Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
March-2023 Volume 62 Issue 3

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2023 Volume 62 Issue 3

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Zinc finger protein‑like 1 is a novel neuroendocrine biomarker for prostate cancer

Retraction in: /10.3892/ijo.2025.5722
  • Authors:
    • Neshat Masud
    • Afaf Aldahish
    • Kenneth A. Iczkowski
    • Ajay Kale
    • Girish V. Shah
  • View Affiliations / Copyright

    Affiliations: Pharmacology, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA, Pathology and Laboratory Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Copyright: © Masud et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 38
    |
    Published online on: February 6, 2023
       https://doi.org/10.3892/ijo.2023.5486
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Prostate‑derived calcitonin (CT) and its receptor induce tumorigenicity and increase metastatic potential of prostate cancer (PC). CT‑inducible genes in human prostate were identified by subtraction hybridization. Among these genes, zinc finger protein like 1 (ZFPL1) protein was interesting since it was abundantly expressed in malignant prostates but was almost absent in benign prostates. ZFPL1 expression was upregulated by CT and androgens, and ZFPL1 protein was secreted by prostate tumor cells through exosomal secretion. Serum levels of ZFPL1 in cancer patients were at least 4‑fold higher than those in the sera of cancer‑free individuals. Cell biology of ZFPL1 suggests its localization in Golgi bodies and exosomes, and its colocalization with chromogranin A and CD44. These results suggested that ZFPL1 is secreted by tumor cells of neuroendocrine (NE)/stem cell phenotype. The knockdown of endogenous ZFPL1 in (PC) cells led to a remarkable decrease in cell proliferation, and invasion while increasing their apoptosis. As expected, the overexpression of ZFPL1 in prostate cells had an opposite effect on these functions. The knockdown of ZFPL1 in PC cells also decreased Akt phosphorylation, suggesting the actions of ZFPL1 may be mediated through the PI3K‑Akt pathway. Moreover, the present results revealed that ZFPL1 is released by tumors cells of NE or androgen‑independent phenotype and its serum levels are significantly higher in cancer patients, suggesting that it may serve as a blood‑based non‑invasive biomarker of aggressive PC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Zhai Z, Zheng Y, Li N, Deng Y, Zhou L, Tian T, Yang S, Hao Q, Song D, Wu Y, et al: Incidence and disease burden of prostate cancer from 1990 to 2017: Results from the Global Burden of Disease Study 2017. Cancer. 126:1969–1978. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Giona S: The Epidemiology of Prostate Cancer. Prostate Cancer Exon Publications; Australia: pp. 1–16. 2021

3 

Liu Y, Hegde P, Zhang F, Hampton G and Jia S: Prostate cancer-a biomarker perspective. Front Endocrinol (Lausanne). 3:722012. View Article : Google Scholar

4 

Christensen E, Evans KR, Menard C, Pintilie M and Bristow RG: Practical approaches to proteomic biomarkers within prostate cancer radiotherapy trials. Cancer Metastasis Rev. 27:375–385. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Schroder FH, Hugosson J, Carlsson S, Tammela T, Määttänen L, Auvinen A, Kwiatkowski M, Recker F and Roobol MJ: Screening for prostate cancer decreases the risk of developing metastatic disease: Findings from the European Randomized study of screening for prostate cancer (ERSPC). Eur Urol. 62:745–752. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Yang Y, Chisholm GD and Habib FK: The distribution of PSA, cathepsin-D, and pS2 in BPH and cancer of the prostate. Prostate. 21:201–208. 1992. View Article : Google Scholar : PubMed/NCBI

7 

Elgamal AA, Cornillie FJ, Van Poppel HP, Van de Voorde WM, McCabe R and Baert LV: Free-to-total prostate specific antigen ratio as a single test for detection of significant stage T1c prostate cancer. J Urol. 156:1042–1047; discussion 1047-1049. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Aksoy Y, Oral A, Aksoy H, Demirel A and Akcay F: PSA density and PSA transition zone density in the diagnosis of prostate cancer in PSA gray zone cases. Ann Clin Lab Sci. 33:320–323. 2003.PubMed/NCBI

9 

Elgamal AA, Ectors NL, Sunardhi-Widyaputra S, Van Poppel HP, Van Damme BJ and Baert LV: Detection of prostate specific antigen in pancreas and salivary glands: A potential impact on prostate cancer overestimation. J Urol. 156(2 Pt 1): 464–468. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Lin J, Zhan T, Duffy D, Hoffman-Censits J, Kilpatrick D, Trabulsi EJ, Lallas CD, Chervoneva I, Limentani K, Kennedy B, et al: A pilot phase II Study of digoxin in patients with recurrent prostate cancer as evident by a rising PSA. Am J Cancer Ther Pharmacol. 2:21–32. 2014.

