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Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5‑FU by promoting the SDF‑1/CXCR4/Akt axis

  • Authors:
    • Quan Zhao
    • Yaxin Long
    • Wen Cheng
    • Yingguang Huang
    • Jinyuan Li
    • Yuejin Li
    • Xing Li
    • Xiaodong Guo
    • Yu Li
    • Guosan Li
    • Kunmei Gong
    • Jian Zhang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery I, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650031, P.R. China, Department of General Surgery I, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650031, P.R. China, Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 75
    |
    Published online on: April 29, 2022
       https://doi.org/10.3892/ijo.2022.5365
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Abstract

5‑Fluorouracil (5‑FU) is the preferred chemotherapeutic drug used in the treatment of colon cancer; however, drug resistance affects its clinical efficacy. Visfatin, an adipokine that promotes tumour development, has the potential to increase resistance to chemotherapy. The present study aimed to verify the effects of visfatin on the sensitivity of colon cancer cells to 5‑FU and to elucidate the potential mechanisms involved. Tissue microarrays (TMAs) were used to analyse visfatin differential expression in normal colon and colon cancer tissues, and the data were further validated in vitro. Cell Counting Kit‑8, clone formation, caspase‑3/7 activity assays, as well as other analyses were used to verify the effects of visfatin on sensitivity to 5‑FU. TMA and correlation analyses were used to predict and verify the correlation between visfatin and stromal cell‑derived factor‑1 (SDF‑1). Rescue experiments and PI3K/Akt inhibitors were used to verify the role of the visfatin/SDF‑1/Akt axis in the sensitivity of colon cancer cells to 5‑FU. Visfatin was found to be highly expressed in colon cancer tissues and cell lines. Moreover, visfatin knockdown increased apoptosis, reduced cell proliferation and enhanced the chemosensitivity of DLD‑1 and SW48 cells to 5‑FU. A positive correlation between visfatin and SDF‑1 was observed, with the knockdown of visfatin enhancing cell sensitivity to 5‑FU chemotherapy by targeting the SDF‑1/C‑X‑C chemokine receptor type 4 (CXCR4) axis. Furthermore, the Akt signalling pathway downstream of SDF‑1/CXCR4 proved to be critical in the decreased sensitisation of colon cancer cells to 5‑FU induced by visfatin. On the whole, the present study demonstrates that visatin can potentially decrease colon cancer cell apoptosis, promote proliferation and decrease colon cancer cell sensitivity to 5‑FU via the visfatin/SDF‑1/Akt axis.
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View References

1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar

3 

Shi Q, Paul J and Grothey A: Duration of adjuvant chemotherapy for stage III colon cancer. N Engl J Med. 379:396–397. 2018.

4 

Dienstmann R, Vermeulen L, Guinney J, Kopetz S, Tejpar S and Tabernero J: Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer. Nat Rev Cancer. 17:79–92. 2017. View Article : Google Scholar

5 

Labianca R, Beretta GD, Kildani B, Milesi L, Merlin F, Mosconi S, Pessi MA, Prochilo T, Quadri A, Gatta G, et al: Colon cancer. Crit Rev Oncol Hematol. 74:106–133. 2010. View Article : Google Scholar

6 

Vodenkova S, Buchler T, Cervena K, Veskrnova V, Vodicka P and Vymetalkova V: 5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future. Pharmacol Ther. 206:1074472020. View Article : Google Scholar

7 

Marin JJG, Macias RIR, Monte MJ, Her raez E, Peleteiro-Vigil A, Blas BS, Sanchon-Sanchez P, Temprano AG, Espinosa-Escudero RA, Lozano E, et al: Cellular mechanisms accounting for the refractoriness of colorectal carcinoma to pharmacological treatment. Cancers (Basel). 12:26052020. View Article : Google Scholar

8 

Lucena-Cacace A, Otero-Albiol D, Jiménez-García MP, Muñoz-Galvan S and Carnero A: NAMPT is a potent oncogene in colon cancer progression that modulates cancer stem cell properties and resistance to therapy through Sirt1 and PARP. Clin Cancer Res. 24:1202–1215. 2018. View Article : Google Scholar

9 

Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H, et al: Visfatin: A protein secreted by visceral fat that mimics the effects of insulin. Science. 307:426–430. 2005. View Article : Google Scholar

