Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
December-2022 Volume 61 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2022 Volume 61 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Exploring histopathological and serum biomarkers in lung adenocarcinoma: Clinical applications and translational opportunities (Review)

  • Authors:
    • Miguel A. Ortega
    • Fátima Navarro
    • Leonel Pekarek
    • Oscar Fraile-Martínez
    • Cielo García-Montero
    • Miguel A. Saez
    • Monica Arroyo
    • Jorge Monserrat
    • Melchor Alvarez-Mon
  • View Affiliations / Copyright

    Affiliations: Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcala, Alcala de Henares, 28801 Madrid, Spain
    Copyright: © Ortega et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 154
    |
    Published online on: October 20, 2022
       https://doi.org/10.3892/ijo.2022.5444
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Lung cancer represents one of the most common neoplasms and the main cause of cancer‑associated death worldwide. Its relationship with different risk factors such as tobacco, which is its main etiological factor, has been clearly established and despite the numerous advances achieved in the diagnosis, treatment and follow‑up of these patients, the life expectancy of these patients is notably limited. Furthermore, its treatment is not exempt from comorbidities and frequently it neither provides optimal control of the disease nor improve the quality of life of these patients. Despite the possibility of performing screening tests in patients at risk, their implementation in daily clinical practice is complex and most of them are diagnosed at an advanced stage of their disease where systemic radiotherapy or chemotherapy treatments slightly improve their prognosis. Lung adenocarcinoma is the most representative type of lung cancer, with specific epidemiological, molecular and clinical features. Thus, a growing number of studies are being conducted to find potential therapeutic targets based on the study of different molecular pathways, improving the outcome for these patients. In addition, a broad spectrum of serological, immunohistochemical and genetic markers are being evaluated for use in the screening and follow‑up of these patients in daily clinical practice, but unlike for other tumors, they are currently not implemented in the early diagnosis of the disease. Therefore, the aim of the present review was to summarize the main advances that have occurred in the development of serological and histological markers and their therapeutic implications in patients diagnosed with lung adenocarcinoma, explaining the limitations that have been observed and analyzing the future perspectives in the clinical management of this disease.
View Figures

Figure 1

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Luo YH, Luo L, Wampfler JA, Wang Y, Liu D, Chen YM, Adjei AA, Midthun DE and Yang P: 5-year overall survival in patients with lung cancer eligible or ineligible for screening according to US Preventive Services Task Force criteria: A prospective, observational cohort study. Lancet Oncol. 20:1098–1108. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Bilfinger TV, Albano D, Perwaiz M, Keresztes R and Nemesure B: Survival outcomes among lung cancer patients treated using a multidisciplinary team approach. Clin Lung Cancer. 19:346–351. 2018. View Article : Google Scholar : PubMed/NCBI

4 

de Groot PM, Wu CC, Carter BW and Munden RF: The epidemiology of lung cancer. Transl Lung Cancer Res. 7:220–233. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Mustafa M, Azizi ARJ, IIIzam EL, Nazirah A, Sharifa AM and Abbas SA: Lung Cancer: Risk Factors, Management, And Prognosis. IOSR J Dent Med Sci. 15:94–101. 2016. View Article : Google Scholar

6 

Brambilla E and Gazdar A: Pathogenesis of lung cancer signalling pathways: Roadmap for therapies. Eur Respir J. 33:1485–1497. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Reitsma M, Kendrick P, Anderson J, Arian N, Feldman R, Gakidou E and Gupta V: Reexamining rates of decline in lung cancer risk after smoking cessation. A meta-analysis. Ann Am Thorac Soc. 17:1126–1132. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Weber MF, Sarich PEA, Vaneckova P, Wade S, Egger S, Ngo P, Joshy G, Goldsbury DE, Yap S, Feletto E, et al: Cancer incidence and cancer death in relation to tobacco smoking in a population-based Australian cohort study. Int J Cancer. 149:1076–1088. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Barta JA, Powell CA and Wisnivesky JP: Global epidemiology of lung cancer. Ann Glob Health. 85:82019. View Article : Google Scholar : PubMed/NCBI

10 

Houston KA, Mitchell KA, King J, White A and Ryan BM: Histologic lung cancer incidence rates and trends vary by race/ethnicity and residential county. J Thorac Oncol. 13:497–509. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Provencio M, Carcereny E, Rodríguez-Abreu D, López-Castro R, Guirado M, Camps C, Bosch-Barrera J, García-Campelo R, Ortega-Granados AL, González-Larriba JL, et al: Lung cancer in Spain: Information from the thoracic tumors registry (TTR study). Transl Lung Cancer Res. 8:461–475. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Navani N and Spiro SG: The Presentation and Diagnosis of Lung Cancer and Mesothelioma. Lung Cancer. John Wiley & Sons, Ltd; Hoboken, NJ: pp. 15–47. 2013, View Article : Google Scholar

