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Article Open Access

Keratin19 promotes pancreatic cancer progression and poor prognosis via activating the Hedgehog pathway

  • Authors:
    • Changsheng Zhou
    • Yi Xiang
    • Yantao Ren
    • Ming Li
    • Xin Gou
    • Wengang Li
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Xiamen University, Xiamen, Fujian 361102, P.R. China, Department of Hepatobiliary Surgery, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, P.R. China, Xiamen Medicine Research Institute, Xiamen, Fujian 361005, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 43
    |
    Published online on: February 21, 2023
       https://doi.org/10.3892/ijo.2023.5491
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Abstract

Pancreatic cancer is a serious threat to human health, with strong invasiveness, rapid progression and poor prognosis. Tumors expressing keratin 19 (K19) have stronger invasiveness and a worse prognosis. However, the role and mechanism of K19 in pancreatic cancer have remained largely elusive. In the present study, K19 expression was detected in pancreatic cancer tissues, its effect on proliferation, apoptosis and metastasis of pancreatic cancer at the cellular, in vivo preclinical and clinical levels was evaluated and its effect on the Hedgehog pathway was analyzed. K19 was significantly overexpressed in pancreatic cancer, promoted pancreatic cancer proliferation and metastasis, inhibited tumor cell apoptosis and was associated with poor prognosis. Mechanistically, these effects were mediated through the activation of the Hedgehog pathway. In conclusion, K19 may be a novel target molecule for pancreatic cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou C, Xiang Y, Ren Y, Li M, Gou X and Li W: Keratin19 promotes pancreatic cancer progression and poor prognosis via activating the Hedgehog pathway. Int J Oncol 62: 43, 2023.
APA
Zhou, C., Xiang, Y., Ren, Y., Li, M., Gou, X., & Li, W. (2023). Keratin19 promotes pancreatic cancer progression and poor prognosis via activating the Hedgehog pathway. International Journal of Oncology, 62, 43. https://doi.org/10.3892/ijo.2023.5491
MLA
Zhou, C., Xiang, Y., Ren, Y., Li, M., Gou, X., Li, W."Keratin19 promotes pancreatic cancer progression and poor prognosis via activating the Hedgehog pathway". International Journal of Oncology 62.3 (2023): 43.
Chicago
Zhou, C., Xiang, Y., Ren, Y., Li, M., Gou, X., Li, W."Keratin19 promotes pancreatic cancer progression and poor prognosis via activating the Hedgehog pathway". International Journal of Oncology 62, no. 3 (2023): 43. https://doi.org/10.3892/ijo.2023.5491
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou C, Xiang Y, Ren Y, Li M, Gou X and Li W: Keratin19 promotes pancreatic cancer progression and poor prognosis via activating the Hedgehog pathway. Int J Oncol 62: 43, 2023.
APA
Zhou, C., Xiang, Y., Ren, Y., Li, M., Gou, X., & Li, W. (2023). Keratin19 promotes pancreatic cancer progression and poor prognosis via activating the Hedgehog pathway. International Journal of Oncology, 62, 43. https://doi.org/10.3892/ijo.2023.5491
MLA
Zhou, C., Xiang, Y., Ren, Y., Li, M., Gou, X., Li, W."Keratin19 promotes pancreatic cancer progression and poor prognosis via activating the Hedgehog pathway". International Journal of Oncology 62.3 (2023): 43.
Chicago
Zhou, C., Xiang, Y., Ren, Y., Li, M., Gou, X., Li, W."Keratin19 promotes pancreatic cancer progression and poor prognosis via activating the Hedgehog pathway". International Journal of Oncology 62, no. 3 (2023): 43. https://doi.org/10.3892/ijo.2023.5491
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