Recent advances in postoperative pulmonary rehabilitation of patients with non‑small cell lung cancer (Review)

Su,Xue-E; Hong,Wan-Ping; He,He-Fan; Lin,Shu; Wu,Shan-Hu; Liu,Fang; Lin,Cui-Liu

doi:10.3892/ijo.2022.5446

Recent advances in postoperative pulmonary rehabilitation of patients with non‑small cell lung cancer (Review)

Authors:
- Xue-E Su
- Wan-Ping Hong
- He-Fan He
- Shu Lin
- Shan-Hu Wu
- Fang Liu
- Cui-Liu Lin
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Affiliations: Department of Anaesthesia, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Centre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Department of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350100, P.R. China
Published online on: November 1, 2022 https://doi.org/10.3892/ijo.2022.5446
Article Number: 156
Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑small cell lung cancer (NSCLC) accounts for ~85% of lung cancer cases and has high morbidity and mortality rates. Over the past decade, treatment strategies for NSCLC have progressed rapidly, particularly with the increasing use of screening programs, leading to improvements in the initial diagnosis and treatment of early‑stage and preinvasive tumors. Surgical intervention remains the primary treatment for early‑stage NSCLC. Thoracoscopic lobectomy has become the main treatment for early‑stage NSCLC, as it results in less postoperative bleeding and pain and fewer complications. However, the complication rate for thoracoscopic lobectomy due to sputum retention and weakened respiratory muscle strength remains as high as 19‑59%. Treating NSCLC remains challenging in terms of postoperative pulmonary rehabilitation. In the present review, recent advances in postoperative pulmonary rehabilitation for patients with NSCLC were presented in order to assist researchers in developing improved treatments to enhance postoperative pulmonary rehabilitation for such patients.

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1	Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI
2	Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI
3	Wang N, Mengersen K, Tong S, Kimlin M, Zhou M and Hu W: Global, regional, and national burden of lung cancer and its attributable risk factors, 1990 to 2017. Cancer. 126:4220–4234. 2020. View Article : Google Scholar : PubMed/NCBI
4	Wei W, Zeng H, Zheng R, Zhang S, An L, Chen R, Wang S, Sun K, Matsuda T, Bray F and He J: Cancer registration in China and its role in cancer prevention and control. Lancet Oncol. 21:e342–e349. 2020. View Article : Google Scholar : PubMed/NCBI
5	Wadowska K, Błasiak P, Rzechonek A, Bil-Lula I and Śliwińska-Mossoń M: New insights on old biomarkers involved in tumor microenvironment changes and their diagnostic relevance in non-small cell lung carcinoma. Biomolecules. 11:12082021. View Article : Google Scholar : PubMed/NCBI
6	Allehebi A, Kattan KA, Rujaib MA, Dayel FA, Black E, Mahrous M, AlNassar M, Hussaini HA, Twairgi AA, Abdelhafeiz N, et al: Management of early-stage resected non-small cell lung cancer: Consensus statement of the lung cancer consortium. Cancer Treat Res Commun. 31:1005382022. View Article : Google Scholar : PubMed/NCBI
7	Zhong WZ; Chinese Thoracic Oncology Group; Chinese Society of Lung Cancer; Lung Cancer Group of Oncology Branch Chinese Medical Association; Multidisciplinary Team Diagnosis and Treatment Committee, Chinses Medical Doctor Association: Chinses expert consensus on the multidisciplinary team diagnosis and treatment of lung cancer. Zhonghua Zhong Liu Za Zhi. 42:817–828. 2020.In Chinese. PubMed/NCBI
8	Moyer J, Lee H and Vu L: Thoracoscopic lobectomy for congenital lung lesions. Clin Perinatol. 44:781–794. 2017. View Article : Google Scholar : PubMed/NCBI
9	Zhang J, Zhao H, Lv L, Yuan J and Sun Y: Uniportal thoracoscopic pulmonary lobectomy in the treatment of lung cancer. Pak J Med Sci. 36:182–186. 2020.PubMed/NCBI
10	Song Y, Zheng C, Zhou S, Cui H, Wang J, Wang J, Wang W, Liu L and Liu J: The application analysis of 8F ultrafine chest drainage tube for thoracoscopic lobectomy of lung cancer. J Cardiothorac Surg. 16:1042021. View Article : Google Scholar : PubMed/NCBI
11	Liang W, Cai K, Chen C, Chen H, Chen Q, Fu J, Hu J, Jiang T, Jiao W, Li S, et al: Expert consensus on neoadjuvant immunotherapy for non-small cell lung cancer. Transl Lung Cancer Res. 9:2696–2715. 2020.
