Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
July-2023 Volume 63 Issue 1

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2023 Volume 63 Issue 1

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Role of telomere length in human carcinogenesis (Review)

  • Authors:
    • Aristidis Tsatsakis
    • Tatiana Oikonomopoulou
    • Taxiarchis Konstantinos Nikolouzakis
    • Elena Vakonaki
    • Manolis Tzatzarakis
    • Matthaios Flamourakis
    • Elisavet Renieri
    • Persefoni Fragkiadaki
    • Evaggelia Iliaki
    • Maria Bachlitzanaki
    • Vasiliki Karzi
    • Ioanna Katsikantami
    • Fotios Kakridonis
    • Eleftheria Hatzidaki
    • Maria Tolia
    • Andrey A. Svistunov
    • Demetrios A. Spandidos
    • Dragana Nikitovic
    • John Tsiaoussis
    • Aikaterini Berdiaki
  • View Affiliations / Copyright

    Affiliations: Laboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Creta InterClinic HHG, 71304 Heraklion, Greece, Laboratory of Microbiology, University Hospital of Heraklion, 71500 Heraklion, Greece, Department of Medical Oncology, Venizeleion General Hospital of Heraklion, 71409 Heraklion, Greece, Department of Spine Surgery and Scoliosis, KAT General Hospital, 14561 Athens, Greece, Department of Neonatology and Neonatal Intensive Care Unit (NICU), University Hospital of Heraklion, 71500 Heraklion, Greece, Department of Radiation Oncology, University Hospital of Crete, 71110 Heraklion, Greece, Department of Pharmacology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Laboratory of Histology‑Embryology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Department of Anatomy, School of Medicine, University of Crete, 71003 Heraklion, Greece
    Copyright: © Tsatsakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 78
    |
    Published online on: May 22, 2023
       https://doi.org/10.3892/ijo.2023.5526
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cancer is considered the most important clinical, social and economic issue regarding cause‑specific disability‑adjusted life years among all human pathologies. Exogenous, endogenous and individual factors, including genetic predisposition, participate in cancer triggering. Telomeres are specific DNA structures positioned at the end of chromosomes and consist of repetitive nucleotide sequences, which, together with shelterin proteins, facilitate the maintenance of chromosome stability, while protecting them from genomic erosion. Even though the connection between telomere status and carcinogenesis has been identified, the absence of a universal or even a cancer‑specific trend renders consent even more complex. It is indicative that both short and long telomere lengths have been associated with a high risk of cancer incidence. When evaluating risk associations between cancer and telomere length, a disparity appears to emerge. Even though shorter telomeres have been adopted as a marker of poorer health status and an older biological age, longer telomeres due to increased cell growth potential are associated with the acquirement of cancer‑initiating somatic mutations. Therefore, the present review aimed to comprehensively present the multifaceted pattern of telomere length and cancer incidence association.
View Figures

Figure 1

View References

1 

Mattiuzzi C and Lippi G: Current cancer epidemiology. J Epidemiol Glob Health. 9:217–222. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Tzanakakis G, Giatagana EM, Kuskov A, Berdiaki A, Tsatsakis A, Neagu M and Nikitovic D: Proteoglycans in the pathogenesis of hormone-dependent cancers: Mediators and effectors. Cancers (Basel). 12:24012020. View Article : Google Scholar : PubMed/NCBI

3 

Maciejowski J and de Lange T: Telomeres in cancer: Tumor suppression and genome instability. Nat Rev Mol Cell Biol. 18:175–186. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Shay JW and Wright WE: Telomeres and telomerase: Three decades of progress. Nat Rev Genet. 20:299–309. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Lim CJ and Cech TR: Shaping human telomeres: From shelterin and CST complexes to telomeric chromatin organization. Nat Rev Mol Cell Biol. 22:283–298. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Dratwa M, Wysoczańska B, Łacina P, Kubik T and Bogunia-Kubik K: TERT-Regulation and roles in cancer formation. Front Immunol. 11:29302020. View Article : Google Scholar

7 

Hrdličková R, Nehyba J and Bose HR: Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation. Mol Cell Biol. 32:4283–4296. 2012. View Article : Google Scholar

8 

Sæbøe-Larssen S, Fossberg E and Gaudernack G: Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): Analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues. BMC Mol Biol. 7:262006. View Article : Google Scholar : PubMed/NCBI

9 

Listerman I, Sun J, Gazzaniga F, Lukas JL and Blackburn EH: The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis. Cancer Res. 73:2817–2828. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Takakura M, Kyo S, Kanaya T, Hirano H, Takeda J, Yutsudo M and Inoue M: Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res. 59:551–557. 1999.PubMed/NCBI

11 

Tsoukalas D, Fragkiadaki P, Docea AO, Alegakis AK, Sarandi E, Vakonaki E, Salataj E, Kouvidi E, Nikitovic D, Kovatsi L, et al: Association of nutraceutical supplements with longer telomere length. Int J Mol Med. 44:218–226. 2019.PubMed/NCBI

12 

Vasilopoulos E, Fragkiadaki P, Kalliora C, Fragou D, Docea AO, Vakonaki E, Tsoukalas D, Calina D, Buga AM, Georgiadis G, et al: The association of female and male infertility with telomere length (Review). Int J Mol Med. 44:375–389. 2019.PubMed/NCBI

13 

Vakonaki E, Tsiminikaki K, Plaitis S, Fragkiadaki P, Tsoukalas D, Katsikantami I, Vaki G, Tzatzarakis MN, Spandidos DA and Tsatsakis AM: Common mental disorders and association with telomere length. Biomed Rep. 8:111–116. 2018.PubMed/NCBI

14 

Razgonova MP, Zakharenko AM, Golokhvast KS, Thanasoula M, Sarandi E, Nikolouzakis K, Fragkiadaki P, Tsoukalas D, Spandidos DA and Tsatsakis A: Telomerase and telomeres in aging theory and chronographic aging theory (Review). Mol Med Rep. 22:1679–1694. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Sfeir A and de Lange T: Removal of shelterin reveals the telomere end-protection problem. Science. 336:593–597. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Blasco MA: Telomeres and human disease: Ageing, cancer and beyond. Nat Rev Genet. 6:611–622. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Jäger K and Walter M: Therapeutic targeting of telomerase. Genes (Basel). 7:392016. View Article : Google Scholar : PubMed/NCBI

18 

Tsatsakis A, Tsoukalas D, Fragkiadaki P, Vakonaki E, Tzatzarakis M, Sarandi E, Nikitovic D, Tsilimidos G and Alegakis AK: Developing BIOTEL: A Semi-Automated spreadsheet for estimating telomere length and biological age. Front Genet. 10:842019. View Article : Google Scholar : PubMed/NCBI

