|
1
|
Warburg O: On the origin of cancer cells.
Science. 123:309–314. 1956. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Warburg O, Wind F and Negelein E: The
metabolism of tumors in the body. J Gen Physiol. 8:519–530. 1927.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Jiang P, Du W and Wu M: Regulation of the
pentose phosphate pathway in cancer. Protein Cell. 5:592–602. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Zheng J: Energy metabolism of cancer:
Glycolysis versus oxidative phosphorylation (Review). Oncol Lett.
4:1151–1157. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Alfarouk KO, Shayoub ME, Muddathir AK,
Elhassan GO and Bashir AH: Evolution of tumor metabolism might
reflect carcinogenesis as a reverse evolution process (Dismantling
of Multicellularity). Cancers (Basel). 3:3002–3017. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Xu XD, Shao SX, Jiang HP, Cao YW, Wang YH,
Yang XC, Wang YL, Wang XS and Niu HT: Warburg effect or reverse
Warburg effect? A review of cancer metabolism. Oncol Res Treat.
38:117–122. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Yoshida GJ: Metabolic reprogramming: The
emerging concept and associated therapeutic strategies. J Exp Clin
Cancer Res. 34:1112015. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Saada A: Mitochondria: Mitochondrial
OXPHOS (dys) function ex vivo-the use of primary fibroblasts. Int J
Biochem Cell Biol. 48:60–65. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Arcucci A, Ruocco MR, Granato G, Sacco AM
and Montagnani S: Cancer: An oxidative crosstalk between solid
tumor cells and cancer associated fibroblasts. Biomed Res Int.
2016:45028462016. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Pertega-Gomes N, Vizcaino JR, Attig J,
Jurmeister S, Lopes C and Baltazar F: A lactate shuttle system
between tumour and stromal cells is associated with poor prognosis
in prostate cancer. BMC Cancer. 14:3522014. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Lee M and Yoon JH: Metabolic interplay
between glycolysis and mitochondrial oxidation: The reverse Warburg
effect and its therapeutic implication. World J Biol Chem.
6:148–161. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Buchsbaum RJ and Oh SY: Breast
cancer-associated fibroblasts: Where we are and where we need to
go. Cancers (Basel). 8:192016. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Catalano V, Turdo A, Di Franco S, Dieli F,
Todaro M and Stassi G: Tumor and its microenvironment: A
synergistic interplay. Semin Cancer Biol. 23:522–532. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Santi A, Kugeratski FG and Zanivan S:
Cancer associated fibroblasts: The architects of stroma remodeling.
Proteomics. 18:e17001672018. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Giannoni E, Bianchini F, Masieri L, Serni
S, Torre E, Calorini L and Chiarugi P: Reciprocal activation of
prostate cancer cells and cancer-associated fibroblasts stimulates
epithelial-mesenchymal transition and cancer stemness. Cancer Res.
70:6945–6956. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Lohr M, Schmidt C, Ringel J, Kluth M,
Müller P, Nizze H and Jesnowski R: Transforming growth factor-beta1
induces desmoplasia in an experimental model of human pancreatic
carcinoma. Cancer Res. 61:550–555. 2001.PubMed/NCBI
|
|
17
|
Shao ZM, Nguyen M and Barsky SH: Human
breast carcinoma desmoplasia is PDGF initiated. Oncogene.
19:4337–4345. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Calvo F, Ege N, Grande-Garcia A, Hooper S,
Jenkins RP, Chaudhry SI, Harrington K, Williamson P, Moeendarbary
E, Charras G and Sahai E: Mechanotransduction and YAP-dependent
matrix remodelling is required for the generation and maintenance
of cancer-associated fibroblasts. Nat Cell Biol. 15:637–646. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Martinez-Outschoorn UE, Balliet RM,
Rivadeneira DB, Chiavarina B, Pavlides S, Wang C, Whitaker-Menezes
D, Daumer KM, Lin Z, Witkiewicz AK, et al: Oxidative stress in
cancer associated fibroblasts drives tumor-stroma co-evolution: A
new paradigm for understanding tumor metabolism, the field effect
and genomic instability in cancer cells. Cell Cycle. 9:3256–3276.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Cirri P and Chiarugi P: Cancer associated
fibroblasts: The dark side of the coin. Am J Cancer Res. 1:482–497.