12	Zheng Y, Mao M, Ji M, Zheng Q, Liu L, Zhao Z, Wang H, Wei X, Wang Y, Chen J, et al: Does a pulmonary rehabilitation based ERAS program (PREP) affect pulmonary complication incidence, pulmonary function and quality of life after lung cancer surgery? Study protocol for a multicenter randomized controlled trial. BMC Pulm Med. 20:442020.PubMed/NCBI
13	Bailey KL, Merchant N, Seo YJ, Elashoff D, Benharash P and Yanagawa J: Short-term readmissions after open, thoracoscopic, and robotic lobectomy for lung cancer based on the nationwide readmissions database. World J Surg. 43:1377–1384. 2019.PubMed/NCBI
14	Yasuura Y, Maniwa T, Mori K, Miyata N, Mizuno K, Shimizu R, Kayata H, Kojima H, Isaka M and Ohde Y: Quantitative computed tomography for predicting cardiopulmonary complications after lobectomy for lung cancer in patients with chronic obstructive pulmonary disease. Gen Thorac Cardiovasc Surg. 67:697–703. 2019.PubMed/NCBI
15	Rami-Porta R, Bolejack V, Giroux DJ, Chansky K, Crowley J, Asamura H and Goldstraw P; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee, Advisory Board Members and Participating Institutions: The IASLC lung cancer staging project: The new database to inform the eighth edition of the TNM classification of lung cancer. J Thorac Oncol. 9:1618–1624. 2014.PubMed/NCBI
16	Rami-Porta R, Asamura H, Travis WD and Rusch VW: Lung cancer-major changes in the American joint committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 67:138–155. 2017.PubMed/NCBI
17	Giroux DJ, Van Schil P, Asamura H, Rami-Porta R, Chansky K, Crowley JJ, Rusch VW and Kernstine K; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee: The IASLC lung cancer staging project: A renewed call to participation. J Thorac Oncol. 13:801–809. 2018.PubMed/NCBI
18	Lim W, Ridge CA, Nicholson AG and Mirsadraee S: The 8th lung cancer TNM classification and clinical staging system: Review of the changes and clinical implications. Quant Imaging Med Surg. 8:709–718. 2018.PubMed/NCBI
19	Mirsadraee S, Oswal D, Alizadeh Y, Caulo A and van Beek E Jr: The 7th lung cancer TNM classification and staging system: Review of the changes and implications. World J Radiol. 4:128–134. 2012.PubMed/NCBI
20	Tan WL, Chua KLM, Lin CC, Lee VHF, Tho LM, Chan AW, Ho GF, Reungwetwattana T, Yang JC, Kim DW, et al: Asian thoracic oncology research group expert consensus statement on optimal management of stage III NSCLC. J Thorac Oncol. 15:324–343. 2020.
21	Rami-Porta R, Bolejack V, Crowley J, Ball D, Kim J, Lyons G, Rice T, Suzuki K, Thomas CF Jr, Travis WD, et al: The IASLC lung cancer staging project: Proposals for the revisions of the T descriptors in the forthcoming eighth edition of the TNM classification for lung cancer. J Thorac Oncol. 10:990–1003. 2015. View Article : Google Scholar : PubMed/NCBI
22	Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR and Winchester DP: The eighth edition AJCC cancer staging manual: Continuing to build a bridge from a population-based to a more 'personalized' approach to cancer staging. CA Cancer J Clin. 67:93–99. 2017. View Article : Google Scholar : PubMed/NCBI
23	Lababede O and Meziane MA: The eighth edition of TNM staging of lung cancer: Reference chart and diagrams. Oncologist. 23:844–848. 2018. View Article : Google Scholar : PubMed/NCBI
24	Ettinger DS, Aisner DL, Wood DE, Akerley W, Bauman J, Chang JY, Chirieac LR, D'Amico TA, Dilling TJ, Dobelbower M, et al: NCCN guidelines insights: Non-small cell lung cancer, version 5.2018. J Natl Compr Canc Netw. 16:807–821. 2018. View Article : Google Scholar : PubMed/NCBI
25	Moulla Y, Gradistanac T, Wittekind C, Eichfeld U, Gockel I and Dietrich A: Predictive risk factors for lymph node metastasis in patients with resected non-small cell lung cancer: A case control study. J Cardiothorac Surg. 14:112019. View Article : Google Scholar : PubMed/NCBI
