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Efficacy of birinapant in combination with carboplatin in targeting platinum‑resistant epithelial ovarian cancers

  • Authors:
    • Tanya Singh
    • Adam Neal
    • Gabriella Dibernardo
    • Neela Raheseparian
    • Neda A. Moatamed
    • Sanaz Memarzadeh
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Copyright: © Singh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 35
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    Published online on: February 21, 2022
       https://doi.org/10.3892/ijo.2022.5325
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Abstract

Patients diagnosed with epithelial ovarian cancers (EOCs) often suffer from disease relapse associated with the emergence of resistance to standard platinum‑based chemotherapy. Treatment of patients with chemo‑resistant disease remains a clinical challenge. One mechanism of chemoresistance includes overexpression of pro‑survival proteins called inhibitors of apoptosis (IAP) which enable cancer cells to evade apoptosis. Due to their anti‑apoptotic activity, association with poor prognosis, and correlation with therapy resistance in multiple malignancies, IAP proteins have become an attractive target for development of anticancer therapeutics. Second mitochondrial activator of caspase (SMAC) mimetics are the most widely used IAP antagonists currently being tested in clinical trials as a monotherapy and in combination with different chemotherapeutic drugs to target different types of cancer. In the present study, the antitumor efficacy of combination therapy with birinapant, a bivalent SMAC mimetic compound, and carboplatin to target platinum‑resistant EOC cells was investigated. A 3D organoid bioassay was utilized to test the efficacy of the combination therapy in a panel of 7 EOC cell lines and 10 platinum‑resistant primary patient tumor samples. Findings from the in vitro studies demonstrated that the birinapant and carboplatin combination was effective in targeting a subset of ovarian cancer cell lines and platinum‑resistant primary patient tumor samples. This combination therapy was also effective in vitro and in vivo in targeting a platinum‑resistant patient‑derived xenograft (PDX) model established from one of the patient tumors tested. Overall, our study demonstrated that birinapant and carboplatin combination could target a subset of platinum‑resistant ovarian cancers and also highlights the potential of the 3D organoid bioassay as a preclinical tool to assess the response to chemotherapy or targeted therapies in ovarian cancer.
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View References

1 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer Statistics, 2021. CA Cancer J Clin. 71:7–33. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Desai A, Xu J, Aysola K, Qin Y, Okoli C, Hariprasad R, Chinemerem U, Gates C, Reddy A, Danner O, et al: Epithelial ovarian cancer: An overview. World J Transl Med. 3:1–8. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Kurnit KC, Fleming GF and Lengyel E: Updates and new options in advanced epithelial ovarian cancer treatment. Obstet Gynecol. 137:108–121. 2021. View Article : Google Scholar

4 

Kaplan DA: Overview of the Updated NCCN Guidelines on Ovarian Cancer. 6:2020.

5 

Berek JS, Crum C and Friedlander M: Cancer of the ovary, fallopian tube, and peritoneum. Int J Gynaecol Obstet. 119(Suppl 2): S118–S129. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Baert T, Ferrero A, Sehouli J, O'Donnell DM, González-Martín A, Joly F, van der Velden J, Blecharz P, Tan DSP, Querleu D, et al: The systemic treatment of recurrent ovarian cancer revisited. Ann Oncol. 32:710–725. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Yang Y, Yang Y, Yang J, Zhao X and Wei X: Tumor microenvironment in ovarian cancer: Function and therapeutic strategy. Front Cell Dev Biol. 8:7582020. View Article : Google Scholar : PubMed/NCBI

8 

Zhou J, Kang Y, Chen L, Wang H, Liu J, Zeng S and Yu L: The drug-resistance mechanisms of five platinum-based antitumor agents. Front Pharmacol. 11:3432020. View Article : Google Scholar : PubMed/NCBI

9 

Dubrez L, Berthelet J and Glorian V: IAP proteins as targets for drug development in oncology. Onco Targets Ther. 9:1285–1304. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Finlay D, Teriete P, Vamos M, Cosford NDP and Vuori K: Inducing death in tumor cells: Roles of the inhibitor of apoptosis proteins. F1000Res. 6:5872017. View Article : Google Scholar : PubMed/NCBI