2011.PubMed/NCBI
|
|
21
|
Hirata E, Girotti MR, Viros A, Hooper S,
Spencer-Dene B, Matsuda M, Larkin J, Marais R and Sahai E:
Intravital imaging reveals how BRAF inhibition generates
drug-tolerant microenvironments with high integrin β1/FAK
signaling. Cancer Cell. 27:574–588. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Massague J: TGFβ signalling in context.
Nat Rev Mol Cell Biol. 13:616–630. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Avagliano A, Granato G, Ruocco MR, Romano
V, Belviso I, Carfora A, Montagnani S and Arcucci A: Metabolic
reprogramming of cancer associated fibroblasts: The slavery of
stromal fibroblasts. Biomed Res Int. 2018:60754032018. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Marin D and Sabater B: The cancer Warburg
effect may be a testable example of the minimum entropy production
rate principle. Phys Biol. 14:0240012017. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Orimo A, Gupta PB, Sgroi DC,
Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL
and Weinberg RA: Stromal fibroblasts present in invasive human
breast carcinomas promote tumor growth and angiogenesis through
elevated SDF-1/CXCL12 secretion. Cell. 121:335–348. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Pereira-Nunes A, Afonso J, Granja S and
Baltazar F: Lactate and lactate transporters as key players in the
maintenance of the warburg effect. Adv Exp Med Biol. 1219:51–74.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Draoui N and Feron O: Lactate shuttles at
a glance: From physiological paradigms to anti-cancer treatments.
Dis Model Mech. 4:727–732. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Lee N and Kim D: Cancer metabolism:
Fueling more than just growth. Mol Cells. 39:847–854. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Wilson RB, Solass W, Archid R, Weinreich
FJ, Konigsrainer A and Reymond MA: Resistance to anoikis in
transcoelomic shedding: The role of glycolytic enzymes. Pleura
Peritoneum. 4:201900032019. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Hsu PP and Sabatini DM: Cancer cell
metabolism: Warburg and beyond. Cell. 134:703–707. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Konjević G, Jurisić V, Jakovljević B and
Spuzić I: Lactate dehydrogenase (LDH) in peripheral blood
lymphocytes (PBL) of patients with solid tumors. Glas Srp Akad
Nauka Med. 137–147. 2002.(In Serbian). PubMed/NCBI
|
|
32
|
Koukourakis MI, Giatromanolaki A, Sivridis
E, Gatter KC and Harris AL: Pyruvate dehydrogenase and pyruvate
dehydrogenase kinase expression in non small cell lung cancer and
tumor-associated stroma. Neoplasia. 7:1–6. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Chen D and Che G: Value of caveolin-1 in
cancer progression and prognosis: Emphasis on cancer-associated
fibroblasts, human cancer cells and mechanism of caveolin-1
expression (Review). Oncol Lett. 8:1409–1421. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Shao S, Qin T, Qian W, Yue Y, Xiao Y, Li
X, Zhang D, Wang Z, Ma Q and Lei J: Positive feedback in Cav-1-ROS
signalling in PSCs mediates metabolic coupling between PSCs and
tumour cells. J Cell Mol Med. 24:9397–9408. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Bist A, Fielding CJ and Fielding PE: p53
regulates caveolin gene transcription, cell cholesterol, and growth
by a novel mechanism. Biochemistry. 39:1966–1972. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Witkiewicz AK, Dasgupta A, Nguyen KH, Liu
C, Kovatich AJ, Schwartz GF, Pestell RG, Sotgia F, Rui H and
Lisanti MP: Stromal caveolin-1 levels predict early DCIS
progression to invasive breast cancer. Cancer Biol Ther.
