Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
February-2023 Volume 62 Issue 2

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2023 Volume 62 Issue 2

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Perspectives on miRNAs directly targeting BDNF for cancer diagnosis and treatment (Review)

  • Authors:
    • Ziteng Xie
    • Xiaomeng Xu
    • Wenbo Cao
    • Luyun He
    • Chen Kou
    • Jiajia He
    • Yaping Guo
    • Mingjin Yue
    • Saijun Mo
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, Henan Tianxing Education and Media Company, Limited, Zhengzhou, Henan 450001, P.R. China
  • Article Number: 30
    |
    Published online on: January 10, 2023
       https://doi.org/10.3892/ijo.2023.5478
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

MicroRNA (miRNA), a non‑coding single‑stranded RNA molecule with a length of 21‑25 nucleotides transcripts, has been identified to play important roles in tumorigenesis and shows great potential applications in cancer diagnosis, prognosis and therapy. Brain derived neurotrophic factor (BDNF) is a member of the nerve growth factor family and usually serves as a biomarker in neurological and neuropsychiatric diseases for diagnosis and treatment by regulating its high‑affinity receptor TrkB (Tyrosine Kinase Receptor B). Abnormal expression of BDNF is also closely related to the development of cancer, cancer‑related pain and depression. However, little significant progress has been made in the application of BDNF in cancers. Recent studies have shown that the expression of BDNF is directly regulated by a cluster of miRNAs. This review concluded and discussed the role and mechanism of miRNAs targeting BDNF in cancers, and provided novel insights into the diagnosis and therapy of cancer in the future.
View Figures

Figure 1

Figure 2

View References

1 

Colucci-D'amato L, Speranza L and Volpicelli F: Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer. Int J Mol Sci. 21:77772020. View Article : Google Scholar : PubMed/NCBI

2 

Radin DP and Patel P: BDNF: An oncogene or tumor suppressor? Anticancer Res. 37:3983–3990. 2017.PubMed/NCBI

3 

Meng L, Liu B, Ji R, Jiang X, Yan X and Xin Y: Targeting the BDNF/TrkB pathway for the treatment of tumors. Oncol Lett. 17:2031–2039. 2019.PubMed/NCBI

4 

Pruunsild P, Kazantseva A, Aid T, Palm K and Timmusk T: Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters. Genomics. 90:397–406. 2007. View Article : Google Scholar : PubMed/NCBI

5 

De la Cruz-Morcillo MA, Berger J, Sánchez-Prieto R, Saada S, Naves T, Guillaudeau A, Perraud A, Sindou P, Lacroix A, Descazeaud A, et al: p75 neurotrophin receptor and pro-BDNF promote cell survival and migration in clear cell renal cell carcinoma. Oncotarget. 7:34480–34497. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Wang X, Ma W, Wang T, Yang J, Wu Z, Liu K, Dai Y, Zang C, Liu W, Liu J, et al: BDNF-TrkB and proBDNF-p75NTR/sortilin signaling pathways are involved in mitochondria-mediated neuronal apoptosis in dorsal root ganglia after sciatic nerve transection. CNS Neurol Disord Drug Targets. 19:66–82. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Xiong J, Zhou L, Yang M, Lim Y, Zhu YH, Fu DL, Li ZW, Zhong JH, Xiao ZC and Zhou XF: ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro. Neuro Oncol. 15:990–1007. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Xiong J, Zhou LI, Lim Y, Yang M, Zhu YH, Li ZW, Fu DL and Zhou XF: Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues. Oncol Lett. 10:223–227. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Yap NY, Tan NYT, Tan CJ, Loh KW, Ng RCH, Ho HK and Chan A: Associations of plasma brain-derived neurotrophic factor (BDNF) and Val66Met polymorphism (rs6265) with long-term cancer-related cognitive impairment in survivors of breast cancer. Breast Cancer Res Treat. 183:683–696. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Hall D, Dhilla A, Charalambous A, Gogos JA and Karayiorgou M: Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Am J Hum Genet. 73:370–376. 2003. View Article : Google Scholar : PubMed/NCBI

