Open Access

Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review)

  • Authors:
    • Yuxiang Chen
    • Mo Chen
    • Kai Deng
  • View Affiliations

  • Published online on: December 27, 2022     https://doi.org/10.3892/ijo.2022.5472
  • Article Number: 24
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) is one of the most common malignant tumor types occurring in the digestive system. The incidence of CRC has exhibits yearly increases and the mortality rate among patients with CRC is high. The Wnt/β‑catenin signaling pathway, which is associated with carcinogenesis, is abnormally activated in CRC. Most patients with CRC have adenomatous polyposis coli mutations, while half of the remaining patients have β‑catenin gene mutations. Therefore, targeting the Wnt/β‑catenin signaling pathway for the treatment of CRC is of clinical value. In recent years, with in‑depth research on the Wnt/β‑catenin signaling pathway, inhibitors have been developed that are able to suppress or hinder the development and progression of CRC. In the present review, the role of the Wnt/β‑catenin signaling pathway in CRC is summarized, the research status on Wnt/β‑catenin pathway inhibitors is outlined and potential targets for inhibition of this pathway are presented.
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February-2023
Volume 62 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Chen Y, Chen M and Deng K: Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review). Int J Oncol 62: 24, 2023
APA
Chen, Y., Chen, M., & Deng, K. (2023). Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review). International Journal of Oncology, 62, 24. https://doi.org/10.3892/ijo.2022.5472
MLA
Chen, Y., Chen, M., Deng, K."Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review)". International Journal of Oncology 62.2 (2023): 24.
Chicago
Chen, Y., Chen, M., Deng, K."Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review)". International Journal of Oncology 62, no. 2 (2023): 24. https://doi.org/10.3892/ijo.2022.5472