13 

Nicholson AG, Tsao MS, Beasley MB, Borczuk AC, Brambilla E, Cooper WA, Dacic S, Jain D, Kerr KM, Lantuejoul S, et al: The 2021 WHO classification of lung tumors: Impact of advances since 2015. J Thorac Oncol. 17:362–387. 2022. View Article : Google Scholar

14 

Ruano-Ravina A, Provencio-Pulla M and Casan Clarà P: Cribado de cáncer de pulmón con tomografía computarizada de baja dosis. No es cuestión de logística. Arch Bronconeumol. 53:593–594. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Nooreldeen R and Bach H: Current and future development in lung cancer diagnosis. Int J Mol Sci. 22:86612021. View Article : Google Scholar : PubMed/NCBI

16 

Zusman I and Ben-Hur H: Serological markers for detection of cancer (Review). Int J Mol Med. 7:547–56. 2001.PubMed/NCBI

17 

Kim HC, Jung CY, Cho DG, Jeon JH, Lee JE, Ahn JS, Kim SJ, Kim Y, Kim YC, Kim JE, et al: Clinical characteristics and prognostic factors of lung cancer in Korea: A pilot study of data from the Korean nationwide lung cancer registry. Tuberc Respir Dis (Seoul). 82:118–125. 2019. View Article : Google Scholar

18 

Kanaji N, Watanabe N, Kita N, Bandoh S, Tadokoro A, Ishii T, Dobashi H and Matsunaga T: Paraneoplastic syndromes associated with lung cancer. World J Clin Oncol. 5:197–223. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Herbst RS, Morgensztern D and Boshoff C: The biology and management of non-small cell lung cancer. Nature. 553:446–454. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Steven A, Fisher SA and Robinson BW: Immunotherapy for lung cancer. Respirology. 21:821–833. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Simmons CP, Koinis F, Fallon MT, Fearon KC, Bowden J, Solheim TS, Gronberg BH, McMillan DC, Gioulbasanis I and Laird BJ: Prognosis in advanced lung cancer-A prospective study examining key clinicopathological factors. Lung Cancer. 88:304–309. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Thai AA, Solomon BJ, Sequist LV, Gainor JF and Heist RS: Lung cancer. Lancet. 398:535–554. 2021. View Article : Google Scholar : PubMed/NCBI

23 

Tarro G, Paolini M and Rossi A: Molecular Biology of Lung Cancer and Future Perspectives for Screening. Mass Spectrometry-Future Perceptions and Applications. Kamble G: IntechOpen; London: 2019, http://dx.doi.org/10.5772/intechopen.85334. View Article : Google Scholar

24 

Lee SH: Chemotherapy for Lung Cancer in the Era of Personalized Medicine. Tuberc Respir Dis (Seoul). 82:179–189. 2019. View Article : Google Scholar

25 

Brown AL, Li M, Goncearenco A and Panchenko AR: Finding driver mutations in cancer: Elucidating the role of background mutational processes. PLoS Comput Biol. 15:e10069812019. View Article : Google Scholar : PubMed/NCBI

26 

Wodarz D, Newell AC and Komarova NL: Passenger mutations can accelerate tumour suppressor gene inactivation in cancer evolution. J R Soc Interface. 15:201709672018. View Article : Google Scholar : PubMed/NCBI

27 

Kris MG, Johnson BE, Berry LD, Kwiatkowski DJ, Iafrate AJ, Wistuba II, Varella-Garcia M, Franklin WA, Aronson SL, Su PF, et al: Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA. 311:1998–2006. 2014. View Article : Google Scholar : PubMed/NCBI

28 

VanderLaan PA, Rangachari D and Costa DB: The rapidly evolving landscape of biomarker testing in non-small cell lung cancer. Cancer Cytopathol. 129:179–181. 2021. View Article : Google Scholar :

29 

Rodríguez-Lescure A, de la Peña FA, Aranda E, Calvo A, Felip E, Garrido P and Vera R: Study of the Spanish Society of Medical Oncology (SEOM) on the access to oncology drugs and predictive biomarkers in Spain. Clin Transl Oncol. 22:2253–2263. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Salas C, Martín-López J, Martínez-Pozo A, Hernández-Iglesias T, Carcedo D, Ruiz de Alda L, García JF and Rojo F: Real-world biomarker testing rate and positivity rate in NSCLC in Spain: Prospective central lung cancer biomarker testing registry (LungPath) from the Spanish Society of Pathology (SEAP). J Clin Pathol. 75:193–200. 2022. View Article : Google Scholar

31 

Normanno N, Barberis M, De Marinis F and Gridelli C; On The Behalf Of The Aiot Expert Panel: Molecular and genomic profiling of lung cancer in the Era of precision medicine: A position paper from the Italian association of thoracic oncology (AIOT). Cancers (Basel). 12:16272020. View Article : Google Scholar

32 

Cainap C, Balacescu O, Cainap SS and Pop LA: Next generation sequencing technology in lung cancer diagnosis. Biology (Basel). 10:8642021.

