Open Access

QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis

  • Authors:
    • Tangliang Zhao
    • Yulin Zhou
    • Qingyun Wang
    • Xiaoming Yi
    • Silun Ge
    • Haowei He
    • Song Xue
    • Bowen Du
    • Jingping Ge
    • Jie Dong
    • Le Qu
    • Linhui Wang
    • Wenquan Zhou
  • View Affiliations

  • Published online on: May 25, 2021     https://doi.org/10.3892/ijo.2021.5228
  • Article Number: 48
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sunitinib is widely used as a first‑line treatment for advanced renal cell carcinoma (RCC). However, a number of patients with RCC who receive sunitinib develop drug resistance; and the biological mechanisms involved in resistance to sunitinib remain unclear. It has previously been suggested that the protein glutaminyl‑peptide cyclotransferase (QPCT) is closely related to sunitinib resistance in RCC. Thus, in the present study, in order to further examine the molecular mechanisms responsible for sunitinib resistance in RCC, sunitinib‑non‑responsive and ‑responsive RCC tissue and plasma samples were collected and additional experiments were performed in order to elucidate the molecular mechanisms responsible for sunitinib resistance in RCC. The upstream and downstream regulatory mechanisms of QPCT were also evaluated. On the whole, the data from the present study suggest that QPCT, CCCTC‑binding factor (CTCF) and phosphatidylinositol‑4,5‑bisphosphate 3‑kinase catalytic subunit alpha (PIK3CA) may be used as targets for predicting, reversing and treating sunitinib‑resistant RCC.
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July-2021
Volume 59 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Zhao T, Zhou Y, Wang Q, Yi X, Ge S, He H, Xue S, Du B, Ge J, Dong J, Dong J, et al: QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis. Int J Oncol 59: 48, 2021
APA
Zhao, T., Zhou, Y., Wang, Q., Yi, X., Ge, S., He, H. ... Zhou, W. (2021). QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis. International Journal of Oncology, 59, 48. https://doi.org/10.3892/ijo.2021.5228
MLA
Zhao, T., Zhou, Y., Wang, Q., Yi, X., Ge, S., He, H., Xue, S., Du, B., Ge, J., Dong, J., Qu, L., Wang, L., Zhou, W."QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis". International Journal of Oncology 59.1 (2021): 48.
Chicago
Zhao, T., Zhou, Y., Wang, Q., Yi, X., Ge, S., He, H., Xue, S., Du, B., Ge, J., Dong, J., Qu, L., Wang, L., Zhou, W."QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis". International Journal of Oncology 59, no. 1 (2021): 48. https://doi.org/10.3892/ijo.2021.5228