Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
June-2023 Volume 62 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2023 Volume 62 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

New insights into lipid metabolism and prostate cancer (Review)

  • Authors:
    • Zhengliang Zhang
    • Weixi Wang
    • Piaoping Kong
    • Kangle Feng
    • Chunhua Liu
    • Tao Sun
    • Yiwen Sang
    • Xiuzhi Duan
    • Zhihua Tao
    • Weiwei Liu
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Blood Transfusion, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 74
    |
    Published online on: May 17, 2023
       https://doi.org/10.3892/ijo.2023.5522
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Prostate cancer (PCa) is the most common malignant tumor of the male urological system and poses a severe threat to the survival of middle‑aged and elderly males worldwide. The development and progression of PCa are affected by a variety of biological processes, including proliferation, apoptosis, migration, invasion and the maintenance of membrane homeostasis of PCa cells. The present review summarizes recent research advances in lipid (fatty acid, cholesterol and phospholipid) metabolic pathways in PCa. In the first section, the metabolism of fatty acids is highlighted, from formation to catabolism and associated proteins. Subsequently, the role of cholesterol in the pathogenesis and evolution of PCa is described in detail. Finally, the different types of phospholipids and their association with PCa progression is also discussed. In addition to the impact of key proteins of lipid metabolism on PCa growth, metastasis and drug resistance, the present review also summarizes the clinical value of fatty acids, cholesterol and phospholipids, as diagnostic and prognostic indicators and therapeutic targets in PCa.
View Figures

Figure 1

Figure 2

View References

1 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2022. CA Cancer J Clin. 72:7–33. 2022.

2 

Culp MB, Soerjomataram I, Efstathiou JA, Bray F and Jemal A: Recent global patterns in prostate cancer incidence and mortality rates. Eur Urol. 77:38–52. 2020.

3 

Milliron BJ, Bruneau M, Obeid E, Gross L, Bealin L, Smaltz C and Giri VN: Diet assessment among men undergoing genetic counseling and genetic testing for inherited prostate cancer: Exploring a teachable moment to support diet intervention. Prostate. 79:778–783. 2019.

4 

Hanahan D: Hallmarks of cancer: New dimensions. Cancer Discov. 12:31–46. 2022.

5 

Pavlova NN, Zhu J and Thompson CB: The hallmarks of cancer metabolism: Still emerging. Cell Metab. 34:355–377. 2022.

6 

Flavahan WA, Gaskell E and Bernstein BE: Epigenetic plasticity and the hallmarks of cancer. Science. 357:eaal23802017.

7 

Liberti MV and Locasale JW: The Warburg effect: How does it benefit cancer cells? Trends Biochem Sci. 41:211–218. 2016.

8 

Chaudagar K, Hieromnimon HM, Khurana R, Labadie B, Hirz T, Mei S, Hasan R, Shafran J, Kelley A, Apostolov E, et al: Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer. Clin Cancer Res. Mar;2023:2023.Epub ahead of print.

9 

Poulose N, Amoroso F, Steele RE, Singh R, Ong CW and Mills IG: Genetics of lipid metabolism in prostate cancer. Nat Genet. 50:169–171. 2018.

10 

Laurent V, Guérard A, Mazerolles C, Le Gonidec S, Toulet A, Nieto L, Zaidi F, Majed B, Garandeau D, Socrier Y, et al: Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity. Nat Commun. 7:102302016.

11 

Fontaine A, Bellanger D, Guibon R, Bruyère F, Brisson L and Fromont G: Lipophagy and prostate cancer: Association with disease aggressiveness and proximity to periprostatic adipose tissue. J Pathol. 255:166–176. 2021.

12 

Kuemmerle NB, Rysman E, Lombardo PS, Flanagan AJ, Lipe BC, Wells WA, Pettus JR, Froehlich HM, Memoli VA, Morganelli PM, et al: Lipoprotein lipase links dietary fat to solid tumor cell proliferation. Mol Cancer Ther. 10:427–436. 2011.

13 

De Piano M, Manuelli V, Zadra G, Otte J, Edqvist PD, Pontén F, Nowinski S, Niaouris A, Grigoriadis A, Loda M, et al: Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases. Oncogene. 39:3666–3679. 2020.

14 

Gazi E, Gardner P, Lockyer NP, Hart CA, Brown MD and Clarke NW: Direct evidence of lipid translocation between adipocytes and prostate cancer cells with imaging FTIR microspectroscopy. J Lipid Res. 48:1846–1856. 2007.

15 

Centenera MM, Scott JS, Machiels J, Nassar ZD, Miller DC, Zinonos I, Dehairs J, Burvenich IJG, Zadra G, Chetta PM, et al: ELOVL5 is a critical and targetable fatty acid elongase in prostate cancer. Cancer Res. 81:1704–1718. 2021.

16 

Yue S, Li J, Lee SY, Lee HJ, Shao T, Song B, Cheng L, Masterson TA, Liu X, Ratliff TL and Cheng JX: Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness. Cell Metab. 19:393–406. 2014.

17 

DeBerardinis RJ and Chandel NS: Fundamentals of cancer metabolism. Sci Adv. 2:e16002002016.

18 

Weiss L, Hoffmann GE, Schreiber R, Andres H, Fuchs E, Körber E and Kolb HJ: Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Biol Chem Hoppe Seyler. 367:905–912. 1986.