33 

Oxnard GR, Thress KS, Alden RS, Lawrance R, Paweletz CP, Cantarini M, Yang JC, Barrett JC and Jänne PA: Association between plasma genotyping and outcomes of treatment with osimertinib (AZD9291) in advanced non-small-cell lung cancer. J Clin Oncol. 34:3375–3382. 2016. View Article : Google Scholar : PubMed/NCBI

34 

da Cunha Santos G, Shepherd FA and Tsao MS: EGFR mutations and lung cancer. Annu Rev Pathol. 6:49–69. 2011. View Article : Google Scholar

35 

Shi Y, Li J, Zhang S, Wang M, Yang S, Li N, Wu G, Liu W, Liao G, Cai K, et al: Molecular Epidemiology of EGFR Mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology-Mainland China subset analysis of the PIONEER study. PLoS One. 10:e01435152015. View Article : Google Scholar

36 

Lohinai Z, Hoda MA, Fabian K, Ostoros G, Raso E, Barbai T, Timar J, Kovalszky I, Cserepes M, Rozsas A, et al: Distinct epidemiology and clinical consequence of classic versus rare EGFR mutations in lung adenocarcinoma. J Thorac Oncol. 10:738–746. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Yoon HY, Ryu JS, Sim YS, Kim D, Lee SY, Choi J, Park S, Ryu YJ, Lee JH and Chang JH: Clinical significance of EGFR mutation types in lung adenocarcinoma: A multi-centre Korean study. PLoS One. 15:e02289252020. View Article : Google Scholar : PubMed/NCBI

38 

Zhang Y, Sheng J, Kang S, Fang W, Yan Y, Hu Z, Hong S, Wu X, Qin T, Liang W and Zhang L: Patients with Exon 19 deletion were associated with longer progression-free survival compared to those with L858R Mutation after First-Line EGFR-TKIs for advanced non-small cell lung cancer: A Meta-Analysis. PLoS One. 9:e1071612014. View Article : Google Scholar : PubMed/NCBI

39 

Wu YL, Tsuboi M, He J, John T, Grohe C, Majem M, Goldman JW, Laktionov K, Kim SW, Kato T, et al: Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer. N Engl J Med. 383:1711–1723. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Mok TS, Wu Y-L, Ahn M-J, Garassino MC, Kim HR, Ramalingam SS, Shepherd FA, He Y, Akamatsu H, Theelen WS, et al: Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer. N Engl J Med. 376:629–640. 2017. View Article : Google Scholar

41 

Chia PL, Mitchell P, Dobrovic A and John T: Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors. Clin Epidemiol. 6:423–432. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Selinger CI, Rogers TM, Russell PA, O'Toole S, Yip P, Wright GM, Wainer Z, Horvath LG, Boyer M, McCaughan B, et al: Testing for ALK rearrangement in lung adenocarcinoma: A multicenter comparison of immunohistochemistry and fluorescent in situ hybridization. Mod Pathol. 26:1545–1553. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Griesinger F, Roeper J, Pöttgen C, Willborn KC and Eberhardt WEE: Brain metastases in ALK-positive NSCLC-time to adjust current treatment algorithms. Oncotarget. 9:35181–35194. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS, Solomon B, Stubbs H, Admane S, McDermott U, et al: Clinical features and outcome of patients with non-small-cell lung cancer who Harbor EML4-ALK. J Clin Oncol. 27:4247–4253. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Britschgi C, Addeo A, Rechsteiner M, Delaloye R, Früh M, Metro G, Banini M, Gautschi O, Rothschild SI, Wild PJ, et al: Real-World treatment patterns and survival outcome in advanced anaplastic lymphoma kinase (ALK) rearranged non-small-cell lung cancer patients. Front Oncol. 10:12992020. View Article : Google Scholar : PubMed/NCBI

46 

Liang H and Wang M: MET oncogene in non-small cell lung cancer: Mechanism of MET dysregulation and agents targeting the HGF/c-Met axis. Onco Targets Ther. 13:2491–2510. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Salgia R: MET in lung cancer: Biomarker selection based on scientific rationale. Mol Cancer Ther. 16:555–565. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Drusbosky LM, Rodriguez E, Dawar R and Ikpeazu CV: Therapeutic strategies in RET gene rearranged non-small cell lung cancer. J Hematol Oncol. 14:502021. View Article : Google Scholar : PubMed/NCBI

49 

Bronte G, Ulivi P, Verlicchi A, Cravero P, Delmonte A and Crinò L: Targeting RET-rearranged non-small-cell lung cancer: Future prospects. Lung Cancer (Auckl). 10:27–36. 2019.