11 

Vickers AJ, Cronin AM, Aus G, Pihl CG, Becker C, Pettersson K, Scardino PT, Hugosson J and Lilja H: Impact of recent screening on predicting the outcome of prostate cancer biopsy in men with elevated prostate-specific antigen: Data from the European Randomized Study of Prostate Cancer Screening in Gothenburg, Sweden. Cancer. 116:2612–2620. 2010.PubMed/NCBI

12 

Pelzer AE, Tewari A, Bektic J, Berger AP, Frauscher F, Bartsch G and Horninger W: Detection rates and biologic significance of prostate cancer with PSA less than 4.0 ng/mL: observation and clinical implications from Tyrol screening project. Urology. 66:1029–1033. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Sella A, Konichezky M, Flex D, Sulkes A and Baniel J: Low PSA metastatic androgen-independent prostate cancer. Eur Urol. 38:250–254. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Pepe P, Panella P, Savoca F, Cacciola A, D'Arrigo L, Dibenedetto G, Pennisi M and Aragona F: Prevalence and clinical significance of prostate cancer among 12,682 men with normal digital rectal examination, low PSA levels (< or =4 ng/ml) and percent free PSA cutoff values of 15 and 20%. Urol Int. 78:308–312. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Trotz C: Prostate cancer with a normal PSA: Small cell carcinoma of the prostate-a rare entity. J Am Board Fam Pract. 16:343–344. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Chien J and Shah GV: Role of stimulatory guanine nucleotide binding protein (GSalpha) in proliferation of PC-3M prostate cancer cells. Int J Cancer. 91:46–54. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Thomas S, Chigurupati S, Anbalagan M and Shah G: Calcitonin increases tumorigenicity of prostate cancer cells: Evidence for the role of protein kinase A and urokinase-type plasminogen receptor. Mol Endocrinol. 20:1894–1911. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Aljameeli A, Thakkar A, Thomas S, Lakshmikanthan V, Iczkowski KA and Shah GV: Calcitonin receptor-zonula occludens-1 interaction is critical for calcitonin-stimulated prostate cancer metastasis. PLoS One. 11:e01500902016. View Article : Google Scholar : PubMed/NCBI

19 

Kale A, Aldahish A and Shah G: Calcitonin receptor is required for T-antigen-induced prostate carcinogenesis. Oncotarget. 11:858–874. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Shah GV, Muralidharan A, Gokulgandhi M, Soan K and Thomas S: Cadherin switching and activation of beta-catenin signaling underlie proinvasive actions of calcitonin-calcitonin receptor axis in prostate cancer. J Biol Chem. 284:1018–1030. 2009. View Article : Google Scholar :

21 

Shah GV, Thomas S, Muralidharan A, Liu Y, Hermonat PL, Williams J and Chaudhary J: Calcitonin promotes in vivo metastasis of prostate cancer cells by altering cell signaling, adhesion, and inflammatory pathways. Endocr Relat Cancer. 15:953–964. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Aldahish A, Kale A, Aljameeli A and Shah GV: Calcitonin induces stem cell-like phenotype in prostate cancer cells. Endocr Relat Cancer. 26:815–828. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Shah GV, Noble MJ, Austenfeld M, Weigel J, Deftos LJ and Mebust WK: Presence of calcitonin-like immunoreactivity (iCT) in human prostate gland: Evidence for iCT secretion by cultured prostate cells. Prostate. 21:87–97. 1992. View Article : Google Scholar : PubMed/NCBI

24 

Aljameeli A, Thakkar A and Shah G: Calcitonin receptor increases invasion of prostate cancer cells by recruiting zonula occludens-1 and promoting PKA-mediated TJ disassembly. Cell Signal. 36:1–13. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Schweinfest C and Papas T: Subtraction hybridization-an approach to the isolation of genes differentially expressed in cancer and other biological-systems. Int J Oncol. 1:499–506. 1992.PubMed/NCBI

