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QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis

  • Authors:
    • Tangliang Zhao
    • Yulin Zhou
    • Qingyun Wang
    • Xiaoming Yi
    • Silun Ge
    • Haowei He
    • Song Xue
    • Bowen Du
    • Jingping Ge
    • Jie Dong
    • Le Qu
    • Linhui Wang
    • Wenquan Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, P.R. China, Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 48
    |
    Published online on: May 25, 2021
       https://doi.org/10.3892/ijo.2021.5228
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Abstract

Sunitinib is widely used as a first‑line treatment for advanced renal cell carcinoma (RCC). However, a number of patients with RCC who receive sunitinib develop drug resistance; and the biological mechanisms involved in resistance to sunitinib remain unclear. It has previously been suggested that the protein glutaminyl‑peptide cyclotransferase (QPCT) is closely related to sunitinib resistance in RCC. Thus, in the present study, in order to further examine the molecular mechanisms responsible for sunitinib resistance in RCC, sunitinib‑non‑responsive and ‑responsive RCC tissue and plasma samples were collected and additional experiments were performed in order to elucidate the molecular mechanisms responsible for sunitinib resistance in RCC. The upstream and downstream regulatory mechanisms of QPCT were also evaluated. On the whole, the data from the present study suggest that QPCT, CCCTC‑binding factor (CTCF) and phosphatidylinositol‑4,5‑bisphosphate 3‑kinase catalytic subunit alpha (PIK3CA) may be used as targets for predicting, reversing and treating sunitinib‑resistant RCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao T, Zhou Y, Wang Q, Yi X, Ge S, He H, Xue S, Du B, Ge J, Dong J, Dong J, et al: QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis. Int J Oncol 59: 48, 2021.
APA
Zhao, T., Zhou, Y., Wang, Q., Yi, X., Ge, S., He, H. ... Zhou, W. (2021). QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis. International Journal of Oncology, 59, 48. https://doi.org/10.3892/ijo.2021.5228
MLA
Zhao, T., Zhou, Y., Wang, Q., Yi, X., Ge, S., He, H., Xue, S., Du, B., Ge, J., Dong, J., Qu, L., Wang, L., Zhou, W."QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis". International Journal of Oncology 59.1 (2021): 48.
Chicago
Zhao, T., Zhou, Y., Wang, Q., Yi, X., Ge, S., He, H., Xue, S., Du, B., Ge, J., Dong, J., Qu, L., Wang, L., Zhou, W."QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis". International Journal of Oncology 59, no. 1 (2021): 48. https://doi.org/10.3892/ijo.2021.5228
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao T, Zhou Y, Wang Q, Yi X, Ge S, He H, Xue S, Du B, Ge J, Dong J, Dong J, et al: QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis. Int J Oncol 59: 48, 2021.
APA
Zhao, T., Zhou, Y., Wang, Q., Yi, X., Ge, S., He, H. ... Zhou, W. (2021). QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis. International Journal of Oncology, 59, 48. https://doi.org/10.3892/ijo.2021.5228
MLA
Zhao, T., Zhou, Y., Wang, Q., Yi, X., Ge, S., He, H., Xue, S., Du, B., Ge, J., Dong, J., Qu, L., Wang, L., Zhou, W."QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis". International Journal of Oncology 59.1 (2021): 48.
Chicago
Zhao, T., Zhou, Y., Wang, Q., Yi, X., Ge, S., He, H., Xue, S., Du, B., Ge, J., Dong, J., Qu, L., Wang, L., Zhou, W."QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis". International Journal of Oncology 59, no. 1 (2021): 48. https://doi.org/10.3892/ijo.2021.5228
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