26	Bezjak A, Temin S, Franklin G, Giaccone G, Govindan R, Johnson ML, Rimner A, Schneider BJ, Strawn J and Azzoli CG: Definitive and adjuvant radiotherapy in locally advanced non-small-cell lung cancer: American society of clinical oncology clinical practice guideline endorsement of the american society for radiation oncology evidence-based clinical practice guideline. J Clin Oncol. 33:2100–2105. 2015. View Article : Google Scholar : PubMed/NCBI
27	Berfield KS, Farjah F and Mulligan MS: Video-assisted thoracoscopic lobectomy for lung cancer. Ann Thorac Surg. 107:603–609. 2019. View Article : Google Scholar
28	McKenna RJ Jr, Houck W and Fuller CB: Video-assisted thoracic surgery lobectomy: Experience with 1,100 cases. Ann Thorac Surg. 81:421–426. 2006. View Article : Google Scholar : PubMed/NCBI
29	Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman J, Chirieac LR, D'Amico TA, DeCamp MM, Dilling TJ, Dobelbower M, et al: Non-small cell lung cancer, version 5.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 15:504–535. 2017. View Article : Google Scholar : PubMed/NCBI
30	Cao J, Yuan P, Wang Y, Xu J, Yuan X, Wang Z, Lv W and Hu J: Survival rates after lobectomy, segmentectomy, and wedge resection for non-small cell lung cancer. Ann Thorac Surg. 105:1483–1491. 2018. View Article : Google Scholar : PubMed/NCBI
31	Li F, Zhao Y, Yuan L, Wang S and Mao Y: Oncologic outcomes of segmentectomy vs lobectomy in pathologic stage IA (≤2 cm) invasive lung adenocarcinoma: A population-based study. J Surg Oncol. 121:1132–1139. 2020. View Article : Google Scholar : PubMed/NCBI
32	Kodama K, Higashiyama M, Okami J, Tokunaga T, Imamura F, Nakayama T, Inoue A and Kuriyama K: Oncologic outcomes of segmentectomy versus lobectomy for clinical T1a N0 M0 non-small cell lung cancer. Ann Thorac Surg. 101:504–511. 2016. View Article : Google Scholar
33	Landreneau RJ, Normolle DP, Christie NA, Awais O, Wizorek JJ, Abbas G, Pennathur A, Shende M, Weksler B, Luketich JD and Schuchert MJ: Recurrence and survival outcomes after anatomic segmentectomy versus lobectomy for clinical stage I non-small-cell lung cancer: A propensity-matched analysis. J Clin Oncol. 32:2449–2455. 2014. View Article : Google Scholar : PubMed/NCBI
34	Nakamura K, Saji H, Nakajima R, Okada M, Asamura H, Shibata T, Nakamura S, Tada H and Tsuboi M: A phase III randomized trial of lobectomy versus limited resection for small-sized peripheral non-small cell lung cancer (JCOG0802/WJOG4607L). Jpn J Clin Oncol. 40:271–274. 2010. View Article : Google Scholar
35	Suzuki K, Saji H, Aokage K, Watanabe SI, Okada M, Mizusawa J, Nakajima R, Tsuboi M, Nakamura S, Nakamura K, et al: Comparison of pulmonary segmentectomy and lobectomy: Safety results of a randomized trial. J Thorac Cardiovasc Surg. 158:895–907. 2019. View Article : Google Scholar : PubMed/NCBI
36	Wang Z, Cheng Y, An T, Gao H, Wang K, Zhou Q, Hu Y, Song Y, Ding C, Peng F, et al: Detection of EGFR mutations in plasma circulating tumour DNA as a selection criterion for first-line gefitinib treatment in patients with advanced lung adenocarcinoma (BENEFIT): A phase 2, single-arm, multicentre clinical trial. Lancet Respir Med. 6:681–690. 2018. View Article : Google Scholar : PubMed/NCBI
37	Sinn K, Gschwandtner E, Steindl A and Taghavi S: Hoda MA. EP117–15. comparison of long-term outcome of wedge resection, anatomical segmentectomy and lobectomy in stage I-II non-small cell lung cancer. J Thorac Oncol. 14(Suppl): S10892019. View Article : Google Scholar
38	Spicer JD, Shewale JB, Nelson DB, Mitchell KG, Bott MJ, Vallières E, Wilshire CL, Vaporciyan AA, Swisher SG, Jones DR, et al: Multimodality therapy for N2 non-small cell lung cancer: An evolving paradigm. Ann Thorac Surg. 107:277–284. 2019. View Article : Google Scholar
39	Dickhoff C, Senan S, Schneiders FL, Veltman J, Hashemi S, Daniels JMA, Fransen M, Heineman DJ, Radonic T, van de Ven PM, et al: Ipilimumab plus nivolumab and chemoradiotherapy followed by surgery in patients with resectable and borderline resectable T3-4N0-1 non-small cell lung cancer: The INCREASE trial. BMC Cancer. 20:7642020. View Article : Google Scholar : PubMed/NCBI
40	Haam S: Video-assisted thoracic surgery pneumonectomy. J Chest Sur. 54:253–257. 2021. View Article : Google Scholar