10 

Hufton SE, Moerkerk PT, Brandwijk R, de Bruïne AP, Arends JW and Hoogenboom HR: A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization. FEBS Lett. 463:77–82. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Nakajima TE, Yamada Y, Hamano T, Furuta K, Matsuda T, Fujita S, Kato K, Hamaguchi T and Shimada Y: Adipocytokines as new promising markers of colorectal tumors: Adiponectin for colorectal adenoma, and resistin and visfatin for colorectal cancer. Cancer Sci. 101:1286–1291. 2010. View Article : Google Scholar

12 

Lucena-Cacace A, Otero-Albiol D, Jiménez-García MP, Peinado-Serrano J and Carnero A: NAMPT overexpression induces cancer stemness and defines a novel tumor signature for glioma prognosis. Oncotarget. 8:99514–99530. 2017. View Article : Google Scholar

13 

Chen M, Wang Y, Li Y, Zhao L, Ye S, Wang S, Yu C and Xie H: Association of plasma visfatin with risk of colorectal cancer: An observational study of Chinese patients. Asia Pac J Clin Oncol. 12:e65–74. 2016. View Article : Google Scholar

14 

Lucas S, Soave C, Nabil G, Ahmed ZSO, Chen G, El-Banna HA, Dou QP and Wang J: Pharmacological inhibitors of NAD biosynthesis as potential an ticancer agents. Recent Pat Anticancer Drug Discov. 12:190–207. 2017. View Article : Google Scholar

15 

Nacarelli T, Fukumoto T, Zundell JA, Fatkhutdinov N, Jean S, Cadungog MG, Borowsky ME and Zhang R: NAMPT inhibition suppresses cancer stem-like cells associated with therapy-induced senescence in ovarian cancer. Cancer Res. 80:890–900. 2020. View Article : Google Scholar

16 

Cao Z, Liang N, Yang H and Li S: Visfatin mediates doxorubicin resistance in human non-small-cell lung cancer via Akt-mediated up-regulation of ABCC1. Cell Prolif. 50:e123662017. View Article : Google Scholar

17 

Ge X, Zhao Y, Dong L, Seng J, Zhang X and Dou D: NAMPT regulates PKM2 nuclear location through 14-3-3ζ: Conferring resistance to tamoxifen in breast cancer. J Cell Physiol. 234:23409–23420. 2019. View Article : Google Scholar

18 

Bi TQ and Che XM: Nampt/PBEF/visfatin and cancer. Cancer Biol Ther. 10:119–125. 2010. View Article : Google Scholar

19 

Li XQ, Lei J, Mao LH, Wang QL, Xu F, Ran T, Zhou ZH and He S: NAMPT and NAPRT, key enzymes in NAD salvage synthesis pathway, are of negative prognostic value in colorectal cancer. Front Oncol. 9:7362019. View Article : Google Scholar : PubMed/NCBI

20 

Ma J, Sun X and Wang Y, Chen B, Qian L and Wang Y: Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling. Cell Commun Signal. 17:1192019. View Article : Google Scholar

21 

Ma J, Su H, Yu B, Guo T, Gong Z, Qi J, Zhao X and Du J: CXCL12 gene silencing down-regulates metastatic potential via blockage of MAPK/PI3K/AP-1 signaling pathway in colon cancer. Clin Transl Oncol. 20:1035–1045. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Conley-LaComb MK, Saliganan A, Kandagatla P, Chen YQ, Cher ML and Chinni SR: PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling. Mol Cancer. 12:852013. View Article : Google Scholar

23 

Zhao Q, Li JY, Zhang J, Long YX, Li YJ, Guo XD, Wei MN and Liu WJ: Role of visfatin in promoting proliferation and invasion of colorectal cancer cells by downregulating SDF-1/CXCR4-mediated miR-140-3p expression. Eur Rev Med Pharmacol Sci. 24:5367–5377. 2020.