19 

Dunham MA, Neumann AA, Fasching CL and Reddel RR: Telomere maintenance by recombination in human cells. Nat Genet. 26:447–450. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Teng SC and Zakian VA: Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae. Mol Cell Biol. 19:8083–8093. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Cesare A and Reddel R: Alternative lengthening of telomeres: Models mechanisms and implications. Nat Rev Genet. 11:319–330. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Henson J, Neumann AA, Yeager TR and Reddel RR: Alternative lengthening of telomeres in mammalian cells. Oncogene. 21:598–610. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Heaphy CM, Subhawong AP, Hong SM, Goggins MG, Montgomery EA, Gabrielson E, Netto GJ, Epstein JI, Lotan TL, Westra WH, et al: Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes. Am J Pathol. 179:1608–1615. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Demanelis K, Jasmine F, Chen LS, Chernoff M, Tong L, Delgado D, Zhang C, Shinkle J, Sabarinathan M, Lin H, et al: Determinants of telomere length across human tissues. Science. 369:eaaz68762020. View Article : Google Scholar : PubMed/NCBI

25 

Peleteiro B, Padrão P, Castro C, Ferro A, Morais S and Lunet N: Worldwide burden of gastric cancer in 2012 that could have been prevented by increasing fruit and vegetable intake and predictions for 2025. Br J Nutr. 115:851–859. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Doherty JA, Grieshober L, Houck JR, Barnett MJ, Tapsoba JD, Thornquist M, Wang CY, Goodman GE and Chen C: Telomere length and lung cancer mortality among heavy smokers. Cancer Epidemiol Biomarkers Prev. 27:829–837. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Leão R, Apolónio JD, Lee D, Figueiredo A, Tabori U and Castelo-Branco P: Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: Clinical impacts in cancer. J Biomed Sci. 251:222018. View Article : Google Scholar

28 

Barthel FP, Wei W, Tang M, Martinez-Ledesma E, Hu X, Amin SB, Akdemir KC, Seth S, Song X, Wang Q, et al: Systematic analysis of telomere length and somatic alterations in 31 cancer types. Nat Genet. 49:349–357. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Albertson DG: Gene amplification in cancer. Trends Genet. 22:447–455. 2006. View Article : Google Scholar : PubMed/NCBI

30 

McClintock B: The fusion of broken ends of chromosomes following nuclear fusion. Proc Natl Acad Sci. 28:458–463. 1942. View Article : Google Scholar : PubMed/NCBI

31 

Valentijn L, Koster J, Zwijnenburg D, Hasselt NE, van Sluis P, Volckmann R, van Noesel MM, George RE, Tytgat GA, Molenaar JJ and Versteeg R: NH-N and 2015 undefined: TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors. Nat Genet. 47:1411–1414. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Kyo S, Takakura M, Fujiwara T and Inoue M: Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers. Wiley Online Libr. 99:1528–1538. 2008.

33 

Lewis KA and Tollefsbol TO: Regulation of the telomerase reverse transcriptase subunit through epigenetic mechanisms. Front Genet. 7:832016. View Article : Google Scholar : PubMed/NCBI

34 

Cheng L, Montironi R and Lopez-Beltran A: TERT promoter mutations occur frequently in urothelial papilloma and papillary urothelial neoplasm of low malignant potential. Eur Urol. 71:497–498. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Deaton AM and Bird A: CpG islands and the regulation of transcription. Genes Dev. 25:1010–1022. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Castelo-Branco P, Choufani S, Mack S, Gallagher D, Zhang C, Lipman T, Zhukova N, Walker EJ, Martin D, Merino D, et al: Methylation of the TERT promoter and risk stratification of childhood brain tumours: An integrative genomic and molecular study. Lancet Oncol. 14:534–542. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Castelo-Branco P, Leão R, Lipman T, Campbell B, Lee D, Price A, Zhang C, Heidari A, Stephens D, Boerno S, et al: A cancer specific hypermethylation signature of the TERT promoter predicts biochemical relapse in prostate cancer: A retrospective cohort study. Oncotarget. 7:57726–57736. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Sepehri Z, Beacon TH, Osman FDS, Jahan S and Davie JR: DNA methylation and chromatin modifications. Nutritional Epigenomics. 13–36. 2019. View Article : Google Scholar

39 

Bert SA, Robinson MD, Strbenac D, Statham AL, Song JZ, Hulf T, Sutherland RL, Coolen MW, Stirzaker C and Clark SJ: Regional Activation of the cancer genome by long-range epigenetic remodeling. Cancer Cell. 23:9–22. 2013. View Article : Google Scholar

40 

Hrdličková R, Nehyba J, Bargmann W and Bose HR: Multiple tumor suppressor microRNAs regulate telomerase and TCF7 an important transcriptional regulator of the Wnt pathway. PLoS One. 9:e869902014. View Article : Google Scholar

41 

Mitomo S, Maesawa C, Ogasawara S, Iwaya T, Shibazaki M, Yashima-Abo A, Kotani K, Oikawa H, Sakurai E, Izutsu N, et al: Downregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines. Cancer Sci. 99:280–286. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Kachuri L, Helby J, Bojesen SE, Christiani DC, Su L, Wu X, Tardón A, Fernández-Tardón G, Field JK, Davies MP, et al: Investigation of leukocyte telomere length and genetic variants in chromosome 5p15.33 as prognostic markers in lung cancer. Cancer Epidemiol Biomarkers Prev. 28:1228–1237. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Xue Y, Guo X, Huang X, Zhu Z, Chen M, Chu J, Yang G, Wang Q and Kong X: Shortened telomere length in peripheral blood leukocytes of patients with lung cancer, chronic obstructive pulmonary disease in a high indoor air pollution region in China. Mutat Res. 858-860:5032502020. View Article : Google Scholar

44 

Steiner B, Ferrucci LM, Mirabello L, Lan Q, Hu W, Liao LM, Savage SA, De Vivo I, Hayes RB, Rajaraman P, et al: Association between coffee drinking and telomere length in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. PLoS One. 15:e02269722020. View Article : Google Scholar : PubMed/NCBI

45 

Sun B, Wang Y, Kota K, Shi Y, Motlak S, Makambi K, Loffredo CA, Shields PG, Yang Q, Harris CC and Zheng YL: Telomere length variation: A potential new telomere biomarker for lung cancer risk. Lung Cancer. 88:297–303. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Jang JS, Choi YY, Lee WK, Choi JE, Cha SI, Kim YJ, Kim CH, Kam S, Jung TH and Park JY: Telomere length and the risk of lung cancer. Cancer Sci. 99:385–1389. 2008. View Article : Google Scholar

