Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
July-2021 Volume 59 Issue 1

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2021 Volume 59 Issue 1

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

A multidisciplinary approach remains the best strategy to improve and strengthen the management of ovarian cancer (Review)

  • Authors:
    • Luca Falzone
    • Giuseppa Scandurra
    • Valentina Lombardo
    • Giuseppe Gattuso
    • Alessandro Lavoro
    • Andrea Benedetto Distefano
    • Giuseppe Scibilia
    • Paolo Scollo
  • View Affiliations / Copyright

    Affiliations: Epidemiology and Biostatistics Unit, National Cancer Institute‑IRCCS Fondazione G. Pascale, I‑80131 Naples, Italy, Medical Oncology Unit, Cannizzaro Hospital, I‑95126 Catania, Italy, Department of Biomedical and Biotechnological Sciences, University of Catania, I‑95123 Catania, Italy, Unit of Obstetrics and Gynecology, Cannizzaro Hospital, I‑95126 Catania, Italy
    Copyright: © Falzone et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 53
    |
    Published online on: June 14, 2021
       https://doi.org/10.3892/ijo.2021.5233
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Ovarian cancer represents one of the most aggressive female tumors worldwide. Over the decades, the therapeutic options for the treatment of ovarian cancer have been improved significantly through the advancement of surgical techniques as well as the availability of novel effective drugs able to extend the life expectancy of patients. However, due to its clinical, biological and molecular complexity, ovarian cancer is still considered one of the most difficult tumors to manage. In this context, several studies have highlighted how a multidisciplinary approach to this pathology improves the prognosis and survival of patients with ovarian cancer. On these bases, the aim of the present review is to present recent advantages in the diagnosis, staging and treatment of ovarian cancer highlighting the benefits of a patient‑centered care approach and on the importance of a multidisciplinary team for the management of ovarian cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Falzone L, Salomone S and Libra M: Evolution of cancer pharmacological treatments at the turn of the third millennium. Front Pharmacol. 9:13002018. View Article : Google Scholar : PubMed/NCBI

3 

Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A and Siegel RL: Ovarian cancer statistics, 2018. CA Cancer J Clin. 68:284–296. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Reid BM, Permuth JB and Sellers TA: Epidemiology of ovarian cancer: A review. Cancer Biol Med. 14:9–32. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Shafrir AL, Rice MS, Gupta M, Terry KL, Rosner BA, Tamimi RM, Hecht JL and Tworoger SS: The association between reproductive and hormonal factors and ovarian cancer by estrogen-α and progesterone receptor status. Gynecol Oncol. 143:628–635. 2016. View Article : Google Scholar : PubMed/NCBI

6 

D'Alonzo M, Bounous VE, Villa M and Biglia N: Current evidence of the oncological benefit-risk profile of hormone replacement therapy. Medicina (Kaunas). 55:5732019. View Article : Google Scholar

7 

Craig ER, Londoño AI, Norian LA and Arend RC: Metabolic risk factors and mechanisms of disease in epithelial ovarian cancer: A review. Gynecol Oncol. 143:674–683. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Fenga C, Gangemi S, Di Salvatore V, Falzone L and Libra M: Immunological effects of occupational exposure to lead (Review). Mol Med Rep. 15:3355–3360. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Falzone L, Marconi A, Loreto C, Franco S, Spandidos DA and Libra M: Occupational exposure to carcinogens: Benzene, pesticides and fibers (Review). Mol Med Rep. 14:4467–4474. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Amir S, Shah STA, Mamoulakis C, Docea AO, Kalantzi OI, Zachariou A, Calina D, Carvalho F, Sofikitis N, Makrigiannakis A and Tsatsakis A: Endocrine disruptors acting on estrogen and androgen pathways cause reproductive disorders through multiple mechanisms: A review. Int J Environ Res Public Health. 18:14642021. View Article : Google Scholar : PubMed/NCBI

11 

Ianoşi S, Ianoşi G, Neagoe D, Ionescu O, Zlatian O, Docea AO, Badiu C, Sifaki M, Tsoukalas D, Tsatsakis AM, et al: Age-dependent endocrine disorders involved in the pathogenesis of refractory acne in women. Mol Med Rep. 14:5501–5506. 2016. View Article : Google Scholar

12 

Del Pup L, Mantovani A, Cavaliere C, Facchini G, Luce A, Sperlongano P, Caraglia M and Berretta M: Carcinogenetic mechanisms of endocrine disruptors in female cancers (Review). Oncol Rep. 36:603–612. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Rachoń D: Endocrine disrupting chemicals (EDCs) and female cancer: Informing the patients. Rev Endocr Metab Disord. 16:359–364. 2015. View Article : Google Scholar

14 

Shulman LP and Dungan JS: Cancer genetics: Risks and mechanisms of cancer in women with inherited susceptibility to epithelial ovarian cancer. Cancer Treat Res. 156:69–85. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Gomes R, Spinola PD, Brant AC, Matta BP, Nascimento CM, de Aquino Paes SM, Bonvicino CR, Dos Santos AC and Moreira MA: Prevalence of germline variants in consensus moderate-to-high-risk predisposition genes to hereditary breast and ovarian cancer in BRCA1/2-negative Brazilian patients. Breast Cancer Res Treat. 185:851–861. 2021. View Article : Google Scholar

16 

Hodgson A and Turashvili G: Pathology of hereditary breast and ovarian cancer. Front Oncol. 10:5317902020. View Article : Google Scholar : PubMed/NCBI

17 

Jara L, Morales S, de Mayo T, Gonzalez-Hormazabal P, Carrasco V and Godoy R: Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations. Biol Res. 50:352017. View Article : Google Scholar : PubMed/NCBI

18 

Tedaldi G, Tebaldi M, Zampiga V, Danesi R, Arcangeli V, Ravegnani M, Cangini I, Pirini F, Petracci E, Rocca A, et al: Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer. Oncotarget. 8:47064–47075. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Hanley GE, McAlpine JN, Miller D, Huntsman D, Schrader KA, Blake Gilks C and Mitchell G: A population-based analysis of germline BRCA1 and BRCA2 testing among ovarian cancer patients in an era of histotype-specific approaches to ovarian cancer prevention. BMC Cancer. 18:2542018. View Article : Google Scholar : PubMed/NCBI

20 

Madariaga A, Lheureux S and Oza AM: Tailoring ovarian cancer treatment: Implications of BRCA1/2 mutations. Cancers (Basel). 11:4162019. View Article : Google Scholar