26 

Ren Y, Sun YP and Shah GV: Calcitonin inhibits prolactin promoter activity in rat pituitary GGH3 cells: Evidence for the involvement of p42/44 mitogen-activated protein kinase in calcitonin action. Endocrine. 20:13–22. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Ren Y, Chien J, Sun YP and Shah GV: Calcitonin is expressed in gonadotropes of the anterior pituitary gland: Its possible role in paracrine regulation of lactotrope function. J Endocrinol. 171:217–228. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Ma J, Feng Y, Xie W and Li X: PP2A (PR65) in Silver Carp: cDNA cloning and expression analysis. J Biochem Mol Toxicol. 29:399–409. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB, Barrette TR, Anstet MJ, Kincead-Beal C, Kulkarni P, et al: Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia. 9:166–180. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e452001. View Article : Google Scholar : PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

33 

Panoskaltsis-Mortari A and Bucy RP: In situ hybridization with digoxigenin-labeled RNA probes: Facts and artifacts. Biotechniques. 18:300–307. 1995.PubMed/NCBI

34 

Gupta A and Pulliam L: Exosomes as mediators of neuroinflammation. J Neuroinflammation. 11:682014. View Article : Google Scholar : PubMed/NCBI

35 

Wiles HB, Bricker JT, Cooley DA, Nihill MR, Frazier OH, Waldenberger F and McNamara DG: Repeated endomyocardial biopsy without complication in an infant after heart transplantation. J Thorac Cardiovasc Surg. 91:637–638. 1986. View Article : Google Scholar : PubMed/NCBI

36 

Chien J, Wong E, Nikes E, Noble MJ, Pantazis CG and Shah GV: Constitutive activation of stimulatory guanine nucleotide binding protein (G(S)alphaQL)-mediated signaling increases invasiveness and tumorigenicity of PC-3M prostate cancer cells. Oncogene. 18:3376–3382. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Alzghoul S, Hailat M, Zivanovic S, Que L and Shah GV: Measurement of serum prostate cancer markers using a nanopore thin film based optofluidic chip. Biosens Bioelectron. 77:491–498. 2016. View Article : Google Scholar

38 

Shah GV, Deftos LJ and Crowley WR: Synthesis and release of calcitonin-like immunoreactivity by anterior pituitary cells: Evidence for a role in paracrine regulation of prolactin secretion. Endocrinology. 132:1367–1372. 1993. View Article : Google Scholar : PubMed/NCBI

39 

Cai MJ, Zhan FX, Kong XN, Zhu SZ, Cui Y and Wang Q: RING domain of zinc finger protein like 1 is essential for cell proliferation in endometrial cancer cell line RL95-2. Gene. 677:17–23. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Thakkar A, Bijnsdorp IV, Geldof AA and Shah GV: Profiling of the calcitonin-calcitonin receptor axis in primary prostate cancer: Clinical implications and molecular correlates. Oncol Rep. 30:1265–1274. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Thomas S and Shah G: Calcitonin induces apoptosis resistance in prostate cancer cell lines against cytotoxic drugs via the Akt/survivin pathway. Cancer Biol Ther. 4:1226–1233. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Fedotova AA, Bonchuk AN, Mogila VA and Georgiev PG: C2H2 zinc finger proteins: The largest but poorly explored family of higher eukaryotic transcription factors. Acta Naturae. 9:47–58. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Hoppener JW, De Wit MJ, Simarro-Doorten AY, Roijers JF, van Herrewaarden HM, Lips CJ, Parente F, Quincey D, Gaudray P, Khodaei S, et al: A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1. Genomics. 50:251–259. 1998. View Article : Google Scholar : PubMed/NCBI

44 

Klap J, Schmid M and Loughlin KR: The relationship between total testosterone levels and prostate cancer: A review of the continuing controversy. J Urol. 193:403–413. 2015. View Article : Google Scholar

45 

Shah GV: Calcitonin. Encyclopedia of Cancer. 2:16–20. 2009.