50 

Minchom A, Tan AC, Massarelli E, Subbiah V, Boni V, Robinson B, Wirth LJ, Hess LM, Jen MH, Kherani J, et al: Patient-Reported outcomes with selpercatinib among patients with RET fusion-positive non-small cell lung cancer in the Phase I/II LIBRETTO-001 Trial. Oncologist. 27:22–29. 2022. View Article : Google Scholar

51 

Gainor JF, Curigliano G, Kim DW, Lee DH, Besse B, Baik CS, Doebele RC, Cassier PA, Lopes G, Tan DSW, et al: Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): A multi-cohort, open-label, phase 1/2 study. Lancet Oncol. 22:959–969. 2021. View Article : Google Scholar : PubMed/NCBI

52 

Bustamante JGB and Otterson GA: Agents to treat BRAF-mutant lung cancer. Drugs in Context. Drugs Context. 8:2125662019. View Article : Google Scholar

53 

Roviello G, D'Angelo A, Sirico M, Pittacolo M, Conter FU and Sobhani N: Advances in anti-BRAF therapies for lung cancer. Invest New Drugs. 39:879–890. 2021. View Article : Google Scholar : PubMed/NCBI

54 

Briggs A, Paracha N, Rosettie K, et al: Estimating Long-Term Survival Outcomes for Tumor-Agnostic Therapies: Larotrectinib Case Study. Oncol. 100:124–129. 2022. View Article : Google Scholar

55 

Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, et al: Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer. Cell. 131:1190–1203. 2007. View Article : Google Scholar : PubMed/NCBI

56 

Joshi A, Pande N, Noronha V, Patil V, Kumar R, Chougule A, Trivedi V, Janu A, Mahajan A and Prabhash K: ROS1 mutation non-small cell lung cancer-access to optimal treatment and outcomes. Ecancermedicalscience. 13:9002019. View Article : Google Scholar : PubMed/NCBI

57 

Shaw AT, Riely GJ, Bang YJ, Kim DW, Camidge DR, Solomon BJ, Varella-Garcia M, Iafrate AJ, Shapiro GI, Usari T, et al: Crizotinib in ROS1-rearranged advanced non-small-cell lung cancer (NSCLC): Updated results, including overall survival, from PROFILE 1001. Ann Oncol. 30:1121–1126. 2019. View Article : Google Scholar : PubMed/NCBI

58 

Michels S, Massutí B, Schildhaus HU, Franklin J, Sebastian M, Felip E, Grohé C, Rodriguez-Abreu D, Abdulla DSY, Bischoff H, et al: Safety and Efficacy of Crizotinib in Patients With Advanced or Metastatic ROS1-Rearranged Lung Cancer (EUCROSS): A European Phase II Clinical Trial. J Thorac Oncol. 14:1266–1276. 2019. View Article : Google Scholar : PubMed/NCBI

59 

Dziadziuszko R, Krebs MG, De Braud F, Siena S, Drilon A, Doebele RC, Patel MR, Cho BC, Liu SV, Ahn MJ, et al: Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Locally Advanced or Metastatic ROS1 Fusion-Positive Non-Small-Cell Lung Cancer. J Clin Oncol. 39:1253–1263. 2021. View Article : Google Scholar : PubMed/NCBI

60 

Shaw AT, Solomon BJ, Chiari R, Riely GJ, Besse B, Soo RA, Kao S, Lin CC, Bauer TM, Clancy JS, et al: Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: A multicentre, open-label, single-arm, phase 1-2 trial. Lancet Oncol. 20:1691–1701. 2019. View Article : Google Scholar : PubMed/NCBI

61 

Yu H, Boyle TA, Zhou C, Rimm DL and Hirsch FR: PD-L1 expression in lung cancer. J Thorac Oncol. 11:964–975. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Aggarwal C, Abreu DR, Felip E, et al: Prevalence of PD-L1 expression in patients with non-small cell lung cancer screened for enrollment in KEYNOTE-001, -010, and -024. Annals Oncol. 27:vi3632016. View Article : Google Scholar

63 

Gandhi L, Rodríguez-Abreu D, Gadgeel S, Esteban E, Felip E, De Angelis F, Domine M, Clingan P, Hochmair MJ, Powell SF, et al: Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N Engl J Med. 378:2078–2092. 2018. View Article : Google Scholar : PubMed/NCBI