24 

Azim HA Jr, Peccatori FA, Brohée S, Branstetter D, Loi S, Viale G, Piccart M, Dougall WC, Pruneri G and Sotiriou C: RANK-ligand (RANKL) expression in young breast cancer patients and during pregnancy. Breast Cancer Res. 17:242015. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

26 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar

27 

Wang W, Guo W, Li L, Fu Z, Liu W, Gao J, Shu Y, Xu Q, Sun Y and Gu Y: Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression. Biochem Pharmacol. 121:8–17. 2016. View Article : Google Scholar

28 

Marjaneh RM, Khazaei M, Ferns GA, Avan A and Aghaee-Bakhtiari SH: The role of microRNAs in 5-FU resistance of colorectal cancer: Possible mechanisms. J Cell Physiol. 234:2306–2316. 2019. View Article : Google Scholar

29 

Wei L, Wang X, Lv L, Zheng Y, Zhang N and Yang M: The emerging role of noncoding RNAs in colorectal cancer chemoresistance. Cell Oncol (Dordr). 42:757–768. 2019. View Article : Google Scholar

30 

Hu T, Li Z, Gao CY and Cho CH: Mechanisms of drug resistance in colon cancer and its therapeutic strategies. World J Gastroenterol. 22:6876–6889. 2016. View Article : Google Scholar

31 

van Staveren MC, Opdam F, Guchelaar HJ, van Kuilenburg AB, Maring JG and Gelderblom H: Influence of metastatic disease on the usefulness of uracil pharmacokinetics as a screening tool for DPD activity in colorectal cancer patients. Cancer Chemother Pharmacol. 76:47–52. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Wang W, Cassidy J, O'Brien V, Ryan KM and Collie-Duguid E: Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells. Cancer Res. 64:8167–8176. 2004. View Article : Google Scholar

33 

Leckband S, Kelsoe J, Dunnenberger H, George AL Jr, Tran E, Berger R, Müller DJ, Whirl-Carrillo M, Caudle KE and Pirmohamed M; Clinical Pharmacogenetics Implementation Consortiu: Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and carbamazepine dosing. Clin Pharmacol Ther. 94:324–328. 2013. View Article : Google Scholar

34 

van Niekerk G and Engelbrecht AM: Role of PKM2 in directing the metabolic fate of glucose in cancer: A potential therapeutic target. Cell Oncol (Dordr). 41:343–351. 2018. View Article : Google Scholar

35 

Kim SH, Kim SC and Ku JL: Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells. Oncotarget. 8:56546–56557. 2017. View Article : Google Scholar :

36 

Fong W and To KKW: Drug repurposing to overcome resistance to various therapies for colorectal cancer. Cell Mol Life Sci. 76:3383–3406. 2019. View Article : Google Scholar

37 

Nagarsheth N, Wicha MS and Zou W: Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy. Nat Rev Immunol. 17:559–572. 2017. View Article : Google Scholar

38 

Yoshitake N, Fukui H, Yamagishi H, Sekikawa A, Fujii S, Tomita S, Ichikawa K, Imura J, Hiraishi H and Fujimori T: Expression of SDF-1 alpha and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer. Br J Cancer. 98:1682–1689. 2008. View Article : Google Scholar

39 

Akishima-Fukasawa Y, Nakanishi Y, Ino Y, Moriya Y, Kanai Y and Hirohashi S: Prognostic significance of CXCL12 expression in patients with colorectal carcinoma. Am J Clin Pathol. 132:202–210; quiz 307. 2009. View Article : Google Scholar

40 

Wang B, Hasan MK, Alvarado E, Yuan H, Wu H and Chen WY: NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response. Oncogene. 30:907–921. 2011. View Article : Google Scholar

41 

Hung AC, Lo S, Hou MF, Lee YC, Tsai CH, Chen YY, Liu W, Su YH, Lo YH, Wang CH, et al: Extracellular visfatin-promoted malignant behavior in breast cancer is mediated through c-Abl and STAT3 activation. Clin Cancer Res. 22:4478–4490. 2016. View Article : Google Scholar

42 

Yang J, Zhang K, Song H, Wu M, Li J, Yong Z, Jiang S, Kuang X and Zhang T: Visfatin is involved in promotion of colorectal carcinoma malignancy through an inducing EMT mechanism. Oncotarget. 7:32306–32317. 2016. View Article : Google Scholar

43 

Cheng G, Liu C, Sun X, Zhang L, Liu L, Ouyang J and Li B: Visfatin promotes osteosarcoma cell migration and invasion via induction of epithelial-mesenchymal transition. Oncol Rep. 34:987–994. 2015. View Article : Google Scholar