47 

Sanchez-Espiridion B, Chen M, Chang JY, Lu C, Chang DW, Roth JA, Wu X and Gu J: Telomere length in peripheral blood leukocytes and lung cancer risk: A large case-control study in Caucasians. Cancer Res. 74:2476–2486. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Jeon HS, Choi JE, Jung DK, Choi YY, Kang HG, Lee WK, Yoo SS, Lim JO and Park JY: Telomerase activity and the risk of lung cancer. J Korean Med Sci. 27:141–145. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Dobija-Kubica K, Zalewska-Ziob M, Bruliński K, Rogoziński P, Wiczkowski A, Gawrychowska A and Gawrychowski J: Telomerase activity in non-small cell lung cancer. Kardiochir Torakochirurgia Pol. 13:15–20. 2016.PubMed/NCBI

50 

Li J, Zhang L, Zhu H, Pan W, Zhang N, Li Y and Yang M: Leukocyte telomere length and clinical outcomes of advanced lung adenocarcinoma patients with epidermal growth factor receptor tyrosine kinase inhibitors treatment. DNA Cell Biol. 37:903–908. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Zhang X, Zhao Q, Zhu W, Liu T, Xie SH, Zhong LX, Cai YY, Li XN, Liang M, Chen W, et al: The association of telomere length in peripheral blood cells with cancer risk: A systematic review and meta-analysis of prospective studies. Cancer Epidemiol Biomarkers Prev. 26:1381–1390. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Cao X, Huang M, Zhu M, Fang R, Ma Z, Jiang T, Dai J, Ma H, Jin G, Shen H, et al: Mendelian randomization study of telomere length and lung cancer risk in East Asian population. Cancer Med. 8:7469–7476. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Machiela MJ, Hsiung CA, Shu XO, Seow WJ, Wang Z, Matsuo K, Hong YC, Seow A, Wu C, Hosgood HD, et al: Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: A report from the female lung cancer consortium in Asia. Int J Cancer. 137:311–319. 2015. View Article : Google Scholar

54 

Yuan JM, Beckman KB, Wang R, Bull C, Adams-Haduch J, Huang JY, Jin A, Opresko P, Newman AB, Zheng YL, et al: Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study. Int J Cancer. 142:2234–2243. 2018. View Article : Google Scholar : PubMed/NCBI

55 

de-Torres JP, Sanchez-Salcedo P, Bastarrika G, Alcaide AB, Pío R, Pajares MJ, Campo A, Berto J, Montuenga L, Del Mar Ocon M, et al: Telomere length, COPD and emphysema as risk factors for lung cancer. Eur Respir J. 49:16015212017. View Article : Google Scholar : PubMed/NCBI

56 

Telomeres Mendelian Randomization Collaboration; Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, et al: Association between telomere length and risk of cancer and non-neoplastic diseases: A mendelian randomization study. JAMA Oncol. 3:636–651. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Goh F, Yang IA, Bowman RV and Fong KM: Subtype variation and actionability of telomere length abnormality in lung cancer. Transl Lung Cancer Res. 7(Suppl 3): S251–S253. 2018. View Article : Google Scholar : PubMed/NCBI

58 

Kachuri L, Latifovic L, Liu G and Hung RJ: Systematic review of genetic variation in chromosome 5p15.33 and telomere length as predictive and prognostic biomarkers for lung cancer. Cancer Epidemiol Biomarkers Prev. 25:1537–1549. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Vaiciulis P, Liutkeviciene R, Liutkevicius V, Vilkeviciute A, Gedvilaite G and Uloza V: Association of relative leucocyte telomere length and gene single nucleotide polymorphisms (TERT, TRF1, TNKS2) in laryngeal squamous cell carcinoma. Cancer Genomics Proteomics. 17:431–439. 2020. View Article : Google Scholar : PubMed/NCBI

60 

Han P, Dang Z, Shen Z, Dai H, Bai Y, Li B and Shao Y: Association of SNPs in the OBFC1 gene and laryngeal carcinoma in Chinese Han male population. Int J Clin Oncol. 24:1042–1048. 2019. View Article : Google Scholar : PubMed/NCBI

61 

Lei H, Feng D, Zhou F, Xu H, Tang T, Yu H, Xie C and Zhou Y: Expression of human protection of telomere 1 correlates with telomere length and radiosensitivity in the human laryngeal cancer Hep-2 cell line. Oncol Lett. 10:1149–1154. 2015. View Article : Google Scholar : PubMed/NCBI

62 

Chen W, Xiao BK, Liu JP, Chen SM and Tao ZZ: Alternative lengthening of telomeres in hTERT-inhibited laryngeal cancer cells. Cancer Sci. 101:1769–1776. 2010. View Article : Google Scholar : PubMed/NCBI

63 

Broberg K, Björk J, Paulsson K, Höglund M and Albin M: Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Carcinogenesis. 26:1263–1271. 2005. View Article : Google Scholar : PubMed/NCBI

64 

Chen M, Xu Y, Xu J, Chancoco H and Gu J: Leukocyte telomere length and bladder cancer risk: A large case-control study and mendelian randomization analysis. Cancer Epidemiol Biomarkers Prev. 30:203–209. 2021. View Article : Google Scholar

65 

Pavanello S, Carta A, Mastrangelo G, Campisi M, Arici C and Porru S: Relationship between telomere length, genetic traits and Environmental/Occupational exposures in bladder cancer risk by structural equation modelling. Int J Environ Res Public Health. 15:52017. View Article : Google Scholar : PubMed/NCBI

66 

McGrath M, Wong JY, Michaud D, Hunter DJ and De Vivo I: Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol Biomarkers Prev. 16:815–819. 2007. View Article : Google Scholar : PubMed/NCBI

67 

Lin J, Blalock JA, Chen M, Ye Y, Gu J, Cohen L, Cinciripini PM and Wu X: Depressive symptoms and short telomere length are associated with increased mortality in bladder cancer patients. Cancer Epidemiol Biomarkers Prev. 24:336–343. 2015. View Article : Google Scholar :

68 

Yu C, Hequn C, Longfei L, Long W, Zhi C, Feng Z, Jinbo C, Chao L and Xiongbing Z: GSTM1 and GSTT1 polymorphisms are associated with increased bladder cancer risk: Evidence from updated meta-analysis. Oncotarget. 8:3246–3258. 2017. View Article : Google Scholar :

69 

Hosen I, Rachakonda PS, Heidenreich B, de Verdier PJ, Ryk C, Steineck G, Hemminki K and Kumar R: Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer. Int J Cancer. 137:1621–1629. 2015. View Article : Google Scholar : PubMed/NCBI

70 

Fernandez-Gomez J, Escaf Barmadah S, Gosalbez D, Rodriguez-Faba O, Jalon A, Gonzalez R, Garcia Miralles T and Calas A: Telomere length on bladder washing samples from patients with bladder cancer correlates with tumor characteristics flow cytometry method for quantitative fluorescence in situ hybridization (flow-FISH technique). Eur Urol. 48:432–437. 2005. View Article : Google Scholar : PubMed/NCBI