46 

Nakamura N: Emerging new roles of GM130, a cis-Golgi matrix protein, in higher order cell functions. J Pharmacol Sci. 112:255–264. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Sun X, Tie HC, Chen B and Lu L: Glycans function as a Golgi export signal to promote the constitutive exocytic trafficking. J Biol Chem. 295:14750–14762. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Chiu CF, Ghanekar Y, Frost L, Diao A, Morrison D, McKenzie E and Lowe M: ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport. EMBO J. 27:934–947. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Appetecchia M, Lauretta R, Sperduti I and Gallucci M: Chromogranin A as a biomarker for prostate cancer: Is it actually relevant for clinical practice? Future Oncol. 14:1233–1235. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Morath I, Hartmann TN and Orian-Rousseau V: CD44: More than a mere stem cell marker. Int J Biochem Cell Biol. 81(Pt A): 166–173. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Iczkowski KA: Cell adhesion molecule CD44: Its functional roles in prostate cancer. Am J Transl Res. 3:1–7. 2010.PubMed/NCBI

52 

van Leenders GJ, Sookhlall R, Teubel WJ, de Ridder CM, Reneman S, Sacchetti A, Vissers KJ, van Weerden W and Jenster G: Activation of c-MET induces a stem-like phenotype in human prostate cancer. PLoS One. 6:e267532011. View Article : Google Scholar : PubMed/NCBI

53 

Kong D, Sethi S, Li Y, Chen W, Sakr WA, Heath E and Sarkar FH: Androgen receptor splice variants contribute to prostate cancer aggressiveness through induction of EMT and expression of stem cell marker genes. Prostate. 75:161–174. 2015. View Article : Google Scholar

54 

Sanchez BG, Bort A, Vara-Ciruelos D and Diaz-Laviada I: Androgen deprivation induces reprogramming of prostate cancer cells to stem-like cells. Cells. 9:14412020. View Article : Google Scholar : PubMed/NCBI

55 

Cerasuolo M, Paris D, Iannotti FA, Melck D, Verde R, Mazzarella E, Motta A and Ligresti A: Neuroendocrine transdifferentiation in human prostate cancer cells: An integrated approach. Cancer Res. 75:2975–2986. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Dhavale M, Abdelaal MK, Alam ABMN, Blazin T, Mohammed LM, Prajapati D, Ballestas NP and Mostafa JA: Androgen receptor signaling and the emergence of lethal neuroendocrine prostate cancer with the treatment-induced suppression of the androgen receptor: A literature review. Cureus. 13:e134022021.PubMed/NCBI

57 

Ito T, Yamamoto S, Ohno Y, Namiki K, Aizawa T, Akiyama A and Tachibana M: Up-regulation of neuroendocrine differentiation in prostate cancer after androgen deprivation therapy, degree and androgen independence. Oncol Rep. 8:1221–1224. 2001.PubMed/NCBI

58 

Chen R, Dong X and Gleave M: Molecular model for neuroendocrine prostate cancer progression. BJU Int. 122:560–570. 2018. View Article : Google Scholar : PubMed/NCBI

59 

Rubin MA, Bristow RG, Thienger PD, Dive C and Imielinski M: Impact of lineage plasticity to and from a neuroendocrine phenotype on progression and response in prostate and lung cancers. Mol Cell. 80:562–577. 2020. View Article : Google Scholar : PubMed/NCBI

60 

Faugeroux V, Pailler E, Oulhen M, Deas O, Brulle-Soumare L, Hervieu C, Marty V, Alexandrova K, Andree KC, Stoecklein NH, et al: Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model. Nat Commun. 11:18842020. View Article : Google Scholar : PubMed/NCBI

61 

Gupta K and Gupta S: Neuroendocrine differentiation in prostate cancer: Key epigenetic players. Transl Cancer Res. 6(Suppl 1): S104–S108. 2017. View Article : Google Scholar : PubMed/NCBI

62 

Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, et al: Clinical and genomic characterization of treatment-emergent small-cell neuroendocrine prostate cancer: A multi-institutional prospective study. J Clin Oncol. 36:2492–2503. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Aggarwal R, Zhang T, Small EJ and Armstrong AJ: Neuroendocrine prostate cancer: Subtypes, biology, and clinical outcomes. J Natl Compr Canc Netw. 12:719–726. 2014. View Article : Google Scholar : PubMed/NCBI

64 

Aggarwal RR and Small EJ: Small-cell/neuroendocrine prostate cancer: A growing threat? Oncology (Williston Park). 28:838–840. 2014.PubMed/NCBI

65 

Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W and Geuze HJ: Exosome: From internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci. 113(Pt 19): 3365–3374. 2000. View Article : Google Scholar : PubMed/NCBI

66 

McAndrews KM and Kalluri R: Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 18:522019. View Article : Google Scholar : PubMed/NCBI