11 

D'Addario C, Bellia F, Benatti B, Grancini B, Vismara M, Pucci M, De Carlo V, Viganò C, Galimberti D, Fenoglio C, et al: Exploring the role of BDNF DNA methylation and hydroxymethylation in patients with obsessive compulsive disorder. J Psychiatr Res. 114:17–23. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Kleimann A, Kotsiari A, Sperling W, Gröschl M, Heberlein A, Kahl KG, Hillemacher T, Bleich S, Kornhuber J and Frieling H: BDNF serum levels and promoter methylation of BDNF exon I, IV and VI in depressed patients receiving electroconvulsive therapy. J Neural Transm (Vienna). 122:925–928. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Zou W, Hu X and Jiang L: Advances in regulating tumorigenicity and metastasis of cancer through TrkB signaling. Curr Cancer Drug Targets. 20:779–788. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Wang CS, Kavalali ET and Monteggia LM: BDNF signaling in context: From synaptic regulation to psychiatric disorders. Cell. 185:62–76. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Arora S, Kanekiyo T and Singh J: Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer's disease pathology in transgenic mouse model. Int J Biol Macromol. 208:901–911. 2022. View Article : Google Scholar : PubMed/NCBI

16 

Mukherjee S, Kuroiwa M, Oakden W, Paul BT, Noman A, Chen J, Lin V, Dimitrijevic A, Stanisz G and Le TN: Local magnetic delivery of adeno-associated virus AAV2(quad Y-F)-mediated BDNF gene therapy restores hearing after noise injury. Mol Ther. 30:519–533. 2022. View Article : Google Scholar : PubMed/NCBI

17 

Hill M and Tran N: miRNA interplay: Mechanisms and consequences in cancer. Dis Model Mech. 14:dmm0476622021. View Article : Google Scholar : PubMed/NCBI

18 

He B, Zhao Z, Cai Q, Zhang Y, Zhang P, Shi S, Xie H, Peng X, Yin W, Tao Y and Wang X: miRNA-based biomarkers, therapies, and resistance in cancer. Int J Biol Sci. 16:2628–2647. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Takahashi RU, Prieto-Vila M, Kohama I and Ochiya T: Development of miRNA-based therapeutic approaches for cancer patients. Cancer Sci. 110:1140–1147. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Cheng F, Yang Z, Huang F, Yin L, Yan G and Gong G: microRNA-107 inhibits gastric cancer cell proliferation and metastasis by targeting PI3K/AKT pathway. Microb Pathog. 121:110–114. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Wei J, Xu H, Wei W, Wang Z, Zhang Q, De W and Shu Y: circHIPK3 promotes cell proliferation and migration of gastric cancer by sponging miR-107 and regulating BDNF expression. Onco Targets Ther. 13:1613–1624. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Ren J, Huang HJ, Gong Y, Yue S, Tang LM and Cheng SY: MicroRNA-206 suppresses gastric cancer cell growth and metastasis. Cell Biosci. 4:262014. View Article : Google Scholar : PubMed/NCBI

23 

Ding D, Hou R, Gao Y and Feng Y: miR-613 inhibits gastric cancer progression through repressing brain derived neurotrophic factor. Exp Ther Med. 15:1735–1741. 2018.PubMed/NCBI

24 

Xu AJ, Fu LN, Wu HX, Yao XL and Meng R: MicroRNA-744 inhibits tumor cell proliferation and invasion of gastric cancer via targeting brain derived neurotrophic factor. Mol Med Rep. 16:5055–5061. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Hong W, Zhang Y, Ding J, Yang Q, Xie H and Gao X: circHIPK3 acts as competing endogenous RNA and promotes non-small-cell lung cancer progression through the miR-107/BDNF signaling pathway. Biomed Res Int. 2020:60759022020. View Article : Google Scholar : PubMed/NCBI