19 

Dirat B, Bochet L, Dabek M, Daviaud D, Dauvillier S, Majed B, Wang YY, Meulle A, Salles B, Le Gonidec S, et al: Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res. 71:2455–2465. 2011.

20 

Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, et al: Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 17:1498–1503. 2011.

21 

Gomaraschi M: Role of lipoproteins in the microenvironment of hormone-dependent cancers. Trends Endocrinol Metab. 31:256–268. 2020.

22 

Watt MJ, Clark AK, Selth LA, Haynes VR, Lister N, Rebello R, Porter LH, Niranjan B, Whitby ST, Lo J, et al: Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer. Sci Transl Med. 11:eaau57582019.

23 

Batchuluun B, Pinkosky SL and Steinberg GR: Lipogenesis inhibitors: Therapeutic opportunities and challenges. Nat Rev Drug Discov. 21:283–305. 2022.

24 

Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, et al: ATP-citrate lyase controls a glucose-to-acetate metabolic switch. Cell Rep. 17:1037–1052. 2016.

25 

Galbraith L, Leung HY and Ahmad I: Lipid pathway deregulation in advanced prostate cancer. Pharmacol Res. 131:177–184. 2018.

26 

Gao Y, Islam MS, Tian J, Lui VWY and Xiao D: Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth. Cancer Lett. 349:15–25. 2014.

27 

Hunkeler M, Hagmann A, Stuttfeld E, Chami M, Guri Y, Stahlberg H and Maier T: Structural basis for regulation of human acetyl-CoA carboxylase. Nature. 558:470–474. 2018.

28 

Rios Garcia M, Steinbauer B, Srivastava K, Singhal M, Mattijssen F, Maida A, Christian S, Hess-Stumpp H, Augustin HG, Müller-Decker K, et al: Acetyl-CoA carboxylase 1-dependent protein acetylation controls breast cancer metastasis and recurrence. Cell Metab. 26:842–855.e5. 2017.

29 

Zhao S, Cheng L, Shi Y, Li J, Yun Q and Yang H: MIEF2 reprograms lipid metabolism to drive progression of ovarian cancer through ROS/AKT/mTOR signaling pathway. Cell Death Dis. 12:182021.

30 

Lally JSV, Ghoshal S, DePeralta DK, Moaven O, Wei L, Masia R, Erstad DJ, Fujiwara N, Leong V, Houde VP, et al: Inhibition of acetyl-CoA carboxylase by phosphorylation or the inhibitor ND-654 suppresses lipogenesis and hepatocellular carcinoma. Cell Metab. 29:174–182.e5. 2019.

31 

Raimondo S, Saieva L, Cristaldi M, Monteleone F, Fontana S and Alessandro R: Label-free quantitative proteomic profiling of colon cancer cells identifies acetyl-CoA carboxylase alpha as antitumor target of Citrus limon-derived nanovesicles. J Proteomics. 173:1–11. 2018.

32 

Brusselmans K, De Schrijver E, Verhoeven G and Swinnen JV: RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res. 65:6719–6725. 2005.

33 

O'Malley J, Kumar R, Kuzmin AN, Pliss A, Yadav N, Balachandar S, Wang J, Attwood K, Prasad PN and Chandra D: Lipid quantification by Raman microspectroscopy as a potential biomarker in prostate cancer. Cancer Lett. 397:52–60. 2017.

34 

Nguyen PL, Ma J, Chavarro JE, Freedman ML, Lis R, Fedele G, Fiore C, Qiu W, Fiorentino M, Finn S, et al: Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival. J Clin Oncol. 28:3958–3964. 2010.

35 

Rossi S, Graner E, Febbo P, Weinstein L, Bhattacharya N, Onody T, Bubley G, Balk S and Loda M: Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. Mol Cancer Res. 1:707–715. 2003.

36 

Li X, Chen YT, Hu P and Huang WC: Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling. Mol Cancer Ther. 13:855–866. 2014.

37 

Migita T, Ruiz S, Fornari A, Fiorentino M, Priolo C, Zadra G, Inazuka F, Grisanzio C, Palescandolo E, Shin E, et al: Fatty acid synthase: A metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst. 101:519–532. 2009.

38 

Wu X, Dong Z, Wang CJ, Barlow LJ, Fako V, Serrano MA, Zou Y, Liu JY and Zhang JT: FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1. Proc Natl Acad Sci USA. 113:E6965–E6973. 2016.

39 

Ventura R, Mordec K, Waszczuk J, Wang Z, Lai J, Fridlib M, Buckley D, Kemble G and Heuer TS: Inhibition of de novo palmitate synthesis by fatty acid synthase induces apoptosis in tumor cells by remodeling cell membranes, inhibiting signaling pathways, and reprogramming gene expression. EBioMedicine. 2:808–824. 2015.

40 

Zadra G, Ribeiro CF, Chetta P, Ho Y, Cacciatore S, Gao X, Syamala S, Bango C, Photopoulos C, Huang Y, et al: Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer. Proc Natl Acad Sci USA. 116:631–640. 2019.

41 

Agostini M, Almeida LY, Bastos DC, Ortega RM, Moreira FS, Seguin F, Zecchin KG, Raposo HF, Oliveira HC, Amoêdo ND, et al: The fatty acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas. Mol Cancer Ther. 13:585–595. 2014.