21 

Ashour M and Ezzat Shafik H: Frequency of germline mutations in BRCA1 and BRCA2 in ovarian cancer patients and their effect on treatment outcome. Cancer Manag Res. 11:6275–6284. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Tsaousis GN, Papadopoulou E, Apessos A, Agiannitopoulos K, Pepe G, Kampouri S, Diamantopoulos N, Floros T, Iosifidou R, Katopodi O, et al: Analysis of hereditary cancer syndromes by using a panel of genes: Novel and multiple pathogenic mutations. BMC Cancer. 19:5352019. View Article : Google Scholar : PubMed/NCBI

23 

Nakonechny QB and Gilks CB: Ovarian cancer in hereditary cancer susceptibility syndromes. Surg Pathol Clin. 9:189–199. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Nishioka Y, Kobayashi K, Sagae S, Sugimura M, Ishioka S, Nagata M, Terasawa K, Tokino T and Kudo R: Mutational analysis of STK11 gene in ovarian carcinomas. Jpn J Cancer Res. 90:629–632. 1999. View Article : Google Scholar : PubMed/NCBI

25 

McLemore MR, Miaskowski C, Aouizerat BE, Chen LM and Dodd MJ: Epidemiological and genetic factors associated with ovarian cancer. Cancer Nurs. 32:281–288. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Faber MT, Kjær SK, Dehlendorff C, Chang-Claude J, Andersen KK, Høgdall E, Webb PM and Jordan SJ; Australian Cancer Study (Ovarian Cancer); Australian Ovarian Cancer Study Group; et al Cigarette smoking and risk of ovarian cancer: A pooled analysis of 21 case-control studies. Cancer Causes Control. 24:989–1004. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Modugno F, Ness RB and Cottreau CM: Cigarette smoking and the risk of mucinous and nonmucinous epithelial ovarian cancer. Epidemiology. 13:467–471. 2002. View Article : Google Scholar : PubMed/NCBI

28 

O'Brien KM, Tworoger SS, Harris HR, Anderson GL, Weinberg CR, Trabert B, Kaunitz AM, D'Aloisio AA, Sandler DP and Wentzensen N: Association of powder use in the genital area with risk of ovarian cancer. JAMA. 323:49–59. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Fletcher NM, Harper AK, Memaj I, Fan R, Morris RT and Saed GM: Molecular basis supporting the association of talcum powder use with increased risk of ovarian cancer. Reprod Sci. 26:1603–1612. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Berge W, Mundt K, Luu H and Boffetta P: Genital use of talc and risk of ovarian cancer: A meta-analysis. Eur J Cancer Prev. 27:248–257. 2018. View Article : Google Scholar

31 

Troisi R, Bjørge T, Gissler M, Grotmol T, Kitahara CM, Myrtveit Saether SM, Ording AG, Sköld C, Sørensen HT, Trabert B and Glimelius I: The role of pregnancy, perinatal factors and hormones in maternal cancer risk: A review of the evidence. J Intern Med. 283:430–445. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Havrilesky LJ, Moorman PG, Lowery WJ, Gierisch JM, Coeytaux RR, Urrutia RP, Dinan M, McBroom AJ, Hasselblad V, Sanders GD and Myers ER: Oral contraceptive pills as primary prevention for ovarian cancer: A systematic review and meta-analysis. Obstet Gynecol. 122:139–147. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Huang Z, Gao Y, Wen W, Li H, Zheng W, Shu XO and Beeghly-Fadiel A: Contraceptive methods and ovarian cancer risk among Chinese women: A report from the shanghai women's health study. Int J Cancer. 137:607–614. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Goff B: Symptoms associated with ovarian cancer. Clin Obstet Gynecol. 55:36–42. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Bankhead CR, Kehoe ST and Austoker J: Symptoms associated with diagnosis of ovarian cancer: A systematic review. BJOG. 112:857–865. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Rossing MA, Wicklund KG, Cushing-Haugen KL and Weiss NS: Predictive value of symptoms for early detection of ovarian cancer. J Natl Cancer Inst. 102:222–229. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Kehoe S: FIGO staging in ovarian carcinoma and histological subtypes. J Gynecol Oncol. 31:e702020. View Article : Google Scholar : PubMed/NCBI

38 

Tokunaga H, Shimada M, Ishikawa M and Yaegashi N: TNM classification of gynaecological malignant tumours, eighth edition: Changes between the seventh and eighth editions. Jpn J Clin Oncol. 49:311–320. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Chua KJC, Patel RD, Trivedi R, Greenberg P, Beiter K, Magliaro T, Patel U and Varughese J: Accuracy in referrals to gynecologic oncologists based on clinical presentation for ovarian mass. Diagnostics (Basel). 10:1062020. View Article : Google Scholar

40 

Barnes D, Rivera R, Gibson S, Craig C, Cragun J, Monk B and Chase D: The utility of patient reported data in a gynecologic oncology clinic. Gynecol Oncol Res Pract. 5:42018. View Article : Google Scholar : PubMed/NCBI

41 

Funston G, Van Melle M, Baun ML, Jensen H, Helsper C, Emery J, Crosbie EJ, Thompson M, Hamilton W and Walter FM: Variation in the initial assessment and investigation for ovarian cancer in symptomatic women: A systematic review of international guidelines. BMC Cancer. 19:10282019. View Article : Google Scholar : PubMed/NCBI

42 

Liu JH and Zanotti KM: Management of the adnexal mass. Obstet Gynecol. 117:1413–1428. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Chan KK, Tam KF, Tse KY and Ngan HY: The role of regular physical examination in the detection of ovarian cancer recurrence. Gynecol Oncol. 110:158–161. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Scholler N and Urban N: CA125 in ovarian cancer. Biomark Med. 1:513–523. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Dochez V, Caillon H, Vaucel E, Dimet J, Winer N and Ducarme G: Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review. J Ovarian Res. 12:282019. View Article : Google Scholar : PubMed/NCBI

46 

Andersen MR, Goff BA, Lowe KA, Scholler N, Bergan L, Drescher CW, Paley P and Urban N: Use of a symptom index, CA125, and HE4 to predict ovarian cancer. Gynecol Oncol. 116:378–383. 2010. View Article : Google Scholar

47 

Bastani A, Asghary A, Heidari MH and Karimi-Busheri F: Evaluation of the sensitivity and specificity of serum level of prostasin, CA125, LDH, AFP, and hCG+β in epithelial ovarian cancer patients. Eur J Gynaecol Oncol. 38:418–424. 2017.

