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circ‑LRP6 contributes to osteosarcoma progression by regulating the miR‑141‑3p/HDAC4/HMGB1 axis

  • Authors:
    • Yali Yu
    • Guixiang Dong
    • Zijun Li
    • Yan Zheng
    • Zhisong Shi
    • Guanghui Wang
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory, Zhengzhou Orthopedic Hospital, Zhengzhou, Henan 450052, P.R. China, Department of Orthopedic Surgery, Zhumadian Central Hospital, Zhumadian, Henan 463000, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 38
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    Published online on: February 23, 2022
       https://doi.org/10.3892/ijo.2022.5328
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Abstract

Circular RNA‑lipoprotein receptor 6 (circ‑LRP6) serves a role in promoting the tumorigenesis of retinoblastoma, esophageal squamous cell cancer and oral squamous cell carcinoma; however, whether circ‑LRP6 demonstrates the same effect in osteosarcoma (OS) is yet to be fully elucidated. The present study aimed to analyze the expression, role and potential molecular mechanism of circ‑LRP6 in OS. The expression levels of circ‑LRP6, microRNA (miR)‑141‑3p, histone deacetylase 4 (HDAC4) and high mobility group protein 1 (HMGB1) were evaluated by reverse transcription-quantitative PCR in OS tissues and cell lines. Cell Counting Kit‑8, Transwell and Matrigel assays were conducted to evaluate cell proliferation, migration and invasion, respectively. Western blotting was also performed to determine HDAC4 and HMGB1 protein expression levels. Bioinformatics and dual‑luciferase reporter assays were used to predict and analyze the interactions between circ‑LRP6 and miR‑141‑3p, miR‑141‑3p and HDAC4, as well as between miR‑141‑3p and HMGB1. Additionally, RNA immunoprecipitation was performed to verify the association between circ‑LRP6 and miR‑141‑3p. The results confirmed that circ‑LRP6 was highly expressed in OS tissues and cell lines. In addition, circ‑LRP6 negatively regulated the expression of miR‑141‑3p and, in turn, miR‑141‑3p negatively regulated HDAC4 and HMGB1 expression. Functional assays revealed that circ‑LRP6 knockdown inhibited the proliferation, migration and invasion of OS cells, whereas the inhibition of miR‑141‑3p or the overexpression of either HDAC4 or HMGB1 partly reversed the inhibitory effect of circ‑LRP6 knockdown. In summary, the present study determined that circ‑LRP6 knockdown inhibited the proliferation, migration and invasion of OS cells by regulating the miR‑141‑3p/HDAC4/HMGB1 axis.
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View References

1 

Sangle NA and Layfield LJ: Telangiectatic osteosarcoma. Arch Pathol Lab Med. 136:572–576. 2012. View Article : Google Scholar

2 

Strobel O, Neoptolemos J, Jäger D and Büchler MW: Optimizing the outcomes of pancreatic cancer surgery. Nat Rev Clin Oncol. 16:11–26. 2019. View Article : Google Scholar

3 

Harrison DJ, Geller DS, Gill JD, Lewis VO and Gorlick R: Current and future therapeutic approaches for osteosarcoma. Expert Rev Anticancer Ther. 18:39–50. 2018. View Article : Google Scholar

4 

Li Z, Ruan Y, Zhang H, Shen Y, Li T and Xiao B: Tumor-suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets. Cancer Sci. 110:3630–3638. 2019. View Article : Google Scholar

5 

Zhang F, Zhang R, Zhang X, Wu Y, Li X, Zhang S, Hou W, Ding Y, Tian J, Sun L and Kong X: Comprehensive analysis of circRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits. Aging (Albany NY). 10:2266–2283. 2018. View Article : Google Scholar

6 

Xu Y, Xu X, Ocansey DKW, Cao H, Qiu W, Tu Q and Mao F: CircRNAs as promising biomarkers of inflammatory bowel disease and its associated-colorectal cancer. Am J Transl Res. 13:1580–1593. 2021.