64 

Paz-Ares L, Luft A, Vicente D, Tafreshi A, Gümüş M, Mazières J, Hermes B, Çay Şenler F, Csőszi T, Fülöp A, et al: Pembrolizumab plus chemotherapy for squamous non-small-cell lung cancer. N Engl J Med. 379:2040–2051. 2018. View Article : Google Scholar : PubMed/NCBI

65 

Reck M, Rodríguez-Abreu D, Robinson AG, Hui R, Csőszi T, Fülöp A, Gottfried M, Peled N, Tafreshi A, Cuffe S, et al: Pembrolizumab versus Chemotherapy for PD-L1-positive non-small-cell lung cancer. N Engl J Med. 375:1823–1833. 2016. View Article : Google Scholar : PubMed/NCBI

66 

Herbst RS, Giaccone G, de Marinis F, Reinmuth N, Vergnenegre A, Barrios CH, Morise M, Felip E, Andric Z, Geater S, et al: Atezolizumab for First-Line Treatment of PD-L1-Selected Patients with NSCLC. N Engl J Med. 383:1328–1339. 2020. View Article : Google Scholar : PubMed/NCBI

67 

Zhou Y, Lin Z, Zhang X, Chen C, Zhao H, Hong S and Zhang L: First-line treatment for patients with advanced non-small cell lung carcinoma and high PD-L1 expression: Pembrolizumab or pembrolizumab plus chemotherapy. J Immunother Cancer. 7:1202019. View Article : Google Scholar : PubMed/NCBI

68 

Shanzhi W, Yiping H, Ling H, Jianming Z and Qiang L: The Relationship between TTF-1 Expression and EGFR mutations in lung adenocarcinomas. PLoS One. 9:e954792014. View Article : Google Scholar : PubMed/NCBI

69 

Yatabe Y, Dacic S, Borczuk AC, Warth A, Russell PA, Lantuejoul S, Beasley MB, Thunnissen E, Pelosi G, Rekhtman N, et al: Best practices recommendations for diagnostic immunohistochemistry in lung cancer. J Thorac Oncol. 14:377–407. 2019. View Article : Google Scholar :

70 

Potter AL, Bajaj SS and Yang CJ: The 2021 USPSTF lung cancer screening guidelines: A new frontier. Lancet Respir Med. 9:689–691. 2021. View Article : Google Scholar : PubMed/NCBI

71 

Wyker A and Henderson WW: Solitary Pulmonary Nodule. StatPearls [Internet]. StatPearls Publishing; Treasure Island, FL: 2022

72 

Grunnet M and Sorensen JB: Carcinoembryonic antigen (CEA) as tumor marker in lung cancer. Lung Cancer. 76:138–143. 2012. View Article : Google Scholar

73 

Xu L, Lina W and Xuejun Y: The diagnostic value of serum CEA, NSE and MMP-9 for on-small cell lung cancer. Open Med (Wars). 11:59–62. 2016. View Article : Google Scholar

74 

Yang Q, Zhang P, Wu R, Lu K and Zhou H: Identifying the Best Marker Combination in CEA, CA125, CY211, NSE, and SCC for lung cancer screening by combining ROC curve and logistic regression analyses: Is it feasible? Dis Markers. 2018:1–12. 2018. View Article : Google Scholar

75 

Gao Y, Song P, Li H, Jia H and Zhang B: Elevated serum CEA levels are associated with the explosive progression of lung adenocarcinoma harboring EGFR mutations. BMC Cancer. 17:4842017. View Article : Google Scholar : PubMed/NCBI

76 

Molina R, Marrades RM, Augé JM, Escudero JM, Viñolas N, Reguart N, Ramirez J, Filella X, Molins L and Agustí A: Assessment of a combined panel of six serum tumor markers for lung cancer. Am J Respir Crit Care Med. 193:427–437. 2016. View Article : Google Scholar

77 

Chen H, Fu F, Zhao Y, Wu H, Hu H, Sun Y and Zhang Y, Xiang J and Zhang Y: The Prognostic Value of Preoperative Serum Tumor Markers in Non-Small Cell Lung Cancer Varies With Radiological Features and Histological Types. Front Oncol. 11:6451592021. View Article : Google Scholar : PubMed/NCBI

78 

Bes-Scartezini F and Saad Junior R: Prognostic assessment of tumor markers in lung carcinomas. Rev Assoc Med Bras (1992). 68:313–317. 2022. View Article : Google Scholar

79 

Lin D, Shen L, Luo M, Zhang K, Li J, Yang Q, Zhu F, Zhou D, Zheng S, Chen Y and Zhou J: Circulating tumor cells: Biology and clinical significance. Signal Transduct Target Ther. 6:4042021. View Article : Google Scholar : PubMed/NCBI

