uPAR, beyond regulating physiological functions, has orchestrated roles in cancer (Review)

  • Authors:
    • Liang Wang
    • Xite Lin
    • Pengming Sun
  • View Affiliations

  • Published online on: October 18, 2022     https://doi.org/10.3892/ijo.2022.5441
  • Article Number: 151
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Abstract

Urokinase‑type plasminogen activator receptor (uPAR) serves as the receptor for uPA and the uPA‑uPAR complex initiates the extracellular matrix degradation cascade. In cancer, aberrantly elevated uPAR expression is associated with invasion and metastasis, as well as cancer proliferation and survival, thereby rendering uPAR an effective marker for prognosis and a target for therapy. Although uPAR is transiently expressed at limited amounts in normal tissues and certain non‑cancer pathological processes, their underlying mechanisms do not overlap with those of tumorigenesis. The present review summarized the fundamental function, signaling pathways and targeted therapeutic strategies, particularly immunotherapy targeting uPAR, as well as its differential roles in non‑cancer and cancer tissues, to objectively evaluate whether this classic molecular pathway is of enduring research value for future study.
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December-2022
Volume 61 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Wang L, Lin X and Sun P: uPAR, beyond regulating physiological functions, has orchestrated roles in cancer (Review). Int J Oncol 61: 151, 2022
APA
Wang, L., Lin, X., & Sun, P. (2022). uPAR, beyond regulating physiological functions, has orchestrated roles in cancer (Review). International Journal of Oncology, 61, 151. https://doi.org/10.3892/ijo.2022.5441
MLA
Wang, L., Lin, X., Sun, P."uPAR, beyond regulating physiological functions, has orchestrated roles in cancer (Review)". International Journal of Oncology 61.6 (2022): 151.
Chicago
Wang, L., Lin, X., Sun, P."uPAR, beyond regulating physiological functions, has orchestrated roles in cancer (Review)". International Journal of Oncology 61, no. 6 (2022): 151. https://doi.org/10.3892/ijo.2022.5441