7 

Wu F, Han B, Wu S, Yang L, Leng S, Li M, Liao J, Wang G, Ye Q, Zhang Y, et al: Circular RNA TLK1 aggravates neuronal injury and neurological deficits after ischemic stroke via miR-335-3p/TIPARP. J Neurosci. 39:7369–7393. 2019. View Article : Google Scholar

8 

Ma W, Xue N, Zhang J, Wang D, Yao X, Lin L and Xu Q: circUBAP2 regulates osteosarcoma progression via the miR-204-3p/HMGA2 axis. Int J Oncol. 58:298–311. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Liu S, Zhang J, Zheng T, Mou X and Xin W: Circ_WWC3 overexpression decelerates the progression of osteosarcoma by regulating miR-421/PDE7B axis. Open Life Sci. 16:229–241. 2021. View Article : Google Scholar :

10 

Huo S and Dou D: Circ_0056285 regulates proliferation, apop- tosis and glycolysis of osteosarcoma cells via miR-1244/TRIM44 axis. Cancer Manag Res. 13:1257–1270. 20210. View Article : Google Scholar

11 

Wen Y, Li B, He M, Teng S, Sun Y and Wang G: circHIPK3 promotes proliferation and migration and invasion via regulation of miR-637/HDAC4 signaling in osteosarcoma cells. Oncol Rep. 45:169–179. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Chen Z, Xu W, Zhang D, Chu J, Shen S, Ma Y, Wang Q, Liu G, Yao T, Huang Y, et al: circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression. Mol Ther Nucleic Acids. 23:1120–1135. 2020. View Article : Google Scholar

13 

Hall IF, Climent M, Quintavalle M, Farina FM, Schorn T, Zani S, Carullo P, Kunderfranco P, Civilini E, Condorelli G and Elia L: Circ_Lrp6, a circular RNA enriched in vascular smooth muscle cells, acts as a sponge regulating miRNA-145 function. Circ Res. 124:498–510. 2019. View Article : Google Scholar

14 

Zheng S, Qian Z, Jiang F, Ge D, Tang J, Chen H, Yang J, Yao Y, Yan J, Zhao L, et al: CircRNA LRP6 promotes the development of osteosarcoma via negatively regulating KLF2 and APC levels. Am J Transl Res. 11:4126–4138. 2019.

15 

Zhang Q, Jiang C, Ren W, Li S, Zheng J, Gao Y, Zhi K and Gao L: Circ-LRP6 mediates epithelial-mesenchymal transition and autophagy in oral squamous cell carcinomas. J Oral Pathol Med. 50:660–667. 2021. View Article : Google Scholar : PubMed/NCBI

16 

Wang J, Zhu W, Tao G and Wang W: Circular RNA circ-LRP6 facilitates Myc-driven tumorigenesis in esophageal squamous cell cancer. Bioengineered. 11:932–938. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Yu Y, Wang L, Li Z, Zheng Y, Shi Z and Wang G: Long noncoding RNA CRNDE functions as a diagnostic and prognostic biomarker in osteosarcoma, as well as promotes its progression via inhibition of miR-335-3p. J Biochem Mol Toxicol. 35:e227342021. View Article : Google Scholar

18 

Gulino R, Forte S, Parenti R, Memeo L and Gulisano M: MicroRNA and pediatric tumors: Future perspectives. Acta Histochem. 117:339–354. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Liu Y, Wang Y, Yang H, Zhao L, Song R, Tan H and Wang L: MicroRNA-873 targets HOXA9 to inhibit the aggressive pheno- type of osteosarcoma by deactivating the Wnt/β-catenin pathway. Int J Oncol. 54:1809–1820. 2019.PubMed/NCBI

20 

Gao S, Wang J, Tian S and Luo J: miR-9 depletion suppresses the proliferation of osteosarcoma cells by targeting p16. Int J Oncol. 54:1921–1932. 2019.PubMed/NCBI

21 

Feng T, Zhu Z, Jin Y, Wang H, Mao X, Liu D, Li Y, Lu L and Zuo G: The microRNA-708-5p/ZEB1/EMT axis mediates the metastatic potential of osteosarcoma. Oncol Rep. 43:491–502. 2020.PubMed/NCBI