48 

Fischerova D and Burgetova A: Imaging techniques for the evaluation of ovarian cancer. Best Pract Res Clin Obstet Gynaecol. 28:697–720. 2014. View Article : Google Scholar : PubMed/NCBI

49 

van Nagell JR Jr and Hoff JT: Transvaginal ultrasonography in ovarian cancer screening: Current perspectives. Int J Womens Health. 6:25–33. 2013. View Article : Google Scholar :

50 

Zhang X, Meng X, Dou T and Sun H: Diagnostic accuracy of transvaginal ultrasound examination for assigning a specific diagnosis to adnexal masses: A meta-analysis. Exp Ther Med. 20:2652020. View Article : Google Scholar : PubMed/NCBI

51 

Meng XF, Zhu SC, Sun SJ, Guo JC and Wang X: Diffusion weighted imaging for the differential diagnosis of benign vs. malignant ovarian neoplasms. Oncol Lett. 11:3795–3802. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Qiao JJ, Yu J, Yu Z, Li N, Song C and Li M: Contrast-enhanced ultrasonography in differential diagnosis of benign and malignant ovarian tumors. PLoS One. 10:e01188722015. View Article : Google Scholar : PubMed/NCBI

53 

Sahdev A: CT in ovarian cancer staging: How to review and report with emphasis on abdominal and pelvic disease for surgical planning. Cancer Imaging. 16:192016. View Article : Google Scholar : PubMed/NCBI

54 

Thabet A, Somarouthu B, Oliva E, Gervais DA, Hahn PF and Lee SI: Image-guided ovarian mass biopsy: Efficacy and safety. J Vasc Interv Radiol. 25:1922–1927.e1. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Khiewvan B, Torigian DA, Emamzadehfard S, Paydary K, Salavati A, Houshmand S, Werner TJ and Alavi A: An update on the role of PET/CT and PET/MRI in ovarian cancer. Eur J Nucl Med Mol Imaging. 44:1079–1091. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Zhao C, Li S, Zhao M, Zhu H and Zhu X: Prognostic values of DNA mismatch repair genes in ovarian cancer patients treated with platinum-based chemotherapy. Arch Gynecol Obstet. 297:153–159. 2018. View Article : Google Scholar :

57 

Hirotsu Y, Nakagomi H, Sakamoto I, Amemiya K, Oyama T, Mochizuki H and Omata M: Multigene panel analysis identified germline mutations of DNA repair genes in breast and ovarian cancer. Mol Genet Genomic Med. 3:459–466. 2015. View Article : Google Scholar : PubMed/NCBI

58 

Missaoui N, Salhi S, Bdioui A, Mestiri S, Abdessayed N, Mokni M and Yacoubi MT: Immunohistochemical characterization improves the reproducibility of the histological diagnosis of ovarian carcinoma. Asian Pac J Cancer Prev. 19:2545–2551. 2018.PubMed/NCBI

59 

Zlatian OM, Comănescu MV, Roşu AF, Roşu L, Cruce M, Găman AE, Călina CD and Sfredel V: Histochemical and immunohistochemical evidence of tumor heterogeneity in colorectal cancer. Rom J Morphol Embryol. 56:175–181. 2015.PubMed/NCBI

60 

Docea AO, Mitruţ P, Grigore D, Pirici D, Călina DC and Gofiţă E: Immunohistochemical expression of TGF beta (TGF-β), TGF beta receptor 1 (TGFBR1), and Ki67 in intestinal variant of gastric adenocarcinomas. Rom J Morphol Embryol. 53(Suppl 3): S683–S692. 2012.

61 

Lee JY, Kim S, Kim YT, Lim MC, Lee B, Jung KW, Kim JW, Park SY and Won YJ: Changes in ovarian cancer survival during the 20 years before the era of targeted therapy. BMC Cancer. 18:6012018. View Article : Google Scholar

62 

Wu J, Sun H, Yang L, Deng Y, Yan Y, Wang S, Yang G and Ma H: Improved survival in ovarian cancer, with widening survival gaps of races and socioeconomic status: A period analysis, 1983-2012. J Cancer. 9:3548–3556. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Timmermans M, Sonke GS, Van de Vijver KK, van der Aa MA and Kruitwagen RF: No improvement in long-term survival for epithelial ovarian cancer patients: A population-based study between 1989 and 2014 in the Netherlands. Eur J Cancer. 88:31–37. 2018. View Article : Google Scholar

64 

Nagle CM, Francis JE, Nelson AE, Zorbas H, Luxford K, de Fazio A, Fereday S, Bowtell DD, Green AC and Webb PM: Reducing time to diagnosis does not improve outcomes for women with symptomatic ovarian cancer: A report from the Australian ovarian cancer study group. J Clin Oncol. 29:2253–2258. 2011. View Article : Google Scholar : PubMed/NCBI

65 

Engel J, Eckel R, Schubert-Fritschle G, Kerr J, Kuhn W, Diebold J, Kimmig R, Rehbock J and Hölzel D: Moderate progress for ovarian cancer in the last 20 years: Prolongation of survival, but no improvement in the cure rate. Eur J Cancer. 38:2435–2445. 2002. View Article : Google Scholar : PubMed/NCBI

66 

Martín-Cameán M, Delgado-Sánchez E, Piñera A, Diestro MD, De Santiago J and Zapardiel I: The role of surgery in advanced epithelial ovarian cancer. Ecancermedicalscience. 10:6662016.PubMed/NCBI

67 

Vinotha T, Anitha T, Ajit S, Rachel C and Abraham P: The role of completion surgery in ovarian cancer. J Obstet Gynaecol India. 66(Suppl 1): S435–S440. 2016. View Article : Google Scholar

68 

Fagotti A, Perelli F, Pedone L and Scambia G: Current recommendations for minimally invasive surgical staging in ovarian cancer. Curr Treat Options Oncol. 17:32016. View Article : Google Scholar : PubMed/NCBI

69 

Hall M, Savvatis K, Nixon K, Kyrgiou M, Hariharan K, Padwick M, Owens O, Cunnea P, Campbell J, Farthing A, et al: Maximal-effort cytoreductive surgery for ovarian cancer patients with a high tumor burden: Variations in practice and impact on outcome. Ann Surg Oncol. 26:2943–2951. 2019. View Article : Google Scholar : PubMed/NCBI