8:1071–1079. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Pavlides S, Tsirigos A, Migneco G,
Whitaker-Menezes D, Chiavarina B, Flomenberg N, Frank PG, Casimiro
MC, Wang C, Pestell RG, et al: The autophagic tumor stroma model of
cancer: Role of oxidative stress and ketone production in fueling
tumor cell metabolism. Cell Cycle. 9:3485–3505. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Chen F, Barman S, Yu Y, Haigh S, Wang Y,
Black SM, Rafikov R, Dou H, Bagi Z, Han W, et al: Caveolin-1 is a
negative regulator of NADPH oxidase-derived reactive oxygen
species. Free Radic Biol Med. 73:201–213. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Sotgia F, Martinez-Outschoorn UE, Pavlides
S, Howell A, Pestell RG and Lisanti MP: Understanding the Warburg
effect and the prognostic value of stromal caveolin-1 as a marker
of a lethal tumor microenvironment. Breast Cancer Res. 13:2132011.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Shen C, Chen X, Xiao K and Che G: New
relationship of E2F1 and BNIP3 with caveolin-1 in lung
cancer-associated fibroblasts. Thorac Cancer. 11:1369–1371. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Semenza GL: HIF-1: Upstream and downstream
of cancer metabolism. Curr Opin Genet Dev. 20:51–56. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Liu Q, Liu L, Zhao Y, Zhang J, Wang D,
Chen J, He Y, Wu J, Zhang Z, Liu Z, et al: Hypoxia induces genomic
DNA demethylation through the activation of HIF-1α and
transcriptional upregulation of MAT2A in hepatoma cells. Mol Cancer
Ther. 10:1113–1123. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Luo W, Hu H, Chang R, Zhong J, Knabel M,
O'Meally R, Cole RN, Pandey A and Semenza GL: Pyruvate kinase M2 is
a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell.
145:732–744. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Wang HJ, Hsieh YJ, Cheng WC, Lin CP, Lin
YS, Yang SF, Chen CC, Izumiya Y, Yu JS, Kung HJ and Wang WC: JMJD5
regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated
glucose metabolism. Proc Natl Acad Sci USA. 111:279–284. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Li X, Xu Q, Wu Y, Li J, Tang D, Han L and
Fan Q: A CCL2/ROS autoregulation loop is critical for
cancer-associated fibroblasts-enhanced tumor growth of oral
squamous cell carcinoma. Carcinogenesis. 35:1362–1370. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Qin X, Yan M, Wang X, Xu Q, Wang X, Zhu X,
Shi J, Li Z, Zhang J, Chen W, et al: Cancer-associated
Fibroblast-derived IL-6 promotes head and neck cancer progression
via the osteopontin-NF-kappa B signaling pathway. Theranostics.
8:921–940. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Chiarugi P and Cirri P: Metabolic
exchanges within tumor microenvironment. Cancer Lett. 380:272–280.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Fiaschi T, Marini A, Giannoni E, Taddei
ML, Gandellini P, De Donatis A, Lanciotti M, Serni S, Cirri P and
Chiarugi P: Reciprocal metabolic reprogramming through lactate
shuttle coordinately influences tumor-stroma interplay. Cancer Res.
72:5130–5140. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Ippolito L, Morandi A, Taddei ML, Parri M,
Comito G, Iscaro A, Raspollini MR, Magherini F, Rapizzi E,
Masquelier J, et al: Cancer-associated fibroblasts promote prostate
cancer malignancy via metabolic rewiring and mitochondrial
transfer. Oncogene. 38:5339–5355. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Martinez-Outschoorn U, Sotgia F and
Lisanti MP: Tumor microenvironment and metabolic synergy in breast
cancers: Critical importance of mitochondrial fuels and function.
Semin Oncol. 41:195–216. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Pavlides S, Whitaker-Menezes D,
Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, Casimiro
MC, Wang C, Fortina P, Addya S, et al: The reverse Warburg effect:
Aerobic glycolysis in cancer associated fibroblasts and the tumor
stroma. Cell Cycle. 8:3984–4001. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Roy A and Bera S: CAF cellular glycolysis:
Linking cancer cells with the microenvironment. Tumour Biol.
37:8503–8514. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Hasebe T, Mukai K, Tsuda H and Ochiai A:
New prognostic histological parameter of invasive ductal carcinoma
of the breast: Clinicopathological significance of fibrotic focus.
Pathol Int. 50:263–272. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Mao Y, Keller ET, Garfield DH, Shen K and
Wang J: Stromal cells in tumor microenvironment and breast cancer.