80 

Yang C, Xia BR, Jin WL and Lou G: Circulating tumor cells in precision oncology: Clinical applications in liquid biopsy and 3D organoid model. Cancer Cell Int. 19:3412019. View Article : Google Scholar : PubMed/NCBI

81 

Scharpenseel H, Hanssen A, Loges S, Mohme M, Bernreuther C, Peine S, Lamszus K, Goy Y, Petersen C, Westphal M, et al: EGFR and HER3 expression in circulating tumor cells and tumor tissue from non-small cell lung cancer patients. Sci Rep. 9:74062019. View Article : Google Scholar : PubMed/NCBI

82 

Kloten V, Lampignano R, Krahn T and Schlange T: Circulating Tumor Cell PD-L1 expression as biomarker for therapeutic efficacy of immune checkpoint inhibition in NSCLC. Cells. 8:8092019. View Article : Google Scholar :

83 

Maly V, Maly O, Kolostova K and Bobek V: Circulating tumor cells in diagnosis and treatment of lung cancer. In Vivo. 33:1027–1037. 2019. View Article : Google Scholar : PubMed/NCBI

84 

Zhang H, Lin X, Huang Y, Wang M, Cen C, Tang S, Dique MR, Cai L, Luis MA, Smollar J, et al: Detection methods and clinical applications of circulating tumor cells in breast cancer. Front Oncol. 11:6522532021. View Article : Google Scholar : PubMed/NCBI

85 

Galletti G, Portella L, Tagawa ST, Kirby BJ, Giannakakou P and Nanus DM: Circulating tumor cells in prostate cancer diagnosis and monitoring: An appraisal of clinical potential. Mol Diagn Ther. 18:389–402. 2014. View Article : Google Scholar : PubMed/NCBI

86 

Hardingham JE, Grover P, Winter M, Hewett PJ, Price TJ and Thierry B: Detection and clinical significance of circulating tumor cells in colorectal cancer-20 years of progress. Mol Med. 21(Suppl 1): S25–S31. 2015. View Article : Google Scholar :

87 

Hou JM, Krebs MG, Lancashire L, Sloane R, Backen A, Swain RK, Priest LJ, Greystoke A, Zhou C, Morris K, et al: Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer. J Clin Oncol. 30:525–532. 2012. View Article : Google Scholar : PubMed/NCBI

88 

Naito T, Tanaka F, Ono A, Yoneda K, Takahashi T, Murakami H, Nakamura Y, Tsuya A, Kenmotsu H, Shukuya T, et al: Prognostic Impact of Circulating Tumor Cells in Patients with Small Cell Lung Cancer. J Thorac Oncol. 7:512–519. 2012. View Article : Google Scholar : PubMed/NCBI

89 

Juan O, Vidal J, Gisbert R, Muñoz J, Maciá S and Gómez-Codina J: Prognostic significance of circulating tumor cells in advanced non-small cell lung cancer patients treated with docetaxel and gemcitabine. Clin Transl Oncol. 16:637–643. 2014. View Article : Google Scholar

90 

Pailler E, Adam J, Barthélémy A, Oulhen M, Auger N, Valent A, Borget I, Planchard D, Taylor M, André F, et al: Detection of circulating tumor cells harboring a unique ALK Rearrangement in ALK-Positive non-small-cell lung cancer. J Clin Oncol. 31:2273–2281. 2013. View Article : Google Scholar : PubMed/NCBI

91 

Ilie M, Hofman V, Long E, Bordone O, Selva E, Washetine K, Marquette CH and Hofman P: Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine? Ann Transl Med. 2:1072014.PubMed/NCBI

92 

Peng Y and Croce CM: The role of MicroRNAs in human cancer. Signal Transduct Target Ther. 1:150042016. View Article : Google Scholar : PubMed/NCBI

93 

Lin PY, Yu SL and Yang PC: MicroRNA in lung cancer. Br J Cancer. 103:1144–1148. 2010. View Article : Google Scholar : PubMed/NCBI

94 

Ramírez-Salazar EG, Gayosso-Gómez LV, Baez-Saldaña R, Ramírez-Salazar EG, Gayosso-Gómez LV, Baez-Saldaña R, Falfán-Valencia R, Pérez-Padilla R, Higuera-Iglesias AL, Vázquez-Manríquez ME and Ortiz-Quintero B: Cigarette smoking alters the expression of circulating microRNAs and its potential diagnostic value in female lung cancer patients. Biology (Basel). 10:7932021.