22 

Sun X, Xu Y, Zhang S, Li X and Wang Y, Zhang Y, Zhao X, Li Y and Wang Y: MicroRNA-183 suppresses the vitality, invasion and migration of human osteosarcoma cells by targeting metastasis-associated protein 1. Exp Ther Med. 15:5058–5064. 2018.PubMed/NCBI

23 

Zhao X, Xu Y, Sun X, Ma Y, Zhang Y and Wang Y, Guan H, Jia Z, Li Y and Wang Y: miR-17-5p promotes proliferation and epithelial-mesenchymal transition in human osteosarcoma cells by targeting SRC kinase signaling inhibitor 1. J Cell Biochem. 120:5495–5504. 2019. View Article : Google Scholar

24 

Wang N, Li P, Liu W, Wang N, Lu Z, Feng J, Zeng X, Yang J, Wang Y and Zhao W: miR-141-3p suppresses proliferation and promotes apoptosis by targeting GLI2 in osteosarcoma cells. Oncol Rep. 39:747–754. 2018.

25 

Wang L: MiR-141-3p overexpression suppresses the malignancy of osteosarcoma by targeting FUS to degrade LDHB. Biosci Rep. Jun 26–2020.Epub ahead of print.

26 

Liang Z, Li X, Liu S, Li C, Wang X and Xing J: MiR-141-3p inhibits cell proliferation, migration and invasion by targeting TRAF5 in colorectal cancer. Biochem Biophys Res Commun. 514:699–705. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Zhou Y, Zhong JH, Gong FS and Xiao J: MiR-141-3p suppresses gastric cancer induced transition of normal fibroblast and BMSC to cancer-associated fibroblasts via targeting STAT4. Exp Mol Pathol. 107:85–94. 2019. View Article : Google Scholar

28 

Jiang J, Sun Y, Xu G, Wang H and Wang L: The role of miRNA, lncRNA and circRNA in the development of intervertebral disk degeneration (review). Exp Ther Med. 21:5552021. View Article : Google Scholar :

29 

Chen F, He L, Qiu L, Zhou Y, Li Z, Chen G, Xin F, Dong X, Xu H, Wang G, et al: Circular RNA CircEPB41L2 functions as tumor suppressor in hepatocellular carcinoma through sponging miR-590-5p. Cancer Manag Res. 13:2969–2981. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Zhang C, Cao J, Lv W and Mou H: CircRNA_100395 carried by exosomes from adipose-derived mesenchymal stem cells inhibits the malignant transformation of non-small cell lung carcinoma through the miR-141-3p-LATS2 axis. Front Cell Dev Biol. 9:6631472021. View Article : Google Scholar : PubMed/NCBI

31 

Huang XY, Huang ZL, Zhang PB, Huang XY, Huang J, Wang HC, Xu B, Zhou J and Tang ZY: CircRNA-100338 is associated with mTOR signaling pathway and poor prognosis in hepatocellular carcinoma. Front Oncol. 9:3922019. View Article : Google Scholar : PubMed/NCBI

32 

Chao F, Song Z, Wang S, Ma Z, Zhuo Z, Meng T, Xu G and Chen G: Novel circular RNA circSOBP governs amoeboid migration through the regulation of the miR-141-3p/MYPT1/p-MLC2 axis in prostate cancer. Clin Transl Med. 11:e3602021. View Article : Google Scholar : PubMed/NCBI

33 

Ma J, Wu Y and He Y: Silencing circRNA LRP6 down-regulates PRMT1 to improve the streptozocin-induced pancreatic β-cell injury and insulin secretion by sponging miR-9-5p. J Bioenerg Biomembr. 53:333–342. 2021. View Article : Google Scholar : PubMed/NCBI

34 

Xue J, Chen C, Luo F, Pan X, Xu H, Yang P, Sun Q, Liu X, Lu L, Yang Q, et al: CircLRP6 regulation of ZEB1 via miR-455 is involved in the epithelial-mesenchymal transition during arsenite-induced malignant transformation of human keratinocytes. Toxicol Sci. 162:450–461. 2018. View Article : Google Scholar