70 

Shih KK and Chi DS: Maximal cytoreductive effort in epithelial ovarian cancer surgery. J Gynecol Oncol. 21:75–80. 2010. View Article : Google Scholar : PubMed/NCBI

71 

Suh DH, Chang SJ, Song T, Lee S, Kang WD, Lee SJ, Roh JW, Joo WD, Yoon JH, Jeong DH, et al: Practice guidelines for management of ovarian cancer in Korea: A Korean society of gynecologic oncology consensus statement. J Gynecol Oncol. 29:e562018. View Article : Google Scholar : PubMed/NCBI

72 

Kim SR, Kotsopoulos J, Sun P, Bernardini M, Laframboise S, Ferguson S, Rosen B, Narod SA and May T: The impacts of neoadjuvant chemotherapy and of cytoreductive surgery on ten-year survival from advanced ovarian cancer. Int J Gynaecol Obstet. 2017.Epub ahead of print.

73 

Choi N, Chang JH, Kim S and Kim HJ: Radiation for persistent or recurrent epithelial ovarian cancer: A need for reassessment. Radiat Oncol J. 35:144–152. 2017. View Article : Google Scholar : PubMed/NCBI

74 

Dowdy SC, Metzinger DS, Gebhart JB, Srivatsa P, Haddock MG, Suman VJ and Podratz KC: Salvage whole-abdominal radiation therapy after second-look laparotomy or secondary debulking surgery in patients with ovarian cancer. Gynecol Oncol. 96:389–394. 2005. View Article : Google Scholar : PubMed/NCBI

75 

Shimada T, Saito T, Shimokawa M, Shimamoto K, Matsushita S, Yamaguchi S, Ariyoshi K and Okadome M: Improvement in the prognosis of ovarian cancer in the era before addition of molecular targeting therapy. Jpn J Clin Oncol. 47:494–498. 2017. View Article : Google Scholar : PubMed/NCBI

76 

Ledermann JA: First-line treatment of ovarian cancer: Questions and controversies to address. Ther Adv Med Oncol. 10:17588359187682322018. View Article : Google Scholar : PubMed/NCBI

77 

Sato S and Itamochi H: Neoadjuvant chemotherapy in advanced ovarian cancer: Latest results and place in therapy. Ther Adv Med Oncol. 6:293–304. 2014. View Article : Google Scholar : PubMed/NCBI

78 

Chambers LM, Son J, Radeva M and DeBernardo R: Evaluation of non-completion of intraperitoneal chemotherapy in patients with advanced epithelial ovarian cancer. J Gynecol Oncol. 30:e932019. View Article : Google Scholar : PubMed/NCBI

79 

Yoon JY, Koo YJ, Kim MJ, Kim TJ, Lim KT and Lee KH: Survival outcomes and toxicity of intraoperative intraperitoneal chemotherapy in advanced epithelial ovarian cancer. Obstet Gynecol Sci. 57:484–491. 2014. View Article : Google Scholar : PubMed/NCBI

80 

Chan JK, Brady MF, Penson RT, Huang H, Birrer MJ, Walker JL, DiSilvestro PA, Rubin SC, Martin LP, Davidson SA, et al: Weekly vs. Every-3-week paclitaxel and carboplatin for ovarian cancer. N Engl J Med. 374:738–748. 2016. View Article : Google Scholar : PubMed/NCBI

81 

Pignata S, Scambia G, Katsaros D, Gallo C, Pujade-Lauraine E, De Placido S, Bologna A, Weber B, Raspagliesi F, Panici PB, et al: Carboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer (MITO-7): A randomised, multicentre, open-label, phase 3 trial. Lancet Oncol. 15:396–405. 2014. View Article : Google Scholar : PubMed/NCBI

82 

Katsumata N, Yasuda M, Isonishi S, Takahashi F, Michimae H, Kimura E, Aoki D, Jobo T, Kodama S, Terauchi F, et al: Long-term results of dose-dense paclitaxel and carboplatin versus conventional paclitaxel and carboplatin for treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (JGOG 3016): A randomised, controlled, open-label trial. Lancet Oncol. 14:1020–1026. 2013. View Article : Google Scholar : PubMed/NCBI

83 

Marchetti C, Muzii L, Romito A and Benedetti Panici P: First-line treatment of women with advanced ovarian cancer: Focus on bevacizumab. Onco Targets Ther. 12:1095–1103. 2019. View Article : Google Scholar : PubMed/NCBI

84 

Komiyama S, Kato K, Inokuchi Y, Takano H, Matsumoto T, Hongo A, Asai-Sato M, Arakawa A, Kamiura S, Tabata T, et al: Bevacizumab combined with platinum-taxane chemotherapy as first-line treatment for advanced ovarian cancer: A prospective observational study of safety and efficacy in Japanese patients (JGOG3022 trial). Int J Clin Oncol. 24:103–114. 2019. View Article : Google Scholar

85 

Perren TJ, Swart AM, Pfisterer J, Ledermann JA, Pujade-Lauraine E, Kristensen G, Carey MS, Beale P, Cervantes A, Kurzeder C, et al: A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med. 365:2484–2496. 2011. View Article : Google Scholar : PubMed/NCBI

86 

Burger RA, Brady MF, Bookman MA, Fleming GF, Monk BJ, Huang H, Mannel RS, Homesley HD, Fowler J, Greer BE, et al: Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med. 365:2473–2483. 2011. View Article : Google Scholar : PubMed/NCBI

87 

Qian X, Qin J, Pan S, Li X, Pan Y and Ma S: Maintenance therapy in ovarian cancer with targeted agents improves PFS and OS: A systematic review and meta-analysis. PLoS One. 10:e01390262015. View Article : Google Scholar : PubMed/NCBI

88 

Hess LM, Rong N, Monahan PO, Gupta P, Thomaskutty C and Matei D: Continued chemotherapy after complete response to primary therapy among women with advanced ovarian cancer: A meta-analysis. Cancer. 116:5251–5260. 2010. View Article : Google Scholar : PubMed/NCBI

89 

Baert T, Ferrero A, Sehouli J, O'Donnell DM, González-Martín A, Joly F, van der Velden J, Blecharz P, Tan DSP, Querleu D, et al: The systemic treatment of recurrent ovarian cancer revisited. Ann Oncol. Mar 3–2021.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