Cancer Metastasis Rev. 32:303–315. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Hu JW, Sun P, Zhang DX, Xiong WJ and Mi J:
Hexokinase 2 regulates G1/S checkpoint through CDK2 in
cancer-associated fibroblasts. Cell Signal. 26:2210–2216. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Pavlides S, Tsirigos A, Vera I, Flomenberg
N, Frank PG, Casimiro MC, Wang C, Pestell RG, Martinez-Outschoorn
UE, Howell A, et al: Transcriptional evidence for the ‘Reverse
Warburg Effect’ in human breast cancer tumor stroma and metastasis:
Similarities with oxidative stress, inflammation, Alzheimer's
disease, and ‘Neuron-Glia Metabolic Coupling’. Aging (Albany NY).
2:185–199. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Chiavarina B, Whitaker-Menezes D,
Martinez-Outschoorn UE, Witkiewicz AK, Birbe R, Howell A, Pestell
RG, Smith J, Daniel R, Sotgia F and Lisanti MP: Pyruvate kinase
expression (PKM1 and PKM2) in cancer-associated fibroblasts drives
stromal nutrient production and tumor growth. Cancer Biol Ther.
12:1101–1113. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Giannoni E, Taddei ML, Morandi A, Comito
G, Calvani M, Bianchini F, Richichi B, Raugei G, Wong N, Tang D and
Chiarugi P: Targeting stromal-induced pyruvate kinase M2 nuclear
translocation impairs oxphos and prostate cancer metastatic spread.
Oncotarget. 6:24061–24074. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Li Z, Yang P and Li Z: The multifaceted
regulation and functions of PKM2 in tumor progression. Biochim
Biophys Acta. 1846:285–296. 2014.PubMed/NCBI
|
|
60
|
Hamabe A, Konno M, Tanuma N, Shima H,
Tsunekuni K, Kawamoto K, Nishida N, Koseki J, Mimori K, Gotoh N, et
al: Role of pyruvate kinase M2 in transcriptional regulation
leading to epithelial-mesenchymal transition. Proc Natl Acad Sci
USA. 111:15526–15531. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Sung JS, Kang CW, Kang S, Jang Y, Chae YC,
Kim BG and Cho NH: ITGB4-mediated metabolic reprogramming of
cancer-associated fibroblasts. Oncogene. 39:664–676. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Qiao A, Gu F, Guo X, Zhang X and Fu L:
Breast cancer-associated fibroblasts: Their roles in tumor
initiation, progression and clinical applications. Front Med.
10:33–40. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Yu T, Yang G, Hou Y, Tang X, Wu C, Wu XA,
Guo L, Zhu Q, Luo H, Du YE, et al: Cytoplasmic GPER translocation
in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic
axis to confer tumor cells with multidrug resistance. Oncogene.
36:2131–2145. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Ziani L, Chouaib S and Thiery J:
Alteration of the antitumor immune response by cancer-associated
fibroblasts. Front Immunol. 9:4142018. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Fu Y, Liu S, Yin S, Niu W, Xiong W, Tan M,
Li G and Zhou M: The reverse Warburg effect is likely to be an
Achilles' heel of cancer that can be exploited for cancer therapy.
Oncotarget. 8:57813–57825. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Martinez-Outschoorn UE, Lisanti MP and
Sotgia F: Catabolic cancer-associated fibroblasts transfer energy
and biomass to anabolic cancer cells, fueling tumor growth. Semin
Cancer Biol. 25:47–60. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Dabiri S, Talebi A, Shahryari J, Meymandi
MS and Safizadeh H: Distribution of myofibroblast cells and
microvessels around invasive ductal carcinoma of the breast and
comparing with the adjacent range of their normal-to-DCIS zones.
Arch Iran Med. 16:93–99. 2013.PubMed/NCBI
|
|
68
|
Capparelli C, Whitaker-Menezes D, Guido C,
Balliet R, Pestell TG, Howell A, Sneddon S, Pestell RG,
Martinez-Outschoorn U, Lisanti MP and Sotgia F: CTGF drives
autophagy, glycolysis and senescence in cancer-associated
fibroblasts via HIF1 activation, metabolically promoting tumor
growth. Cell Cycle. 11:2272–2284. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Khan HY and Orimo A: Transforming growth
factor-β: Guardian of catabolic metabolism in carcinoma-associated
fibroblasts. Cell Cycle. 11:4302–4303. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Hou X, Zhang J, Wang Y, Xiong W and Mi J:
TGFBR-IDH1-Cav1 axis promotes TGF-β signalling in cancer-associated
fibroblast. Oncotarget. 8:83962–83974. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Trimmer C, Sotgia F, Whitaker-Menezes D,
Balliet RM, Eaton G, Martinez-Outschoorn UE, Pavlides S, Howell A,
Iozzo RV, Pestell RG, et al: Caveolin-1 and mitochondrial SOD2
(MnSOD) function as tumor suppressors in the stromal
microenvironment: A new genetically tractable model for human
cancer associated fibroblasts. Cancer Biol Ther. 11:383–394. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Panday A, Inda ME, Bagam P, Sahoo MK,
Osorio D and Batra S: Transcription factor NF-κB: An update on
intervention strategies. Arch Immunol Ther Exp (Warsz). 64:463–483.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Zwaans BM and Lombard DB: Interplay
between sirtuins, MYC and hypoxia-inducible factor in
cancer-associated metabolic reprogramming. Dis Model Mech.
