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Review

Recent progress of circular RNAs in different types of human cancer: Technological landscape, clinical opportunities and challenges (Review)

  • Authors:
    • Ashish Ranjan Sharma
    • Shreya Banerjee
    • Manojit Bhattacharya
    • Abinit Saha
    • Sang-Soo Lee
    • Chiranjib Chakraborty
  • View Affiliations / Copyright

    Affiliations: Institute for Skeletal Aging and Orthopedic Surgery, Hallym University‑Chuncheon Sacred Heart Hospital, Chuncheon, Gangwon 24252, Republic of Korea, Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal 700126, India, Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore, Odisha 756020, India
  • Article Number: 56
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    Published online on: March 31, 2022
       https://doi.org/10.3892/ijo.2022.5346
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Abstract

Circular RNAs (circRNAs) are a novel class of endogenous non‑coding RNAs that have been recently regarded as functionally active. CircRNAs are remarkably stable and known to possess several biological functions such as microRNA sponging, regulating transcription and splicing and occasionally acting as polypeptide‑producing templates. CircRNAs show tissue‑specific expression and have been reported to be associated with the progression of several types of malignancies. Given the recent progress in genome sequencing and bioinformatics techniques, a rapid increment in the biological role of circRNAs has been observed. Concurrently, the patent search from different patent databases shows that the patent number of circRNA is increasing very quickly. These phenomena reveal a rapid development of the technological landscape. In the present review, the recent progress on circRNAs in various kinds of cancer has been investigated and their function as biomarkers or therapeutic targets and their technological landscape have been appreciated. A new insight into circRNAs structure and functional capabilities in cancer has been reviewed. Continually increasing knowledge on their critical role during cancer progression is projecting them as biomarkers or therapeutic targets for various kinds of cancer. Thus, recent updates on the functional role of circRNAs in terms of the technological landscape, clinical opportunities (biomarkers and therapeutic targets), and challenges in cancer have been illustrated.
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Copy and paste a formatted citation
Spandidos Publications style
Sharma AR, Banerjee S, Bhattacharya M, Saha A, Lee S and Chakraborty C: Recent progress of circular RNAs in different types of human cancer: Technological landscape, clinical opportunities and challenges (Review). Int J Oncol 60: 56, 2022.
APA
Sharma, A.R., Banerjee, S., Bhattacharya, M., Saha, A., Lee, S., & Chakraborty, C. (2022). Recent progress of circular RNAs in different types of human cancer: Technological landscape, clinical opportunities and challenges (Review). International Journal of Oncology, 60, 56. https://doi.org/10.3892/ijo.2022.5346
MLA
Sharma, A. R., Banerjee, S., Bhattacharya, M., Saha, A., Lee, S., Chakraborty, C."Recent progress of circular RNAs in different types of human cancer: Technological landscape, clinical opportunities and challenges (Review)". International Journal of Oncology 60.5 (2022): 56.
Chicago
Sharma, A. R., Banerjee, S., Bhattacharya, M., Saha, A., Lee, S., Chakraborty, C."Recent progress of circular RNAs in different types of human cancer: Technological landscape, clinical opportunities and challenges (Review)". International Journal of Oncology 60, no. 5 (2022): 56. https://doi.org/10.3892/ijo.2022.5346
Copy and paste a formatted citation
x
Spandidos Publications style
Sharma AR, Banerjee S, Bhattacharya M, Saha A, Lee S and Chakraborty C: Recent progress of circular RNAs in different types of human cancer: Technological landscape, clinical opportunities and challenges (Review). Int J Oncol 60: 56, 2022.
APA
Sharma, A.R., Banerjee, S., Bhattacharya, M., Saha, A., Lee, S., & Chakraborty, C. (2022). Recent progress of circular RNAs in different types of human cancer: Technological landscape, clinical opportunities and challenges (Review). International Journal of Oncology, 60, 56. https://doi.org/10.3892/ijo.2022.5346
MLA
Sharma, A. R., Banerjee, S., Bhattacharya, M., Saha, A., Lee, S., Chakraborty, C."Recent progress of circular RNAs in different types of human cancer: Technological landscape, clinical opportunities and challenges (Review)". International Journal of Oncology 60.5 (2022): 56.
Chicago
Sharma, A. R., Banerjee, S., Bhattacharya, M., Saha, A., Lee, S., Chakraborty, C."Recent progress of circular RNAs in different types of human cancer: Technological landscape, clinical opportunities and challenges (Review)". International Journal of Oncology 60, no. 5 (2022): 56. https://doi.org/10.3892/ijo.2022.5346
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