35 

Cai JY, Xu TT, Wang Y, Chang JJ, Li J, Chen XY, Chen X, Yin YF and Ni XJ: Histone deacetylase HDAC4 promotes the proliferation and invasion of glioma cells. Int J Oncol. 53:2758–2768. 2018.PubMed/NCBI

36 

Xiao Q, Huang L, Zhang Z, Chen X, Luo J, Zhang Z, Chen S, Shu Y, Han Z and Cao K: Overexpression of miR-140 inhibits proliferation of osteosarcoma cells via suppression of histone deacetylase 4. Oncol Res. 25:267–275. 2017. View Article : Google Scholar

37 

Zeng LS, Yang XZ, Wen YF, Mail SJ, Wang MH, Zhang MY, Zheng XF and Wang HY: Overexpressed HDAC4 is associated with poor survival and promotes tumor progression in esophageal carcinoma. Aging (Albany NY). 8:1236–1249. 2016. View Article : Google Scholar

38 

Cao K, Wang H, Fang Y, Wang Y, Wei L, Chen X, Jiang Z, Wei X and Hu Y: Histone deacetylase 4 promotes osteosarcoma cell proliferation and invasion by regulating expression of proliferating cell nuclear antigen. Front Oncol. 9:8702019. View Article : Google Scholar

39 

Wang H, Feng L, Zheng Y, Li W, Liu L, Xie S, Zhou Y, Chen C and Cheng D: LINC00680 promotes the progression of non-small cell lung cancer and functions as a sponge of miR-410-3p to enhance HMGB1 expression. Onco Targets Ther. 13:8183–8196. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Zhang H, Wang J, Li J, Zhou X, Yin L, Wang Y, Gu Y, Niu X, Yang Y, Ji H and Zhang Q: HMGB1 is a key factor for tamoxifen resistance and has the potential to predict the efficacy of CDK4/6 inhibitors in breast cancer. Cancer Sci. 112:1603–1613. 2021. View Article : Google Scholar : PubMed/NCBI

41 

Nakamura T, Okui T, Hasegawa K, Ryumon S, Ibaragi S, Ono K, Kunisada Y, Obata K, Masui M, Shimo T and Sasaki A: High mobility group box 1 induces bone pain associated with bone invasion in a mouse model of advanced head and neck cancer. Oncol Rep. 44:2547–2558. 2020. View Article : Google Scholar :

42 

Zhu X, Sun L and Wang Y: High mobility group box 1 (HMGB1) is upregulated by the Epstein-Barr virus infection and promotes the proliferation of human nasopharyngeal carcinoma cells. Acta Otolaryngol. 136:87–94. 2016. View Article : Google Scholar

43 

Yuan C and Yang L: Long non-coding RNA PITPNA-AS1 accelerates the progression of colorectal cancer through miR-129-5p/HMGB1 axis. Cancer Manag Res. 12:12497–12507. 2020. View Article : Google Scholar :

44 

Guan H, Liu J, Lv P, Zhou L, Zhang J and Cao W: MicroRNA-590 inhibits migration, invasion and epithelial-to-mesenchymal transition of esophageal squamous cell carcinoma by targeting low-density lipoprotein receptor-related protein 6. Oncol Rep. 44:1385–1392. 2020.

45 

Zhang F, Cheng N, Du J, Zhang H and Zhang C: MicroRNA-200b-3p promotes endothelial cell apoptosis by targeting HDAC4 in atherosclerosis. BMC Cardiovasc Disord. 21:1722021. View Article : Google Scholar : PubMed/NCBI

46 

Lu Z, Wang D, Wang X, Zou J, Sun J and Bi Z: MiR-206 regulates the progression of osteoporosis via targeting HDAC4. Eur J Med Res. 26:82021. View Article : Google Scholar : PubMed/NCBI

47 

Gondaliya P, P Dasare A, Jash K, Tekade RK, Srivastava A and Kalia K: miR-29b attenuates histone deacetylase-4 mediated podocyte dysfunction and renal fibrosis in diabetic nephropathy. J Diabetes Metab Disord. 19:13–27. 2019. View Article : Google Scholar

