Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
October-2022 Volume 61 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2022 Volume 61 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase‑7

  • Authors:
    • So-Hee Kim
    • Kwang-Hyun Baek
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, CHA University, Seongnam‑Si, Gyeonggi‑Do 13488, Republic of Korea
  • Article Number: 127
    |
    Published online on: September 7, 2022
       https://doi.org/10.3892/ijo.2022.5417
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Most proteins maintain protein homeostasis via post‑translational modifications, including the ubiquitin‑proteasome system. Deubiquitinating enzymes (DUBs) have essential intercellular roles, such as responses to DNA damage, proteolysis and apoptosis. Therefore, it is important to understand DUB‑related diseases to identify DUBs that target abnormally regulated proteins in cells. Ovarian tumor deubiquitinase 6A (OTUD6A) was previously reported as a downregulated DUB in HCT116 cells with p53 knockdown. Therefore, it was expected that the relationship between OTUD6A and p53 would affect cell proliferation. In the present study, putative substrates of OTUD6A related to the p53 signaling pathway were identified. Application of liquid chromatography‑tandem mass spectrometry and proteomic analysis led to the identification of nucleolin (known to bind p53) as a binding protein. In addition, immunoprecipitation studies determined that caspase‑7, an apoptotic protein, is associated with p53 signaling and is regulated by OTUD6A. It was further identified that OTUD6A regulates the protein stability of nucleolin, but not caspase‑7. It was also demonstrated that OTUD6A acts as a respective DUB through the deubiquitination of K48‑linked polyubiquitin chain of nucleolin and the K63‑linked polyubiquitin chain of caspase‑7. Furthermore, overexpression of OTUD6A induced cell proliferation via enhancing cell cycle progression of MCF7 cells. Taken together, OTUD6A may be proposed as a target for anticancer therapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Chondrogianni N and Gonos ES: Proteasome function determines cellular homeostasis and the rate of aging. Adv Exp Med Biol. 694:38–46. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Bard JAM, Goodall EA, Greene ER, Jonsson E, Dong KC and Martin A: Structure and function of the 26S proteasome. Annu Rev Biochem. 87:697–724. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Bachiller S, Alonso-Bellido IM, Real LM, Pérez-Villegas EM, Venero JL, Deierborg T, Armengol JA and Ruiz R: The ubiquitin proteasome system in neuromuscular disorders: Moving beyond movement. Int J Mol Sci. 21:64292020. View Article : Google Scholar : PubMed/NCBI

4 

Park HB, Kim JW and Baek KH: Regulation of Wnt signaling through ubiquitination and deubiquitination in cancers. Int J Mol Sci. 21:39042020. View Article : Google Scholar : PubMed/NCBI

5 

Park HB and Baek KH: E3 ligases and deubiquitinating enzymes regulating the MAPK signaling pathway in cancers. Biochim Biophys Acta Rev Cancer. 1877:1887362022. View Article : Google Scholar : PubMed/NCBI

6 

Caputi FF, Rullo L, Stamatakos S, Candeletti S and Romualdi P: Interplay between the endogenous opioid system and proteasome complex: Beyond signaling. Int J Mol Sci. 20:14412019. View Article : Google Scholar : PubMed/NCBI

7 

Suresh B, Lee J, Kim H and Ramakrishna S: Regulation of pluripotency and differentiation by deubiquitinating enzymes. Cell Death Differ. 23:1257–1264. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Suresh B, Lee J, Kim KS and Ramakrishna S: The importance of ubiquitination and deubiquitination in cellular reprogramming. Stem Cells Int. 2016:67059272016. View Article : Google Scholar : PubMed/NCBI

9 

Grice GL and Nathan JA: The recognition of ubiquitinated proteins by the proteasome. Cell Mol Life Sci. 73:3497–3506. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Kwon YT and Ciechanover A: The ubiquitin code in the ubiquitin-proteasome system and autophagy. Trends Biochem Sci. 42:873–886. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Dosa A and Csizmadia T: The role of K63-linked polyubiquitin in several types of autophagy. Biol Futur. 73:137–148. 2022. View Article : Google Scholar : PubMed/NCBI

12 

Lafont E, Hartwig T and Walczak H: Paving TRAIL's path with ubiquitin. Trends Biochem Sci. 43:44–60. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Yuan T, Yan F, Ying M, Cao J, He Q, Zhu H and Yang B: Inhibition of ubiquitin-specific proteases as a novel anticancer therapeutic strategy. Front Pharmacol. 9:10802018. View Article : Google Scholar : PubMed/NCBI

14 

Lange SM, Armstrong LA and Kulathu Y: Deubiquitinases: From mechanisms to their inhibition by small molecules. Mol Cell. 82:15–29. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Fhu CW and Ali A: Dysregulation of the ubiquitin proteasome system in human malignancies: A window for therapeutic intervention. Cancers (Basel). 13:15132021. View Article : Google Scholar : PubMed/NCBI