11 

Pluta P, Jeziorski A, Cebula-Obrzut AP, Wierzbowska A, Piekarski J and Smolewski P: Expression of IAP family proteins and its clinical importance in breast cancer patients. Neoplasma. 62:666–673. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Hofmann HS, Simm A, Hammer A, Silber RE and Bartling B: Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer. J Cancer Res Clin Oncol. 128:554–560. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Imoto I, Tsuda H, Hirasawa A, Miura M, Sakamoto M, Hirohashi S and Inazawa J: Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Cancer Res. 62:4860–4866. 2002.PubMed/NCBI

14 

Miyamoto M, Takano M, Iwaya K, Shinomiya N, Kato M, Aoyama T, Sasaki N, Goto T, Suzuki A, Hitrata J and Furuya K: X-chromosome-linked inhibitor of apoptosis as a key factor for chemoresistance in clear cell carcinoma of the ovary. Br J Cancer. 110:2881–2886. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Cai Y, Ma W, Huang X, Cao L, Li H, Jiang Y, Lu N and Yin Y: Effect of survivin on tumor growth of colorectal cancer in vivo. Int J Clin Exp Pathol. 8:13267–13272. 2015.

16 

Zhao G, Wang Q, Wu Z, Tian X, Yan H, Wang B, Dong P, Watari H, Pfeffer LM, Guo Y, et al: Ovarian primary and metastatic tumors suppressed by survivin knockout or a novel survivin inhibitor. Mol Cancer Ther. 18:2233–2245. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Park E, Gang EJ, Hsieh YT, Schaefer P, Chae S, Klemm L, Huantes S, Loh M, Conway EM, Kang ES, et al: Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. Blood. 118:2191–2199. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Moriai R, Tsuji N, Moriai M, Kobayashi D and Watanabe N: Survivin plays as a resistant factor against tamoxifen-induced apoptosis in human breast cancer cells. Breast Cancer Res Treat. 117:261–271. 2009. View Article : Google Scholar

19 

Span PN, Sweep FCGJ, Wiegerinck ET, Tjan-Heijnen VC, Manders P, Beex LV and de Kok JB: Survivin is an independent prognostic marker for risk stratification of breast cancer patients. Clin Chem. 50:1986–1993. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Sui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K and Tokuda M: Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. Int J Oncol. 21:315–320. 2002.PubMed/NCBI

21 

Morrish E, Brumatti G and Silke J: Future therapeutic directions for Smac-Mimetics. Cells. 9:4062020. View Article : Google Scholar :

22 

Eytan DF, Snow GE, Carlson S, Derakhshan A, Saleh A, Schiltz S, Cheng H, Mohan S, Cornelius S, Coupar J, et al: SMAC mimetic birinapant plus radiation eradicates human head and neck cancers with genomic amplifications of cell death genes FADD and BIRC2. Cancer Res. 76:5442–5454. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Lalaoui N, Merino D, Giner G, Vaillant F, Chau D, Liu L, Kratina T, Pal B, Whittle JR, Etemadi N, et al: Targeting triple-negative breast cancers with the Smac-mimetic birinapant. Cell Death Differ. 27:2768–2780. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Xie X, Lee J, Liu H, Pearson T, Lu AY, Tripathy D, Devi GR, Bartholomeusz C and Ueno NT: Birinapant enhances gemcitabine's antitumor efficacy in triple-negative breast cancer by inducing intrinsic pathway-dependent apoptosis. Mol Cancer Ther. 20:296–306. 2021. View Article : Google Scholar

25 

Colombo M, Marabese M, Vargiu G, Broggini M and Caiola E: Activity of birinapant, a SMAC mimetic compound, alone or in combination in NSCLCs with different mutations. Front Oncol. 10:5322922020. View Article : Google Scholar : PubMed/NCBI

26 

Hernandez LF, Dull AB, Korrapati S and Annunziata CM: Smac-mimetic enhances antitumor effect of standard chemotherapy in ovarian cancer models via Caspase 8-independent mechanism. Cell Death Discov. 7:1342021. View Article : Google Scholar : PubMed/NCBI