48 

Malavika D, Shreya S, Raj Priya V, Rohini M, He Z, Partridge NC and Selvamurugan N: miR-873-3p targets HDAC4 to stimulate matrix metalloproteinase-13 expression upon parathyroid hormone exposure in rat osteoblasts. J Cell Physiol. 235:7996–8009. 2020. View Article : Google Scholar : PubMed/NCBI

49 

Zhang Y, Chu X and Wei Q: MiR-451 Promotes cell apoptosis and inhibits autophagy in pediatric acute myeloid leukemia by targeting HMGB1. J Environ Pathol Toxicol Oncol. 40:45–53. 2021. View Article : Google Scholar

50 

Feng XE: miR-548b suppresses melanoma cell growth, migration, and invasion by negatively regulating its target gene HMGB1. Cancer Biother Radiopharm. 36:189–201. 2021. View Article : Google Scholar

51 

Shen H, Xu L, You C, Tang H, Wu H, Zhang Y and Xie M: miR-665 is downregulated in glioma and inhibits tumor cell proliferation, migration and invasion by targeting high mobility group box 1. Oncol Lett. 21:1562021. View Article : Google Scholar

52 

Dong H and Song J: miR-142-3p reduces the viability of human cervical cancer cells by negatively regulating the cytoplasmic localization of HMGB1. Exp Ther Med. 21:2122021. View Article : Google Scholar

53 

Qiu M, Liu D and Fu Q: MiR-129-5p shuttled by human synovial mesenchymal stem cell-derived exosomes relieves IL-1β induced osteoarthritis via targeting HMGB1. Life Sci. 269:1189872021. View Article : Google Scholar

54 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

55 

Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, et al: Microarray expression profile and functional analysis of circular RNAs in osteosarcoma. Cell Physiol Biochem. 43:969–985. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Guan H, Mei Y, Mi Y, Li C, Sun X, Zhao X, Liu J, Cao W, Li Y and Wang Y: Downregulation of lncRNA ANRIL suppresses growth and metastasis in human osteosarcoma cells. Onco Targets Ther. 11:4893–4899. 2018. View Article : Google Scholar

57 

Lei S and Xiang L: Up-regulation of circRNA hsa_circ_0003074 expression is a reliable diagnostic and prognostic biomarker in patients with osteosarcoma. Cancer Manag Res. 12:9315–9325. 2020. View Article : Google Scholar

58 

Nie WB, Zhao LM, Guo R, Wang MX and Ye FG: Circular RNA circ-NT5C2 acts as a potential novel biomarker for prognosis of osteosarcoma. Eur Rev Med Pharmacol Sci. 22:6239–6244. 2018.PubMed/NCBI

59 

Kun-Peng Z, Chun-Lin Z, Jian-Ping H and Lei Z: A novel circulating hsa_circ_0081001 act as a potential biomarker for diagnosis and prognosis of osteosarcoma. Int J Biol Sci. 14:1513–1520. 2018. View Article : Google Scholar : PubMed/NCBI

60 

Wang Z, Deng M, Chen L, Wang W, Liu G, Liu D, Han Z and Zhou Y: Circular RNA Circ-03955 promotes epithelial-mesenchymal transition in osteosarcoma by regulating miR-3662/metadherin pathway. Front Oncol. 10:5454602020. View Article : Google Scholar :

61 

Wan J, Liu Y, Long F, Tian J and Zhang C: circPVT1 promotes osteosarcoma glycolysis and metastasis by sponging miR-423-5p to activate Wnt5a/Ror2 signaling. Cancer Sci. 112:1707–1722. 2021. View Article : Google Scholar

62 

Yi Y, Liu Y, Wu W, Wu K and Zhang W: Reconstruction and analysis of circRNA-miRNA-mRNA network in the pathology of cervical cancer. Oncol Rep. 41:2209–2225. 2019.PubMed/NCBI

63 

Zhang J, Yang Y, Yang T, Liu Y, Li A, Fu S, Wu M, Pan Z and Zhou W: microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity. Br J Cancer. 103:1215–1220. 2010. View Article : Google Scholar : PubMed/NCBI

