Open Access

Claudin‑9 is a novel prognostic biomarker for endometrial cancer

  • Authors:
    • Yuta Endo
    • Kotaro Sugimoto
    • Makoto Kobayashi
    • Yasuyuki Kobayashi
    • Manabu Kojima
    • Shigenori Furukawa
    • Shu Soeda
    • Takafumi Watanabe
    • Atsuko Y. Higashi
    • Tomohito Higashi
    • Yuko Hashimoto
    • Keiya Fujimori
    • Hideki Chiba
  • View Affiliations

  • Published online on: September 21, 2022     https://doi.org/10.3892/ijo.2022.5425
  • Article Number: 135
  • Copyright: © Endo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The tight‑junction protein claudin‑9 (CLDN9) is barely distributed in normal adult tissues but is ectopically expressed in various cancer types. Although multiple databases indicated upregulation of CLDN9 in endometrial cancers at the mRNA level, its protein expression and biological roles remain obscure. In the present study, the prognostic significance of CLDN9 expression in endometrial cancer was evaluated by immunohistochemical staining and semi‑quantification using formalin‑fixed paraffin‑embedded specimens obtained from 248 endometrial carcinoma cases. A total of 43 cases (17.3%) had high CLDN9 expression, whereas 205 cases (82.7%) exhibited low CLDN9 expression. The 5‑year disease‑specific survival rates in the high and low CLDN9 expression groups were 62.8 and 87.8% (P<0.001), respectively. In addition, multivariate analysis revealed that high CLDN9 expression was an independent prognostic factor (hazard ratio, 4.99; 95% CI, 1.96‑12.70; P<0.001). Furthermore, CLDN9 expression was significantly correlated with the expression of CLDN6 (P<0.001), which is the closest CLDN member to CLDN9 and a poor prognostic factor for endometrial carcinoma. The 5‑year disease‑specific survival rate of cases with CLDN6‑high/CLDN9‑high, CLDN6‑high/CLDN9‑low and CLDN6‑low/CLDN9‑high status was 30.0, 37.5 and 72.7%, respectively, whereas that of CLDN6‑low/CLDN9‑low was 89.8% (P=0.004). In conclusion, aberrant CLDN9 expression is a predictor of poor prognosis for endometrial cancer and may be utilized in combination with CLDN6 to achieve higher sensitivity.
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November-2022
Volume 61 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Endo Y, Sugimoto K, Kobayashi M, Kobayashi Y, Kojima M, Furukawa S, Soeda S, Watanabe T, Higashi AY, Higashi T, Higashi T, et al: Claudin‑9 is a novel prognostic biomarker for endometrial cancer. Int J Oncol 61: 135, 2022
APA
Endo, Y., Sugimoto, K., Kobayashi, M., Kobayashi, Y., Kojima, M., Furukawa, S. ... Chiba, H. (2022). Claudin‑9 is a novel prognostic biomarker for endometrial cancer. International Journal of Oncology, 61, 135. https://doi.org/10.3892/ijo.2022.5425
MLA
Endo, Y., Sugimoto, K., Kobayashi, M., Kobayashi, Y., Kojima, M., Furukawa, S., Soeda, S., Watanabe, T., Higashi, A. Y., Higashi, T., Hashimoto, Y., Fujimori, K., Chiba, H."Claudin‑9 is a novel prognostic biomarker for endometrial cancer". International Journal of Oncology 61.5 (2022): 135.
Chicago
Endo, Y., Sugimoto, K., Kobayashi, M., Kobayashi, Y., Kojima, M., Furukawa, S., Soeda, S., Watanabe, T., Higashi, A. Y., Higashi, T., Hashimoto, Y., Fujimori, K., Chiba, H."Claudin‑9 is a novel prognostic biomarker for endometrial cancer". International Journal of Oncology 61, no. 5 (2022): 135. https://doi.org/10.3892/ijo.2022.5425