42 

Menendez JA, Vellon L and Lupu R: Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: Blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene. Ann Oncol. 16:1253–1267. 2005.

43 

Wright C, Iyer AKV, Kaushik V and Azad N: Anti-tumorigenic potential of a novel orlistat-AICAR combination in prostate cancer cells. J Cell Biochem. 118:3834–3845. 2017.

44 

Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avancès C, Allory Y, de la Taille A, Culine S, Blancou H, et al: Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther. 9:1740–1754. 2010.

45 

Kim SJ, Choi H, Park SS, Chang C and Kim E: Stearoyl CoA desaturase (SCD) facilitates proliferation of prostate cancer cells through enhancement of androgen receptor transactivation. Mol Cells. 31:371–377. 2011.

46 

Contreras-López EF, Cruz-Hernández CD, Cortés-Ramírez SA, Ramírez-Higuera A, Peña-Montes C, Rodríguez-Dorantes M and Oliart-Ros RM: Inhibition of stearoyl-CoA desaturase by sterculic oil reduces proliferation and induces apoptosis in prostate cancer cell lines. Nutr Cancer. 74:1308–1321. 2022.

47 

Yi J, Zhu J, Wu J, Thompson CB and Jiang X: Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis. Proc Natl Acad Sci USA. 117:31189–31197. 2020.

48 

Berquin IM, Edwards IJ, Kridel SJ and Chen YQ: Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev. 30:295–309. 2011.

49 

Staubach S and Hanisch FG: Lipid rafts: Signaling and sorting platforms of cells and their roles in cancer. Expert Rev Proteomics. 8:263–277. 2011.

50 

Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS and Stockwell BR: Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci USA. 113:E4966–E4975. 2016.

51 

Tamura K, Makino A, Hullin-Matsuda F, Kobayashi T, Furihata M, Chung S, Ashida S, Miki T, Fujioka T, Shuin T, et al: Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism. Cancer Res. 69:8133–8140. 2009.

52 

Hu T, Zhang H, Du Y, Luo S, Yang X, Zhang H, Feng J, Chen X, Tu X, Wang C and Zhang Y: ELOVL2 restrains cell proliferation, migration, and invasion of prostate cancer via regulation of the tumor suppressor INPP4B. Cell Signal. 96:1103732022.

53 

Xu H, Li S, Sun Y, Xu L, Hong X, Wang Z and Hu H: ELOVL5-mediated long chain fatty acid elongation contributes to enzalutamide resistance of prostate cancer. Cancers (Basel). 13:39572021.

54 

Chen M, Zhang J, Sampieri K, Clohessy JG, Mendez L, Gonzalez-Billalabeitia E, Liu XS, Lee YR, Fung J, Katon JM, et al: An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. Nat Genet. 50:206–218. 2018.

55 

Lee HJ, Jung YH, Choi GE, Ko SH, Lee SJ, Lee SH and Han HJ: BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells. Redox Biol. 13:426–443. 2017.

56 

Huang WC, Li X, Liu J, Lin J and Chung LWK: Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells. Mol Cancer Res. 10:133–142. 2012.

57 

Hsieh PF, Jiang WP, Basavaraj P, Huang SY, Ruangsai P, Wu JB, Huang GJ and Huang WC: Cell suspension culture extract of Eriobotrya japonica attenuates growth and induces apoptosis in prostate cancer cells via targeting SREBP-1/FASN-driven metabolism and AR. Phytomedicine. 93:1538062021.

58 

Kanagasabai T, Li G, Shen TH, Gladoun N, Castillo-Martin M, Celada SI, Xie Y, Brown LK, Mark ZA, Ochieng J, et al: MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway. Cancer Lett. 525:46–54. 2022.

59 

Shangguan X, Ma Z, Yu M, Ding J, Xue W and Qi J: Squalene epoxidase metabolic dependency is a targetable vulnerability in castration-resistant prostate cancer. Cancer Res. 82:3032–3044. 2022.

60 

Krycer JR, Phan L and Brown AJ: A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products. Biochem J. 446:191–201. 2012.

61 

Storch J and Corsico B: The emerging functions and mechanisms of mammalian fatty acid-binding proteins. Annu Rev Nutr. 28:73–95. 2008.

62 

Li B, Hao J, Zeng J and Sauter ER: SnapShot: FABP functions. Cell. 182:1066–1066.e1. 2020.

63 

Cher ML, Bova GS, Moore DH, Small EJ, Carroll PR, Pin SS, Epstein JI, Isaacs WB and Jensen RH: Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping. Cancer Res. 56:3091–3102. 1996.

64 

Taylor BS, Schultz N, Hieronymus H, Gopalan A, Xiao Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, et al: Integrative genomic profiling of human prostate cancer. Cancer Cell. 18:11–22. 2010.

65 

Yang PB, Hou PP, Liu FY, Hong WB, Chen HZ, Sun XY, Li P, Zhang Y, Ju CY, Luo LJ, et al: Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression. Proc Natl Acad Sci USA. 117:27412–27422. 2020.

66 

Liu RZ and Godbout R: An amplified fatty acid-binding protein gene cluster in prostate cancer: Emerging roles in lipid metabolism and metastasis. Cancers (Basel). 12:38232020.

67 

Guo Y, Liu Y, Zhao S, Xu W, Li Y, Zhao P, Wang D, Cheng H, Ke Y and Zhang X: Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages. Nat Commun. 12:70942021.

