Open Access

Hepatocellular carcinoma: Novel understandings and therapeutic strategies based on bile acids (Review)

  • Authors:
    • Wenyu Luo
    • Shiqi Guo
    • Yang Zhou
    • Junfeng Zhu
    • Jingwen Zhao
    • Mengyao Wang
    • Lixuan Sang
    • Bingyuan Wang
    • Bing Chang
  • View Affiliations

  • Published online on: August 5, 2022     https://doi.org/10.3892/ijo.2022.5407
  • Article Number: 117
  • Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bile acids (BAs) are the major components of bile and products of cholesterol metabolism. Cholesterol is catalyzed by a variety of enzymes in the liver to form primary BAs, which are excreted into the intestine with bile, and secondary BAs are formed under the modification of the gut microbiota. Most of the BAs return to the liver via the portal vein, completing the process of enterohepatic circulation. BAs have an important role in the development of hepatocellular carcinoma (HCC), which may participate in the progression of HCC by recognizing receptors such as farnesoid X receptor (FXR) and mediating multiple downstream pathways. Certain BAs, such as ursodeoxycholic acid and obeticholic acid, were indicated to be able to delay liver injury and HCC progression. In the present review, the structure and function of BAs were introduced and the metabolism of BAs and the process of enterohepatic circulation were outlined. Furthermore, the mechanisms by which BAs participate in the development of HCC were summarized and possible strategies for targeting BAs and key sites of their metabolic processes to treat HCC were suggested.

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October-2022
Volume 61 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Luo W, Guo S, Zhou Y, Zhu J, Zhao J, Wang M, Sang L, Wang B and Chang B: Hepatocellular carcinoma: Novel understandings and therapeutic strategies based on bile acids (Review). Int J Oncol 61: 117, 2022
APA
Luo, W., Guo, S., Zhou, Y., Zhu, J., Zhao, J., Wang, M. ... Chang, B. (2022). Hepatocellular carcinoma: Novel understandings and therapeutic strategies based on bile acids (Review). International Journal of Oncology, 61, 117. https://doi.org/10.3892/ijo.2022.5407
MLA
Luo, W., Guo, S., Zhou, Y., Zhu, J., Zhao, J., Wang, M., Sang, L., Wang, B., Chang, B."Hepatocellular carcinoma: Novel understandings and therapeutic strategies based on bile acids (Review)". International Journal of Oncology 61.4 (2022): 117.
Chicago
Luo, W., Guo, S., Zhou, Y., Zhu, J., Zhao, J., Wang, M., Sang, L., Wang, B., Chang, B."Hepatocellular carcinoma: Novel understandings and therapeutic strategies based on bile acids (Review)". International Journal of Oncology 61, no. 4 (2022): 117. https://doi.org/10.3892/ijo.2022.5407