Open Access

New insights into lipid metabolism and prostate cancer (Review)

  • Authors:
    • Zhengliang Zhang
    • Weixi Wang
    • Piaoping Kong
    • Kangle Feng
    • Chunhua Liu
    • Tao Sun
    • Yiwen Sang
    • Xiuzhi Duan
    • Zhihua Tao
    • Weiwei Liu
  • View Affiliations

  • Published online on: May 17, 2023     https://doi.org/10.3892/ijo.2023.5522
  • Article Number: 74
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Prostate cancer (PCa) is the most common malignant tumor of the male urological system and poses a severe threat to the survival of middle‑aged and elderly males worldwide. The development and progression of PCa are affected by a variety of biological processes, including proliferation, apoptosis, migration, invasion and the maintenance of membrane homeostasis of PCa cells. The present review summarizes recent research advances in lipid (fatty acid, cholesterol and phospholipid) metabolic pathways in PCa. In the first section, the metabolism of fatty acids is highlighted, from formation to catabolism and associated proteins. Subsequently, the role of cholesterol in the pathogenesis and evolution of PCa is described in detail. Finally, the different types of phospholipids and their association with PCa progression is also discussed. In addition to the impact of key proteins of lipid metabolism on PCa growth, metastasis and drug resistance, the present review also summarizes the clinical value of fatty acids, cholesterol and phospholipids, as diagnostic and prognostic indicators and therapeutic targets in PCa.
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June-2023
Volume 62 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Z, Wang W, Kong P, Feng K, Liu C, Sun T, Sang Y, Duan X, Tao Z, Liu W, Liu W, et al: New insights into lipid metabolism and prostate cancer (Review). Int J Oncol 62: 74, 2023
APA
Zhang, Z., Wang, W., Kong, P., Feng, K., Liu, C., Sun, T. ... Liu, W. (2023). New insights into lipid metabolism and prostate cancer (Review). International Journal of Oncology, 62, 74. https://doi.org/10.3892/ijo.2023.5522
MLA
Zhang, Z., Wang, W., Kong, P., Feng, K., Liu, C., Sun, T., Sang, Y., Duan, X., Tao, Z., Liu, W."New insights into lipid metabolism and prostate cancer (Review)". International Journal of Oncology 62.6 (2023): 74.
Chicago
Zhang, Z., Wang, W., Kong, P., Feng, K., Liu, C., Sun, T., Sang, Y., Duan, X., Tao, Z., Liu, W."New insights into lipid metabolism and prostate cancer (Review)". International Journal of Oncology 62, no. 6 (2023): 74. https://doi.org/10.3892/ijo.2023.5522