26 

Li F, Wang X and Yang L: MicroRNA-147 targets BDNF to inhibit cell proliferation, migration and invasion in non-small cell lung cancer. Oncol Lett. 20:1931–1937. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Ma R, Zhu P, Liu S, Gao B and Wang W: miR-496 suppress tumorigenesis via targeting BDNF-mediated PI3K/Akt signaling pathway in non-small cell lung cancer. Biochem Biophys Res Commun. 518:273–277. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Gao B, Hao S, Tian W, Jiang Y, Zhang S, Guo L, Zhao J, Zhang G, Yan J and Luo D: MicroRNA-107 is downregulated and having tumor suppressive effect in breast cancer by negatively regulating brain-derived neurotrophic factor. J Gene Med. 19:e29322017. View Article : Google Scholar

29 

Zhang HY, Xing MQ, Guo J, Zhao JC, Chen X, Jiang Z, Zhang H and Dong Q: Long noncoding RNA DLX6-AS1 promotes neuroblastoma progression by regulating miR-107/BDNF pathway. Cancer Cell Int. 19:3132019. View Article : Google Scholar : PubMed/NCBI

30 

Gao L, Yan P, Guo FF, Liu HJ and Zhao ZF: MiR-1-3p inhibits cell proliferation and invasion by regulating BDNF-TrkB signaling pathway in bladder cancer. Neoplasma. 65:89–96. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Long J, Jiang C, Liu B, Fang S and Kuang M: MicroRNA-15a-5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF. Tumour Biol. 37:5821–5828. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Sun YX, Yang J, Wang PY, Li YJ, Xie SY and Sun RP: Cisplatin regulates SH-SY5Y cell growth through downregulation of BDNF via miR-16. Oncol Rep. 30:2343–2349. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Sun Z, Guo X, Zang M, Wang P, Xue S and Chen G: Long non-coding RNA LINC00152 promotes cell growth and invasion of papillary thyroid carcinoma by regulating the miR-497/BDNF axis. J Cell Physiol. 234:1336–1345. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Hu X, Zou W, Liu D, Qin G and Jiang L: The down-regulation of TrkB alleviates the malignant biological behavior and cancer stem-like property of laryngeal cancer. Cancer Manag Res. 12:6865–6875. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Yan H, Wu W, Ge H, Li P and Wang Z: Up-regulation of miR-204 enhances anoikis sensitivity in epithelial ovarian cancer cell line via brain-derived neurotrophic factor pathway in vitro. Int J Gynecol Cancer. 25:944–952. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Song D, Diao J, Yang Y and Chen Y: MicroRNA-382 inhibits cell proliferation and invasion of retinoblastoma by targeting BDNFmediated PI3K/AKT signalling pathway. Mol Med Rep. 16:6428–6436. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Fei X, Jin HY, Gao Y, Kong LM and Tan XD: Hsa-miR-10a-5p promotes pancreatic cancer growth by BDNF/SEMA4C pathway. J Biol Regul Homeost Agents. 34:927–934. 2020.PubMed/NCBI

38 

Nagpal N, Ahmad HM, Molparia B and Kulshreshtha R: MicroRNA-191, an estrogen-responsive microRNA, functions as an oncogenic regulator in human breast cancer. Carcinogenesis. 34:1889–1899. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Nagpal N, Sharma S, Maji S, Durante G, Ferracin M, Thakur JK and Kulshreshtha R: Essential role of MED1 in the transcriptional regulation of ER-dependent oncogenic miRNAs in breast cancer. Sci Rep. 8:118052018. View Article : Google Scholar : PubMed/NCBI

40 

Xu Y, Fu Z, Gao X, Wang R and Li Q: Long non-coding RNA XIST promotes retinoblastoma cell proliferation, migration, and invasion by modulating microRNA-191-5p/brain derived neurotrophic factor. Bioengineered. 12:1587–1598. 2021. View Article : Google Scholar : PubMed/NCBI

41 

Dong X, Fu X, Yu M and Li Z: Long intergenic non-protein coding RNA 1094 promotes initiation and progression of glioblastoma by promoting microRNA-577-regulated stabilization of brain-derived neurotrophic factor. Cancer Manag Res. 12:5619–5631. 2020. View Article : Google Scholar : PubMed/NCBI

