Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review)

  • Authors:
    • Jianyu Hua
    • Guohong Zhuang
    • Zhongquan Qi
  • View Affiliations

  • Published online on: May 21, 2021     https://doi.org/10.3892/ijo.2021.5226
  • Article Number: 46
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Tumour necrosis factor (TNF)‑α‑inducible protein 8 (TNFAIP8) is the founding member of the TIPE family. According to accumulating evidence, TNFAIP8 plays a pivotal role in the regulation of a variety of tumours, as well as inflammatory diseases. TNFAIP8 is suggested to act as an anti‑apoptotic protein, affecting proliferation, metastasis, invasion, angiogenesis, drug resistance and immune response through multiple signalling pathways. From the clinical point of view, further studies should be required to confirm the prognostic value of TNFAIP8 and also clarify its possible contribution to the development of a novel therapeutic strategy to treat patients with tumours, including those of the breast, colon and lung, and inflammatory diseases. The present review focuses on the TIPE family member TNFAIP8 and describes the molecular mechanisms with regard to how TNFAIP8 could participate in the development of tumours as well as other conditions.
View Figures
View References

Related Articles

Journal Cover

July-2021
Volume 59 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hua J, Zhuang G and Qi Z: Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review). Int J Oncol 59: 46, 2021
APA
Hua, J., Zhuang, G., & Qi, Z. (2021). Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review). International Journal of Oncology, 59, 46. https://doi.org/10.3892/ijo.2021.5226
MLA
Hua, J., Zhuang, G., Qi, Z."Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review)". International Journal of Oncology 59.1 (2021): 46.
Chicago
Hua, J., Zhuang, G., Qi, Z."Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review)". International Journal of Oncology 59, no. 1 (2021): 46. https://doi.org/10.3892/ijo.2021.5226