68 

Montaigne D, Butruille L and Staels B: PPAR control of metabolism and cardiovascular functions. Nat Rev Cardiol. 18:809–823. 2021.

69 

Aguilar-Recarte D, Barroso E, Gumà A, Pizarro-Delgado J, Peña L, Ruart M, Palomer X, Wahli W and Vázquez-Carrera M: GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK. Cell Rep. 36:1095012021.

70 

Ahmad I, Mui E, Galbraith L, Patel R, Tan EH, Salji M, Rust AG, Repiscak P, Hedley A, Markert E, et al: Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer. Proc Natl Acad Sci USA. 113:8290–8295. 2016.

71 

Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, et al: A hormone complex of FABP4 and nucleoside kinases regulates islet function. Nature. 600:720–726. 2021.

72 

Massillo C, Dalton GN, Porretti J, Scalise GD, Farré PL, Piccioni F, Secchiari F, Pascuali N, Clyne C, Gardner K, et al: CTBP1/CYP19A1/estradiol axis together with adipose tissue impacts over prostate cancer growth associated to metabolic syndrome. Int J Cancer. 144:1115–1127. 2019.

73 

Harraz AM, Atia N, Ismail A, Shady A, Farg H, Gabr H, Fouda M, Abol-Enein H and Abdel-Aziz AF: Evaluation of serum fatty acid binding protein-4 (FABP-4) as a novel biomarker to predict biopsy outcomes in prostate biopsy naïve patients. Int Urol Nephrol. 52:1483–1490. 2020.

74 

Carbonetti G, Wilpshaar T, Kroonen J, Studholme K, Converso C, d'Oelsnitz S and Kaczocha M: FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. Sci Rep. 9:189442019.

75 

Hou Y, Wei D, Zhang Z, Guo H, Li S, Zhang J, Zhang P, Zhang L and Zhao Y: FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism. Cell Rep. 41:1116682022.

76 

Carbonetti G, Converso C, Clement T, Wang C, Trotman LC, Ojima I and Kaczocha M: Docetaxel/cabazitaxel and fatty acid binding protein 5 inhibitors produce synergistic inhibition of prostate cancer growth. Prostate. 80:88–98. 2020.

77 

Adamson J, Morgan EA, Beesley C, Mei Y, Foster CS, Fujii H, Rudland PS, Smith PH and Ke Y: High-level expression of cutaneous fatty acid-binding protein in prostatic carcinomas and its effect on tumorigenicity. Oncogene. 22:2739–2749. 2003.

78 

O'Sullivan SE and Kaczocha M: FABP5 as a novel molecular target in prostate cancer. Drug Discov Today. Sep 20–2020.Epub ahead of print.

79 

Liu RZ, Choi WS, Jain S, Dinakaran D, Xu X, Han WH, Yang XH, Glubrecht DD, Moore RB, Lemieux H and Godbout R: The FABP12/PPARγ pathway promotes metastatic transformation by inducing epithelial-to-mesenchymal transition and lipid-derived energy production in prostate cancer cells. Mol Oncol. 14:3100–3120. 2020.

80 

Javed S and Langley SEM: Importance of HOX genes in normal prostate gland formation, prostate cancer development and its early detection. BJU Int. 113:535–540. 2014.

81 

Xu F, Shangguan X, Pan J, Yue Z, Shen K, Ji Y, Zhang W, Zhu Y, Sha J, Wang Y, et al: HOXD13 suppresses prostate cancer metastasis and BMP4-induced epithelial-mesenchymal transition by inhibiting SMAD1. Int J Cancer. 148:3060–3070. 2021.

82 

Long Z, Li Y, Gan Y, Zhao D, Wang G, Xie N, Lovnicki JM, Fazli L, Cao Q, Chen K and Dong X: Roles of the HOXA10 gene during castrate-resistant prostate cancer progression. Endocr Relat Cancer. 26:279–292. 2019.

83 

Hatanaka Y, de Velasco MA, Oki T, Shimizu N, Nozawa M, Yoshimura K, Yoshikawa K, Nishio K and Uemura H: HOXA10 expression profiling in prostate cancer. Prostate. 79:554–563. 2019.

84 

Carracedo A, Cantley LC and Pandolfi PP: Cancer metabolism: Fatty acid oxidation in the limelight. Nat Rev Cancer. 13:227–232. 2013.

85 

Liu Y: Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer. Prostate Cancer Prostatic Dis. 9:230–234. 2006.

86 

Tennakoon JB, Shi Y, Han JJ, Tsouko E, White MA, Burns AR, Zhang A, Xia X, Ilkayeva OR, Xin L, et al: Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch. Oncogene. 33:5251–5261. 2014.

87 

Bramhecha YM, Guérard KP, Audet-Walsh É, Rouzbeh S, Kassem O, Pernet E, Scarlata E, Hamel L, Brimo F, Divangahi M, et al: Fatty acid oxidation enzyme Δ3, Δ2-enoyl-CoA isomerase 1 (ECI1) drives aggressive tumor phenotype and predicts poor clinical outcome in prostate cancer patients. Oncogene. 41:2798–2810. 2022.

88 

Bravo-Sagua R, Parra V, López-Crisosto C, Díaz P, Quest AF and Lavandero S: Calcium transport and signaling in mitochondria. Compr Physiol. 7:623–634. 2017.

