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Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells

  • Authors:
    • Xuan-Mei Piao
    • Byungdoo Hwang
    • Pildu Jeong
    • Young Joon Byun
    • Ho Won Kang
    • Sung Phil Seo
    • Won Tae Kim
    • Jong-Young Lee
    • Yun-Sok Ha
    • Young-Suk Lee
    • Isaac Y. Kim
    • Yung Hyun Choi
    • Eun-Jong Cha
    • Sung-Kwon Moon
    • Seok Joong Yun
    • Wun-Jae Kim
  • View Affiliations / Copyright

    Affiliations: Department of Urology, College of Medicine, Chungbuk National University, Cheongju, Chungcheongbuk 28644, Republic of Korea, Department of Food Science and Technology, Chung‑Ang University, Anseong, Gyeonggi 456‑756, Republic of Korea, Oneomics Institute, Seoul 04158, Republic of Korea, Department of Urology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea, Department of Urology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Gyeongsangnam 51353, Republic of Korea, Section of Urologic Oncology and Dean and Betty Gallo Prostate Cancer Center, The Cancer Institute of New Jersey and Robert Wood Johnson Medical School, New Brunswick, NJ 08903‑2681, USA, Department of Biochemistry, College of Oriental Medicine, Dong‑Eui University, Busan 614‑052, Republic of Korea, Department of Biomedical Engineering, Chungbuk National University College of Medicine, Cheongju, Chungcheongbuk 28644, Republic of Korea
  • Article Number: 37
    |
    Published online on: May 7, 2021
       https://doi.org/10.3892/ijo.2021.5217
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Abstract

The bladder cancer (BCa) microenvironment comprises heterogeneous tumor cell populations, the surrounding stroma and the extracellular matrix (ECM). Collagen, the scaffold of the tumor microenvironment, regulates ECM remodeling to promote tumor infiltration, angiogenesis, invasion and migration. The present study examined how collagen type VI‑α (COL6A) 1 and 2 function during BCa pathogenesis and progression, with the aim of facilitating the development of precision therapeutics, risk stratification and molecular diagnosis. COL6A1 and COL6A2 mRNA expression in non‑muscle invasive BCa (NMIBC) and MIBC tissue samples was measured using reverse transcription‑quantitative PCR. In addition, the tumor‑suppressive effects of COL6A1 and COL6A2 in human BCa EJ cells (MGH‑U1) were assessed. Compared with normal controls, COL6A1 and COL6A2 mRNA expression was downregulated in both NMIBC and MIBC tissue samples (P<0.05, respectively). COL6A1 and COL6A2 effectively inhibited the proliferation of human BCa EJ cells (MGH‑U1) and induced cell cycle arrest at the G1 phase. Additionally, COL6A1 and COL6A2 served roles in MAPK and AKT signaling by increasing p38 MAPK phosphorylation and decreasing AKT phosphorylation. Finally, COL6A1 and COL6A2 inhibited wound healing and invasion by suppressing the activity of matrix metalloproteinase (MMP)‑2 and MMP‑9. In conclusion, COL6A1 and COL6A2 may act as classical collagens by forming a physical barrier to inhibit BCa tumor growth and invasion.
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Copy and paste a formatted citation
Spandidos Publications style
Piao X, Hwang B, Jeong P, Byun YJ, Kang HW, Seo SP, Kim WT, Lee J, Ha Y, Lee Y, Lee Y, et al: Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells. Int J Oncol 59: 37, 2021.
APA
Piao, X., Hwang, B., Jeong, P., Byun, Y.J., Kang, H.W., Seo, S.P. ... Kim, W. (2021). Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells. International Journal of Oncology, 59, 37. https://doi.org/10.3892/ijo.2021.5217
MLA
Piao, X., Hwang, B., Jeong, P., Byun, Y. J., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J., Ha, Y., Lee, Y., Kim, I. Y., Choi, Y. H., Cha, E., Moon, S., Yun, S. J., Kim, W."Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells". International Journal of Oncology 59.1 (2021): 37.
Chicago
Piao, X., Hwang, B., Jeong, P., Byun, Y. J., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J., Ha, Y., Lee, Y., Kim, I. Y., Choi, Y. H., Cha, E., Moon, S., Yun, S. J., Kim, W."Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells". International Journal of Oncology 59, no. 1 (2021): 37. https://doi.org/10.3892/ijo.2021.5217
Copy and paste a formatted citation
x
Spandidos Publications style
Piao X, Hwang B, Jeong P, Byun YJ, Kang HW, Seo SP, Kim WT, Lee J, Ha Y, Lee Y, Lee Y, et al: Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells. Int J Oncol 59: 37, 2021.
APA
Piao, X., Hwang, B., Jeong, P., Byun, Y.J., Kang, H.W., Seo, S.P. ... Kim, W. (2021). Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells. International Journal of Oncology, 59, 37. https://doi.org/10.3892/ijo.2021.5217
MLA
Piao, X., Hwang, B., Jeong, P., Byun, Y. J., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J., Ha, Y., Lee, Y., Kim, I. Y., Choi, Y. H., Cha, E., Moon, S., Yun, S. J., Kim, W."Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells". International Journal of Oncology 59.1 (2021): 37.
Chicago
Piao, X., Hwang, B., Jeong, P., Byun, Y. J., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J., Ha, Y., Lee, Y., Kim, I. Y., Choi, Y. H., Cha, E., Moon, S., Yun, S. J., Kim, W."Collagen type VI‑α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells". International Journal of Oncology 59, no. 1 (2021): 37. https://doi.org/10.3892/ijo.2021.5217
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