90 

Lindemann K, Gao B, Mapagu C, Fereday S, Emmanuel C, Alsop K, Traficante N; Australian Ovarian Cancer Study Group; Harnett PR, Bowtell DDL and DeFazio A: Response rates to second-line platinum-based therapy in ovarian cancer patients challenge the clinical definition of platinum resistance. Gynecol Oncol. 150:239–246. 2018. View Article : Google Scholar : PubMed/NCBI

91 

Guo B, Lian W, Liu S, Cao Y and Liu J: Comparison of diagnostic values between CA125 combined with CA199 and ultrasound combined with CT in ovarian cancer. Oncol Lett. 17:5523–5528. 2019.PubMed/NCBI

92 

Mancari R, Cutillo G, Bruno V, Vincenzoni C, Mancini E, Baiocco E, Bruni S, Vocaturo G, Chiofalo B and Vizza E: Development of new medical treatment for epithelial ovarian cancer recurrence. Gland Surg. 9:1149–1163. 2020. View Article : Google Scholar : PubMed/NCBI

93 

Kozłowska E, Vallius T, Hynninen J, Hietanen S, Färkkilä A and Hautaniemi S: Virtual clinical trials identify effective combination therapies in ovarian cancer. Sci Rep. 9:186782019. View Article : Google Scholar

94 

Burger RA, Sill MW, Monk BJ, Greer BE and Sorosky JI: Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: A gynecologic oncology group study. J Clin Oncol. 25:5165–5171. 2007. View Article : Google Scholar : PubMed/NCBI

95 

Bamias A, Gibbs E, Khoon Lee C, Davies L, Dimopoulos M, Zagouri F, Veillard AS, Kosse J, Santaballa A, Mirza MR, et al: Bevacizumab with or after chemotherapy for platinum-resistant recurrent ovarian cancer: Exploratory analyses of the AURELIA trial. Ann Oncol. 28:1842–1848. 2017. View Article : Google Scholar : PubMed/NCBI

96 

Luvero D, Milani A and Ledermann JA: Treatment options in recurrent ovarian cancer: Latest evidence and clinical potential. Ther Adv Med Oncol. 6:229–239. 2014. View Article : Google Scholar : PubMed/NCBI

97 

Dockery LE, Tew WP, Ding K and Moore KN: Tolerance and toxicity of the PARP inhibitor olaparib in older women with epithelial ovarian cancer. Gynecol Oncol. 147:509–513. 2017. View Article : Google Scholar : PubMed/NCBI

98 

Kaufman B, Shapira-Frommer R, Schmutzler RK, Audeh MW, Friedlander M, Balmaña J, Mitchell G, Fried G, Stemmer SM, Hubert A, et al: Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. J Clin Oncol. 33:244–250. 2015. View Article : Google Scholar

99 

Lheureux S, Braunstein M and Oza AM: Epithelial ovarian cancer: Evolution of management in the era of precision medicine. CA Cancer J Clin. 69:280–304. 2019.PubMed/NCBI

100 

Cortez AJ, Tudrej P, Kujawa KA and Lisowska KM: Advances in ovarian cancer therapy. Cancer Chemother Pharmacol. 81:17–38. 2018. View Article : Google Scholar :

101 

Jiang X, Li W, Li X, Bai H and Zhang Z: Current status and future prospects of PARP inhibitor clinical trials in ovarian cancer. Cancer Manag Res. 11:4371–4390. 2019. View Article : Google Scholar : PubMed/NCBI

102 

Moore K, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, et al: Maintenance olaparib in patients with newly diagnosed advanced ovarian cancer. N Engl J Med. 379:2495–2505. 2018. View Article : Google Scholar : PubMed/NCBI

103 

Banerjee S, Gonzalez-Martin A, Harter P, Lorusso D, Moore KN, Oaknin A and Ray-Coquard I: First-line PARP inhibitors in ovarian cancer: Summary of an ESMO Open-Cancer Horizons round-table discussion. ESMO Open. 5:e0011102020. View Article : Google Scholar

104 

Ray-Coquard I, Pautier P, Pignata S, Pérol D, González-Martín A, Berger R, Fujiwara K, Vergote I, Colombo N, Mäenpää J, et al: Olaparib plus bevacizumab as first-line maintenance in ovarian cancer. N Engl J Med. 381:2416–2428. 2019. View Article : Google Scholar : PubMed/NCBI

105 

González-Martín A, Pothuri B, Vergote I, DePont Christensen R, Graybill W, Mirza MR, McCormick C, Lorusso D, Hoskins P, Freyer G, et al: Niraparib in patients with newly diagnosed advanced ovarian cancer. N Engl J Med. 381:2391–2402. 2019. View Article : Google Scholar : PubMed/NCBI

106 

Pujade-Lauraine E, Ledermann JA, Selle F, Gebski V, Penson RT, Oza AM, Korach J, Huzarski T, Poveda A, Pignata S, et al: Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): A double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Oncol. 18:1274–1284. 2017. View Article : Google Scholar : PubMed/NCBI

107 

Mirza MR, Monk BJ, Herrstedt J, Oza AM, Mahner S, Redondo A, Fabbro M, Ledermann JA, Lorusso D, Vergote I, et al: Niraparib maintenance therapy in platinum-sensitive, recurrent ovarian cancer. N Engl J Med. 375:2154–2164. 2016. View Article : Google Scholar : PubMed/NCBI

108 

Ledermann J, Harter P, Gourley C, Friedlander M, Vergote I, Rustin G, Scott CL, Meier W, Shapira-Frommer R, Safra T, et al: Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: A preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. Lancet Oncol. 15:852–861. 2014. View Article : Google Scholar : PubMed/NCBI

109 

Balasubramaniam S, Beaver JA, Horton S, Fernandes LL, Tang S, Horne HN, Liu J, Liu C, Schrieber SJ, Yu J, et al: FDA approval summary: Rucaparib for the treatment of patients with deleterious BRCA mutation-associated advanced ovarian cancer. Clin Cancer Res. 23:7165–7170. 2017. View Article : Google Scholar : PubMed/NCBI

110 

Leonardi GC, Candido S, Falzone L, Spandidos DA and Libra M: Cutaneous melanoma and the immunotherapy revolution (Review). Int J Oncol. 57:609–618. 2020. View Article : Google Scholar : PubMed/NCBI

