Open Access

MUC1 is an oncoprotein with a significant role in apoptosis (Review)

  • Authors:
    • Katarzyna Supruniuk
    • Iwona Radziejewska
  • View Affiliations

  • Published online on: July 15, 2021     https://doi.org/10.3892/ijo.2021.5248
  • Article Number: 68
  • Copyright: © Supruniuk et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mucin 1 (MUC1) is a membrane‑bound, highly glycosylated protein that is overexpressed in all stages of malignant transformation. Overexpression of MUC1 together with loss of polarization and hypoglycosylation are associated with resistance to apoptosis, which is the process that results in efficient removal of damaged cells. Inhibition of the apoptotic process is responsible for tumor development, tumor progression and drug resistance. MUC1 is considered as an oncogenic molecule that is involved in various signaling pathways responsible for the regulation of apoptosis. Based on this, the aim of the present study was to discuss the involvement of MUC1 in the divergent mechanisms regulating programmed cell death.

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September-2021
Volume 59 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Supruniuk K and Supruniuk K: MUC1 is an oncoprotein with a significant role in apoptosis (Review). Int J Oncol 59: 68, 2021
APA
Supruniuk, K., & Supruniuk, K. (2021). MUC1 is an oncoprotein with a significant role in apoptosis (Review). International Journal of Oncology, 59, 68. https://doi.org/10.3892/ijo.2021.5248
MLA
Supruniuk, K., Radziejewska, I."MUC1 is an oncoprotein with a significant role in apoptosis (Review)". International Journal of Oncology 59.3 (2021): 68.
Chicago
Supruniuk, K., Radziejewska, I."MUC1 is an oncoprotein with a significant role in apoptosis (Review)". International Journal of Oncology 59, no. 3 (2021): 68. https://doi.org/10.3892/ijo.2021.5248