71 

Wang H, Wang Y, Kota KK, Kallakury B, Mikhail NN, Sayed D, Mokhtar A, Maximous D, Yassin EH, Gouda I, et al: Strong association between long and heterogeneous telomere length in blood lymphocytes and bladder cancer risk in Egyptian. Carcinogenesis. 36:1284–1290. 2015. View Article : Google Scholar : PubMed/NCBI

72 

Gu J, Chen M, Shete S, Amos CI, Kamat A, Ye Y, Lin J, Dinney CP and Wu X: A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. Cancer Prev Res (Phila). 4:514–521. 2011. View Article : Google Scholar : PubMed/NCBI

73 

Holzmann K, Blin N, Welter C, Zang KD, Seitz G and Henn W: Telomeric associations and loss of telomeric DNA repeats in renal tumors. Genes Chromosomes Cancer. 6:178–181. 1993. View Article : Google Scholar : PubMed/NCBI

74 

Mehle C, Ljungberg B and Roos G: Telomere shortening in renal cell carcinoma. Cancer Res. 54:236–241. 1994.PubMed/NCBI

75 

Dahse R, Fiedler W, Junker K, Schlichter A, Schubert J and Claussen U: Telomerase activity and telomere lengths: Alterations in renal cell carcinomas. Kidney Int. 56:1289–1290. 1999. View Article : Google Scholar : PubMed/NCBI

76 

Pal D, Sharma U, Khajuria R, Singh SK, Kakkar N and Prasad R: Augmented telomerase activity, reduced telomere length and the presence of alternative lengthening of telomere in renal cell carcinoma: Plausible predictive and diagnostic markers. Gene. 562:145–151. 2015. View Article : Google Scholar : PubMed/NCBI

77 

Callahan CL, Schwartz K, Ruterbusch JJ, Shuch B, Graubard BI, Lan Q, Cawthon R, Baccarelli AA, Chow WH, Rothman N, et al: Leukocyte telomere length and renal cell carcinoma survival in two studies. Br J Cancer. 117:752–755. 2017. View Article : Google Scholar : PubMed/NCBI

78 

Hofmann JN, Lan Q, Cawthon R, Hosgood HD III, Shuch B, Moore LE, Rothman N, Chow WH and Purdue MP: A prospective study of leukocyte telomere length and risk of renal cell carcinoma. Cancer Epidemiol Biomarkers Prev. 22:997–1000. 2013. View Article : Google Scholar : PubMed/NCBI

79 

Hofmann JN, Baccarelli A, Schwartz K, Davis FG, Ruterbusch JJ, Hoxha M, McCarthy BJ, Savage SA, Wacholder S, Rothman N, et al: Risk of renal cell carcinoma in relation to blood telomere length in a population-based case-control study. Br J Cancer. 105:1772–1775. 2011. View Article : Google Scholar : PubMed/NCBI

80 

Svenson U, Ljungberg B and Roos G: Telomere length in peripheral blood predicts survival in clear cell renal cell carcinoma. Cancer Res. 69:2896–2901. 2009. View Article : Google Scholar : PubMed/NCBI

81 

Morais M, Dias F, Teixeira AL and Medeiros R: Telomere length in renal cell carcinoma: The Jekyll and Hyde biomarker of ageing of the kidney. Cancer Manag Res. 12:1669–1679. 2020. View Article : Google Scholar : PubMed/NCBI

82 

Machiela MJ, Hofmann JN, Carreras-Torres R, Brown KM, Johansson M, Wang Z, Foll M, Li P, Rothman N, Savage SA, et al: Genetic variants related to longer telomere length are associated with increased risk of renal cell carcinoma. Eur Urol. 72:747–754. 2017. View Article : Google Scholar : PubMed/NCBI

83 

de Martino M, Taus C, Lucca I, Hofbauer SL, Haitel A, Shariat SF and Klatte T: Association of human telomerase reverse transcriptase gene polymorphisms, serum levels, and telomere length with renal cell carcinoma risk and pathology. Mol Carcinog. 55:1458–1466. 2016. View Article : Google Scholar

84 

Svenson U, Grönlund E, Söderström I, Sitaram RT, Ljungberg B and Roos G: Telomere length in relation to immunological parameters in patients with renal cell carcinoma. PLoS One. 8:e555432013. View Article : Google Scholar : PubMed/NCBI

85 

Endén K, Tainio J, Hou M, Suominen A, Pakarinen M, Huang T, Söder O, Jalanko H, Jahnukainen K and Jahnukainen T: Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer-A cross-sectional study. Pediatr Transplant. 23:e135502019. View Article : Google Scholar : PubMed/NCBI

86 

HaydeéCottliar AS, Noriega MF, Narbaitz M, Rodríguez A and Slavutsky IR: Association between telomere length and BCL2 gene rearrangements in low- and high-grade non-Hodgkin lymphomas. Cancer Genet Cytogenet. 171:1–8. 2006. View Article : Google Scholar

87 

Widmann TA, Herrmann M, Taha N, König J and Pfreundschuh M: Short telomeres in aggressive non-Hodgkin's lymphoma as a risk factor in lymphomagenesis. Exp Hematol. 35:939–946. 2007. View Article : Google Scholar : PubMed/NCBI

88 

Lan Q, Cawthon R, Shen M, Weinstein SJ, Virtamo J, Lim U, Hosgood HD III, Albanes D and Rothman N: A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma. Clin Cancer Res. 15:7429–7433. 2009. View Article : Google Scholar : PubMed/NCBI

89 

Machiela MJ, Lan Q, Slager SL, Vermeulen RC, Teras LR, Camp NJ, Cerhan JR, Spinelli JJ, Wang SS, Nieters A, et al: Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. Hum Mol Genet. 25:1663–1676. 2016. View Article : Google Scholar : PubMed/NCBI

90 

Lee JJ, Nam CE, Cho SH, Park KS, Chung IJ and Kim HJ: Telomere length shortening in non-Hodgkin's lymphoma patients undergoing chemotherapy. Ann Hematol. 82:492–495. 2003. View Article : Google Scholar : PubMed/NCBI

91 

Remes K, Norrback KF, Rosenquist R, Mehle C, Lindh J and Roos G: Telomere length and telomerase activity in malignant lymphomas at diagnosis and relapse. Br J Cancer. 82:601–607. 2000. View Article : Google Scholar : PubMed/NCBI

92 

Adamson DJ, King DJ and Haites NE: Significant telomere shortening in childhood leukemia. Cancer Genet Cytogenet. 61:204–206. 1992. View Article : Google Scholar : PubMed/NCBI

93 

Engelhardt M, Ozkaynak MF, Drullinsky P, Sandoval C, Tugal O, Jayabose S and Moore MA: Telomerase activity and telomere length in pediatric patients with malignancies undergoing chemotherapy. Leukemia. 12:13–24. 1998. View Article : Google Scholar : PubMed/NCBI