27 

Noonan AM, Bunch KP, Chen JQ, Herrmann MA, Lee JM, Kohn EC, O'Sullivan CC, Jordan E, Houston N, Takebe N, et al: Pharmacodynamic markers and clinical results from the phase II Study of the SMAC-Mimetic birinapant in women with relapsed platinum-resistant or refractory epithelial ovarian cancer. Cancer. 122:588–597. 2016. View Article : Google Scholar

28 

Phan N, Hong JJ, Tofig B, Mapua M, Elashoff D, Moatamed NA, Huang J, Memarzadeh S, Damoiseaux R and Soragni A: A simple high-throughput approach identifies actionable drug sensitivities in patient-derived tumor organoids. Commun Biol. 2:782019. View Article : Google Scholar : PubMed/NCBI

29 

Nguyen HTL and Soragni A: Patient-derived tumor organoid rings for histologic characterization and high-throughput screening. STAR Protoc. 1:1000562020. View Article : Google Scholar : PubMed/NCBI

30 

Ianevski A, Giri AK and Aittokallio T: SynergyFinder 2.0: Visual analytics of multi-drug combination synergies. Nucleic Acids Res. 48(W1): W488–W493. 2020. View Article : Google Scholar : PubMed/NCBI

31 

National Cancer Institute: Oxaliplatin. Accessed September 15, 2021. Available from: https://www.cancer.gov/about-cancer/treatment/drugs/oxaliplatin.

32 

National Cancer Institute: Cisplatin. Accessed September 15, 2021. Available from: https://www.cancer.gov/about-cancer/treatment/drugs/cisplatin.

33 

National Cancer Institute: Discovery-Cisplatin and The Treatment of Testicular and Other Cancers. Accessed September 15, 2021. Available from: https://www.cancer.gov/research/progress/discovery/cisplatin.

34 

Decatris MP, Sundar S and O'Byrne KJ: Platinum-based chemotherapy in metastatic breast cancer: Current status. Cancer Treat Rev. 30:53–81. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Burstein HJ, Mangu PB, Somerfield MR, Schrag D, Samson D, Holt L, Zelman D and Ajani JA; American Society of Clinical Oncology: American Society of Clinical Oncology clinical practice guideline update on the use of chemotherapy sensitivity and resistance assays. J Clin Oncol. 29:3328–3330. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Haley J, Tomar S, Pulliam N, Xiong S, Perkins SM, Karpf AR, Mitra S, Nephew KP and Mitra AK: Functional characterization of a panel of high-grade serous ovarian cancer cell lines as representative experimental models of the disease. Oncotarget. 7:32810–32820. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Beaufort CM, Helmijr JC, Piskorz AM, Hoogstraat M, Ruigrok-Ritstier K, Besselink N, Murtaza M, van IJcken WF, Heine AA, Smid M, et al: Ovarian cancer cell line panel (OCCP): Clinical importance of in vitro morphological subtypes. PLoS One. 9:e1039882014. View Article : Google Scholar : PubMed/NCBI

38 

Kopper O, de Witte CJ, Lõhmussaar K, Valle-Inclan JE, Hami N, Kester L, Balgobind AV, Korving J, Proost N, Begthel H, et al: An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity. Nat Med. 25:838–849. 2019. View Article : Google Scholar : PubMed/NCBI

39 

LaCasse EC, Mahoney DJ, Cheung HH, Plenchette S, Baird S and Korneluk RG: IAP-targeted therapies for cancer. Oncogene. 27:6252–6275. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Thibault B, Genre L, Le Naour A, Broca C, Mery E, Vuagniaux G, Delord JP, Wiedemann N and Couderc B: DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death. Sci Rep. 8:178622018. View Article : Google Scholar : PubMed/NCBI

41 

Rabik CA and Dolan ME: Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat Rev. 33:9–23. 2007. View Article : Google Scholar :

42 

Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, et al: IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis. Cell. 131:682–693. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Probst BL, Liu L, Ramesh V, Li L, Sun H, Minna JD and Wang L: Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner. Cell Death Differ. 17:1645–1654. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Amaravadi RK, Senzer NN, Martin LP, Schilde RJ, LoRusso P, Papadopoulos KP, Weng DE, Graham M and Adjei AA: A phase I study of birinapant (TL32711) combined with multiple chemotherapies evaluating tolerability and clinical activity for solid tumor patients. J Clin Oncol. 31(Suppl 15): S25042013. View Article : Google Scholar

