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Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review)

  • Authors:
    • Xiuzhen Zhang
    • Tong Meng
    • Shuaishuai Cui
    • Dongwu Liu
    • Qiuxiang Pang
    • Ping Wang
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    Affiliations: Anti‑aging and Regenerative Medicine Research Institution, School of Life Sciences and Medicine, Shandong University of Technology, Zibo, Shandong 255000, P.R. China, Tongji University Cancer Center, Shanghai Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai 200092, P.R. China, School of Life Sciences and Medicine, Shandong University of Technology, Zibo, Shandong 255000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 84
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    Published online on: May 25, 2022
       https://doi.org/10.3892/ijo.2022.5374
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Abstract

The interaction between a tumor and the tumor microenvironment (TME) plays a key role in tumorigenesis and tumor progression. Ubiquitination, a crucial post‑translational modification for regulating protein degradation and turnover, plays a role in regulating the crosstalk between a tumor and the TME. Thus, identifying the roles of ubiquitination in the process may assist researchers to investigate the mechanisms underlying tumorigenesis and tumor progression. In the present review article, new insights into the substrates for ubiquitination that are involved in the regulation of hypoxic environments, angiogenesis, chronic inflammation‑mediated tumor formation, and the function of cancer‑associated fibroblasts and infiltrating immune cells (tumor‑associated macrophages, T‑cells, myeloid‑derived suppressor cells, dendritic cells, and natural killer cells) are summarized. In addition, the potential targets of the ubiquitination proteasome system within the TME for cancer therapy and their therapeutic effects are reviewed and discussed.
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Spandidos Publications style
Zhang X, Meng T, Cui S, Liu D, Pang Q and Wang P: Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review). Int J Oncol 61: 84, 2022.
APA
Zhang, X., Meng, T., Cui, S., Liu, D., Pang, Q., & Wang, P. (2022). Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review). International Journal of Oncology, 61, 84. https://doi.org/10.3892/ijo.2022.5374
MLA
Zhang, X., Meng, T., Cui, S., Liu, D., Pang, Q., Wang, P."Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review)". International Journal of Oncology 61.1 (2022): 84.
Chicago
Zhang, X., Meng, T., Cui, S., Liu, D., Pang, Q., Wang, P."Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review)". International Journal of Oncology 61, no. 1 (2022): 84. https://doi.org/10.3892/ijo.2022.5374
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Meng T, Cui S, Liu D, Pang Q and Wang P: Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review). Int J Oncol 61: 84, 2022.
APA
Zhang, X., Meng, T., Cui, S., Liu, D., Pang, Q., & Wang, P. (2022). Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review). International Journal of Oncology, 61, 84. https://doi.org/10.3892/ijo.2022.5374
MLA
Zhang, X., Meng, T., Cui, S., Liu, D., Pang, Q., Wang, P."Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review)". International Journal of Oncology 61.1 (2022): 84.
Chicago
Zhang, X., Meng, T., Cui, S., Liu, D., Pang, Q., Wang, P."Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review)". International Journal of Oncology 61, no. 1 (2022): 84. https://doi.org/10.3892/ijo.2022.5374
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