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The inhibitory effect of CTAB on human osteosarcoma through the PI3K/AKT signaling pathway

  • Authors:
    • Wacili Da
    • Lin Tao
    • Yue Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Da et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 42
    |
    Published online on: May 14, 2021
       https://doi.org/10.3892/ijo.2021.5222
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Abstract

Osteosarcoma (OS) metastasis and recurrence and multidrug resistance are three major obstacles in the clinic. New highly effective and low toxicity drugs for osteosarcoma are needed. The antitumoral efficacy of cetrimonium bromide (CTAB), a quaternary ammonium compound, is gradually being investigated. The aim of the present study was to investigate the effects of CTAB on OS cells and the underlying mechanisms. CTAB inhibited the proliferation of osteosarcoma cells in a concentration‑ and time‑dependent manner, resulting in cell cycle arrest in G1 phase. CTAB also suppressed the migration and invasion of HOS and MG63 cells at a low concentration without inhibiting the growth of human osteoblasts. Moreover, CTAB promoted caspase‑mediated apoptosis of osteosarcoma cells through the PI3K/AKT cascade, and this effect was accompanied by obvious mitochondrial toxicity. In vivo, CTAB inhibited OS proliferation without inducing organ toxicity. In conclusion, this study reveals that CTAB has an inhibitory effect on OS by suppressing proliferation and metastasis and inducing apoptosis through the PI3K/AKT signaling pathway and identifies CTAB as a potential therapeutic drug.
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Copy and paste a formatted citation
Spandidos Publications style
Da W, Tao L and Zhu Y: The inhibitory effect of CTAB on human osteosarcoma through the PI3K/AKT signaling pathway. Int J Oncol 59: 42, 2021.
APA
Da, W., Tao, L., & Zhu, Y. (2021). The inhibitory effect of CTAB on human osteosarcoma through the PI3K/AKT signaling pathway. International Journal of Oncology, 59, 42. https://doi.org/10.3892/ijo.2021.5222
MLA
Da, W., Tao, L., Zhu, Y."The inhibitory effect of CTAB on human osteosarcoma through the PI3K/AKT signaling pathway". International Journal of Oncology 59.1 (2021): 42.
Chicago
Da, W., Tao, L., Zhu, Y."The inhibitory effect of CTAB on human osteosarcoma through the PI3K/AKT signaling pathway". International Journal of Oncology 59, no. 1 (2021): 42. https://doi.org/10.3892/ijo.2021.5222
Copy and paste a formatted citation
x
Spandidos Publications style
Da W, Tao L and Zhu Y: The inhibitory effect of CTAB on human osteosarcoma through the PI3K/AKT signaling pathway. Int J Oncol 59: 42, 2021.
APA
Da, W., Tao, L., & Zhu, Y. (2021). The inhibitory effect of CTAB on human osteosarcoma through the PI3K/AKT signaling pathway. International Journal of Oncology, 59, 42. https://doi.org/10.3892/ijo.2021.5222
MLA
Da, W., Tao, L., Zhu, Y."The inhibitory effect of CTAB on human osteosarcoma through the PI3K/AKT signaling pathway". International Journal of Oncology 59.1 (2021): 42.
Chicago
Da, W., Tao, L., Zhu, Y."The inhibitory effect of CTAB on human osteosarcoma through the PI3K/AKT signaling pathway". International Journal of Oncology 59, no. 1 (2021): 42. https://doi.org/10.3892/ijo.2021.5222
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