95 

Nymark P, Guled M, Borze I, Faisal A, Lahti L, Salmenkivi K, Kettunen E, Anttila S and Knuutila S: Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer. Genes Chromosomes Cancer. 50:585–597. 2011. View Article : Google Scholar : PubMed/NCBI

96 

Wu X, Bhayani MK, Dodge CT, Nicoloso MS, Chen Y, Yan X, Adachi M, Thomas L, Galer CE, Jiffar T, et al: Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a*. Oncotarget. 4:1388–1398. 2013. View Article : Google Scholar : PubMed/NCBI

97 

Han F, He J, Li F, Yang J, Wei J, Cho WC and Liu X: Emerging roles of MicroRNAs in EGFR-Targeted therapies for lung cancer. Biomed Res Int. 2015:6727592015. View Article : Google Scholar : PubMed/NCBI

98 

Vishwamitra D, Li Y, Wilson D, Manshouri R, Curry CV, Shi B, Tang XM, Sheehan AM, Wistuba II, Shi P and Amin HM: MicroRNA 96 is a post-transcriptional suppressor of anaplastic lymphoma kinase expression. Am J Pathol. 180:1772–1780. 2012. View Article : Google Scholar : PubMed/NCBI

99 

Yan C, Zhang W, Shi X, Zheng J, Jin X and Huo J: MiR-760 suppresses non-small cell lung cancer proliferation and metastasis by targeting ROS1. Environ Sci Pollut Res Int. 25:18385–18391. 2018. View Article : Google Scholar : PubMed/NCBI

100 

Fan Q, Hu X, Zhang H, Wang S, Zhang H, You C, Zhang CY, Liang H, Chen X and Ba Y: MiR-193a-3p is an important tumour suppressor in lung cancer and directly targets KRAS. Cell Physiol Biochem. 44:1311–1324. 2017. View Article : Google Scholar : PubMed/NCBI

101 

Pop-Bica C, Pintea S, Magdo L, Cojocneanu R, Gulei D, Ferracin M and Berindan-Neagoe I: The Clinical Utility of miR-21 and let-7 in Non-small Cell Lung Cancer (NSCLC). A systematic review and meta-analysis. Front Oncol. 10:5168502020. View Article : Google Scholar : PubMed/NCBI

102 

Xie Q, Yu Z, Lu Y, Fan J, Ni Y and Ma L: microRNA-148a-3p inhibited the proliferation and epithelial-mesenchymal transition progression of non-small-cell lung cancer via modulating Ras/MAPK/Erk signaling. J Cell Physiol. 234:12786–12799. 2018. View Article : Google Scholar : PubMed/NCBI

103 

Bishop JA, Benjamin H, Cholakh H, Chajut A, Clark DP and Westra WH: Accurate classification of non-small cell lung carcinoma using a novel MicroRNA-based approach. Clin Cancer Res. 16:610–619. 2010. View Article : Google Scholar : PubMed/NCBI

104 

Lebanony D, Benjamin H, Gilad S, Ezagouri M, Dov A, Ashkenazi K, Gefen N, Izraeli S, Rechavi G, Pass H, et al: Diagnostic Assay Based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma. J Clin Oncol. 27:2030–2037. 2009. View Article : Google Scholar : PubMed/NCBI

105 

Zhang YK, Zhu WY, He JY, Chen DD, Huang YY, Le HB and Liu XG: MiRNAs expression profiling to distinguish lung squamous-cell carcinoma from adenocarcinoma subtypes. J Cancer Res Clin Oncol. 138:1641–1650. 2012. View Article : Google Scholar : PubMed/NCBI

106 

Montani F, Marzi MJ, Dezi F, Dama E, Carletti RM, Bonizzi G, Bertolotti R, Bellomi M, Rampinelli C, Maisonneuve P, et al: MiR-Test: A blood test for lung cancer early detection. J Natl Cancer Inst. 107:djv0632015. View Article : Google Scholar : PubMed/NCBI

107 

Sozzi G, Boeri M, Rossi M, Verri C, Suatoni P, Bravi F, Roz L, Conte D, Grassi M, Sverzellati N, et al: Clinical utility of a plasma-based miRNA signature classifier within computed tomography lung cancer screening: A correlative MILD Trial Study. J Clin Oncol. 32:768–773. 2014. View Article : Google Scholar : PubMed/NCBI

108 

Asakura K, Kadota T, Matsuzaki J, Yoshida Y, Yamamoto Y, Nakagawa K, Takizawa S, Aoki Y, Nakamura E, Miura J, et al: A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy. Commun Biol. 3:1342020. View Article : Google Scholar : PubMed/NCBI

109 

Xiao W, Zhong Y, Wu L, Yang D, Ye S and Zhang M: Prognostic value of microRNAs in lung cancer: A systematic review and meta-analysis. Mol Clin Oncol. 10:67–77. 2019.PubMed/NCBI

