Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells

  • Authors:
    • Xuan-Mei Piao
    • Byungdoo Hwang
    • Pildu Jeong
    • Young Joon Byun
    • Ho Won Kang
    • Sung Phil Seo
    • Won Tae Kim
    • Jong-Young Lee
    • Yun-Sok Ha
    • Young-Suk Lee
    • Isaac Y. Kim
    • Yung Hyun Choi
    • Eun-Jong Cha
    • Sung-Kwon Moon
    • Seok Joong Yun
    • Wun-Jae Kim
  • View Affiliations

  • Published online on: May 7, 2021     https://doi.org/10.3892/ijo.2021.5217
  • Article Number: 37
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The bladder cancer (BCa) microenvironment comprises heterogeneous tumor cell populations, the surrounding stroma and the extracellular matrix (ECM). Collagen, the scaffold of the tumor microenvironment, regulates ECM remodeling to promote tumor infiltration, angiogenesis, invasion and migration. The present study examined how collagen type VI‑α (COL6A) 1 and 2 function during BCa pathogenesis and progression, with the aim of facilitating the development of precision therapeutics, risk stratification and molecular diagnosis. COL6A1 and COL6A2 mRNA expression in non‑muscle invasive BCa (NMIBC) and MIBC tissue samples was measured using reverse transcription‑quantitative PCR. In addition, the tumor‑suppressive effects of COL6A1 and COL6A2 in human BCa EJ cells (MGH‑U1) were assessed. Compared with normal controls, COL6A1 and COL6A2 mRNA expression was downregulated in both NMIBC and MIBC tissue samples (P<0.05, respectively). COL6A1 and COL6A2 effectively inhibited the proliferation of human BCa EJ cells (MGH‑U1) and induced cell cycle arrest at the G1 phase. Additionally, COL6A1 and COL6A2 served roles in MAPK and AKT signaling by increasing p38 MAPK phosphorylation and decreasing AKT phosphorylation. Finally, COL6A1 and COL6A2 inhibited wound healing and invasion by suppressing the activity of matrix metalloproteinase (MMP)‑2 and MMP‑9. In conclusion, COL6A1 and COL6A2 may act as classical collagens by forming a physical barrier to inhibit BCa tumor growth and invasion.
View References

Related Articles

Journal Cover

July-2021
Volume 59 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Piao X, Hwang B, Jeong P, Byun YJ, Kang HW, Seo SP, Kim WT, Lee J, Ha Y, Lee Y, Lee Y, et al: Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells. Int J Oncol 59: 37, 2021
APA
Piao, X., Hwang, B., Jeong, P., Byun, Y.J., Kang, H.W., Seo, S.P. ... Kim, W. (2021). Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells. International Journal of Oncology, 59, 37. https://doi.org/10.3892/ijo.2021.5217
MLA
Piao, X., Hwang, B., Jeong, P., Byun, Y. J., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J., Ha, Y., Lee, Y., Kim, I. Y., Choi, Y. H., Cha, E., Moon, S., Yun, S. J., Kim, W."Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells". International Journal of Oncology 59.1 (2021): 37.
Chicago
Piao, X., Hwang, B., Jeong, P., Byun, Y. J., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J., Ha, Y., Lee, Y., Kim, I. Y., Choi, Y. H., Cha, E., Moon, S., Yun, S. J., Kim, W."Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells". International Journal of Oncology 59, no. 1 (2021): 37. https://doi.org/10.3892/ijo.2021.5217