94 

Borssén M, Cullman I, Norén-Nyström U, Sundström C, Porwit A, Forestier E and Roos G: hTERT promoter methylation and telomere length in childhood acute lymphoblastic leukemia: Associations with immunophenotype and cytogenetic subgroup. Exp Hematol. 39:1144–1151. 2011. View Article : Google Scholar : PubMed/NCBI

95 

Wang Y, Fang M, Sun X and Sun J: Telomerase activity and telomere length in acute leukemia: Correlations with disease progression, subtypes and overall survival. Int J Lab Hematol. 32:230–238. 2010. View Article : Google Scholar

96 

Eskandari E, Hashemi M, Naderi M, Bahari G, Safdari V and Taheri M: Leukocyte telomere length shortening, hTERT genetic polymorphisms and risk of childhood acute lymphoblastic leukemia. Asian Pac J Cancer Prev. 19:1515–1521. 2018.PubMed/NCBI

97 

Sheng X, Zhang L, Luo D, Tong N, Wang M, Fang Y, Li J and Zhang Z: A common variant near TERC and telomere length are associated with susceptibility to childhood acute lymphoblastic leukemia in Chinese. Leuk Lymphoma. 53:1688–1692. 2012. View Article : Google Scholar : PubMed/NCBI

98 

Takauchi K, Tashiro S, Ohtaki M and Kamada N: Telomere reduction of specific chromosome translocation in acute myelocytic leukemia. Jpn J Cancer Res. 85:127–130. 1994. View Article : Google Scholar : PubMed/NCBI

99 

Sieglová Z, Zilovcová S, Cermák J, Ríhová H, Brezinová D, Dvoráková R, Marková M, Maaloufová J, Sajdová J, Brezinová J, et al: Dynamics of telomere erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemia arising from MDS: A marker of disease prognosis? Leuk Res. 28:1013–1021. 2004. View Article : Google Scholar : PubMed/NCBI

100 

Lansdorp PM: Maintenance of telomere length in AML. Blood Adv. 1:2467–2472. 2017. View Article : Google Scholar

101 

Wang Y, Wang T, Dagnall C, Haagenson M, Spellman SR, Hicks B, Jones K, Lee SJ, Savage SA and Gadalla SM: Relative telomere length before hematopoietic cell transplantation and outcome after unrelated donor hematopoietic cell transplantation for acute leukemia. Biol Blood Marrow Transplant. 23:1054–1058. 2017. View Article : Google Scholar : PubMed/NCBI

102 

Swiggers SJ, Kuijpers MA, de Cort MJ, Beverloo HB and Zijlmans JM: Critically short telomeres in acute myeloid leukemia with loss or gain of parts of chromosomes. Genes Chromosomes Cancer. 45:247–256. 2006. View Article : Google Scholar

103 

Behrens YL, Thomay K, Hagedorn M, Ebersold J, Schmidt G, Lentes J, Davenport C, Schlegelberger B and Göhring G: Jumping translocations: Short telomeres or pathogenic TP53 variants as underlying mechanism in acute myeloid leukemia and myelodysplastic syndrome? Genes Chromosomes Cancer. 58:139–148. 2019. View Article : Google Scholar : PubMed/NCBI

104 

Watts JM, Dumitriu B, Hilden P, Kishtagari A, Rapaport F, Chen C, Ahn J, Devlin SM, Stein EM, Rampal R, et al: Telomere length and associations with somatic mutations and clinical outcomes in acute myeloid leukemia. Leuk Res. 49:62–65. 2016. View Article : Google Scholar : PubMed/NCBI

105 

Li AM, Hyagu S, Maze D, Schreiber R, Sirrs S, Stockler-Ipsiroglu S, Sutherland H, Vercauteren S and Schultz KR: Prolonged granulocyte colony stimulating factor use in glycogen storage disease type 1b associated with acute myeloid leukemia and with shortened telomere length. Pediatr Hematol Oncol. 35:45–51. 2018. View Article : Google Scholar : PubMed/NCBI

106 

Aalbers AM, Calado RT, Young NS, Zwaan CM, Wu C, Kajigaya S, Coenen EA, Baruchel A, Geleijns K, de Haas V, et al: Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia. Leukemia. 27:1786–1789. 2013. View Article : Google Scholar : PubMed/NCBI

107 

Song DY, Kim JA, Jeong D, Yun J, Kim SM, Lim K, Park SN, Im K, Choi S, Yoon SS and Lee DS: Telomere length and its correlation with gene mutations in chronic lymphocytic leukemia in a Korean population. PLoS One. 14:e02201772019. View Article : Google Scholar : PubMed/NCBI

108 

Jebaraj BMC, Tausch E, Landau DA, Bahlo J, Robrecht S, Taylor-Weiner AN, Bloehdorn J, Scheffold A, Mertens D, Böttcher S, et al: Short telomeres are associated with inferior outcome, genomic complexity, and clonal evolution in chronic lymphocytic leukemia. Leukemia. 33:2183–2194. 2019. View Article : Google Scholar : PubMed/NCBI

109 

Thomay K, Fedder C, Hofmann W, Kreipe H, Stadler M, Titgemeyer J, Zander I, Schlegelberger B and Göhring G: Telomere shortening, TP53 mutations and deletions in chronic lymphocytic leukemia result in increased chromosomal instability and breakpoint clustering in heterochromatic regions. Ann Hematol. 96:1493–1500. 2017. View Article : Google Scholar : PubMed/NCBI

110 

Steinbrecher D, Jebaraj BMC, Schneider C, Edelmann J, Cymbalista F, Leblond V, Delmer A, Ibach S, Tausch E, Scheffold A, et al: Telomere length in poor-risk chronic lymphocytic leukemia: Associations with disease characteristics and outcome. Leuk Lymphoma. 59:1614–1623. 2018. View Article : Google Scholar

111 

Strefford JC, Kadalayil L, Forster J, Rose-Zerilli MJ, Parker A, Lin TT, Heppel N, Norris K, Gardiner A, Davies Z, et al: Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: Data from the UK LRF CLL4 trial. Leukemia. 29:2411–2414. 2015. View Article : Google Scholar : PubMed/NCBI

112 

Dos Santos P, Panero J, Palau Nagore V, Stanganelli C, Bezares RF and Slavutsky I: Telomere shortening associated with increased genomic complexity in chronic lymphocytic leukemia. Tumour Biol. 36:8317–8324. 2015. View Article : Google Scholar : PubMed/NCBI

113 

Palma M, Parker A, Hojjat-Farsangi M, Forster J, Kokhaei P, Hansson L, Osterborg A and Mellstedt H: Telomere length and expression of human telomerase reverse transcriptase splice variants in chronic lymphocytic leukemia. Exp Hematol. 41:615–626. 2013. View Article : Google Scholar : PubMed/NCBI

