinmetz MO and Akhmanova A: Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Nat Cell Biol. 19:480–492. 2017. View Article : Google Scholar : PubMed/NCBI

11 

An X, Huang Y and Zhao P: Expression of ASPM in colonic adenocarcinoma and its clinicopathologic significance. Int J Clin Exp Pathol. 10:8968–8973. 2017.PubMed/NCBI

12 

Chen X, Huang L, Yang Y, Chen S, Sun J, Ma C, Xie J, Song Y and Yang J: ASPM promotes glioblastoma growth by regulating G1 restriction point progression and Wnt-β-catenin signaling. Aging (Albany NY). 12:224–241. 2020. View Article : Google Scholar

13 

Xie JJ, Zhuo YJ, Zheng Y, Mo RJ, Liu ZZ, Li BW, Cai ZD, Zhu XJ, Liang YX, He HC and de Zhong W: High expression of ASPM correlates with tumor progression and predicts poor outcome in patients with prostate cancer. Int Urol Nephrol. 49:817–823. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Timaner M and Shaked Y: Elucidating the roles of ASPM isoforms reveals a novel prognostic marker for pancreatic cancer. J Pathol. 250:123–125. 2020. View Article : Google Scholar

15 

Alsiary R, Bruning-Richardson A, Bond J, Morrison EE, Wilkinson N and Bell SM: Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression. PLoS One. 9:e970592014. View Article : Google Scholar : PubMed/NCBI

16 

Lin SY, Pan HW, Liu SH, Jeng YM, Hu FC, Peng SY, Lai PL and Hsu HC: ASPM is a novel marker for vascular invasion, early recurrence, and poor prognosis of hepatocellular carcinoma. Clin Cancer Res. 14:4814–4820. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Xu Z, Zhang Q, Luh F, Jin B and Liu X: Overexpression of the ASPM gene is associated with aggressiveness and poor outcome in bladder cancer. Oncol Lett. 17:1865–1876. 2019.PubMed/NCBI

18 

Chansky K, Detterbeck FC, Nicholson AG, Rusch VW, Vallieres E, Groome P, Kennedy C, Krasnik M, Peake M, Shemanski L, et al: The IASLC lung cancer staging project: External validation of the revision of the TNM stage groupings in the eighth edition of the TNM classification of lung cancer. J Thorac Oncol. 12:1109–1121. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Liang J, Li H, Han J, Jiang J, Wang J, Li Y, Feng Z, Zhao R, Sun Z, Lv B and Tian H: Mex3a interacts with LAMA2 to promote lung adenocarcinoma metastasis via PI3K/AKT pathway. Cell Death Dis. 11:6142020. View Article : Google Scholar : PubMed/NCBI

20 

Lu TP, Tsai MH, Lee JM, Hsu CP, Chen PC, Lin CW, Shih JY, Yang PC, Hsiao CK, Lai LC and Chuang EY: Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women. Cancer Epidemiol Biomarkers Prev. 19:2590–2597. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Moreno Leon L, Gautier M, Allan R, Ilie M, Nottet N, Pons N, Paquet A, Lebrigand K, Truchi M, Fassy J, et al: The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative stress. Oncogene. 38:7146–7165. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Okayama H, Kohno T, Ishii Y, Shimada Y, Shiraishi K, Iwakawa R, Furuta K, Tsuta K, Shibata T, Yamamoto S, et al: Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas. Cancer Res. 72:100–111. 2012. View Article : Google Scholar

23 

Director's Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma; Shedden K, Taylor JM, Enkemann SA, Tsao MS, Yeatman TJ, Gerald WL, Eschrich S, Jurisica I, Giordano TJ, et al: Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study. Nat Med. 14:822–827. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Huang da W, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar

26 

Yeo W, Chan SL, Mo FK, Chu CM, Hui JW, Tong JH, Chan AWH, Koh J, Hui EP, Loong H, et al: Phase I/II study of temsirolimus for patients with unresectable hepatocellular carcinoma (HCC)-a correlative study to explore potential biomarkers for response. BMC Cancer. 15:3952015. View Article : Google Scholar

27 

Azim HA Jr, Peccatori FA, Brohee S, Branstetter D, Loi S, Viale G, Piccart M, Dougall WC, Pruneri G and Sotiriou C: RANK-ligand (RANKL) expression in young breast cancer patients and during pregnancy. Breast Cancer Res. 17:242015. View Article : Google Scholar : PubMed/NCBI

28 

Su D, Liao Z, Feng B, Wang T, Shan B, Zeng Q, Song J and Song Y: Pulsatilla chinensis saponins cause liver injury through interfering ceramide/sphingomyelin balance that promotes lipid metabolism dysregulation and apoptosis. Phytomedicine. 76:1532652020. View Article : Google Scholar : PubMed/NCBI

29 

Shan B, Ai Z, Zeng S, Song Y, Song J, Zeng Q, Liao Z, Wang T, Huang C and Su D: Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway. Psychoneuroendocrinology. 117:1046992020. View Article : Google Scholar : PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

31 

Larue L and Bellacosa A: Epithelial-mesenchymal transition in development and cancer: Role of phosphatidylinositol 3′ kinase/AKT pathways. Oncogene. 24:7443–7454. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Paolillo M and Schinelli S: Extracellular matrix alterations in metastatic processes. Int J Mol Sci. 20:49472019. View Article : Google Scholar :

33 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2020. CA Cancer J Clin. 70:7–30. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Oudkerk M, Liu S, Heuvelmans MA, Walter JE and Field JK: Lung cancer LDCT screening and mortality reduction-evidence, pitfalls and future perspectives. Nat Rev Clin Oncol. 18:135–151. 2021. View Article : Google Scholar