16 

Shi L, Liu J, Peng Y, Zhang J, Dai X, Zhang S, Wang Y, Liu J and Long J: Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission. Mol Oncol. 14:3169–3183. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Kim HJ and Kim J: OTUD6A Is an aurora kinase a-specific deubiquitinase. Int J Mol Sci. 22:19362021. View Article : Google Scholar : PubMed/NCBI

18 

Fu X, Zhao J, Yu G, Zhang X, Sun J, Li L, Yin J, Niu Y, Ren S, Zhu Y, et al: OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR. Commun Biol. 5:1822022. View Article : Google Scholar : PubMed/NCBI

19 

Peng Y, Liu J, Wang Z, Cui C, Zhang T, Zhang S, Gao P, Hou Z, Liu H, Guo J, et al: Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc. Cell Death Differ. 29:1730–1743. 2022. View Article : Google Scholar : PubMed/NCBI

20 

Zhao Y, Huang X, Zhu D, Wei M, Luo J, Yu S, Tian Y and Zheng X: Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. Cell Death Differ. Jun 29–2022.(Epub ahead of print). View Article : Google Scholar

21 

Kim SY, Kwon SK, Lee SY and Baek KH: Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53−/− HCT116 cells. Int J Oncol. 52:1705–1714. 2018.PubMed/NCBI

22 

Lim KH, Park JJ, Gu BH, Kim JO, Park SG and Baek KH: HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response. Sci Rep. 5:127932015. View Article : Google Scholar : PubMed/NCBI

23 

Park JH, Kim SY, Cho HJ, Lee SY and Baek KH: YOD1 deubiquitinates NEDD4 involved in the hippo signaling pathway. Cell Physiol Biochem. 54:1–14. 2020.PubMed/NCBI

24 

Roth JA, Swisher SG and Meyn RE: p53 tumor suppressor gene therapy for cancer. Oncology (Williston Park). 13:148–154. 1999.PubMed/NCBI

25 

Bhatt P, d'Avout C, Kane NS, Borowiec JA and Saxena A: Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination. FEBS J. 279:370–383. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Daniely Y, Dimitrova DD and Borowiec JA: Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation. Mol Cell Biol. 22:6014–6022. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Jia W, Yao Z, Zhao J, Guan Q and Gao L: New perspectives of physiological and pathological functions of nucleolin (NCL). Life Sci. 186:1–10. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Yan Y, Narayan A, Cho S, Cheng Z, Liu JO, Zhu H, Wang G, Wharram B, Lisok A, Brummet M, et al: CRYbetaB2 enhances tumorigenesis through upregulation of nucleolin in triple negative breast cancer. Oncogene. 40:5752–5763. 2021. View Article : Google Scholar : PubMed/NCBI

29 

Mahib MR, Hosojima S, Kushiyama H, Kinoshita T, Shiroishi T, Suda T and Tsuchiya K: Caspase-7 mediates caspase-1-induced apoptosis independently of Bid. Microbiol Immunol. 64:143–152. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Wang W, Luo J, Xiang F, Liu X, Jiang M, Liao L and Hu J: Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. PLoS One. 9:e1101012014. View Article : Google Scholar : PubMed/NCBI

31 

McClurg UL and Robson CN: Deubiquitinating enzymes as oncotargets. Oncotarget. 6:9657–9668. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Poondla N, Chandrasekaran AP, Kim KS and Ramakrishna S: Deubiquitinating enzymes as cancer biomarkers: New therapeutic opportunities? BMB Rep. 52:181–189. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Zhu X, Zhang Y, Luo Q, Wu X, Huang F, Shu T, Wan Y, Chen H and Liu Z: The deubiquitinase USP11 promotes ovarian cancer chemoresistance by stabilizing BIP. Signal Transduct Target Ther. 6:2642021. View Article : Google Scholar : PubMed/NCBI

34 

Zhang Z, Li J, Ou Y, Yang G, Deng K, Wang Q, Wang Z, Wang W, Zhang Q, Wang H, et al: CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism. Signal Transduct Target Ther. 5:252020. View Article : Google Scholar : PubMed/NCBI

35 

Machado-Silva A, Perrier S and Bourdon JC: p53 family members in cancer diagnosis and treatment. Semin Cancer Biol. 20:57–62. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Hollstein M, Sidransky D, Vogelstein B and Harris CC: p53 mutations in human cancers. Science. 253:49–53. 1991. View Article : Google Scholar : PubMed/NCBI

37 

Yuan X, He J, Sun F and Gu J: Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 6:2651–2667. 2013.PubMed/NCBI