111 

Vivarelli S, Falzone L, Grillo CM, Scandurra G, Torino F and Libra M: Cancer management during COVID-19 pandemic: Is immune checkpoint inhibitors-based immunotherapy harmful or beneficial? Cancers (Basel). 12:22372020. View Article : Google Scholar

112 

Christofi T, Baritaki S, Falzone L, Libra M and Zaravinos A: Current perspectives in cancer immunotherapy. Cancers (Basel). 11:14722019. View Article : Google Scholar

113 

Liu JF, Gordon M, Veneris J, Braiteh F, Balmanoukian A, Eder JP, Oaknin A, Hamilton E, Wang Y, Sarkar I, et al: Safety, clinical activity and biomarker assessments of atezolizumab from a Phase I study in advanced/recurrent ovarian and uterine cancers. Gynecol Oncol. 154:314–322. 2019. View Article : Google Scholar : PubMed/NCBI

114 

Varga A, Piha-Paul S, Ott PA, Mehnert JM, Berton-Rigaud D, Morosky A, Yang P, Ruman J and Matei D: Pembrolizumab in patients with programmed death ligand 1-positive advanced ovarian cancer: Analysis of KEYNOTE-028. Gynecol Oncol. 152:243–250. 2019. View Article : Google Scholar

115 

Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, Kanai M, Mori Y, Matsumoto S, Chikuma S, et al: Safety and antitumor activity of anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer. J Clin Oncol. 33:4015–4022. 2015. View Article : Google Scholar : PubMed/NCBI

116 

Hodi FS, Butler M, Oble DA, Seiden MV, Haluska FG, Kruse A, Macrae S, Nelson M, Canning C, Lowy I, et al: Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci USA. 105:3005–3010. 2008. View Article : Google Scholar : PubMed/NCBI

117 

Zamarin D, Burger RA, Sill MW, Powell DJ Jr, Lankes HA, Feldman MD, Zivanovic O, Gunderson C, Ko E, Mathews C, et al: Randomized phase II trial of nivolumab versus nivolumab and ipilimumab for recurrent or persistent ovarian cancer: An NRG oncology study. J Clin Oncol. 38:1814–1823. 2020. View Article : Google Scholar : PubMed/NCBI

118 

Palaia I, Tomao F, Sassu CM, Musacchio L and Benedetti Panici P: Immunotherapy for ovarian cancer: Recent advances and combination therapeutic approaches. Onco Targets Ther. 13:6109–6129. 2020. View Article : Google Scholar : PubMed/NCBI

119 

Chandra A, Pius C, Nabeel M, Nair M, Vishwanatha JK, Ahmad S and Basha R: Ovarian cancer: Current status and strategies for improving therapeutic outcomes. Cancer Med. 8:7018–7031. 2019. View Article : Google Scholar : PubMed/NCBI

120 

Gotlieb WH, Amant F, Advani S, Goswami C, Hirte H, Provencher D, Somani N, Yamada SD, Tamby JF and Vergote I: Intravenous aflibercept for treatment of recurrent symptomatic malignant ascites in patients with advanced ovarian cancer: A phase 2, randomised, double-blind, placebo-controlled study. Lancet Oncol. 13:154–162. 2012. View Article : Google Scholar

121 

McGee J, Bookman M, Harter P, Marth C, McNeish I, Moore KN, Poveda A, Hilpert F, Hasegawa K, Bacon M, et al: Fifth ovarian cancer consensus conference: Individualized therapy and patient factors. Ann Oncol. 28:702–710. 2017. View Article : Google Scholar : PubMed/NCBI

122 

Aletti GD, Garbi A, Messori P, Achilarre MT, Zanagnolo V, Rizzo S, Alessi S, Bocciolone L, Landoni F, Biffi R, et al: Multidisciplinary approach in the management of advanced ovarian cancer patients: A personalized approach. Results from a specialized ovarian cancer unit. Gynecol Oncol. 144:468–473. 2017. View Article : Google Scholar : PubMed/NCBI

123 

Pillay B, Wootten AC, Crowe H, Corcoran N, Tran B, Bowden P, Crowe J and Costello AJ: The impact of multidisciplinary team meetings on patient assessment, management and outcomes in oncology settings: A systematic review of the literature. Cancer Treat Rev. 42:56–72. 2016. View Article : Google Scholar

124 

Junor EJ, Hole DJ and Gillis CR: Management of ovarian cancer: Referral to a multidisciplinary team matters. Br J Cancer. 70:363–370. 1994. View Article : Google Scholar : PubMed/NCBI

125 

Gleeson M, Meiser B, Barlow-Stewart K, Trainer AH, Tucker K, Watts KJ, Friedlander M and Kasparian N: Communication and information needs of women diagnosed with ovarian cancer regarding treatment-focused genetic testing. Oncol Nurs Forum. 40:275–283. 2013. View Article : Google Scholar : PubMed/NCBI

126 

Stead ML, Brown JM, Fallowfield L and Selby P: Lack of communication between healthcare professionals and women with ovarian cancer about sexual issues. Br J Cancer. 88:666–671. 2003. View Article : Google Scholar : PubMed/NCBI

127 

Selby P, Gillis C and Haward R: Benefits from specialised cancer care. Lancet. 348:313–318. 1996. View Article : Google Scholar : PubMed/NCBI

128 

August DA, Carpenter LC, Harness JK, Delosh T, Cody RL, Adler DD, Oberman H, Wilkins E, Schottenfeld D and McNeely SG: Benefits of a multidisciplinary approach to breast care. J Surg Oncol. 53:161–167. 1993. View Article : Google Scholar : PubMed/NCBI

129 

Vinciguerra V, Degnan TJ, Sciortino A, O'Connell M, Moore T, Brody R, Budman D, Eng M and Carlton D: A comparative assessment of home versus hospital comprehensive treatment for advanced cancer patients. J Clin Oncol. 4:1521–1528. 1986. View Article : Google Scholar : PubMed/NCBI

130 

Heudel PE, Devouassoux-Shisheboran M, Taieb S, Genestie C, Selle F, Morice P, Rouzier R and Ray-Coquard I: Multidisciplinary management of advanced ovarian cancer for an optimal therapeutic strategy. Eur J Gynaecol Oncol. 38:175–180. 2017.PubMed/NCBI