41	Ng CS, Wan S, Lee TW, Wan IY, Arifi AA and Yim AP: Video-assisted thoracic surgery in spontaneous pneumothorax. Can Respir J. 9:122–127. 2002. View Article : Google Scholar : PubMed/NCBI
42	Paul S, Altorki NK, Sheng S, Lee PC, Harpole DH, Onaitis MW, Stiles BM, Port JL and D'Amico TA: Thoracoscopic lobectomy is associated with lower morbidity than open lobectomy: A propensity-matched analysis from the STS database. J Thorac Cardiovasc Surg. 139:366–378. 2010. View Article : Google Scholar : PubMed/NCBI
43	Han D, Cao Y, Wu H, Wang H, Jiang L, Zhao D, Yao F, Li S, Zhang C, Zheng B, et al: Uniportal video-assisted thoracic surgery for the treatment of lung cancer: A consensus report from Chinese society for thoracic and cardiovascular surgery (CSTCVS) and Chinese association of thoracic surgeons (CATS). Transl Lung Cancer Res. 9:971–987. 2020. View Article : Google Scholar : PubMed/NCBI
44	Scott WJ, Howington J, Feigenberg S, Movsas B and Pisters K; American College of Chest Physicians: Treatment of non-small cell lung cancer stage I and stage II: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 132(3 Suppl): 234S–242S. 2007. View Article : Google Scholar : PubMed/NCBI
45	Dziedzic D and Orlowski T: The role of VATS in lung cancer surgery: Current status and prospects for development. Minim Invasive Surg. 2015:9384302015.PubMed/NCBI
46	Ng CS, Gonzalez-Rivas D, D'Amico TA and Rocco G: Uniportal VATS-a new era in lung cancer surgery. J Thorac Dis. 7:1489–1491. 2015.PubMed/NCBI
47	Gao Y, Abulimiti A, He D, Ran A and Luo D: Comparison of single- and triple-port VATS for lung cancer: A meta-analysis. Open Med (Wars). 16:1228–1239. 2021. View Article : Google Scholar
48	Bertolaccini L, Batirel H, Brunelli A, Gonzalez-Rivas D, Ismail M, Ucar AM, Ng CSH, Scarci M, Sihoe ADL, Ugalde PA, et al: Corrigendum to 'uniportal video-assisted thoracic surgery lobectomy: A consensus report from the uniportal VATS interest group (UVIG) of the European society of thoracic surgeons (ESTS)'. Eur J Cardiothorac Surg. 2019.56:224–9. View Article : Google Scholar : PubMed/NCBI Eur J Cardiothorac Surg. 56:628–629. 2019. View Article : Google Scholar
49	Wang BY, Liu CY, Hsu PK, Shih CS and Liu CC: Single-incision versus multiple-incision thoracoscopic lobectomy and segmentectomy: A propensity-matched analysis. Ann Surg. 261:793–799. 2015. View Article : Google Scholar
50	Han KN, Kim HK, Lee HJ and Choi YH: Single-port video-assisted thoracoscopic pulmonary segmentectomy: A report on 30 cases†. Eur J Cardiothorac Surg. 49(Suppl 1): i42–i47. 2016.
51	Sihoe ADL: Uniportal lung cancer surgery: State of the evidence. Ann Thorac Surg. 107:962–972. 2019. View Article : Google Scholar
52	Shen Y, Zhang Y, Sun J, Gu J, Yuan Y and Wang Q: Transaxillary uniportal video assisted thoracoscopic surgery for right upper lobectomy. J Thorac Dis. 10:E214–E217. 2018. View Article : Google Scholar : PubMed/NCBI
53	Zieliński M, Nabialek T and Pankowski J: Transcervical uniportal pulmonary lobectomy. J Vis Surg. 4:422018. View Article : Google Scholar
54	Palleschi A, Mendogni P, Mariolo AV, Nosotti M and Rosso L: An alternative chest tube placement after uniportal video-assisted thoracic surgery. J Thorac Dis. 10:3078–3080. 2018. View Article : Google Scholar : PubMed/NCBI
55	Kao CN, Chang CW, Hsieh MC, Liu YW and Chou SH: Pre-embedding subcutaneous suture for chest-tube insertion in uniportal video-assisted thoracoscopic surgery. J Thorac Dis. 9:E938–E940. 2017. View Article : Google Scholar : PubMed/NCBI
56	Global Burden of Disease 2019 Cancer Collaboration; Kocarnik JM, Compton K, Dean FE, Fu W, Gaw BL, Harvey JD, Henrikson HJ, Lu D, Pennini A, et al: Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: A systematic analysis for the global burden of disease study 2019. JAMA Oncol. 8:420–444. 2022. View Article : Google Scholar :
57	Yang X, Man J, Chen H, Zhang T, Yin X, He Q and Lu M: Temporal trends of the lung cancer mortality attributable to smoking from 1990 to 2017: A global, regional and national analysis. Lung Cancer. 152:49–57. 2021. View Article : Google Scholar