35 

Li Z, Qi F and Li F: Establishment of a gene signature to predict prognosis for patients with lung adenocarcinoma. Int J Mol Sci. 21:84792020. View Article : Google Scholar :

36 

Li L, Peng M, Xue W, Fan Z, Wang T, Lian J, Zhai Y, Lian W, Qin D and Zhao J: Integrated analysis of dysregulated long non-coding RNAs/microRNAs/mRNAs in metastasis of lung adenocarcinoma. J Transl Med. 16:3722018. View Article : Google Scholar : PubMed/NCBI

37 

Hsu CC, Liao WY, Chan TS, Chen WY, Lee CT, Shan YS, Huang PJ, Hou YC, Li CR and Tsai KK: The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosis. J Pathol. 249:498–508. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Tang J, Lu M, Cui Q, Zhang D, Kong D, Liao X, Ren J, Gong Y and Wu G: Overexpression of ASPM, CDC20, and TTK confer a poorer prognosis in breast cancer identified by gene co-expression network analysis. Front Oncol. 9:3102019. View Article : Google Scholar : PubMed/NCBI

39 

Zhou JW, Wang H, Sun W, Han NN and Chen L: ASPM is a predictor of overall survival and has therapeutic potential in endometrial cancer. Am J Transl Res. 12:1942–1953. 2020.PubMed/NCBI

40 

Bikeye SN, Colin C, Marie Y, Vampouille R, Ravassard P, Rousseau A, Boisselier B, Idbaih A, Calvo CF, Leuraud P, et al: ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target. Cancer Cell Int. 10:12010. View Article : Google Scholar : PubMed/NCBI

41 

Yuan YJ, Sun Y, Gao R, Yin ZZ, Yuan ZY and Xu LM: Abnormal spindle-like microcephaly-associated protein (ASPM) contributes to the progression of lung squamous cell carcinoma (LSCC) by regulating CDK4. J Cancer. 11:5413–5423. 2020. View Article : Google Scholar : PubMed/NCBI

42 

Santamaria PG, Moreno-Bueno G, Portillo F and Cano A: EMT: Present and future in clinical oncology. Mol Oncol. 11:718–738. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Aiello NM and Kang Y: Context-dependent EMT programs in cancer metastasis. J Exp Med. 216:1016–1026. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Karimi Roshan M, Soltani A, Soleimani A, Rezaie Kahkhaie K, Afshari AR and Soukhtanloo M: Role of AKT and mTOR signaling pathways in the induction of epithelial-mesenchymal transition (EMT) process. Biochimie. 165:229–234. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Papadimitrakopoulou V: Development of PI3K/AKT/mTOR pathway inhibitors and their application in personalized therapy for non-small-cell lung cancer. J Thorac Oncol. 7:1315–1326. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Wang F, Li J, Liu J and Zhao Q: Controversial role of the possible oxyntic stem cell marker ASPM in gastric cancer. J Pathol. 241:559–561. 2017. View Article : Google Scholar

47 

Pai VC, Hsu CC, Chan TS, Liao WY, Chuu CP, Chen WY, Li CR, Lin CY, Huang SP, Chen LT and Tsai KK: ASPM promotes prostate cancer stemness and progression by augmenting Wnt-Dvl-3-β-catenin signaling. Oncogene. 38:1340–1353. 2019. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Liang J, Li H, Han J, Jiang J, Li Y, Feng Z, Zhao R and Tian H: Oncogenic role of abnormal spindle‑like microcephaly‑associated protein in lung adenocarcinoma. Int J Oncol 58: 23, 2021.
APA
Wang, J., Liang, J., Li, H., Han, J., Jiang, J., Li, Y. ... Tian, H. (2021). Oncogenic role of abnormal spindle‑like microcephaly‑associated protein in lung adenocarcinoma. International Journal of Oncology, 58, 23. https://doi.org/10.3892/ijo.2021.5203
MLA
Wang, J., Liang, J., Li, H., Han, J., Jiang, J., Li, Y., Feng, Z., Zhao, R., Tian, H."Oncogenic role of abnormal spindle‑like microcephaly‑associated protein in lung adenocarcinoma". International Journal of Oncology 58.5 (2021): 23.
Chicago
Wang, J., Liang, J., Li, H., Han, J., Jiang, J., Li, Y., Feng, Z., Zhao, R., Tian, H."Oncogenic role of abnormal spindle‑like microcephaly‑associated protein in lung adenocarcinoma". International Journal of Oncology 58, no. 5 (2021): 23. https://doi.org/10.3892/ijo.2021.5203
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Liang J, Li H, Han J, Jiang J, Li Y, Feng Z, Zhao R and Tian H: Oncogenic role of abnormal spindle‑like microcephaly‑associated protein in lung adenocarcinoma. Int J Oncol 58: 23, 2021.
APA
Wang, J., Liang, J., Li, H., Han, J., Jiang, J., Li, Y. ... Tian, H. (2021). Oncogenic role of abnormal spindle‑like microcephaly‑associated protein in lung adenocarcinoma. International Journal of Oncology, 58, 23. https://doi.org/10.3892/ijo.2021.5203
MLA
Wang, J., Liang, J., Li, H., Han, J., Jiang, J., Li, Y., Feng, Z., Zhao, R., Tian, H."Oncogenic role of abnormal spindle‑like microcephaly‑associated protein in lung adenocarcinoma". International Journal of Oncology 58.5 (2021): 23.
Chicago
Wang, J., Liang, J., Li, H., Han, J., Jiang, J., Li, Y., Feng, Z., Zhao, R., Tian, H."Oncogenic role of abnormal spindle‑like microcephaly‑associated protein in lung adenocarcinoma". International Journal of Oncology 58, no. 5 (2021): 23. https://doi.org/10.3892/ijo.2021.5203
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