131 

Bjørn SF, Schnack TH, Lajer H, Christensen IJ, Lundvall L, Thomsen LN and Høgdall C: Classification of ovarian cancer surgery facilitates treatment decisions in a gynecological multi-disciplinary team. Int J Gynecol Cancer. 27:382–389. 2017. View Article : Google Scholar

132 

Pozzar RA and Berry DL: Patient-centered research priorities in ovarian cancer: A systematic review of potential determinants of guideline care. Gynecol Oncol. 147:714–722. 2017. View Article : Google Scholar : PubMed/NCBI

133 

Moterani VC, Tiezzi DG, de Andrade JM and Candido Dos Reis FJ: Analysis of the relationship between hospital characteristics and survival in ovarian cancer: A historical cohort. J Surg Oncol. 122:1802–1807. 2020. View Article : Google Scholar : PubMed/NCBI

134 

Wright JD, Chen L, Hou JY, Burke WM, Tergas AI, Ananth CV, Neugut AI and Hershman DL: Association of hospital volume and quality of care with survival for ovarian cancer. Obstet Gynecol. 130:545–553. 2017. View Article : Google Scholar : PubMed/NCBI

135 

Vernooij F, Heintz AP, Coebergh JW, Massuger LF, Witteveen PO and van der Graaf Y: Specialized and high-volume care leads to better outcomes of ovarian cancer treatment in the Netherlands. Gynecol Oncol. 112:455–461. 2009. View Article : Google Scholar : PubMed/NCBI

136 

Ke KM, Blazeby JM, Strong S, Carroll FE, Ness AR and Hollingworth W: Are multidisciplinary teams in secondary care cost-effective? A systematic review of the literature. Cost Eff Resour Alloc. 11:72013. View Article : Google Scholar : PubMed/NCBI

137 

Mercado C, Zingmond D, Karlan BY, Sekaris E, Gross J, Maggard-Gibbons M, Tomlinson JS and Ko CY: Quality of care in advanced ovarian cancer: The importance of provider specialty. Gynecol Oncol. 117:18–22. 2010. View Article : Google Scholar : PubMed/NCBI

138 

Long B, Chang J, Ziogas A, Tewari KS, Anton-Culver H and Bristow RE: Impact of race, socioeconomic status, and the health care system on the treatment of advanced-stage ovarian cancer in California. Am J Obstet Gynecol. 212:468.e1–9. 2015. View Article : Google Scholar

139 

Scott R, Hawarden A, Russell B and Edmondson RJ: Decision-making in gynaecological oncology multidisciplinary team meetings: A cross-sectional, observational study of ovarian cancer cases. Oncol Res Treat. 43:70–77. 2020. View Article : Google Scholar

140 

Rausei S, Uccella S, D'Alessandro V, Gisone B, Frattini F, Lianos G, Rovera F, Boni L, Dionigi G and Ghezzi F: Aggressive surgery for advanced ovarian cancer performed by a multidisciplinary team: A retrospective analysis on a large series of patients. Surg Open Sci. 1:43–47. 2019. View Article : Google Scholar : PubMed/NCBI

141 

Burton E, Chase D, Yamamoto M, de Guzman J, Imagawa D and Berman ML: Surgical management of recurrent ovarian cancer: The advantage of collaborative surgical management and a multidisciplinary approach. Gynecol Oncol. 120:29–32. 2011. View Article : Google Scholar

142 

Forstner R, Meissnitzer M and Cunha TM: Update on imaging of ovarian cancer. Curr Radiol Rep. 4:312016. View Article : Google Scholar : PubMed/NCBI

143 

Guerriero S, Saba L, Alcazar JL, Pascual MA, Ajossa S, Perniciano M, Piras A, Sedda F, Peddes C, Fabbri P, et al: Past, present and future ultrasonographic techniques for analyzing ovarian masses. Womens Health (Lond). 11:369–383. 2015. View Article : Google Scholar

144 

Avril S: Histopathological markers of treatment response and recurrence risk in ovarian cancers and borderline tumors. Pathologe. 38(Suppl 3): S180–S191. 2017. View Article : Google Scholar

145 

Rojas V, Hirshfield KM, Ganesan S and Rodriguez-Rodriguez L: Molecular characterization of epithelial ovarian cancer: Implications for diagnosis and treatment. Int J Mol Sci. 17:21132016. View Article : Google Scholar

146 

Ramalingam P: Morphologic, immunophenotypic, and molecular features of epithelial ovarian cancer. Oncology (Williston Park). 30:166–176. 2016.

147 

Lalwani N, Prasad SR, Vikram R, Shanbhogue AK, Huettner PC and Fasih N: Histologic, molecular, and cytogenetic features of ovarian cancers: Implications for diagnosis and treatment. Radiographics. 31:625–646. 2011. View Article : Google Scholar : PubMed/NCBI

148 

Kim H, Choi DH, Park W, Im YH, Ahn JS, Park YH, Nam SJ, Kim SW, Lee JE, Yu JH, et al: The association between non-breast and ovary cancers and BRCA mutation in first- and second-degree relatives of high-risk breast cancer patients: A large-scale study of Koreans. Hered Cancer Clin Pract. 17:12019. View Article : Google Scholar : PubMed/NCBI

149 

Pruthi S, Gostout BS and Lindor NM: Identification and management of women with BRCA mutations or hereditary predisposition for breast and ovarian cancer. Mayo Clin Proc. 85:1111–1120. 2010. View Article : Google Scholar : PubMed/NCBI

150 

Di Furia L, Rusciano MR, Nardini L, Rossi P, Giammarchi C, Vittori E, Tilocca S, Russo FL, Montuori P, Triassi M, et al: A nutritional approach to the prevention of cancer: From assessment to personalized intervention. Transl Med UniSa. 13:33–41. 2016.PubMed/NCBI

151 

Zheng B, Shen H, Han H, Han T and Qin Y: Dietary fiber intake and reduced risk of ovarian cancer: A meta-analysis. Nutr J. 17:992018. View Article : Google Scholar : PubMed/NCBI

152 

Crane TE, Khulpateea BR, Alberts DS, Basen-Engquist K and Thomson CA: Dietary intake and ovarian cancer risk: A systematic review. Cancer Epidemiol Biomarkers Prev. 23:255–273. 2014. View Article : Google Scholar :