44 

Ye C, Qi L, Li X, Wang J, Yu J, Zhou B, Guo C, Chen J and Zheng S: Targeting the NAD+ salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level. Cell Commun Signal. 18:162020. View Article : Google Scholar

45 

Ding D, Zhang P, Liu Y and Wang Y, Sun W, Yu Z, Cheng Z and Wang Y: Runx2 was correlated with neurite outgrowth and schwann cell differentiation, migration after sciatic nerve crush. Neurochem Res. 43:2423–2434. 2018. View Article : Google Scholar

46 

Yu JS and Cui W: Proliferation, survival and metabolism: The role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination. Development. 143:3050–3060. 2016. View Article : Google Scholar

47 

Celià-Terrassa T and Jolly MK: Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis. Cold Spring Harb Perspect Med. 10:a0369052020. View Article : Google Scholar

48 

Amara S, Chaar I, Khiari M, Ounissi D, Weslati M, Boughriba R, Hmida AB and Bouraoui S: Stromal cell derived factor-1 and CXCR4 expression in colorectal cancer promote liver metastasis. Cancer Biomark. 15:869–879. 2015. View Article : Google Scholar

49 

Jung Y, Cackowski FC, Yumoto K, Decker AM, Wang J, Kim JK, Lee E, Wang Y, Chung JS, Gursky AM, et al: CXCL12γ promotes metastatic castration-resistant prostate cancer by inducing cancer stem cell and neuroendocrine phenotypes. Cancer Res. 78:2026–2039. 2018. View Article : Google Scholar

50 

Jung MJ, Rho JK, Kim YM, Jung JE, Jin YB, Ko YG, Lee JS, Lee SJ, Lee JC and Park MJ: Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells. Oncogene. 32:209–221. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhao Q, Long Y, Cheng W, Huang Y, Li J, Li Y, Li X, Guo X, Li Y, Li G, Li G, et al: Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5‑FU by promoting the SDF‑1/CXCR4/Akt axis. Int J Oncol 60: 75, 2022.
APA
Zhao, Q., Long, Y., Cheng, W., Huang, Y., Li, J., Li, Y. ... Zhang, J. (2022). Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5‑FU by promoting the SDF‑1/CXCR4/Akt axis. International Journal of Oncology, 60, 75. https://doi.org/10.3892/ijo.2022.5365
MLA
Zhao, Q., Long, Y., Cheng, W., Huang, Y., Li, J., Li, Y., Li, X., Guo, X., Li, Y., Li, G., Gong, K., Zhang, J."Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5‑FU by promoting the SDF‑1/CXCR4/Akt axis". International Journal of Oncology 60.6 (2022): 75.
Chicago
Zhao, Q., Long, Y., Cheng, W., Huang, Y., Li, J., Li, Y., Li, X., Guo, X., Li, Y., Li, G., Gong, K., Zhang, J."Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5‑FU by promoting the SDF‑1/CXCR4/Akt axis". International Journal of Oncology 60, no. 6 (2022): 75. https://doi.org/10.3892/ijo.2022.5365
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Q, Long Y, Cheng W, Huang Y, Li J, Li Y, Li X, Guo X, Li Y, Li G, Li G, et al: Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5‑FU by promoting the SDF‑1/CXCR4/Akt axis. Int J Oncol 60: 75, 2022.
APA
Zhao, Q., Long, Y., Cheng, W., Huang, Y., Li, J., Li, Y. ... Zhang, J. (2022). Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5‑FU by promoting the SDF‑1/CXCR4/Akt axis. International Journal of Oncology, 60, 75. https://doi.org/10.3892/ijo.2022.5365
MLA
Zhao, Q., Long, Y., Cheng, W., Huang, Y., Li, J., Li, Y., Li, X., Guo, X., Li, Y., Li, G., Gong, K., Zhang, J."Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5‑FU by promoting the SDF‑1/CXCR4/Akt axis". International Journal of Oncology 60.6 (2022): 75.
Chicago
Zhao, Q., Long, Y., Cheng, W., Huang, Y., Li, J., Li, Y., Li, X., Guo, X., Li, Y., Li, G., Gong, K., Zhang, J."Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5‑FU by promoting the SDF‑1/CXCR4/Akt axis". International Journal of Oncology 60, no. 6 (2022): 75. https://doi.org/10.3892/ijo.2022.5365
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