42 

Amuti A, Liu D, Maimaiti A, Yu Y, Yasen Y, Ma H, Li R, Deng S, Pang F and Tian Y: Doxorubicin inhibits osteosarcoma progression by regulating circ_0000006/miR-646/BDNF axis. J Orthop Surg Res. 16:6452021. View Article : Google Scholar : PubMed/NCBI

43 

Liu Y, Qi L, Zhang K and Wang F: MicroRNA-10a suppresses cell metastasis by targeting BDNF and predicted patients survival in renal cell carcinoma. J BUON. 26:250–258. 2021.PubMed/NCBI

44 

Liu S, Jiang T, Zhong Y and Yu Y: miR-210 inhibits cell migration and invasion by targeting the brain-derived neurotrophic factor in glioblastoma. J Cell Biochem. 120:11375–11382. 2019. View Article : Google Scholar

45 

Imam JS, Plyler JR, Bansal H, Prajapati S, Bansal S, Rebeles J, Chen HI, Chang YF, Panneerdoss S, Zoghi B, et al: Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization. PLoS One. 7:e523972012. View Article : Google Scholar : PubMed/NCBI

46 

Zhong KZ, Chen WW, Hu XY, Jiang AL and Zhao J: Clinicopathological and prognostic significance of microRNA-107 in human non small cell lung cancer. Int J Clin Exp Pathol. 7:4545–4551. 2014.PubMed/NCBI

47 

Zhai L, Li Y, Lan X and Ai L: MicroRNA-10a-5p suppresses cancer proliferation and division in human cervical cancer by targeting BDNF. Exp Ther Med. 14:6147–6151. 2017.PubMed/NCBI

48 

Zheng B and Chen T: MiR-489-3p inhibits cell proliferation, migration, and invasion, and induces apoptosis, by targeting the BDNF-mediated PI3K/AKT pathway in glioblastoma. Open Life Sci. 15:274–283. 2020. View Article : Google Scholar : PubMed/NCBI

49 

Wang L, Liu Y and Song J: MicroRNA-103 suppresses glioma cell proliferation and invasion by targeting the brain-derived neurotrophic factor. Mol Med Rep. 17:4083–4089. 2018.PubMed/NCBI

50 

Ye J, Xie W, Zuo Y, Jing G and Tong J: MicroRNA-496 suppresses tumor cell proliferation by targeting BDNF in osteosarcoma. Exp Ther Med. 19:1425–1431. 2020.PubMed/NCBI

51 

Song Y, Wang G, Zhuang J, Ni J, Zhang S, Ye Y and Xia W: MicroRNA-584 prohibits hepatocellular carcinoma cell proliferation and invasion by directly targeting BDNF. Mol Med Rep. 20:1994–2001. 2019.PubMed/NCBI

52 

Climent M, Viggiani G, Chen YW, Coulis G and Castaldi A: MicroRNA and ROS crosstalk in cardiac and pulmonary diseases. Int J Mol Sci. 21:43702020. View Article : Google Scholar : PubMed/NCBI

53 

Bjorkman KK, Buvoli M, Pugach EK, Polmear MM and Leinwand LA: miR-1/206 downregulates splicing factor Srsf9 to promote C2C12 differentiation. Skelet Muscle. 9:312019. View Article : Google Scholar : PubMed/NCBI

54 

Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, Wojcik SE, Aqeilan RI, Zupo S, Dono M, et al: miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA. 102:13944–13949. 2005. View Article : Google Scholar : PubMed/NCBI

55 

Zhu W, Zhu D, Lu S, Wang T, Wang J, Jiang B, Shu Y and Liu P: miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2. Med Oncol. 29:384–391. 2012. View Article : Google Scholar : PubMed/NCBI

56 

Tajbakhsh A, Mokhtari-Zaer A, Rezaee M, Afzaljavan F, Rivandi M, Hassanian SM, Ferns GA, Pasdar A and Avan A: Therapeutic potentials of BDNF/TrkB in breast cancer; current status and perspectives. J Cell Biochem. 118:2502–2515. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Guo D, Sun W, Zhu L, Zhang H, Hou X, Liang J, Jiang X and Liu C: Knockdown of BDNF suppressed invasion of HepG2 and HCCLM3 cells, a mechanism associated with inactivation of RhoA or Rac1 and actin skeleton disorganization. APMIS. 120:469–476. 2012. View Article : Google Scholar : PubMed/NCBI