58	Jeon J, Holford TR, Levy DT, Feuer EJ, Cao P, Tam J, Clarke L, Clarke J, Kong CY and Meza R: Smoking and Lung cancer mortality in the United States from 2015 to 2065: A comparative modeling approach. Ann Intern Med. 169:684–693. 2018. View Article : Google Scholar : PubMed/NCBI
59	No authors listed. WHO Guidelines Approved by the Guidelines Review Committee WHO Handbook on indoor radon: A public health perspective. Geneva: World Health Organization; 2009
60	Kim SH, Hwang WJ, Cho JS and Kang DR: Attributable risk of lung cancer deaths due to indoor radon exposure. Ann Occup Environ Med. 28:82016. View Article : Google Scholar : PubMed/NCBI
61	Peterson E, Aker A, Kim J, Li Y, Brand K and Copes R: Lung cancer risk from radon in Ontario, Canada: How many lung cancers can we prevent? Cancer Causes Control. 24:2013–2020. 2013. View Article : Google Scholar : PubMed/NCBI
62	Al-Zoughool M and Krewski D: Health effects of radon: A review of the literature. Int J Radiat Biol. 85:57–69. 2009. View Article : Google Scholar : PubMed/NCBI
63	Enflo A: Lung cancer risks from residential radon among smokers and non-smokers. J Radiol Prot. 22:A95–A99. 2002. View Article : Google Scholar : PubMed/NCBI
64	Al-Rubaie A, Wise AF, Sozo F, De Matteo R, Samuel CS, Harding R and Ricardo SD: The therapeutic effect of mesenchymal stem cells on pulmonary myeloid cells following neonatal hyperoxic lung injury in mice. Respir Res. 19:1142018. View Article : Google Scholar : PubMed/NCBI
65	Ning J, Li P, Zhang B, Han B, Su X, Wang Q, Wang X, Li B, Kang H, Zhou L, et al: miRNAs deregulation in serum of mice is associated with lung cancer related pathway deregulation induced by PM2.5. Environ Pollut. 254:1128752019. View Article : Google Scholar : PubMed/NCBI
66	Yang B and Xiao C: PM2.5 exposure significantly improves the exacerbation of A549 tumor-bearing CB17-SCID mice. Environ Toxicol Pharmacol. 60:169–175. 2018. View Article : Google Scholar : PubMed/NCBI
67	Jiang L, Sun YQ, Langhammer A, Brumpton BM, Chen Y, Nilsen TI, Leivseth L, Wahl SGF and Mai XM: Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study. Sci Rep. 11:45392021. View Article : Google Scholar : PubMed/NCBI
68	Szalontai K, Gémes N, Furák J, Varga T, Neuperger P, Balog JÁ, Puskás LG and Szebeni GJ: Chronic obstructive pulmonary disease: Epidemiology, biomarkers, and paving the way to lung cancer. J Clin Med. 10:28892021. View Article : Google Scholar : PubMed/NCBI
69	Huang J and Wang H: Targeted therapy and mechanism of drug resistance in non-small cell lung cancer with epidermal growth factor receptor gene mutation. Zhongguo Fei Ai Za Zhi. 25:183–192. 2022.In Chinese. PubMed/NCBI
70	Halvorsen AR, Silwal-Pandit L, Meza-Zepeda LA, Vodak D, Vu P, Sagerup C, Hovig E, Myklebost O, Børresen-Dale AL, Brustugun OT and Helland Å: TP53 mutation spectrum in smokers and never smoking lung cancer patients. Front Genet. 7:852016. View Article : Google Scholar : PubMed/NCBI
71	Winton T, Livingston R, Johnson D, Rigas J, Johnston M, Butts C, Cormier Y, Goss G, Inculet R, Vallieres E, et al: Vinorelbine plus cisplatin vs observation in resected non-small-cell lung cancer. N Engl J Med. 352:2589–2597. 2005. View Article : Google Scholar : PubMed/NCBI
72	Lou F, Huang J, Sima CS, Dycoco J, Rusch V and Bach PB: Patterns of recurrence and second primary lung cancer in early-stage lung cancer survivors followed with routine computed tomography surveillance. J Thorac Cardiovasc Surg. 145:75–82. 2013. View Article : Google Scholar
73	Pignon JP, Tribodet H, Scagliotti GV, Douillard JY, Shepherd FA, Stephens RJ, Dunant A, Torri V, Rosell R, Seymour L, et al: Lung adjuvant cisplatin evaluation: A pooled analysis by the LACE collaborative group. J Clin Oncol. 26:3552–3559. 2008. View Article : Google Scholar : PubMed/NCBI
74	Tandberg DJ, Tong BC, Ackerson BG and Kelsey CR: Surgery versus stereotactic body radiation therapy for stage I non-small cell lung cancer: A comprehensive review. Cancer. 124:667–678. 2018. View Article : Google Scholar