67 

Bang C and Thum T: Exosomes: New players in cell-cell communication. Int J Biochem Cell Biol. 44:2060–2064. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Rappa G, Mercapide J, Anzanello F, Pope RM and Lorico A: Biochemical and biological characterization of exosomes containing prominin-1/CD133. Mol Cancer. 12:622013. View Article : Google Scholar : PubMed/NCBI

69 

Cindolo L, Cantile M, Vacherot F, Terry S and de la Taille A: Neuroendocrine differentiation in prostate cancer: From lab to bedside. Urol Int. 79:287–296. 2007. View Article : Google Scholar : PubMed/NCBI

70 

Beltran H, Rickman DS, Park K, Chae SS, Sboner A, MacDonald TY, Wang Y, Sheikh KL, Terry S, Tagawa ST, et al: Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets. Cancer Discov. 1:487–495. 2011. View Article : Google Scholar

71 

Terry S and Beltran H: The many faces of neuroendocrine differentiation in prostate cancer progression. Front Oncol. 4:602014. View Article : Google Scholar : PubMed/NCBI

72 

Thomas S, Muralidharan A and Shah GV: Knock-down of calcitonin receptor expression induces apoptosis and growth arrest of prostate cancer cells. Int J Oncol. 31:1425–1437. 2007.PubMed/NCBI

73 

Pompura SL and Dominguez-Villar M: The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function. J Leukoc Biol. Jan 22–2018.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

74 

Bluemn EG, Paulson KG, Higgins EE, Sun Y, Nghiem P and Nelson PS: Merkel cell polyomavirus is not detected in prostate cancers, surrounding stroma, or benign prostate controls. J Clin Virol. 44:164–166. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Masud N, Aldahish A, Iczkowski KA, Kale A and Shah GV: Zinc finger protein‑like 1 is a novel neuroendocrine biomarker for prostate cancer Retraction in /10.3892/ijo.2025.5722. Int J Oncol 62: 38, 2023.
APA
Masud, N., Aldahish, A., Iczkowski, K.A., Kale, A., & Shah, G.V. (2023). Zinc finger protein‑like 1 is a novel neuroendocrine biomarker for prostate cancer Retraction in /10.3892/ijo.2025.5722. International Journal of Oncology, 62, 38. https://doi.org/10.3892/ijo.2023.5486
MLA
Masud, N., Aldahish, A., Iczkowski, K. A., Kale, A., Shah, G. V."Zinc finger protein‑like 1 is a novel neuroendocrine biomarker for prostate cancer Retraction in /10.3892/ijo.2025.5722". International Journal of Oncology 62.3 (2023): 38.
Chicago
Masud, N., Aldahish, A., Iczkowski, K. A., Kale, A., Shah, G. V."Zinc finger protein‑like 1 is a novel neuroendocrine biomarker for prostate cancer Retraction in /10.3892/ijo.2025.5722". International Journal of Oncology 62, no. 3 (2023): 38. https://doi.org/10.3892/ijo.2023.5486
Copy and paste a formatted citation
x
Spandidos Publications style
Masud N, Aldahish A, Iczkowski KA, Kale A and Shah GV: Zinc finger protein‑like 1 is a novel neuroendocrine biomarker for prostate cancer Retraction in /10.3892/ijo.2025.5722. Int J Oncol 62: 38, 2023.
APA
Masud, N., Aldahish, A., Iczkowski, K.A., Kale, A., & Shah, G.V. (2023). Zinc finger protein‑like 1 is a novel neuroendocrine biomarker for prostate cancer Retraction in /10.3892/ijo.2025.5722. International Journal of Oncology, 62, 38. https://doi.org/10.3892/ijo.2023.5486
MLA
Masud, N., Aldahish, A., Iczkowski, K. A., Kale, A., Shah, G. V."Zinc finger protein‑like 1 is a novel neuroendocrine biomarker for prostate cancer Retraction in /10.3892/ijo.2025.5722". International Journal of Oncology 62.3 (2023): 38.
Chicago
Masud, N., Aldahish, A., Iczkowski, K. A., Kale, A., Shah, G. V."Zinc finger protein‑like 1 is a novel neuroendocrine biomarker for prostate cancer Retraction in /10.3892/ijo.2025.5722". International Journal of Oncology 62, no. 3 (2023): 38. https://doi.org/10.3892/ijo.2023.5486
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team