45 

Fichtner M, Bozkurt E, Salvucci M, McCann C, McAllister KA, Halang L, Düssmann H, Kinsella S, Crawford N, Sessler T, et al: Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant. Cell Death Dis. 11:10202020. View Article : Google Scholar : PubMed/NCBI

46 

Eytan DF, Snow GE, Carlson SG, Schiltz S, Chen Z and Van Waes C: Combination effects of SMAC mimetic birinapant with TNFα, TRAIL, and docetaxel in preclinical models of HNSCC. Laryngoscope. 125:E118–E124. 2015. View Article : Google Scholar

47 

Michie J, Beavis PA, Freeman AJ, Vervoort SJ, Ramsbottom KM, Narasimhan V, Lelliott EJ, Lalaoui N, Ramsay RG, Johnstone RW, et al: Antagonism of IAPs Enhances CAR T-cell Efficacy. Cancer Immunol Res. 7:183–192. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Zinngrebe J, Schlichtig F, Kraus JM, Meyer M, Boldrin E, Kestler HA, Meyer LH, Fischer-Posovszky P and Debatin KM: Biomarker profile for prediction of response to SMAC mimetic monotherapy in pediatric precursor B-cell acute lymphoblastic leukemia. Int J Cancer. 146:3219–3231. 2020. View Article : Google Scholar

49 

McCann C, Matveeva A, McAllister K, Van Schaeybroeck S, Sessler T, Fichtner M, Carberry S, Rehm M, Prehn JHM and Longley DB: Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer. FEBS J. 288:5374–5388. 2021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Singh T, Neal A, Dibernardo G, Raheseparian N, Moatamed NA and Memarzadeh S: Efficacy of birinapant in combination with carboplatin in targeting platinum‑resistant epithelial ovarian cancers. Int J Oncol 60: 35, 2022.
APA
Singh, T., Neal, A., Dibernardo, G., Raheseparian, N., Moatamed, N.A., & Memarzadeh, S. (2022). Efficacy of birinapant in combination with carboplatin in targeting platinum‑resistant epithelial ovarian cancers. International Journal of Oncology, 60, 35. https://doi.org/10.3892/ijo.2022.5325
MLA
Singh, T., Neal, A., Dibernardo, G., Raheseparian, N., Moatamed, N. A., Memarzadeh, S."Efficacy of birinapant in combination with carboplatin in targeting platinum‑resistant epithelial ovarian cancers". International Journal of Oncology 60.3 (2022): 35.
Chicago
Singh, T., Neal, A., Dibernardo, G., Raheseparian, N., Moatamed, N. A., Memarzadeh, S."Efficacy of birinapant in combination with carboplatin in targeting platinum‑resistant epithelial ovarian cancers". International Journal of Oncology 60, no. 3 (2022): 35. https://doi.org/10.3892/ijo.2022.5325
Copy and paste a formatted citation
x
Spandidos Publications style
Singh T, Neal A, Dibernardo G, Raheseparian N, Moatamed NA and Memarzadeh S: Efficacy of birinapant in combination with carboplatin in targeting platinum‑resistant epithelial ovarian cancers. Int J Oncol 60: 35, 2022.
APA
Singh, T., Neal, A., Dibernardo, G., Raheseparian, N., Moatamed, N.A., & Memarzadeh, S. (2022). Efficacy of birinapant in combination with carboplatin in targeting platinum‑resistant epithelial ovarian cancers. International Journal of Oncology, 60, 35. https://doi.org/10.3892/ijo.2022.5325
MLA
Singh, T., Neal, A., Dibernardo, G., Raheseparian, N., Moatamed, N. A., Memarzadeh, S."Efficacy of birinapant in combination with carboplatin in targeting platinum‑resistant epithelial ovarian cancers". International Journal of Oncology 60.3 (2022): 35.
Chicago
Singh, T., Neal, A., Dibernardo, G., Raheseparian, N., Moatamed, N. A., Memarzadeh, S."Efficacy of birinapant in combination with carboplatin in targeting platinum‑resistant epithelial ovarian cancers". International Journal of Oncology 60, no. 3 (2022): 35. https://doi.org/10.3892/ijo.2022.5325
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