75	Choi SY, Moon MH and Moon Y: The prognosis of small-sized non-small cell lung cancer with visceral pleural invasion after sublobar resection. Transl Cancer Res. 9:6431–6443. 2020. View Article : Google Scholar : PubMed/NCBI
76	Zheng YW, Li RM, Zhang XW and Ren XB: Current adoptive immunotherapy in non-small cell lung cancer and potential influence of therapy outcome. Cancer Invest. 31:197–205. 2013. View Article : Google Scholar : PubMed/NCBI
77	Malik PS and Raina V: Lung cancer: Prevalent trends & emerging concepts. Indian J Med Res. 141:5–7. 2015. View Article : Google Scholar : PubMed/NCBI
78	Detterbeck FC, Chansky K, Groome P, Bolejack V, Crowley J, Shemanski L, Kennedy C, Krasnik M, Peake M, Rami-Porta R, et al: The IASLC lung cancer staging project: Methodology and validation used in the development of proposals for revision of the stage classification of NSCLC in the forthcoming (eighth) edition of the TNM classification of lung cancer. J Thorac Oncol. 11:1433–1446. 2016. View Article : Google Scholar : PubMed/NCBI
79	Yoon SM, Shaikh T and Hallman M: Therapeutic management options for stage III non-small cell lung cancer. World J Clin Oncol. 8:1–20. 2017. View Article : Google Scholar : PubMed/NCBI
80	Iyengar P, Kavanagh BD, Wardak Z, Smith I, Ahn C, Gerber DE, Dowell J, Hughes R, Abdulrahman R, Camidge DR, et al: Phase II trial of stereotactic body radiation therapy combined with erlotinib for patients with limited but progressive metastatic non-small-cell lung cancer. J Clin Oncol. 32:3824–3830. 2014. View Article : Google Scholar : PubMed/NCBI
81	Jack S, West MA, Raw D, Marwood S, Ambler G, Cope TM, Shrotri M, Sturgess RP, Calverley PM, Ottensmeier CH and Grocott MP: The effect of neoadjuvant chemotherapy on physical fitness and survival in patients undergoing oesophagogastric cancer surgery. Eur J Surg Oncol. 40:1313–1320. 2014. View Article : Google Scholar : PubMed/NCBI
82	Ni HJ, Pudasaini B, Yuan XT, Li HF and Yuan P: Exercise training for patients pre- and postsurgically treated for non-small cell lung cancer: A systematic review and meta-analysis. Integr Cancer Ther. 16:63–73. 2017. View Article : Google Scholar
83	Pan H, Pei Y, Li B, Wang Y, Liu J and Lin H: Tai Chi Chuan in postsurgical non-small cell lung cancer patients: Study protocol for a randomized controlled trial. Trials. 19:22018. View Article : Google Scholar : PubMed/NCBI
84	Rochester CL, Vogiatzis I, Holland AE, Lareau SC, Marciniuk DD, Puhan MA, Spruit MA, Masefield S, Casaburi R, Clini EM, et al: An official american thoracic society/European respiratory society policy statement: Enhancing implementation, use, and delivery of pulmonary rehabilitation. Am J Respir Crit Care Med. 192:1373–1386. 2015. View Article : Google Scholar : PubMed/NCBI
85	Hill K, Vogiatzis I and Burtin C: The importance of components of pulmonary rehabilitation, other than exercise training, in COPD. Eur Respir Rev. 22:405–413. 2013. View Article : Google Scholar : PubMed/NCBI
86	Wouters EF, Posthuma R, Koopman M, Liu WY, Sillen MJ, Hajian B, Sastry M, Spruit MA and Franssen FM: An update on pulmonary rehabilitation techniques for patients with chronic obstructive pulmonary disease. Expert Rev Respir Med. 14:149–161. 2020. View Article : Google Scholar : PubMed/NCBI
87	Wilson JS, O'Neill B, Reilly J, MacMahon J and Bradley JM: Education in pulmonary rehabilitation: The patient's perspective. Arch Phys Med Rehabil. 88:1704–1709. 2007. View Article : Google Scholar : PubMed/NCBI
88	Aldhahir AM, Rajeh AMA, Aldabayan YS, Drammeh S, Subbu V, Alqahtani JS, Hurst JR and Mandal S: Nutritional supplementation during pulmonary rehabilitation in COPD: A systematic review. Chron Respir Dis. 17:14799731209049532020. View Article : Google Scholar : PubMed/NCBI
89	Poston G, Tait D, Beattie R, Byrne C, Chapman J, Devereux L, Glynne-Jones R, Harrison M, Holman C, Ilyas M, et al: National institute for health and clinical excellence: The diagnosis and management of colorectal cancer: Full guideline. 2011.