58 

Zhou Y, Sinha S, Schwartz JL and Adami GR: A subtype of oral, laryngeal, esophageal, and lung, squamous cell carcinoma with high levels of TrkB-T1 neurotrophin receptor mRNA. BMC Cancer. 19:6072019. View Article : Google Scholar : PubMed/NCBI

59 

Garofalo S, D'Alessandro G, Chece G, Brau F, Maggi L, Rosa A, Porzia A, Mainiero F, Esposito V, Lauro C, et al: Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice. Nat Commun. 6:66232015. View Article : Google Scholar : PubMed/NCBI

60 

Li Z, Chang Z, Chiao LJ, Kang Y, Xia Q, Zhu C, Fleming JB, Evans DB and Chiao PJ: TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation. Cancer Res. 69:7851–7859. 2009. View Article : Google Scholar : PubMed/NCBI

61 

Gao J, Zhang X, Jiang L, Li Y and Zheng Q: Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling. Cell Commun Signal. 20:972022. View Article : Google Scholar : PubMed/NCBI

62 

Zhou C, Liu Q, Xiang Y, Gou X and Li W: Role of the tumor immune microenvironment in tumor immunotherapy. Oncol Lett. 23:532022. View Article : Google Scholar : PubMed/NCBI

63 

Cao L, Liu X, Lin EJ, Wang C, Choi EY, Riban V, Lin B and During MJ: Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition. Cell. 142:52–64. 2010. View Article : Google Scholar : PubMed/NCBI

64 

Liu X, McMurphy T, Xiao R, Slater A, Huang W and Cao L: Hypothalamic gene transfer of BDNF inhibits breast cancer progression and metastasis in middle age obese mice. Mol Ther. 22:1275–1284. 2014. View Article : Google Scholar : PubMed/NCBI

65 

Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, et al: Environmental and genetic activation of hypothalamic BDNF modulates T-cell immunity to exert an anticancer phenotype. Cancer Immunol Res. 4:488–497. 2016. View Article : Google Scholar : PubMed/NCBI

66 

Zhou J, Yu L, Gao X, Hu J, Wang J, Dai Z, Wang JF, Zhang Z, Lu S, Huang X, et al: Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. J Clin Oncol. 29:4781–4788. 2011. View Article : Google Scholar : PubMed/NCBI

67 

Ng EKO, Chong WWS, Jin H, Lam EKY, Shin VY, Yu J, Poon TCW, Ng SSM and Sung JJY: Differential expression of microRNAs in plasma of patients with colorectal cancer: A potential marker for colorectal cancer screening. Gut. 58:1375–1381. 2009. View Article : Google Scholar : PubMed/NCBI

68 

Huang Z, Huang D, Ni S, Peng Z, Sheng W and Du X: Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer. Int J Cancer. 127:118–126. 2010. View Article : Google Scholar : PubMed/NCBI

69 

Toden S, Zumwalt TJ and Goel A: Non-coding RNAs and potential therapeutic targeting in cancer. Biochim Biophys Acta Rev Cancer. 1875:1884912021. View Article : Google Scholar : PubMed/NCBI

70 

Saw PE, Xu X, Chen J and Song EW: Non-coding RNAs: The new central dogma of cancer biology. Sci China Life Sci. 64:22–50. 2021. View Article : Google Scholar : PubMed/NCBI

71 

Zhang S, Cheng Z, Wang Y and Han T: The risks of miRNA therapeutics: In a drug target perspective. Drug Des Devel Ther. 15:721–733. 2021. View Article : Google Scholar : PubMed/NCBI

72 

Chu YY, Ko CY, Wang SM, Lin PI, Wang HY, Lin WC, Wu DY, Wang LH and Wang JM: Bortezomib-induced miRNAs direct epigenetic silencing of locus genes and trigger apoptosis in leukemia. Cell Death Dis. 8:e31672017. View Article : Google Scholar : PubMed/NCBI