110 

Yu S, Qin X, Chen T, Zhou L, Xu X and Feng J: MicroRNA-106b-5p regulates cisplatin chemosensitivity by targeting polycystic kidney disease-2 in non-small-cell lung cancer. AntiCancer Drugs. 28:852–860. 2017. View Article : Google Scholar : PubMed/NCBI

111 

Qiu T, Zhou L, Wang T, Xu J, Wang J, Chen W, Zhou X, Huang Z, Zhu W, Shu Y and Liu P: MiR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin by targeting Bcl-2. Int J Mol Med. 32:593–598. 2013. View Article : Google Scholar : PubMed/NCBI

112 

Li Q, Yang Z, Chen M and Liu Y: Downregulation of microRNA-196a enhances the sensitivity of non-small cell lung cancer cells to cisplatin treatment. Int J Mol Med. 37:1067–1074. 2016. View Article : Google Scholar : PubMed/NCBI

113 

Bisagni A, Pagano M, Maramotti S, Zanelli F, Bonacini M, Tagliavini E, Braglia L, Paci M, Mozzarelli A and Croci S: Higher expression of miR-133b is associated with better efficacy of erlotinib as the second or third line in non-small cell lung cancer patients. PLoS One. 13:e01963502018. View Article : Google Scholar : PubMed/NCBI

114 

Condrat CE, Thompson DC, Barbu MG, Bugnar OL, Boboc A, Cretoiu D, Suciu N, Cretoiu SM and Voinea SC: MiRNAs as biomarkers in disease: Latest findings regarding their role in diagnosis and prognosis. Cells. 9:2762020. View Article : Google Scholar :

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ortega MA, Navarro F, Pekarek L, Fraile-Martínez O, García-Montero C, Saez MA, Arroyo M, Monserrat J and Alvarez-Mon M: Exploring histopathological and serum biomarkers in lung adenocarcinoma: Clinical applications and translational opportunities (Review). Int J Oncol 61: 154, 2022.
APA
Ortega, M.A., Navarro, F., Pekarek, L., Fraile-Martínez, O., García-Montero, C., Saez, M.A. ... Alvarez-Mon, M. (2022). Exploring histopathological and serum biomarkers in lung adenocarcinoma: Clinical applications and translational opportunities (Review). International Journal of Oncology, 61, 154. https://doi.org/10.3892/ijo.2022.5444
MLA
Ortega, M. A., Navarro, F., Pekarek, L., Fraile-Martínez, O., García-Montero, C., Saez, M. A., Arroyo, M., Monserrat, J., Alvarez-Mon, M."Exploring histopathological and serum biomarkers in lung adenocarcinoma: Clinical applications and translational opportunities (Review)". International Journal of Oncology 61.6 (2022): 154.
Chicago
Ortega, M. A., Navarro, F., Pekarek, L., Fraile-Martínez, O., García-Montero, C., Saez, M. A., Arroyo, M., Monserrat, J., Alvarez-Mon, M."Exploring histopathological and serum biomarkers in lung adenocarcinoma: Clinical applications and translational opportunities (Review)". International Journal of Oncology 61, no. 6 (2022): 154. https://doi.org/10.3892/ijo.2022.5444
Copy and paste a formatted citation
x
Spandidos Publications style
Ortega MA, Navarro F, Pekarek L, Fraile-Martínez O, García-Montero C, Saez MA, Arroyo M, Monserrat J and Alvarez-Mon M: Exploring histopathological and serum biomarkers in lung adenocarcinoma: Clinical applications and translational opportunities (Review). Int J Oncol 61: 154, 2022.
APA
Ortega, M.A., Navarro, F., Pekarek, L., Fraile-Martínez, O., García-Montero, C., Saez, M.A. ... Alvarez-Mon, M. (2022). Exploring histopathological and serum biomarkers in lung adenocarcinoma: Clinical applications and translational opportunities (Review). International Journal of Oncology, 61, 154. https://doi.org/10.3892/ijo.2022.5444
MLA
Ortega, M. A., Navarro, F., Pekarek, L., Fraile-Martínez, O., García-Montero, C., Saez, M. A., Arroyo, M., Monserrat, J., Alvarez-Mon, M."Exploring histopathological and serum biomarkers in lung adenocarcinoma: Clinical applications and translational opportunities (Review)". International Journal of Oncology 61.6 (2022): 154.
Chicago
Ortega, M. A., Navarro, F., Pekarek, L., Fraile-Martínez, O., García-Montero, C., Saez, M. A., Arroyo, M., Monserrat, J., Alvarez-Mon, M."Exploring histopathological and serum biomarkers in lung adenocarcinoma: Clinical applications and translational opportunities (Review)". International Journal of Oncology 61, no. 6 (2022): 154. https://doi.org/10.3892/ijo.2022.5444
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team