7:1023–1032. 2014.PubMed/NCBI
|
|
74
|
De Francesco EM, Lappano R, Santolla MF,
Marsico S, Caruso A and Maggiolini M: HIF-1α/GPER signaling
mediates the expression of VEGF induced by hypoxia in breast cancer
associated fibroblasts (CAFs). Breast Cancer Res. 15:R642013.
View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Zhou F, Du J and Wang J: Albendazole
inhibits HIF-1α-dependent glycolysis and VEGF expression in
non-small cell lung cancer cells. Mol Cell Biochem. 428:171–178.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Fiaschi T and Chiarugi P: Oxidative
stress, tumor microenvironment, and metabolic reprogramming: A
diabolic liaison. Int J Cell Biol. 2012:7628252012. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Ullah MS, Davies AJ and Halestrap AP: The
plasma membrane lactate transporter MCT4, but not MCT1, is
up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J
Biol Chem. 281:9030–9037. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Sun K, Tang S, Hou Y, Xi L, Chen Y, Yin J,
Peng M, Zhao M, Cui X and Liu M: Oxidized ATM-mediated glycolysis
enhancement in breast cancer-associated fibroblasts contributes to
tumor invasion through lactate as metabolic coupling. EBioMedicine.
41:370–383. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Erez N, Truitt M, Olson P, Arron ST and
Hanahan D: Cancer-associated fibroblasts are activated in incipient
neoplasia to orchestrate tumor-promoting inflammation in an
NF-kappaB-dependent manner. Cancer Cell. 17:135–147. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Zhu Y, Shi C, Zeng L, Liu G, Jiang W,
Zhang X, Chen S, Guo J, Jian X, Ouyang J, et al: High COX-2
expression in cancer-associated fibiroblasts contributes to poor
survival and promotes migration and invasiveness in nasopharyngeal
carcinoma. Mol Carcinog. 59:265–280. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Chan JS, Tan MJ, Sng MK, Teo Z, Phua T,
Choo CC, Li L, Zhu P and Tan NS: Cancer-associated fibroblasts
enact field cancerization by promoting extratumoral oxidative
stress. Cell Death Dis. 8:e25622017. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Guido C, Whitaker-Menezes D, Capparelli C,
Balliet R, Lin Z, Pestell RG, Howell A, Aquila S, Andò S,
Martinez-Outschoorn U, et al: Metabolic reprogramming of
cancer-associated fibroblasts by TGF-β drives tumor growth:
Connecting TGF-β signaling with ‘Warburg-like’ cancer metabolism
and L-lactate production. Cell Cycle. 11:3019–3035. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Sampson N, Koziel R, Zenzmaier C,
Bubendorf L, Plas E, Jansen-Dürr P and Berger P: ROS signaling by
NOX4 drives fibroblast-to-myofibroblast differentiation in the
diseased prostatic stroma. Mol Endocrinol. 25:503–515. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Zhang D, Wang Y, Shi Z, Liu J, Sun P, Hou
X, Zhang J, Zhao S, Zhou BP and Mi J: Metabolic reprogramming of
cancer-associated fibroblasts by IDH3α downregulation. Cell Rep.