90	Jamison DT, Gelband H, Horton S, Jha P, Laxminarayan R, Mock CN and Nugent R: Disease control priorities: Improving health and reducing poverty. 3rd edition. Washington (DC): The International Bank for Reconstruction and Development/The World Bank; 2017
91	Tiep B, Sun V, Koczywas M, Kim J, Raz D, Hurria A and Hayter J: Pulmonary rehabilitation and palliative care for the lung cancer patient. J Hosp Palliat Nurs. 17:462–468. 2015. View Article : Google Scholar : PubMed/NCBI
92	Vagvolgyi A, Rozgonyi Z, Kerti M, Agathou G, Vadasz P and Varga J: Effectiveness of pulmonary rehabilitation and correlations in between functional parameters, extent of thoracic surgery and severity of post-operative complications: Randomized clinical trial. J Thorac Dis. 10:3519–3531. 2018. View Article : Google Scholar : PubMed/NCBI
93	Choi J, Yang Z, Lee J, Lee JH, Kim HK, Yong HS and Lee SY: Usefulness of pulmonary rehabilitation in non-small cell lung cancer patients based on pulmonary function tests and muscle analysis using computed tomography images. Cancer Res Treat. 54:793–802. 2022. View Article : Google Scholar
94	Mao X, Ni Y, Niu Y and Jiang L: The clinical value of pulmonary rehabilitation in reducing postoperative complications and mortality of lung cancer resection: A systematic review and meta-analysis. Front Surg. 8:6854852021. View Article : Google Scholar : PubMed/NCBI
95	Tenconi S, Mainini C, Rapicetta C, Braglia L, Galeone C, Cavuto S, Merlo DF, Costi S, Paci M, Piro R and Fugazzaro S: Rehabilitation for lung cancer patients undergoing surgery: Results of the PUREAIR randomized trial. Eur J Phys Rehabil Med. 57:1002–1011. 2021. View Article : Google Scholar : PubMed/NCBI
96	Brocki BC, Andreasen JJ, Langer D, Souza DS and Westerdahl E: Postoperative inspiratory muscle training in addition to breathing exercises and early mobilization improves oxygenation in high-risk patients after lung cancer surgery: A randomized controlled trial. Eur J Cardiothorac Surg. 49:1483–1491. 2016. View Article : Google Scholar
97	Liu JF, Kuo NY, Fang TP, Chen JO, Lu HI and Lin HL: A six-week inspiratory muscle training and aerobic exercise improves respiratory muscle strength and exercise capacity in lung cancer patients after video-assisted thoracoscopic surgery: A randomized controlled trial. Clin Rehabil. 35:840–850. 2021. View Article : Google Scholar
98	Gao S, Zhang Z, Brunelli A, Chen C, Chen C, Chen G, Chen H, Chen JS, Cassivi S, Chai Y, et al: The society for translational medicine: Clinical practice guidelines for mechanical ventilation management for patients undergoing lobectomy. J Thorac Dis. 9:3246–3254. 2017. View Article : Google Scholar : PubMed/NCBI
99	Yuan J, Cen S, Li J, Wang K, Chen Q, Li H and Zhang Y: Effect of lung protective ventilation combined with flurbiprofen axetil on immune function during thoracoscopic radical resection of lung cancer. Front Surg. 9:8404202022. View Article : Google Scholar : PubMed/NCBI
100	Marret E, Cinotti R, Berard L, Piriou V, Jobard J, Barrucand B, Radu D, Jaber S and Bonnet F; PPV study group: Protective ventilation during anaesthesia reduces major postoperative complications after lung cancer surgery: A double-blind randomised controlled trial. Eur J Anaesthesiol. 35:727–735. 2018. View Article : Google Scholar : PubMed/NCBI
101	Yang M, Ahn HJ, Kim K, Kim JA, Yi CA, Kim MJ and Kim HJ: Does a protective ventilation strategy reduce the risk of pulmonary complications after lung cancer surgery?: A randomized controlled trial. Chest. 139:530–537. 2011. View Article : Google Scholar
102	Lederman D, Easwar J, Feldman J and Shapiro V: Anesthetic considerations for lung resection: Preoperative assessment, intraoperative challenges and postoperative analgesia. Ann Transl Med. 7:3562019. View Article : Google Scholar : PubMed/NCBI
103	Amar D, Zhang H, Pedoto A, Desiderio DP, Shi W and Tan KS: Protective lung ventilation and morbidity after pulmonary resection: A propensity score-matched analysis. Anesth Analg. 125:190–199. 2017. View Article : Google Scholar : PubMed/NCBI
104	Kiss T, Wittenstein J, Becker C, Birr K, Cinnella G, Cohen E, El Tahan MR, Falcão LF, Gregoretti C, Granell M, et al: Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): Study protocol for a randomized controlled trial. Trials. 20:2132019. View Article : Google Scholar : PubMed/NCBI
105	Deng QW, Tan WC, Zhao BC, Wen SH, Shen JT and Xu M: Intraoperative ventilation strategies to prevent postoperative pulmonary complications: A network meta-analysis of randomised controlled trials. Br J Anaesth. 124:324–335. 2020. View Article : Google Scholar : PubMed/NCBI
106	Haro GJ, Sheu B, Marcus SG, Sarin A, Campbell L, Jablons DM and Kratz JR: Perioperative lung resection outcomes after implementation of a multidisciplinary, evidence-based thoracic ERAS program. Ann Surg. 274:e1008–e1013. 2021. View Article : Google Scholar