114 

Sellmann L, de Beer D, Bartels M, Opalka B, Nückel H, Dührsen U, Dürig J, Seifert M, Siemer D, Küppers R, et al: Telomeres and prognosis in patients with chronic lymphocytic leukaemia. Int J Hematol. 93:74–82. 2011. View Article : Google Scholar : PubMed/NCBI

115 

Roos G, Kröber A, Grabowski P, Kienle D, Bühler A, Döhner H, Rosenquist R and Stilgenbauer S: Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia. Blood. 111:2246–2252. 2008. View Article : Google Scholar

116 

Lin TT, Letsolo BT, Jones RE, Rowson J, Pratt G, Hewamana S, Fegan C, Pepper C and Baird DM: Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: Evidence for a telomere crisis. Blood. 116:1899–1907. 2010. View Article : Google Scholar : PubMed/NCBI

117 

Ojha J, Codd V, Nelson CP, Samani NJ, Smirnov IV, Madsen NR, Hansen HM, de Smith AJ, Bracci PM, Wiencke JK, et al: ENGAGE Consortium Telomere Group. Genetic variation associated with longer telomere length increases risk of chronic lymphocytic leukemia. Cancer Epidemiol Biomarkers Prev. 25:1043–1049. 2016. View Article : Google Scholar : PubMed/NCBI

118 

Wysoczanska B, Dratwa M, Gebura K, Mizgala J, Mazur G, Wrobel T and Bogunia-Kubik K: Variability within the human TERT gene, telomere length and predisposition to chronic lymphocytic leukemia. Onco Targets Ther. 12:4309–4320. 2019. View Article : Google Scholar : PubMed/NCBI

119 

Furtado FM, Scheucher PS, Santana BA, Scatena NF, Calado RT, Rego EM, Matos DM and Falcão RP: Telomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A. Braz J Med Biol Res. 50:e60192017. View Article : Google Scholar : PubMed/NCBI

120 

Yang L, Kost SEF, Beiggi S, Zhang Y, Schmidt R, Nugent Z, Marshall A, Banerji V, Gibson SB and Johnston JB: Buccal cell telomere length is not a useful marker for comorbidities in chronic lymphocytic leukemia. Leuk Res. 86:1062202019. View Article : Google Scholar : PubMed/NCBI

121 

Kaifie A, Schikowsky C, Vasko T, Kraus T, Brümmendorf TH and Ziegler P: Additional benefits of telomere length (TL) measurements in chronic lymphocytic leukemia. Leuk Lymphoma. 60:541–543. 2019. View Article : Google Scholar

122 

Iwama H, Ohyashiki K, Ohyashiki JH, Hayashi S, Kawakubo K, Shay JW and Toyama K: The relationship between telomere length and therapy-associated cytogenetic responses in patients with chronic myeloid leukemia. Cancer. 79:1552–1560. 1997. View Article : Google Scholar : PubMed/NCBI

123 

Brümmendorf TH, Holyoake TL, Rufer N, Barnett MJ, Schulzer M, Eaves CJ, Eaves AC and Lansdorp PM: Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry. Blood. 95:1883–1890. 2000. View Article : Google Scholar : PubMed/NCBI

124 

Bouillon AS, Ventura Ferreira MS, Awad SA, Richter J, Hochhaus A, Kunzmann V, Dengler J, Janssen J, Ossenkoppele G, Westerweel PE, et al: Telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia. Blood Adv. 2:1572–1579. 2018. View Article : Google Scholar : PubMed/NCBI

125 

Boultwood J, Fidler C, Shepherd P, Watkins F, Snowball J, Haynes S, Kusec R, Gaiger A, Littlewood TJ, Peniket AJ and Wainscoat JS: Telomere length shortening is associated with disease evolution in chronic myelogenous leukemia. Am J Hematol. 61:5–9. 1999. View Article : Google Scholar : PubMed/NCBI

126 

Drummond M, Lennard A, Brûmmendorf T and Holyoake T: Telomere shortening correlates with prognostic score at diagnosis and proceeds rapidly during progression of chronic myeloid leukemia. Leuk Lymphoma. 45:1775–1781. 2004. View Article : Google Scholar : PubMed/NCBI

127 

Keller G, Brassat U, Braig M, Heim D, Wege H and Brümmendorf TH: Telomeres and telomerase in chronic myeloid leukaemia: Impact for pathogenesis, disease progression and targeted therapy. Hematol Oncol. 27:123–129. 2009. View Article : Google Scholar : PubMed/NCBI

128 

Boultwood J, Peniket A, Watkins F, Shepherd P, McGale P, Richards S, Fidler C, Littlewood TJ and Wainscoat JS: Telomere length shortening in chronic myelogenous leukemia is associated with reduced time to accelerated phase. Blood. 96:358–361. 2000. View Article : Google Scholar : PubMed/NCBI

129 

Caocci G, Greco M, Delogu G, Secchi C, Martino B, Labate C, Abruzzese E, Trawinska MM, Galimberti S, Orru F, et al: Telomere length shortening is associated with treatment-free remission in chronic myeloid leukemia patients. J Hematol Oncol. 9:632016. View Article : Google Scholar : PubMed/NCBI

130 

Samassekou O, Ntwari A, Hébert J and Yan J: Individual telomere lengths in chronic myeloid leukemia. Neoplasia. 11:1146–1154. 2009. View Article : Google Scholar : PubMed/NCBI

131 

Nikolouzakis TK, Falzone L, Lasithiotakis K, Krüger-Krasagakis S, Kalogeraki A, Sifaki M, Spandidos DA, Chrysos E, Tsatsakis A and Tsiaoussis J: Current and future trends in molecular biomarkers for diagnostic, prognostic, and predictive purposes in non-melanoma skin cancer. J Clin Med. 9:28682020. View Article : Google Scholar : PubMed/NCBI

132 

Llorca-Cardeñosa MJ, Peña-Chilet M, Mayor M, Gomez-Fernandez C, Casado B, Martin-Gonzalez M, Carretero G, Lluch A, Martinez-Cadenas C, Ibarrola-Villava M and Ribas G: Long telomere length and a TERT-CLPTM1 locus polymorphism association with melanoma risk. Eur J Cancer. 50:3168–3177. 2014. View Article : Google Scholar : PubMed/NCBI

133 

Anic GM, Sondak VK, Messina JL, Fenske NA, Zager JS, Cherpelis BS, Lee JH, Fulp WJ, Epling-Burnette PK, Park JY and Rollison DE: Telomere length and risk of melanoma, squamous cell carcinoma, and basal cell carcinoma. Cancer Epidemiol. 37:434–439. 2013. View Article : Google Scholar : PubMed/NCBI