89 

Butler LM, Centenera MM and Swinnen JV: Androgen control of lipid metabolism in prostate cancer: Novel insights and future applications. Endocr Relat Cancer. 23:R219–R227. 2016.

90 

Adamopoulos PG, Kontos CK and Scorilas A: Molecular characterization, genomic structure and expression analysis of a gene (CATL1/CPT1C) encoding a third member of the human carnitine acyltransferase family. Genomics. May 22–2019.Epub ahead of print.

91 

Fondevila MF, Fernandez U, Heras V, Parracho T, Gonzalez-Rellan MJ, Novoa E, Porteiro B, Alonso C, Mayo R, da Silva Lima N, et al: Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis. J Hepatol. 77:15–28. 2022.

92 

Joshi M, Stoykova GE, Salzmann-Sullivan M, Dzieciatkowska M, Liebman LN, Deep G and Schlaepfer IR: CPT1A supports castration-resistant prostate cancer in androgen-deprived conditions. Cells. 8:11152019.

93 

Abudurexiti M, Zhu W, Wang Y, Wang J, Xu W, Huang Y, Zhu Y, Shi G, Zhang H, Zhu Y, et al: Targeting CPT1B as a potential therapeutic strategy in castration-resistant and enzalutamide-resistant prostate cancer. Prostate. 80:950–961. 2020.

94 

Simons K and Ikonen E: How cells handle cholesterol. Science. 290:1721–1726. 2000.

95 

El-Kenawi A, Dominguez-Viqueira W, Liu M, Awasthi S, Abraham-Miranda J, Keske A, Steiner KK, Noel L, Serna AN, Dhillon J, et al: Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer. Cancer Res. 81:5477–5490. 2021.

96 

Garcia-Bermudez J, Baudrier L, Bayraktar EC, Shen Y, La K, Guarecuco R, Yucel B, Fiore D, Tavora B, Freinkman E, et al: Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. 567:118–122. 2019.

97 

Revilla G, Cedó L, Tondo M, Moral A, Pérez JI, Corcoy R, Lerma E, Fuste V, Reddy ST, Blanco-Vaca F, et al: LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies. Semin Cancer Biol. 73:134–157. 2021.

98 

Shen WJ, Azhar S and Kraemer FB: SR-B1: A unique multifunctional receptor for cholesterol influx and efflux. Annu Rev Physiol. 80:95–116. 2018.

99 

Leon CG, Locke JA, Adomat HH, Etinger SL, Twiddy AL, Neumann RD, Nelson CC, Guns ES and Wasan KM: Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model. Prostate. 70:390–400. 2010.

100 

Ediriweera MK: Use of cholesterol metabolism for anti-cancer strategies. Drug Discov Today. 27:Sep 7–2022.Epub ahead of print.

101 

Hilvo M, Denkert C, Lehtinen L, Müller B, Brockmöller S, Seppänen-Laakso T, Budczies J, Bucher E, Yetukuri L, Castillo S, et al: Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Res. 71:3236–3245. 2011.

102 

Gordon JA, Noble JW, Midha A, Derakhshan F, Wang G, Adomat HH, Tomlinson Guns ES, Lin YY, Ren S, Collins CC, et al: Upregulation of scavenger receptor B1 is required for steroidogenic and nonsteroidogenic cholesterol metabolism in prostate cancer. Cancer Res. 79:3320–3331. 2019.

103 

Wang B, Rong X, Palladino END, Wang J, Fogelman AM, Martín MG, Alrefai WA, Ford DA and Tontonoz P: Phospholipid remodeling and cholesterol availability regulate intestinal stemness and tumorigenesis. Cell Stem Cell. 22:206–220.e4. 2018.

104 

Pandey M, Cuddihy G, Gordon JA, Cox ME and Wasan KM: Inhibition of scavenger receptor class B type 1 (SR-B1) expression and activity as a potential novel target to disrupt cholesterol availability in castration-resistant prostate cancer. Pharmaceutics. 13:15092021.

105 

Pommier AJC, Alves G, Viennois E, Bernard S, Communal Y, Sion B, Marceau G, Damon C, Mouzat K, Caira F, et al: Liver X receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Oncogene. 29:2712–2723. 2010.

106 

Locke JA, Wasan KM, Nelson CC, Guns ES and Leon CG: Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A: Cholesterol acyltransferase (ACAT). Prostate. 68:20–33. 2008.

107 

Raftopulos NL, Washaya TC, Niederprüm A, Egert A, Hakeem-Sanni MF, Varney B, Aishah A, Georgieva ML, Olsson E, Dos Santos DZ, et al: Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover. Cancer Metab. 10:12022.

108 

Cai C and Balk SP: Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy. Endocr Relat Cancer. 18:R175–R182. 2011.

109 

An T, Zhang X, Li H, Dou L, Huang X, Man Y, Zhang X, Shen T, Li G, Li J and Tang W: GPR120 facilitates cholesterol efflux in macrophages through activation of AMPK signaling pathway. FEBS J. 287:5080–5095. 2020.

110 

Hu YW, Yang JY, Ma X, Chen ZP, Hu YR, Zhao JY, Li SF, Qiu YR, Lu JB, Wang YC, et al: A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis. J Lipid Res. 55:681–697. 2014.

