MUC1 is an oncoprotein with a significant role in apoptosis (Review)
- Katarzyna Supruniuk
- Iwona Radziejewska
Affiliations: Department of Medical Chemistry, Medical University of Białystok, 15‑222 Białystok, Poland
- Published online on: July 15, 2021 https://doi.org/10.3892/ijo.2021.5248
Copyright: © Supruniuk
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
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Mucin 1 (MUC1) is a membrane‑bound, highly glycosylated protein that is overexpressed in all stages of malignant transformation. Overexpression of MUC1 together with loss of polarization and hypoglycosylation are associated with resistance to apoptosis, which is the process that results in efficient removal of damaged cells. Inhibition of the apoptotic process is responsible for tumor development, tumor progression and drug resistance. MUC1 is considered as an oncogenic molecule that is involved in various signaling pathways responsible for the regulation of apoptosis. Based on this, the aim of the present study was to discuss the involvement of MUC1 in the divergent mechanisms regulating programmed cell death.