134 

Bodelon C, Pfeiffer RM, Bollati V, Debbache J, Calista D, Ghiorzo P, Fargnoli MC, Bianchi-Scarra G, Peris K, Hoxha M, et al: On the interplay of telomeres, nevi and the risk of melanoma. PLoS One. 7:e524662012. View Article : Google Scholar

135 

Han J, Qureshi AA, Prescott J, Guo Q, Ye L, Hunter DJ and De Vivo I: A prospective study of telomere length and the risk of skin cancer. J Invest Dermatol. 129:415–421. 2009. View Article : Google Scholar :

136 

Nan H, Du M, De Vivo I, Manson JE, Liu S, McTiernan A, Curb JD, Lessin LS, Bonner MR, Guo Q, et al: Shorter telomeres associate with a reduced risk of melanoma development. Cancer Res. 71:6758–6763. 2011. View Article : Google Scholar : PubMed/NCBI

137 

Burke LS, Hyland PL, Pfeiffer RM, Prescott J, Wheeler W, Mirabello L, Savage SA, Burdette L, Yeager M, Chanock S, et al: Telomere length and the risk of cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations. PLoS One. 8:711212013. View Article : Google Scholar

138 

Caini S, Raimondi S, Johansson H, De Giorgi V, Zanna I, Palli D and Gandini S: Telomere length and the risk of cutaneous melanoma and non-melanoma skin cancer: A review of the literature and meta-analysis. J Dermatol Sci. 80:168–174. 2015. View Article : Google Scholar : PubMed/NCBI

139 

Rachakonda S, Srinivas N, Mahmoudpour SH, Garcia-Casado Z, Requena C, Traves V, Soriano V, Cardelli M, Pjanova D, Molven A, et al: Telomere length and survival in primary cutaneous melanoma patients. Sci Rep. 8:109472018. View Article : Google Scholar : PubMed/NCBI

140 

Viceconte N, Dheur MS, Majerova E, Pierreux CE, Baurain JF, van Baren N and Decottignies A: Highly aggressive metastatic melanoma cells unable to maintain telomere length. Cell Rep. 19:2529–2543. 2017. View Article : Google Scholar : PubMed/NCBI

141 

Menin C, Bojnik E, Del Bianco P, Elefanti L, Gianesin K, Keppel S, Stagni C, Mocellin S, Vecchiato A and De Rossi A: Differences in telomere length between sporadic and familial cutaneous melanoma. Br J Dermatol. 175:937–943. 2016. View Article : Google Scholar : PubMed/NCBI

142 

Kammori M, Takubo K, Nakamura K, Furugouri E, Endo H, Kanauchi H, Mimura Y and Kaminishi M: Telomerase activity and telomere length in benign and malignant human thyroid tissues. Cancer Lett. 159:175–181. 2000. View Article : Google Scholar : PubMed/NCBI

143 

Matthews P, Jones CJ, Skinner J, Haughton M, de Micco C and Wynford-Thomas D: Telomerase activity and telomere length in thyroid neoplasia: Biological and clinical implications. J Pathol. 194:183–193. 2001. View Article : Google Scholar : PubMed/NCBI

144 

Dong C and Hemminki K: Modification of cancer risks in offspring by sibling and parental cancers from 2,112,616 nuclear families. Int J Cancer. 92:144–150. 2001. View Article : Google Scholar : PubMed/NCBI

145 

Jendrzejewski J, Tomsic J, Lozanski G, Labanowska J, He H, Liyanarachchi S, Nagy R, Ringel MD, Kloos RT, Heerema NA and de la Chapelle A: Telomere length and telomerase reverse transcriptase gene copy number in patients with papillary thyroid carcinoma. J Clin Endocrinol Metab. 96:1876–1880. 2011. View Article : Google Scholar

146 

Capezzone M, Cantara S, Marchisotta S, Filetti S, De Santi MM, Rossi B, Ronga G, Durante C and Pacini F: Short telomeres, telomerase reverse transcriptase gene amplification, and increased telomerase activity in the blood of familial papillary thyroid cancer patients. J Clin Endocrinol Metab. 93:3950–3957. 2008. View Article : Google Scholar : PubMed/NCBI

147 

Capezzone M, Cantara S, Marchisotta S, Busonero G, Formichi C, Benigni M, Capuano S, Toti P, Pazaitou-Panayiotou K, Caruso G, et al: Telomere length in neoplastic and nonneoplastic tissues of patients with familial and sporadic papillary thyroid cancer. J Clin Endocrinol Metab. 96:1852–1856. 2011. View Article : Google Scholar

148 

He M, Bian B, Gesuwan K, Gulati N, Zhang L, Nilubol N and Kebebew E: Telomere length is shorter in affected members of families with familial nonmedullary thyroid cancer. Thyroid. 23:301–307. 2013. View Article : Google Scholar :

149 

Gramatges MM, Morton LM, Yasui Y, Arnold MA, Neglia JP, Leisenring WM, Machiela MJ, Dagnall CL, Chanock SJ, Armstrong GT, et al: Telomere length-associated genetic variants and the risk of thyroid cancer in survivors of childhood cancer: A report from the childhood cancer survivor study (CCSS). Cancer Epidemiol Biomarkers Prev. 28:417–419. 2019. View Article : Google Scholar :

150 

Li J, An C, Zheng H, Lei T, Zhang N, Zheng Y and Yang M: Leukocyte telomere length and risk of papillary thyroid carcinoma. J Clin Endocrinol Metab. 104:2712–2718. 2019. View Article : Google Scholar : PubMed/NCBI

151 

Graham MK and Meeker A: Telomeres and telomerase in prostate cancer development and therapy. Nat Rev Urol. 14:607–619. 2017. View Article : Google Scholar : PubMed/NCBI

152 

Xu J, Chang WS, Tsai CW, Bau DT, Xu Y, Davis JW, Thompson TC, Logothetis CJ and Gu J: Leukocyte telomere length is associated with aggressive prostate cancer in localized prostate cancer patients. EBioMedicine. 52:1026162020. View Article : Google Scholar : PubMed/NCBI

153 

Tsai CW, Chang WS, Xu J, Xu Y, Huang M, Pettaway C, Bau DT and Gu J: Leukocyte telomere length is associated with aggressive prostate cancer in localized African American prostate cancer patients. Carcinogenesis. 41:1213–1218. 2020. View Article : Google Scholar : PubMed/NCBI

154 

Hu R, Hua XG and Jiang QC: Associations of telomere length in risk and recurrence of prostate cancer: A meta-analysis. Andrologia. 51:e133042019. View Article : Google Scholar : PubMed/NCBI