153 

Montagnese C, Porciello G, Vitale S, Palumbo E, Crispo A, Grimaldi M, Calabrese I, Pica R, Prete M, Falzone L, et al: Quality of life in women diagnosed with breast cancer after a 12-month treatment of lifestyle modifications. Nutrients. 13:1362020. View Article : Google Scholar

154 

Porciello G, Montagnese C, Crispo A, Grimaldi M, Libra M, Vitale S, Palumbo E, Pica R, Calabrese I, Cubisino S, et al: Mediterranean diet and quality of life in women treated for breast cancer: A baseline analysis of DEDiCa multicentre trial. PLoS One. 15:e02398032020. View Article : Google Scholar : PubMed/NCBI

155 

Hansen JM, Nagle CM, Ibiebele TI, Grant PT, Obermair A, Friedlander ML, DeFazio A and Webb PM; Ovarian Cancer Prognosis Lifestyle Study Group: A healthy lifestyle and survival among women with ovarian cancer. Int J Cancer. 147:3361–3369. 2020. View Article : Google Scholar : PubMed/NCBI

156 

Thomson CA, E Crane T, Wertheim BC, Neuhouser ML, Li W, Snetselaar LG, Basen-Engquist KM, Zhou Y and Irwin ML: Diet quality and survival after ovarian cancer: Results from the women's health initiative. J Natl Cancer Inst. 106. pp. dju3142014, View Article : Google Scholar

157 

Peres LC, Cushing-Haugen KL, Anglesio M, Wicklund K, Bentley R, Berchuck A, Kelemen LE, Nazeran TM, Gilks CB, Harris HR, et al: Histotype classification of ovarian carcinoma: A comparison of approaches. Gynecol Oncol. 151:53–60. 2018. View Article : Google Scholar : PubMed/NCBI

158 

Jacome LS, Deshmukh SK, Thulasiraman P, Holliday NP and Singh S: Impact of COVID-19 pandemic on ovarian cancer management: Adjusting to the new normal. Cancer anag Res. 13:359–366. 2021.

159 

Vivarelli S, Falzone L, Torino F, Scandurra G, Russo G, Bordonaro R, Pappalardo F, Spandidos DA, Raciti G and Libra M: Immune-checkpoint inhibitors from cancer to COVID-19: A promising avenue for the treatment of patients with COVID-19 (Review). Int J Oncol. 58:145–157. 2021. View Article : Google Scholar : PubMed/NCBI

160 

Tsatsakis A, Calina D, Falzone L, Petrakis D, Mitrut R, Siokas V, Pennisi M, Lanza G, Libra M, Doukas SG, et al: SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19. Food Chem Toxicol. 146:1117692020. View Article : Google Scholar : PubMed/NCBI

161 

Zimmerman BS, Seidman D, Berger N, Cascetta KP, Nezolosky M, Trlica K, Ryncarz A, Keeton C, Moshier E and Tiersten A: Patient perception of telehealth services for breast and gynecologic oncology care during the COVID-19 pandemic: A single center survey-based study. J Breast Cancer. 23:542–552. 2020. View Article : Google Scholar : PubMed/NCBI

162 

Mancebo G, Solé-Sedeño JM, Membrive I, Taus A, Castells M, Serrano L, Carreras R and Miralpeix E: Gynecologic cancer surveillance in the era of SARS-CoV-2 (COVID-19). Int J Gynecol Cancer. 5:ijgc-2020–001942. 2020.

163 

Frey MK, Ellis AE, Zeligs K, Chapman-Davis E, Thomas C, Christos PJ, Kolev V, Prasad-Hayes M, Cohen S, Holcomb K and Blank SV: Impact of the coronavirus disease 2019 pandemic on the quality of life for women with ovarian cancer. Am J Obstet Gynecol. 223:725.e1–725.e9. 2020. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Falzone L, Scandurra G, Lombardo V, Gattuso G, Lavoro A, Distefano AB, Scibilia G and Scollo P: A multidisciplinary approach remains the best strategy to improve and strengthen the management of ovarian cancer (Review). Int J Oncol 59: 53, 2021.
APA
Falzone, L., Scandurra, G., Lombardo, V., Gattuso, G., Lavoro, A., Distefano, A.B. ... Scollo, P. (2021). A multidisciplinary approach remains the best strategy to improve and strengthen the management of ovarian cancer (Review). International Journal of Oncology, 59, 53. https://doi.org/10.3892/ijo.2021.5233
MLA
Falzone, L., Scandurra, G., Lombardo, V., Gattuso, G., Lavoro, A., Distefano, A. B., Scibilia, G., Scollo, P."A multidisciplinary approach remains the best strategy to improve and strengthen the management of ovarian cancer (Review)". International Journal of Oncology 59.1 (2021): 53.
Chicago
Falzone, L., Scandurra, G., Lombardo, V., Gattuso, G., Lavoro, A., Distefano, A. B., Scibilia, G., Scollo, P."A multidisciplinary approach remains the best strategy to improve and strengthen the management of ovarian cancer (Review)". International Journal of Oncology 59, no. 1 (2021): 53. https://doi.org/10.3892/ijo.2021.5233
Copy and paste a formatted citation
x
Spandidos Publications style
Falzone L, Scandurra G, Lombardo V, Gattuso G, Lavoro A, Distefano AB, Scibilia G and Scollo P: A multidisciplinary approach remains the best strategy to improve and strengthen the management of ovarian cancer (Review). Int J Oncol 59: 53, 2021.
APA
Falzone, L., Scandurra, G., Lombardo, V., Gattuso, G., Lavoro, A., Distefano, A.B. ... Scollo, P. (2021). A multidisciplinary approach remains the best strategy to improve and strengthen the management of ovarian cancer (Review). International Journal of Oncology, 59, 53. https://doi.org/10.3892/ijo.2021.5233
MLA
Falzone, L., Scandurra, G., Lombardo, V., Gattuso, G., Lavoro, A., Distefano, A. B., Scibilia, G., Scollo, P."A multidisciplinary approach remains the best strategy to improve and strengthen the management of ovarian cancer (Review)". International Journal of Oncology 59.1 (2021): 53.
Chicago
Falzone, L., Scandurra, G., Lombardo, V., Gattuso, G., Lavoro, A., Distefano, A. B., Scibilia, G., Scollo, P."A multidisciplinary approach remains the best strategy to improve and strengthen the management of ovarian cancer (Review)". International Journal of Oncology 59, no. 1 (2021): 53. https://doi.org/10.3892/ijo.2021.5233
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team