Open Access

Combined PARP inhibitors and small molecular inhibitors in solid tumor treatment (Review)

  • Authors:
    • Ning Jin
    • Yu Xia
    • Qinglei Gao
  • View Affiliations

  • Published online on: January 4, 2023     https://doi.org/10.3892/ijo.2023.5476
  • Article Number: 28
  • Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

With the development of precision medicine, targeted therapy has attracted extensive attention. Poly(ADP‑ribose) polymerase inhibitors (PARPi) are critical clinical drugs designed to induce cell death and are major antitumor targeted agents. However, preclinical and clinical data have revealed the limitations of PARPi monotherapy. Therefore, their combination with other targeted drugs has become a research hotspot in tumor treatment. Recent studies have demonstrated the critical role of small molecular inhibitors in multiple haematological cancers and solid tumors via cellular signalling modulation, exhibiting potential as a combined pharmacotherapy. In the present review, studies focused on small molecular inhibitors targeting the homologous recombination pathway were summarized and clinical trials evaluating the safety and efficacy of combined treatment were discussed.
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February-2023
Volume 62 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Jin N, Xia Y and Gao Q: Combined PARP inhibitors and small molecular inhibitors in solid tumor treatment (Review). Int J Oncol 62: 28, 2023
APA
Jin, N., Xia, Y., & Gao, Q. (2023). Combined PARP inhibitors and small molecular inhibitors in solid tumor treatment (Review). International Journal of Oncology, 62, 28. https://doi.org/10.3892/ijo.2023.5476
MLA
Jin, N., Xia, Y., Gao, Q."Combined PARP inhibitors and small molecular inhibitors in solid tumor treatment (Review)". International Journal of Oncology 62.2 (2023): 28.
Chicago
Jin, N., Xia, Y., Gao, Q."Combined PARP inhibitors and small molecular inhibitors in solid tumor treatment (Review)". International Journal of Oncology 62, no. 2 (2023): 28. https://doi.org/10.3892/ijo.2023.5476