111 

Locke JA, Nelson CC, Adomat HH, Hendy SC, Gleave ME and Guns ES: Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts. J Steroid Biochem Mol Biol. 115:126–136. 2009.

112 

Stopsack KH, Gerke TA, Sinnott JA, Penney KL, Tyekucheva S, Sesso HD, Andersson SO, Andrén O, Cerhan JR, Giovannucci EL, et al: Cholesterol metabolism and prostate cancer lethality. Cancer Res. 76:4785–4790. 2016.

113 

Dambal S, Alfaqih M, Sanders S, Maravilla E, Ramirez-Torres A, Galvan GC, Reis-Sobreiro M, Rotinen M, Driver LM, Behrove MS, et al: 27-Hydroxycholesterol impairs plasma membrane lipid raft signaling as evidenced by inhibition of IL6-JAK-STAT3 signaling in prostate cancer cells. Mol Cancer Res. 18:671–684. 2020.

114 

Zhuang L, Lin J, Lu ML, Solomon KR and Freeman MR: Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells. Cancer Res. 62:2227–2231. 2002.

115 

Freeman MR and Solomon KR: Cholesterol and prostate cancer. J Cell Biochem. 91:54–69. 2004.

116 

Jiang S, Wang X, Song D, Liu X, Gu Y, Xu Z, Wang X, Zhang X, Ye Q, Tong Z, et al: Cholesterol induces epithelial-to-mesenchymal transition of prostate cancer cells by suppressing degradation of EGFR through APMAP. Cancer Res. 79:3063–3075. 2019.

117 

Waugh MG, Lawson D and Hsuan JJ: Epidermal growth factor receptor activation is localized within low-buoyant density, non-caveolar membrane domains. Biochem J. 337:591–597. 1999.

118 

Márquez DC, Chen HW, Curran EM, Welshons WV and Pietras RJ: Estrogen receptors in membrane lipid rafts and signal transduction in breast cancer. Mol Cell Endocrinol. 246:91–100. 2006.

119 

Freeman MR, Cinar B and Lu ML: Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer. Trends Endocrinol Metab. 16:273–279. 2005.

120 

Legembre P, Daburon S, Moreau P, Ichas F, de Giorgi F, Moreau JF and Taupin JL: Amplification of Fas-mediated apoptosis in type II cells via microdomain recruitment. Mol Cell Biol. 25:6811–6820. 2005.

121 

Priolo C, Pyne S, Rose J, Regan ER, Zadra G, Photopoulos C, Cacciatore S, Schultz D, Scaglia N, McDunn J, et al: AKT1 and MYC induce distinctive metabolic fingerprints in human prostate cancer. Cancer Res. 74:7198–7204. 2014.

122 

Dong P, Flores J, Pelton K and Solomon KR: Prohibitin is a cholesterol-sensitive regulator of cell cycle transit. J Cell Biochem. 111:1367–1374. 2010.

123 

Lee BH, Taylor MG, Robinet P, Smith JD, Schweitzer J, Sehayek E, Falzarano SM, Magi-Galluzzi C, Klein EA and Ting AH: Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1. Cancer Res. 73:1211–1218. 2013.

124 

Migita T, Takayama KI, Urano T, Obinata D, Ikeda K, Soga T, Takahashi S and Inoue S: ACSL3 promotes intratumoral steroidogenesis in prostate cancer cells. Cancer Sci. 108:2011–2021. 2017.

125 

Locke JA, Guns ES, Lehman ML, Ettinger S, Zoubeidi A, Lubik A, Margiotti K, Fazli L, Adomat H, Wasan KM, et al: Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance. Prostate. 70:239–251. 2010.

126 

Masko EM, Allott EH and Freedland SJ: The relationship between nutrition and prostate cancer: Is more always better? Eur Urol. 63:810–820. 2013.

127 

Pardo JC, Ruiz de Porras V, Gil J, Font A, Puig-Domingo M and Jordà M: Lipid metabolism and epigenetics crosstalk in prostate cancer. Nutrients. 14:8512022.

128 

Allott EH and Freedland SJ: Words of wisdom. Re: Impact of circulating cholesterol levels on growth and intratumoral androgen concentration of prostate tumors. Eur Urol. 63:178–179. 2013.

129 

Zhuang L, Kim J, Adam RM, Solomon KR and Freeman MR: Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest. 115:959–968. 2005.

130 

Platz EA, Till C, Goodman PJ, Parnes HL, Figg WD, Albanes D, Neuhouser ML, Klein EA, Thompson IM Jr and Kristal AR: Men with low serum cholesterol have a lower risk of high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev. 18:2807–2813. 2009.

131 

Magura L, Blanchard R, Hope B, Beal JR, Schwartz GG and Sahmoun AE: Hypercholesterolemia and prostate cancer: A hospital-based case-control study. Cancer Causes Control. 19:1259–1266. 2008.

132 

Platz EA, Leitzmann MF, Visvanathan K, Rimm EB, Stampfer MJ, Willett WC and Giovannucci E: Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst. 98:1819–1825. 2006.

133 

Sherwin RW, Wentworth DN, Cutler JA, Hulley SB, Kuller LH and Stamler J: Serum cholesterol levels and cancer mortality in 361,662 men screened for the multiple risk factor intervention trial. JAMA. 257:943–948. 1987.

134 

Ribas V, García-Ruiz C and Fernández-Checa JC: Mitochondria, cholesterol and cancer cell metabolism. Clin Transl Med. 5:222016.