73 

Ye LL, Cheng ZG, Cheng XE and Huang YL: Propofol regulates miR-1-3p/IGF1 axis to inhibit the proliferation and accelerates apoptosis of colorectal cancer cells. Toxicol Res (Camb). 10:696–705. 2021. View Article : Google Scholar : PubMed/NCBI

74 

Cui P, Hu J, Wang X, Xia Y, Ruan X and Cai M: Effects of propofol on invasion, migration and epithelial-mesenchymal transition of breast cancer MDA-MB-231 cells by up-regulating miR-204. Chin J Immunol. 36:2100–2104. 2020.(In Chinese).

75 

Wang D, Yang T, Liu J, Liu Y, Xing N, He J, Yang J and Ai Y: Propofol inhibits the migration and invasion of glioma cells by blocking the PI3K/AKT pathway through miR-206/ROCK1 axis. Onco Targets Ther. 13:361–370. 2020. View Article : Google Scholar : PubMed/NCBI

76 

Shi A, Luo J and Cao H: Propofol affects invasion and metastasis of lung adenocarcinoma cells by regulating hypoxia inducible factor-1α/microRNA-210 signaling pathway. Chin J Clin Pharmacol. 35:2314–2317. 2019.(In Chinese).

77 

Wang L, Li K, Lin X, Yao Z, Wang S, Xiong X, Ning Z, Wang J, Xu X, Jiang Y, et al: Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis. Cancer Lett. 450:22–31. 2019. View Article : Google Scholar : PubMed/NCBI

78 

Wang Y, Chen X, Li J and Xia C: Quercetin antagonizes esophagus cancer by modulating miR-1-3p/TAGLN2 pathway-dependent growth and metastasis. Nutr Cancer. 74:1872–1881. 2022. View Article : Google Scholar : PubMed/NCBI

79 

Zhao J, Fang Z, Zha Z, Sun Q, Wang H, Sun M and Qiao B: Quercetin inhibits cell viability, migration and invasion by regulating miR-16/HOXA10 axis in oral cancer. Eur J Pharmacol. 847:11–18. 2019. View Article : Google Scholar : PubMed/NCBI

80 

Ahmed Youness R, Amr Assal R, Mohamed Ezzat S, Zakaria Gad M and Abdel Motaal A: A methoxylated quercetin glycoside harnesses HCC tumor progression in a TP53/miR-15/miR-16 dependent manner. Nat Prod Res. 34:1475–1480. 2020. View Article : Google Scholar : PubMed/NCBI

81 

Wang N, Feng T, Liu X and Liu Q: Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway. Acta Pharm. 70:399–409. 2020. View Article : Google Scholar : PubMed/NCBI

82 

Ran H, Chen H, Pu J, Li M, Zhang Z and He Y: Effect of curcumin on apoptosis of PC3 cell line via down-regulating the expressions of MiR210 and TLR4/NF-κB signaling pathway. Pharmacol Clin Chin Mater. 37:64–68. 2021.(In Chinese).

83 

Li Y, Lin Q, Chang S, Zhang R and Wang J: Vitamin D3 mediates miR-15a-5p inhibition of liver cancer cell proliferation via targeting E2F3. Oncol Lett. 20:292–298. 2020. View Article : Google Scholar : PubMed/NCBI

84 

Zhang J, Ren L, Yu M, Liu X, Ma W, Huang L, Li X and Ye X: S-equol inhibits proliferation and promotes apoptosis of human breast cancer MCF-7 cells via regulating miR-10a-5p and PI3K/AKT pathway. Arch Biochem Biophys. 672:1080642019. View Article : Google Scholar : PubMed/NCBI

85 

Zhang W, Li W and Han X: Skullcapflavone I inhibits proliferation of human colorectal cancer cells via down-regulation of miR-107 expression. Neoplasma. 66:203–210. 2019. View Article : Google Scholar : PubMed/NCBI

86 

Li H, Xia Z, Liu L, Pan G, Ding J, Liu J, Kang J, Li J, Jiang D and Liu W: Astragalus IV undermines multi-drug resistance and glycolysis of MDA-MB-231/ADR Cell line by depressing hsa_circ_0001982-miR-206/miR-613 axis. Cancer Manag Res. 13:5821–5833. 2021. View Article : Google Scholar : PubMed/NCBI

87 

Dan H, Lei H and JinMing H: Andrographolide inhibits proliferation and promotes apoptosis of prostate cancer cells by regulating miR-206/STC2. Chin J Gerontol. 39:4802–4807. 2019.