10:1335–1348. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Wu F, Wang S, Zeng Q, Liu J, Yang J, Mu J,
Xu H, Wu L, Gao Q, He X, et al: TGF-βRII regulates glucose
metabolism in oral cancer-associated fibroblasts via promoting PKM2
nuclear translocation. Cell Death Discov. 8:32022. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Smith ER and Hewitson TD: TGF-β1 is a
regulator of the pyruvate dehydrogenase complex in fibroblasts. Sci
Rep. 10:179142020. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Pupo M, Maggiolini M and Musti AM: GPER
mediates non-genomic effects of estrogen. Methods Mol Biol.
1366:471–488. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Madeo A and Maggiolini M: Nuclear
alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced
gene expression and migration in breast cancer-associated
fibroblasts. Cancer Res. 70:6036–6046. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Vivacqua A, Romeo E, De Marco P, De
Francesco EM, Abonante S and Maggiolini M: GPER mediates the Egr-1
expression induced by 17β-estradiol and 4-hydroxitamoxifen in
breast and endometrial cancer cells. Breast Cancer Res Treat.
133:1025–1035. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
De Francesco EM, Sims AH, Maggiolini M,
Sotgia F, Lisanti MP and Clarke RB: GPER mediates the angiocrine
actions induced by IGF1 through the HIF-1alpha/VEGF pathway in the
breast tumor microenvironment. Breast Cancer Res. 19:1292017.
View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Yang K and Yao Y: Mechanism of GPER
promoting proliferation, migration and invasion of triple-negative
breast cancer cells through CAF. Am J Transl Res. 11:5858–5868.
2019.PubMed/NCBI
|
|
92
|
Grivennikov SI, Greten FR and Karin M:
Immunity, inflammation, and cancer. Cell. 140:883–899. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Bromberg J and Wang TC: Inflammation and
cancer: IL-6 and STAT3 complete the link. Cancer Cell. 15:79–80.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Kinoshita H, Hirata Y, Nakagawa H,
Sakamoto K, Hayakawa Y, Takahashi R, Nakata W, Sakitani K, Serizawa
T, Hikiba Y, et al: Interleukin-6 mediates epithelial-stromal
interactions and promotes gastric tumorigenesis. PLoS One.
8:e609142013. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Ramteke A, Ting H, Agarwal C, Mateen S,
Somasagara R, Hussain A, Graner M, Frederick B, Agarwal R and Deep
G: Exosomes secreted under hypoxia enhance invasiveness and
stemness of prostate cancer cells by targeting adherens junction
molecules. Mol Carcinog. 54:554–565. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Erez N, Glanz S, Raz Y, Avivi C and
Barshack I: Cancer associated fibroblasts express pro-inflammatory
factors in human breast and ovarian tumors. Biochem Biophys Res
Commun. 437:397–402. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Ando M, Uehara I, Kogure K, Asano Y,
Nakajima W, Abe Y, Kawauchi K and Tanaka N: Interleukin 6 enhances
glycolysis through expression of the glycolytic enzymes hexokinase
2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3. J
Nippon Med Sch. 77:97–105. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Khan MA, Chen HC, Zhang D and Fu J: Twist:
A molecular target in cancer therapeutics. Tumour Biol.
34:2497–2506. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Lee KW, Yeo SY, Sung CO and Kim SH: Twist1
is a key regulator of cancer-associated fibroblasts. Cancer Res.
75:73–85. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Schmitz SU, Grote P and Herrmann BG:
Mechanisms of long noncoding RNA function in development and
disease. Cell Mol Life Sci. 73:2491–2509. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Garen A: From a retrovirus infection of
mice to a long noncoding RNA that induces proto-oncogene
transcription and oncogenesis via an epigenetic transcription
switch. Signal Transduct Target Ther. 1:160072016. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Ma MZ, Zhang Y, Weng MZ, Wang SH, Hu Y,
Hou ZY, Qin YY, Gong W, Zhang YJ, Kong X, et al: Long Noncoding RNA
GCASPC, a Target of miR-17-3p, negatively regulates pyruvate
carboxylase-dependent cell proliferation in gallbladder cancer.
Cancer Res. 76:5361–5371. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Hanahan D and Weinberg RA: Hallmarks of
cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Zhao L, Ji G, Le X, Wang C, Xu L, Feng M,
Zhang Y, Yang H, Xuan Y, Yang Y, et al: Long Noncoding RNA
LINC00092 acts in cancer-associated fibroblasts to drive glycolysis
and progression of ovarian cancer. Cancer Res. 77:1369–1382. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
105
|
He Z, You C and Zhao D: Long non-coding
RNA UCA1/miR-182/PFKFB2 axis modulates glioblastoma-associated
stromal cells-mediated glycolysis and invasion of glioma cells.