135 

Solomon KR and Freeman MR: The complex interplay between cholesterol and prostate malignancy. Urol Clin North Am. 38:243–259. 2011.

136 

Komoroski RA, Holder JC, Pappas AA and Finkbeiner AE: 31P NMR of phospholipid metabolites in prostate cancer and benign prostatic hyperplasia. Magn Reson Med. 65:911–913. 2011.

137 

Philips BWJ, van Uden MJ, Rietsch SHG, Orzada S and Scheenen TWJ: A multitransmit external body array combined with a 1 H and 31 P endorectal coil to enable a multiparametric and multimetabolic MRI examination of the prostate at 7T. Med Phys. 46:3893–3905. 2019.

138 

Kwan KH, Burvenich IJG, Centenera MM, Goh YW, Rigopoulos A, Dehairs J, Swinnen JV, Raj GV, Hoy AJ, Butler LM, et al: Synthesis and fluorine-18 radiolabeling of a phospholipid as a PET imaging agent for prostate cancer. Nucl Med Biol. 93:37–45. 2021.

139 

Randall EC, Zadra G, Chetta P, Lopez BGC, Syamala S, Basu SS, Agar JN, Loda M, Tempany CM, Fennessy FM and Agar NYR: Molecular characterization of prostate cancer with associated gleason score using mass spectrometry imaging. Mol Cancer Res. 17:1155–1165. 2019.

140 

Lin HM, Mahon KL, Weir JM, Mundra PA, Spielman C, Briscoe K, Gurney H, Mallesara G, Marx G, Stockler MR, et al: A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer. Int J Cancer. 141:2112–2120. 2017.

141 

Patton KT, Chen HM, Joseph L and Yang XJ: Decreased annexin I expression in prostatic adenocarcinoma and in high-grade prostatic intraepithelial neoplasia. Histopathology. 47:597–601. 2005.

142 

Beyene DA, Naab TJ, Kanarek NF, Apprey V, Esnakula A, Khan FA, Blackman MR, Brown CA and Hudson TS: Differential expression of annexin 2, SPINK1, and Hsp60 predict progression of prostate cancer through bifurcated WHO Gleason score categories in African American men. Prostate. 78:801–811. 2018.

143 

Köllermann J, Schlomm T, Bang H, Schwall GP, von Eichel-Streiber C, Simon R, Schostak M, Huland H, Berg W, Sauter G, et al: Expression and prognostic relevance of annexin A3 in prostate cancer. Eur Urol. 54:1314–1323. 2008.

144 

Liu S, Li X, Lin Z, Su L, Yan S, Zhao B and Miao J: SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis. Cancer Lett. 416:11–23. 2018.

145 

Miyazawa Y, Sekine Y, Kato H, Furuya Y, Koike H and Suzuki K: Simvastatin up-regulates annexin A10 that can inhibit the proliferation, migration, and invasion in androgen-independent human prostate cancer cells. Prostate. 77:337–349. 2017.

146 

Sharma B and Kanwar SS: Phosphatidylserine: A cancer cell targeting biomarker. Semin Cancer Biol. 52:17–25. 2018.

147 

Blomme A, Ford CA, Mui E, Patel R, Ntala C, Jamieson LE, Planque M, McGregor GH, Peixoto P, Hervouet E, et al: 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer. Nat Commun. 11:25082020.

148 

Dong Y, Chen Y, Zhu D, Shi K, Ma C, Zhang W, Rocchi P, Jiang L and Liu X: Self-assembly of amphiphilic phospholipid peptide dendrimer-based nanovectors for effective delivery of siRNA therapeutics in prostate cancer therapy. J Control Release. 322:416–425. 2020.

149 

Ioannidou A, Watts EL, Perez-Cornago A, Platz EA, Mills IG, Key TJ, Travis RC; PRACTICAL consortium, CRUK, C3; et al: The relationship between lipoprotein A and other lipids with prostate cancer risk: A multivariable Mendelian randomisation study. PLoS Med. 19:e10038592022.

150 

Liu Y, Wang Y, Hao S, Qin Y and Wu Y: Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer. Prostaglandins Other Lipid Mediat. 153:1065372021.

151 

Freedland SJ, Howard LE, Ngo A, Ramirez-Torres A, Csizmadi I, Cheng S, Mack A and Lin PH: Low carbohydrate diets and estimated cardiovascular and metabolic syndrome risk in prostate cancer. J Urol. 206:1411–1419. 2021.

152 

Henrich SE, McMahon KM, Plebanek MP, Calvert AE, Feliciano TJ, Parrish S, Tavora F, Mega A, De Souza A, Carneiro BA and Thaxton CS: Prostate cancer extracellular vesicles mediate intercellular communication with bone marrow cells and promote metastasis in a cholesterol-dependent manner. J Extracell Vesicles. 10:e120422020.

153 

Scheinberg T, Mak B, Butler L, Selth L and Horvath LG: Targeting lipid metabolism in metastatic prostate cancer. Ther Adv Med Oncol. 15:175883592311528392023.

154 

Kaulanjan K, Lavigne D, Saad F, Karakiewicz PI, Flammia RS, Kluth LA, Mandel P, Chun FK, Taussky D and Hoeh B: Impact of statin use on localized prostate cancer outcomes after radiation therapy: Long-term follow-up. Cancers (Basel). 14:36062022.