88 

Buist M, Fuss D and Rastegar M: Transcriptional regulation of MECP2E1-E2 isoforms and BDNF by Metformin and Simvastatin through analyzing nascent RNA synthesis in a human brain cell Line. Biomolecules. 11:12532021. View Article : Google Scholar : PubMed/NCBI

89 

Kumar P, Barua CC, Sulakhiya K and Sharma RK: Curcumin ameliorates cisplatin-induced nephrotoxicity and potentiates its anticancer activity in SD rats: Potential role of curcumin in breast cancer chemotherapy. Front Pharmacol. 8:1322017. View Article : Google Scholar : PubMed/NCBI

90 

Alhusban L, Ayoub N and Alhusban A: ProBDNF is a novel mediator of the interaction between MDA-MB-231 breast cancer cells and brain microvascular endothelial cells. Curr Mol Med. 21:914–921. 2020. View Article : Google Scholar : PubMed/NCBI

91 

Iqbal MUN, Yaqoob T, Ali SA and Khan TA: A functional polymorphism (rs6265, G>A) of brain-derived neurotrophic factor gene and breast cancer: An association study. Breast Cancer (Auckl). 13:11782234198449772019.PubMed/NCBI

92 

Kim JM, Kang HJ, Kim SY, Kim SW, Shin IS, Kim HR, Park MH, Shin MG, Yoon JH and Yoon JS: BDNF promoter methylation associated with suicidal ideation in patients with breast cancer. Int J Psychiatry Med. 49:75–94. 2015. View Article : Google Scholar : PubMed/NCBI

93 

Lin X, Dinglin X, Cao S, Zheng S, Wu C, Chen W, Li Q, Hu Q, Zheng F, Wu Z, et al: Enhancer-driven lncRNA BDNF-AS induces endocrine resistance and malignant progression of breast cancer through the RNH1/TRIM21/mTOR cascade. Cell Rep. 31:1077532020. View Article : Google Scholar : PubMed/NCBI

94 

Huang G, Xiang Z, Wu H, He Q, Dou R, Lin Z, Yang C, Huang S, Song J, Di Z, et al: The lncRNA BDNF-AS/WDR5/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination. Int J Biol Sci. 18:1415–1433. 2022. View Article : Google Scholar : PubMed/NCBI

95 

Koh MJ, Jeung HC, Namkoong K, Chung HC and Kang JI: Influence of the BDNF Val66Met polymorphism on coping response to stress in patients with advanced gastric cancer. J Psychosom Res. 77:76–80. 2014. View Article : Google Scholar : PubMed/NCBI

96 

Guo JC, Yang YJ, Zheng JF, Guo M, Wang XD, Gao YS, Fu LQ, Jiang XL, Fu LM and Huang T: Functional rs6265 polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in posttraumatic stress disorder among Chinese patients with hepatocellular carcinoma. J Cell Biochem. 120:10434–10443. 2019. View Article : Google Scholar : PubMed/NCBI

97 

Bai L, Zhang S, Zhou X, Li Y and Bai J: Brain-derived neurotrophic factor induces thioredoxin-1 expression through TrkB/Akt/CREB pathway in SH-SY5Y cells. Biochimie. 160:55–60. 2019. View Article : Google Scholar : PubMed/NCBI

98 

Hua Z, Gu X, Dong Y, Tan F, Liu Z, Thiele CJ and Li Z: PI3K and MAPK pathways mediate the BDNF/TrkB-increased metastasis in neuroblastoma. Tumour Biol. 37:16227–16236. 2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