107	Mittaz Hager AG, Mathieu N, Lenoble-Hoskovec C, Swanenburg J, de Bie R and Hilfiker R: Effects of three home-based exercise programmes regarding falls, quality of life and exercise-adherence in older adults at risk of falling: Protocol for a randomized controlled trial. BMC Geriatr. 19:132019. View Article : Google Scholar : PubMed/NCBI
108	Skórkowska-Telichowska K, Kropielnicka K, Bulińska K, Pilch U, Woźniewski M, Szuba A and Jasiński R: Nordic walking in the second half of life. Aging Clin Exp Res. 28:1035–1046. 2016. View Article : Google Scholar : PubMed/NCBI
109	Xian H, Li Y, Zou B, Chen Y, Yin H, Li X and Pan Y: Identification of TIMELESS and RORA as key clock molecules of non-small cell lung cancer and the comprehensive analysis. BMC Cancer. 22:1072022. View Article : Google Scholar : PubMed/NCBI
110	Iyer S, Taylor-Stokes G and Roughley A: Symptom burden and quality of life in advanced non-small cell lung cancer patients in France and Germany. Lung Cancer. 81:288–293. 2013. View Article : Google Scholar : PubMed/NCBI
111	Simmons CP, Macleod N and Laird BJ: Clinical management of pain in advanced lung cancer. Clin Med Insights Oncol. 6:331–346. 2012. View Article : Google Scholar : PubMed/NCBI
112	Yang FM, Yao L, Wang SJ, Guo Y, Xu ZF, Zhang CH, Zhang K, Fang YX and Liu YY: Current tracking on effectiveness and mechanisms of acupuncture therapy: A literature review of high-quality studies. Chin J Integr Med. 26:310–320. 2020. View Article : Google Scholar
113	Kuang R, Xiong G, Lv W, Zhao Y, Yu M and Jiang J: Efficacy and safety of acupuncture combined with analgesics on lung cancer pain: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 100:e262252021. View Article : Google Scholar
114	Ebede CC, Jang Y and Escalante CP: Cancer-related fatigue in cancer survivorship. Med Clin North Am. 101:1085–1097. 2017. View Article : Google Scholar : PubMed/NCBI
115	Li H and Liu H: Combined effects of acupuncture and auricular acupressure for relieving cancer-related fatigue in patients during lung cancer chemotherapy: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 100:e275022021. View Article : Google Scholar
116	Wei TT, Chen XC, Hou YX and Radiotherapy DO: Relationship between cancer-related insomnia and relevant symptoms of tumor in patients with lung cancer during chemotherapy. Chin Gen Pract. 2015.
117	Yue H, Zhou S, Wu H, Yin X, Li S, Liang T, Li Y, Fang Z, Zhang X, Wang L, et al: Efficacy and safety of electro-acupuncture (EA) on insomnia in patients with lung cancer: Study protocol of a randomized controlled trial. Trials. 21:7882020. View Article : Google Scholar : PubMed/NCBI
118	Turcott JG, Del Rocío Guillen Núñez M, Flores-Estrada D, Oñate-Ocaña LF, Zatarain-Barrón ZL, Barrón F and Arrieta O: The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: A randomized, double-blind clinical trial. Support Care Cancer. 26:3029–3038. 2018. View Article : Google Scholar : PubMed/NCBI
119	Matsutani N and Kawamura M: Significant improvement of chronic pain by Pregabalin after thoracotomy: Report of four cases. Surg Today. 43:915–917. 2013. View Article : Google Scholar
120	Chen P, Wang D, Shen H, Yu L, Gao Q, Mao L, Jiang F, Luo Y, Xie M, Zhang Y, et al: Physical activity and health in Chinese children and adolescents: Expert consensus statement (2020). Br J Sports Med. 54:1321–1331. 2020. View Article : Google Scholar : PubMed/NCBI
121	Song Y, Sun D, István B, Thirupathi A, Liang M, Teo EC and Gu Y: Current evidence on traditional Chinese exercise for cancers: A systematic review of randomized controlled trials. Int J Environ Res Public Health. 17:50112020. View Article : Google Scholar :
122	Liu J, Chen P, Wang R, Yuan Y, Wang X and Li C: Effect of Tai Chi on mononuclear cell functions in patients with non-small cell lung cancer. BMC Complement Altern Med. 15:32015. View Article : Google Scholar : PubMed/NCBI
123	Zhang LL, Wang SZ, Chen HL and Yuan AZ: Tai Chi exercise for cancer-related fatigue in patients with lung cancer under-going chemotherapy: A randomized controlled trial. J Pain Symptom Manage. 51:504–511. 2016. View Article : Google Scholar : PubMed/NCBI
124	Sebio García R, Yáñez-Brage MI, Giménez Moolhuyzen E, Salorio Riobo M, Lista Paz A and Borro Mate JM: Preoperative exercise training prevents functional decline after lung resection surgery: A randomized, single-blind controlled trial. Clin Rehabil. 31:1057–1067. 2017. View Article : Google Scholar : PubMed/NCBI
125	Huang L, Xie D, Yu Y, Liu H, Shi Y, Shi T and Wen C: TCMID 2.0: A comprehensive resource for TCM. Nucleic Acids Res. 46(D1): D1117–D1120. 2018. View Article : Google Scholar :