155 

Chan JM, Litwack-Harrison S, Bauer SR, Daniels NA, Wilt TJ, Shannon J and Bauer DC: Statin use and risk of prostate cancer in the prospective osteoporotic fractures in men (MrOS) study. Cancer Epidemiol Biomarkers Prev. 21:1886–1888. 2012.

156 

Jacobs EJ, Newton CC, Thun MJ and Gapstur SM: Long-term use of cholesterol-lowering drugs and cancer incidence in a large United States cohort. Cancer Res. 71:1763–1771. 2011.

157 

Alfaqih MA, Allott EH, Hamilton RJ, Freeman MR and Freedland SJ: The current evidence on statin use and prostate cancer prevention: are we there yet? Nat Rev Urol. 14:107–119. 2017.

158 

Kafka M, Gruber R, Neuwirt H, Ladurner M and Eder IE: Long-term treatment with simvastatin leads to reduced migration capacity of prostate cancer cells. Biomedicines. 11:292022.

159 

Mak B, Lin HM, Duong T, Mahon KL, Joshua AM, Stockler MR, Gurney H, Parnis F, Zhang A, Scheinberg T, et al: Modulation of plasma lipidomic profiles in metastatic castration-resistant prostate cancer by simvastatin. Cancers (Basel). 14:47922022.

160 

Joshua AM, Armstrong A, Crumbaker M, Scher HI, de Bono J, Tombal B, Hussain M, Sternberg CN, Gillessen S, Carles J, et al: Statin and metformin use and outcomes in patients with castration-resistant prostate cancer treated with enzalutamide: A meta-analysis of AFFIRM, PREVAIL and PROSPER. Eur J Cancer. 170:285–295. 2022.

161 

Allott EH, Arab L, Su LJ, Farnan L, Fontham ET, Mohler JL, Bensen JT and Steck SE: Saturated fat intake and prostate cancer aggressiveness: Results from the population-based North Carolina-Louisiana prostate cancer project. Prostate Cancer Prostatic Dis. 20:48–54. 2017.

162 

Iannelli F, Roca MS, Lombardi R, Ciardiello C, Grumetti L, De Rienzo S, Moccia T, Vitagliano C, Sorice A, Costantini S, et al: Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting CSCs compartment via YAP inhibition. J Exp Clin Cancer Res. 39:2132020.

163 

Peltomaa AI, Raittinen P, Talala K, Taari K, Tammela TLJ, Auvinen A and Murtola TJ: Prostate cancer prognosis after initiation of androgen deprivation therapy among statin users. A population-based cohort study. Prostate Cancer Prostatic Dis. 24:917–924. 2021.

164 

Butler LM, Mah CY, Machiels J, Vincent AD, Irani S, Mutuku SM, Spotbeen X, Bagadi M, Waltregny D, Moldovan M, et al: Lipidomic profiling of clinical prostate cancer reveals targetable alterations in membrane lipid composition. Cancer Res. 81:4981–4993. 2021.

165 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Wang W, Kong P, Feng K, Liu C, Sun T, Sang Y, Duan X, Tao Z, Liu W, Liu W, et al: New insights into lipid metabolism and prostate cancer (Review). Int J Oncol 62: 74, 2023.
APA
Zhang, Z., Wang, W., Kong, P., Feng, K., Liu, C., Sun, T. ... Liu, W. (2023). New insights into lipid metabolism and prostate cancer (Review). International Journal of Oncology, 62, 74. https://doi.org/10.3892/ijo.2023.5522
MLA
Zhang, Z., Wang, W., Kong, P., Feng, K., Liu, C., Sun, T., Sang, Y., Duan, X., Tao, Z., Liu, W."New insights into lipid metabolism and prostate cancer (Review)". International Journal of Oncology 62.6 (2023): 74.
Chicago
Zhang, Z., Wang, W., Kong, P., Feng, K., Liu, C., Sun, T., Sang, Y., Duan, X., Tao, Z., Liu, W."New insights into lipid metabolism and prostate cancer (Review)". International Journal of Oncology 62, no. 6 (2023): 74. https://doi.org/10.3892/ijo.2023.5522
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Wang W, Kong P, Feng K, Liu C, Sun T, Sang Y, Duan X, Tao Z, Liu W, Liu W, et al: New insights into lipid metabolism and prostate cancer (Review). Int J Oncol 62: 74, 2023.
APA
Zhang, Z., Wang, W., Kong, P., Feng, K., Liu, C., Sun, T. ... Liu, W. (2023). New insights into lipid metabolism and prostate cancer (Review). International Journal of Oncology, 62, 74. https://doi.org/10.3892/ijo.2023.5522
MLA
Zhang, Z., Wang, W., Kong, P., Feng, K., Liu, C., Sun, T., Sang, Y., Duan, X., Tao, Z., Liu, W."New insights into lipid metabolism and prostate cancer (Review)". International Journal of Oncology 62.6 (2023): 74.
Chicago
Zhang, Z., Wang, W., Kong, P., Feng, K., Liu, C., Sun, T., Sang, Y., Duan, X., Tao, Z., Liu, W."New insights into lipid metabolism and prostate cancer (Review)". International Journal of Oncology 62, no. 6 (2023): 74. https://doi.org/10.3892/ijo.2023.5522
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team