99 

Yuan Y, Ye HQ and Ren QC: Upregulation of the BDNF/TrKB pathway promotes epithelial-mesenchymal transition, as well as the migration and invasion of cervical cancer. Int J Oncol. 52:461–472. 2018.PubMed/NCBI

100 

Okugawa Y, Tanaka K, Inoue Y, Kawamura M, Kawamoto A, Hiro J, Saigusa S, Toiyama Y, Ohi M, Uchida K, et al: Brain-derived neurotrophic factor/tropomyosin-related kinase B pathway in gastric cancer. Br J Cancer. 108:121–130. 2013. View Article : Google Scholar : PubMed/NCBI

101 

Kojadinovic A, Laderian B and Mundi PS: Targeting TRK: A fast-tracked application of precision oncology and future directions. Crit Rev Oncol Hematol. 165:1034512021. View Article : Google Scholar : PubMed/NCBI

102 

Bhangoo MS and Sigal D: TRK inhibitors: Clinical development of larotrectinib. Curr Oncol Rep. 21:142019. View Article : Google Scholar : PubMed/NCBI

103 

Peng Y, Wang Y, Zhou C, Mei W and Zeng C: PI3K/Akt/mTOR pathway and its role in cancer therapeutics: Are we making headway? Front Oncol. 12:8191282022. View Article : Google Scholar : PubMed/NCBI

104 

Kaboli PJ, Imani S, Jomhori M and Ling KH: Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy. Am J Cancer Res. 11:5155–5183. 2021.PubMed/NCBI

105 

Duan Y, Haybaeck J and Yang Z: Therapeutic potential of PI3K/AKT/mTOR pathway in gastrointestinal stromal tumors: Rationale and progress. Cancers (Basel). 12:29722020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xie Z, Xu X, Cao W, He L, Kou C, He J, Guo Y, Yue M and Mo S: Perspectives on miRNAs directly targeting BDNF for cancer diagnosis and treatment (Review). Int J Oncol 62: 30, 2023.
APA
Xie, Z., Xu, X., Cao, W., He, L., Kou, C., He, J. ... Mo, S. (2023). Perspectives on miRNAs directly targeting BDNF for cancer diagnosis and treatment (Review). International Journal of Oncology, 62, 30. https://doi.org/10.3892/ijo.2023.5478
MLA
Xie, Z., Xu, X., Cao, W., He, L., Kou, C., He, J., Guo, Y., Yue, M., Mo, S."Perspectives on miRNAs directly targeting BDNF for cancer diagnosis and treatment (Review)". International Journal of Oncology 62.2 (2023): 30.
Chicago
Xie, Z., Xu, X., Cao, W., He, L., Kou, C., He, J., Guo, Y., Yue, M., Mo, S."Perspectives on miRNAs directly targeting BDNF for cancer diagnosis and treatment (Review)". International Journal of Oncology 62, no. 2 (2023): 30. https://doi.org/10.3892/ijo.2023.5478
Copy and paste a formatted citation
x
Spandidos Publications style
Xie Z, Xu X, Cao W, He L, Kou C, He J, Guo Y, Yue M and Mo S: Perspectives on miRNAs directly targeting BDNF for cancer diagnosis and treatment (Review). Int J Oncol 62: 30, 2023.
APA
Xie, Z., Xu, X., Cao, W., He, L., Kou, C., He, J. ... Mo, S. (2023). Perspectives on miRNAs directly targeting BDNF for cancer diagnosis and treatment (Review). International Journal of Oncology, 62, 30. https://doi.org/10.3892/ijo.2023.5478
MLA
Xie, Z., Xu, X., Cao, W., He, L., Kou, C., He, J., Guo, Y., Yue, M., Mo, S."Perspectives on miRNAs directly targeting BDNF for cancer diagnosis and treatment (Review)". International Journal of Oncology 62.2 (2023): 30.
Chicago
Xie, Z., Xu, X., Cao, W., He, L., Kou, C., He, J., Guo, Y., Yue, M., Mo, S."Perspectives on miRNAs directly targeting BDNF for cancer diagnosis and treatment (Review)". International Journal of Oncology 62, no. 2 (2023): 30. https://doi.org/10.3892/ijo.2023.5478
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team