64 

Hsieh TH, Hsu CY, Tsai CF, Long CY, Chai CY, Hou MF, Lee JN, Wu DC, Wang SC and Tsai EM: miR-125a-5p is a prognostic biomarker that targets HDAC4 to suppress breast tumorigenesis. Oncotarget. 6:494–509. 2015. View Article : Google Scholar

65 

Shen YF, Wei AM, Kou Q, Zhu QY and Zhang L: Histone deacetylase 4 increases progressive epithelial ovarian cancer cells via repression of p21 on fibrillar collagen matrices. Oncol Rep. 35:948–954. 2016. View Article : Google Scholar

66 

Zhang Y, Lv F, Qiao L and Zhao Q: MiR-505 inhibits prostate cancer cell invasion, metastasis and epithelial-to-mesenchymal transition through targeting HMGB-1. J BUON. 25:2036–2044. 2020.PubMed/NCBI

67 

Luan X, Ma C, Wang P and Lou F: HMGB1 is negatively correlated with the development of endometrial carcinoma and prevents cancer cell invasion and metastasis by inhibiting the process of epithelial-to-mesenchymal transition. Onco Targets Ther. 10:1389–1402. 2017. View Article : Google Scholar :

68 

Meng Q, Zhao J, Liu H, Zhou G, Zhang W, Xu X and Zheng M: HMGB1 promotes cellular proliferation and invasion, suppresses cellular apoptosis in osteosarcoma. Tumour Biol. 35:12265–12274. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yu Y, Dong G, Li Z, Zheng Y, Shi Z and Wang G: circ‑LRP6 contributes to osteosarcoma progression by regulating the miR‑141‑3p/HDAC4/HMGB1 axis. Int J Oncol 60: 38, 2022.
APA
Yu, Y., Dong, G., Li, Z., Zheng, Y., Shi, Z., & Wang, G. (2022). circ‑LRP6 contributes to osteosarcoma progression by regulating the miR‑141‑3p/HDAC4/HMGB1 axis. International Journal of Oncology, 60, 38. https://doi.org/10.3892/ijo.2022.5328
MLA
Yu, Y., Dong, G., Li, Z., Zheng, Y., Shi, Z., Wang, G."circ‑LRP6 contributes to osteosarcoma progression by regulating the miR‑141‑3p/HDAC4/HMGB1 axis". International Journal of Oncology 60.4 (2022): 38.
Chicago
Yu, Y., Dong, G., Li, Z., Zheng, Y., Shi, Z., Wang, G."circ‑LRP6 contributes to osteosarcoma progression by regulating the miR‑141‑3p/HDAC4/HMGB1 axis". International Journal of Oncology 60, no. 4 (2022): 38. https://doi.org/10.3892/ijo.2022.5328
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Y, Dong G, Li Z, Zheng Y, Shi Z and Wang G: circ‑LRP6 contributes to osteosarcoma progression by regulating the miR‑141‑3p/HDAC4/HMGB1 axis. Int J Oncol 60: 38, 2022.
APA
Yu, Y., Dong, G., Li, Z., Zheng, Y., Shi, Z., & Wang, G. (2022). circ‑LRP6 contributes to osteosarcoma progression by regulating the miR‑141‑3p/HDAC4/HMGB1 axis. International Journal of Oncology, 60, 38. https://doi.org/10.3892/ijo.2022.5328
MLA
Yu, Y., Dong, G., Li, Z., Zheng, Y., Shi, Z., Wang, G."circ‑LRP6 contributes to osteosarcoma progression by regulating the miR‑141‑3p/HDAC4/HMGB1 axis". International Journal of Oncology 60.4 (2022): 38.
Chicago
Yu, Y., Dong, G., Li, Z., Zheng, Y., Shi, Z., Wang, G."circ‑LRP6 contributes to osteosarcoma progression by regulating the miR‑141‑3p/HDAC4/HMGB1 axis". International Journal of Oncology 60, no. 4 (2022): 38. https://doi.org/10.3892/ijo.2022.5328
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