38 

Ohashi T, Idogawa M, Sasaki Y and Tokino T: p53 mediates the suppression of cancer cell invasion by inducing LIMA1/EPLIN. Cancer Lett. 390:58–66. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Taha M, Aldirawi M, Marz S, Seebach J, Odenthal-Schnittler M, Bondareva O, Bojovic V, Schmandra T, Wirth B, Mietkowska M, et al: EPLIN-alpha and -beta Isoforms modulate endothelial cell dynamics through a spatiotemporally differentiated interaction with actin. Cell Rep. 29:1010–1026.e6. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Lamkanfi M and Kanneganti TD: Caspase-7: A protease involved in apoptosis and inflammation. Int J Biochem Cell Biol. 42:21–24. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Chen Y, Yang SH, Hueng DY, Syu JP, Liao CC and Wu YC: Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway. Chem Biol Interact. 216:17–25. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Yang C, Kaushal V, Haun RS, Seth R, Shah SV and Kaushal GP: Transcriptional activation of caspase-6 and −7 genes by cisplatin-induced p53 and its functional significance in cisplatin nephrotoxicity. Cell Death Differ. 15:530–544. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Zhou B and Zeng L: Conventional and unconventional ubiquitination in plant immunity. Mol Plant Pathol. 18:1313–1330. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Akutsu M, Dikic I and Bremm A: Ubiquitin chain diversity at a glance. J Cell Sci. 129:875–880. 2016.PubMed/NCBI

45 

Ohtake F, Tsuchiya H, Saeki Y and Tanaka K: K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains. Proc Natl Acad Sci USA. 115:E1401–E1408. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Valerio-Fernandes A, Fonseca NA, Goncalves N, Cruz AF, Pereira MI, Gregório AC, Moura V, Ladeirinha AF, Alarcão A, Gonçalves J, et al: Nucleolin overexpression predicts patient prognosis while providing a framework for targeted therapeutic intervention in lung cancer. Cancers (Basel). 14:22172022. View Article : Google Scholar : PubMed/NCBI

47 

Firlej V, Soyeux P, Nourieh M, Huet E, Semprez F, Allory Y, Londono-Vallejo A, de la Taille A, Vacherot F and Destouches D: Overexpression of nucleolin and associated genes in prostate cancer. Int J Mol Sci. 23:44912022. View Article : Google Scholar : PubMed/NCBI

48 

Shin SH, Lee GY, Lee M, Lee M, Kang J, Shin HW, Chun YS and Park JW: Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway. Nat Commun. 9:41132018. View Article : Google Scholar : PubMed/NCBI

49 

Yu Y, Jin H, Xu J, Gu J, Li X, Xie Q, Huang H, Li J, Tian Z, Jiang G, et al: XIAP overexpression promotes bladder cancer invasion in vitro and lung metastasis in vivo via enhancing nucleolin-mediated Rho-GDIbeta mRNA stability. Int J Cancer. 142:2040–2055. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Yan J, Zhang Y, Ren C, Shi W and Chen L: Involvement of nuclear protein C23 in activation of EGFR signaling in cervical cancer. Tumour Biol. 37:905–910. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Wolfson E, Goldenberg M, Solomon S, Frishberg A and Pinkas-Kramarski R: Nucleolin-binding by ErbB2 enhances tumorigenicity of ErbB2-positive breast cancer. Oncotarget. 7:65320–65334. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Wolfson E, Solomon S, Schmukler E, Goldshmit Y and Pinkas-Kramarski R: Nucleolin and ErbB2 inhibition reduces tumorigenicity of ErbB2-positive breast cancer. Cell Death Dis. 9:472018. View Article : Google Scholar : PubMed/NCBI

53 

Gilles ME, Maione F, Cossutta M, Carpentier G, Caruana L, Maria SD, Houppe C, Destouches D, Shchors K, Prochasson C, et al: Nucleolin targeting impairs the progression of pancreatic cancer and promotes the normalization of tumor vasculature. Cancer Res. 76:7181–7193. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E and Boise LH: Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biol. 14:322013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim S and Baek K: Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase‑7. Int J Oncol 61: 127, 2022.
APA
Kim, S., & Baek, K. (2022). Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase‑7. International Journal of Oncology, 61, 127. https://doi.org/10.3892/ijo.2022.5417
MLA
Kim, S., Baek, K."Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase‑7". International Journal of Oncology 61.4 (2022): 127.
Chicago
Kim, S., Baek, K."Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase‑7". International Journal of Oncology 61, no. 4 (2022): 127. https://doi.org/10.3892/ijo.2022.5417
Copy and paste a formatted citation
x
Spandidos Publications style
Kim S and Baek K: Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase‑7. Int J Oncol 61: 127, 2022.
APA
Kim, S., & Baek, K. (2022). Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase‑7. International Journal of Oncology, 61, 127. https://doi.org/10.3892/ijo.2022.5417
MLA
Kim, S., Baek, K."Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase‑7". International Journal of Oncology 61.4 (2022): 127.
Chicago
Kim, S., Baek, K."Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase‑7". International Journal of Oncology 61, no. 4 (2022): 127. https://doi.org/10.3892/ijo.2022.5417
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team