Open Access

Parenteral high‑dose ascorbate - A possible approach for the treatment of glioblastoma (Review)

  • Authors:
    • Olga Renner
    • Markus Burkard
    • Holger Michels
    • Claudia Vollbracht
    • Tobias Sinnberg
    • Sascha Venturelli
  • View Affiliations

  • Published online on: May 6, 2021     https://doi.org/10.3892/ijo.2021.5215
  • Article Number: 35
  • Copyright: © Renner et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

For glioblastoma, the treatment with standard of care therapy comprising resection, radiation, and temozolomide results in overall survival of approximately 14-18 months after initial diagnosis. Even though several new therapy approaches are under investigation, it is difficult to achieve life prolongation and/or improvement of patient's quality of life. The aggressiveness and progression of glioblastoma is initially orchestrated by the biological complexity of its genetic phenotype and ability to respond to cancer therapy via changing its molecular patterns, thereby developing resistance. Recent clinical studies of pharmacological ascorbate have demonstrated its safety and potential efficacy in different cancer entities regarding patient's quality of life and prolongation of survival. In this review article, the actual glioblastoma treatment possibilities are summarized, the evidence for pharmacological ascorbate in glioblastoma treatment is examined and questions are posed to identify current gaps of knowledge regarding accessibility of ascorbate to the tumor area. Experiments with glioblastoma cell lines and tumor xenografts have demonstrated that high‑dose ascorbate induces cytotoxicity and oxidative stress largely selectively in malignant cells compared to normal cells suggesting ascorbate as a potential therapeutic agent. Further investigations in larger cohorts and randomized placebo‑controlled trials should be performed to confirm these findings as well as to improve delivery strategies to the brain, through the inherent barriers and ultimately to the malignant cells.
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June-2021
Volume 58 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Renner O, Burkard M, Michels H, Vollbracht C, Sinnberg T and Venturelli S: Parenteral high‑dose ascorbate - A possible approach for the treatment of glioblastoma (Review). Int J Oncol 58: 35, 2021
APA
Renner, O., Burkard, M., Michels, H., Vollbracht, C., Sinnberg, T., & Venturelli, S. (2021). Parenteral high‑dose ascorbate - A possible approach for the treatment of glioblastoma (Review). International Journal of Oncology, 58, 35. https://doi.org/10.3892/ijo.2021.5215
MLA
Renner, O., Burkard, M., Michels, H., Vollbracht, C., Sinnberg, T., Venturelli, S."Parenteral high‑dose ascorbate - A possible approach for the treatment of glioblastoma (Review)". International Journal of Oncology 58.6 (2021): 35.
Chicago
Renner, O., Burkard, M., Michels, H., Vollbracht, C., Sinnberg, T., Venturelli, S."Parenteral high‑dose ascorbate - A possible approach for the treatment of glioblastoma (Review)". International Journal of Oncology 58, no. 6 (2021): 35. https://doi.org/10.3892/ijo.2021.5215