Biochem Biophys Res Commun. 500:569–576. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Ahn YH and Kim JS: Long Non-Coding RNAs as
regulators of interactions between cancer-associated fibroblasts
and cancer cells in the tumor microenvironment. Int J Mol Sci.
21:74842020. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Mitra AK, Zillhardt M, Hua Y, Tiwari P,
Murmann AE, Peter ME and Lengyel E: MicroRNAs reprogram normal
fibroblasts into cancer-associated fibroblasts in ovarian cancer.
Cancer Discov. 2:1100–1108. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Li P, Shan JX, Chen XH, Zhang D, Su LP,
Huang XY, Yu BQ, Zhi QM, Li CL, Wang YQ, et al: Epigenetic
silencing of microRNA-149 in cancer-associated fibroblasts mediates
prostaglandin E2/interleukin-6 signaling in the tumor
microenvironment. Cell Res. 25:588–603. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Zeng Z, Hu P, Tang X, Zhang H, Du Y, Wen S
and Liu M: Dectection and analysis of miRNA expression in breast
cancer-associated fibroblasts. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi.
30:1071–1075. 2014.(In Chinese). PubMed/NCBI
|
|
110
|
Wang Z, Tan Y, Yu W, Zheng S, Zhang S, Sun
L and Ding K: Small role with big impact: miRNAs as communicators
in the cross-talk between cancer-associated fibroblasts and cancer
cells. Int J Biol Sci. 13:339–348. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Vallabhaneni KC, Hassler MY, Abraham A,
Whitt J, Mo YY, Atfi A and Pochampally R: Mesenchymal Stem/Stromal
cells under stress increase osteosarcoma migration and apoptosis
resistance via extracellular vesicle mediated communication. PLoS
One. 11:e01660272016. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Tang H, Lee M, Sharpe O, Salamone L,
Noonan EJ, Hoang CD, Levine S, Robinson WH and Shrager JB:
Oxidative stress-responsive microRNA-320 regulates glycolysis in
diverse biological systems. FASEB J. 26:4710–4721. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Sun P, Hu JW, Xiong WJ and Mi J: miR-186
regulates glycolysis through Glut1 during the formation of
cancer-associated fibroblasts. Asian Pac J Cancer Prev.
15:4245–4250. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Chen S, Chen X, Shan T, Ma J, Lin W, Li W
and Kang Y: MiR-21-mediated Metabolic alteration of
cancer-associated fibroblasts and its effect on pancreatic cancer
cell behavior. Int J Biol Sci. 14:100–110. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Grasso C, Jansen G and Giovannetti E: Drug
resistance in pancreatic cancer: Impact of altered energy
metabolism. Crit Rev Oncol Hematol. 114:139–152. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Kurtoglu M, Maher JC and Lampidis TJ:
Differential toxic mechanisms of 2-deoxy-D-glucose versus
2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells.
Antioxid Redox Signal. 9:1383–1390. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Nancolas B, Guo L, Zhou R, Nath K, Nelson
DS, Leeper DB, Blair IA, Glickson JD and Halestrap AP: The
anti-tumour agent lonidamine is a potent inhibitor of the
mitochondrial pyruvate carrier and plasma membrane monocarboxylate
transporters. Biochem J. 473:929–936. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Gatenby RA and Gillies RJ: Glycolysis in
cancer: A potential target for therapy. Int J Biochem Cell Biol.
39:1358–1366. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Zhang Y, Wei J, Xu J, Leong WS, Liu G, Ji
T, Cheng Z, Wang J, Lang J, Zhao Y, et al: Suppression of tumor
energy supply by liposomal nanoparticle-mediated inhibition of
aerobic glycolysis. ACS Appl Mater Interfaces. 10:2347–2353. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Lu L, Chen Y and Zhu Y: The molecular
basis of targeting PFKFB3 as a therapeutic strategy against cancer.
Oncotarget. 8:62793–62802. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Clem BF, O'Neal J, Tapolsky G, Clem AL,
Imbert-Fernandez Y, Kerr DA II, Klarer AC, Redman R, Miller DM,
Trent JO, et al: Targeting 6-phosphofructo-2-kinase (PFKFB3) as a
therapeutic strategy against cancer. Mol Cancer Ther. 12:1461–1470.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Lisanti MP, Martinez-Outschoorn UE and
Sotgia F: Oncogenes induce the cancer-associated fibroblast
phenotype: Metabolic symbiosis and ‘fibroblast addiction’ are new
therapeutic targets for drug discovery. Cell Cycle. 12:2723–2732.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Lamb R, Ozsvari B, Bonuccelli G, Smith DL,
Pestell RG, Martinez-Outschoorn UE, Clarke RB, Sotgia F and Lisanti
MP: Dissecting tumor metabolic heterogeneity: Telomerase and large
cell size metabolically define a sub-population of stem-like,
mitochondrial-rich, cancer cells. Oncotarget. 6:21892–21905. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Benjamin D, Robay D, Hindupur SK, Pohlmann
J, Colombi M, El-Shemerly MY, Maira SM, Moroni C, Lane HA and Hall
MN: Dual Inhibition of the lactate transporters MCT1 and MCT4 is
synthetic lethal with metformin due to NAD+ depletion in cancer
cells. Cell Rep. 25:3047–3058.e4. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Polanski R, Hodgkinson CL, Fusi A, Nonaka
D, Priest L, Kelly P, Trapani F, Bishop PW, White A, Critchlow SE,
et al: Activity of the monocarboxylate transporter 1 inhibitor
AZD3965 in small cell lung cancer. Clin Cancer Res. 20:926–937.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Monti D, Sotgia F, Whitaker-Menezes D,
Tuluc M, Birbe R, Berger A, Lazar M, Cotzia P, Draganova-Tacheva R,
Lin Z, et al: Pilot study demonstrating metabolic and
anti-proliferative effects of in vivo anti-oxidant supplementation
with N-Acetylcysteine in Breast Cancer. Semin Oncol. 44:226–232.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Crawford S: Anti-inflammatory/antioxidant
use in long-term maintenance cancer therapy: A new therapeutic
approach to disease progression and recurrence. Ther Adv Med Oncol.
6:52–68. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Martinez-Outschoorn UE, Pavlides S,
Whitaker-Menezes D, Daumer KM, Milliman JN, Chiavarina B, Migneco
G, Witkiewicz AK, Martinez-Cantarin MP, Flomenberg N, et al: Tumor
cells induce the cancer associated fibroblast phenotype via
caveolin-1 degradation: Implications for breast cancer and DCIS
therapy with autophagy inhibitors. Cell Cycle. 9:2423–2433. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Martinez-Outschoorn UE, Whitaker-Menezes
D, Valsecchi M, Martinez-Cantarin MP, Dulau-Florea A, Gong J,
Howell A, Flomenberg N, Pestell RG, Wagner J, et al: Reverse
Warburg effect in a patient with aggressive B-cell lymphoma: Is
lactic acidosis a paraneoplastic syndrome? Semin Oncol. 40:403–418.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
130
|
Gao P, Zhang H, Dinavahi R, Li F, Xiang Y,
Raman V, Bhujwalla ZM, Felsher DW, Cheng L, Pevsner J, et al:
HIF-dependent antitumorigenic effect of antioxidants in vivo.
Cancer Cell. 12:230–238. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Morales AI, Detaille D, Prieto M, Puente
A, Briones E, Arévalo M, Leverve X, López-Novoa JM and El-Mir MY:
Metformin prevents experimental gentamicin-induced nephropathy by a
mitochondria-dependent pathway. Kidney Int. 77:861–869. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Sonnenblick A, Agbor-Tarh D, Bradbury I,
Di Cosimo S, Azim HA Jr, Fumagalli D, Sarp S, Wolff AC, Andersson
M, Kroep J, et al: Impact of diabetes, insulin, and metformin use
on the outcome of patients with human epidermal growth factor
receptor 2-positive primary breast cancer: Analysis from the ALTTO
PHASE III randomized Trial. J Clin Oncol. 35:1421–1429. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Cirri P and Chiarugi P:
Cancer-associated-fibroblasts and tumour cells: A diabolic liaison
driving cancer progression. Cancer Metastasis Rev. 31:195–208.
2012. View Article : Google Scholar : PubMed/NCBI
|