155 

Luxton JJ, McKenna MJ, Lewis AM, Taylor LE, Jhavar SG, Swanson GP and Bailey SM: Telomere length dynamics and chromosomal instability for predicting individual radiosensitivity and risk via machine learning. J Pers Med. 11:1882021. View Article : Google Scholar : PubMed/NCBI

156 

Gu CY, Jin SM, Qin XJ, Zhu Y, Bo D, Lin GW, Shi GH and Ye DW: Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk. J Cancer. 10:6170–6174. 2019. View Article : Google Scholar : PubMed/NCBI

157 

Hurwitz LM, Heaphy CM, Joshu CE, Isaacs WB, Konishi Y, De Marzo AM, Isaacs SD, Wiley KE, Platz EA and Meeker AK: Telomere length as a risk factor for hereditary prostate cancer. Prostate. 74:359–364. 2014. View Article : Google Scholar

158 

Julin B, Shui I, Heaphy CM, Joshu CE, Meeker AK, Giovannucci E, De Vivo I and Platz EA: Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer. Br J Cancer. 112:769–776. 2015. View Article : Google Scholar : PubMed/NCBI

159 

Renner W, Krenn-Pilko S, Gruber HJ, Herrmann M and Langsenlehner T: Relative telomere length and prostate cancer mortality. Prostate Cancer Prostatic Dis. 21:579–583. 2018. View Article : Google Scholar : PubMed/NCBI

160 

Svenson U, Roos G and Wikström P: Long leukocyte telomere length in prostate cancer patients at diagnosis is associated with poor metastasis-free and cancer-specific survival. Tumour Biol. 39:10104283176922362017. View Article : Google Scholar : PubMed/NCBI

161 

Wulaningsih W, Astuti Y, Matsuguchi T, Anggrandariyanny P and Watkins J; PILAR Research Network: Circulating Prostate-specific antigen and telomere length in a nationally representative sample of men without history of prostate cancer. Prostate. 77:22–32. 2017. View Article : Google Scholar

162 

Heaphy CM, Haffner MC, Graham MK, Lim D, Davis C, Corey E, Epstein JI, Eisenberger MA, Wang H, De Marzo AM, et al: Telomere lengths differ significantly between small-cell neuroendocrine prostate carcinoma and adenocarcinoma of the prostate. Hum Pathol. 101:70–79. 2020. View Article : Google Scholar : PubMed/NCBI

163 

Mirabello L, Huang WY, Wong JY, Chatterjee N, Reding D, Crawford ED, De Vivo I, Hayes RB and Savage SA: The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer. Aging Cell. 8:405–413. 2009. View Article : Google Scholar : PubMed/NCBI

164 

Joshu CE, Peskoe SB, Heaphy CM, Kenfield SA, Mucci LA, Giovannucci EL, Stampfer MJ, Yoon G, Lee TK, Hicks JL, et al: Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells. Prostate. 78:233–238. 2018. View Article : Google Scholar :

165 

Heaphy CM, Joshu CE, Barber JR, Davis C, Zarinshenas R, De Marzo AM, Lotan TL, Sfanos KS, Meeker AK, Platz EA, et al: Racial difference in prostate cancer cell telomere lengths in men with higher grade prostate cancer: A clue to the racial disparity in prostate cancer outcomes. Cancer Epidemiol Biomarkers Prev. 29:676–680. 2020. View Article : Google Scholar : PubMed/NCBI

166 

Luu HN, Long J, Wen W, Zheng Y, Cai Q, Gao YT, Zheng W and Shu XO: Association between genetic risk score for telomere length and risk of breast cancer. Cancer Causes Control. 27:1219–1228. 2016. View Article : Google Scholar : PubMed/NCBI

167 

Kroupa M, Rachakonda S, Vymetalkova V, Tomasova K, Liska V, Vodenkova S, Cumova A, Rossnerova A, Vodickova L, Hemminki K, et al: Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients. Mutagenesis. 35:491–497. 2020. View Article : Google Scholar : PubMed/NCBI

168 

Samavat H, Xun X, Jin A, Wang R, Koh WP and Yuan JM: Association between prediagnostic leukocyte telomere length and breast cancer risk: The Singapore Chinese Health Study. Breast Cancer Res. 21:502019. View Article : Google Scholar : PubMed/NCBI

169 

Pellatt AJ, Wolff RK, Torres-Mejia G, John EM, Herrick JS, Lundgreen A, Baumgartner KB, Giuliano AR, Hines LM, Fejerman L, et al: Telomere length, telomere-related genes, and breast cancer risk: The breast cancer health disparities study. Genes Chromosomes Cancer. 52:595–609. 2013.PubMed/NCBI

170 

Wang Z, Zhang Z, Guo Y, Shui H, Liu G, Jin T and Wang H: Shorter telomere length is associated with increased breast cancer risk in a Chinese Han population: A Case-Control analysis. J Breast Cancer. 21:391–398. 2018. View Article : Google Scholar

171 

Shen J, Terry MB, Gurvich I, Liao Y, Senie RT and Santella RM: Short telomere length and breast cancer risk: A study in sister sets. Cancer Res. 67:5538–5544. 2007. View Article : Google Scholar : PubMed/NCBI

172 

Pavanello S, Varesco L, Gismondi V, Bruzzi P and Bolognesi C: Leucocytes telomere length and breast cancer risk/susceptibility: A case-control study. PLoS One. 13:e01975222018. View Article : Google Scholar

173 

Duggan C, Risques R, Alfano C, Prunkard D, Imayama I, Holte S, Baumgartner K, Baumgartner R, Bernstein L, Ballard-Barbash R, et al: Change in peripheral blood leukocyte telomere length and mortality in breast cancer survivors. J Natl Cancer Inst. 106:dju0352014. View Article : Google Scholar : PubMed/NCBI

174 

Ceja-Rangel HA, Sánchez-Suárez P, Castellanos-Juárez E, Peñaroja-Flores R, Arenas-Aranda DJ, Gariglio P and Benítez-Bribiesca L: Shorter telomeres and high telomerase activity correlate with a highly aggressive phenotype in breast cancer cell lines. Tumour Biol. 37:11917–11926. 2016. View Article : Google Scholar : PubMed/NCBI

175 

Kammori M, Sugishita Y, Okamoto T, Kobayashi M, Yamazaki K, Yamada E and Yamada T: Telomere shortening in breast cancer correlates with the pathological features of tumor progression. Oncol Rep. 34:627–632. 2015. View Article : Google Scholar : PubMed/NCBI

176 

Barczak W, Rozwadowska N, Romaniuk A, Lipińska N, Lisiak N, Grodecka-Gazdecka S, Książek K and Rubiś B: Telomere length assessment in leukocytes presents potential diagnostic value in patients with breast cancer. Oncol Lett. 11:2305–2309. 2016. View Article : Google Scholar : PubMed/NCBI

177 

Eyüboğlu İP, Yenmiş G, Bingöl EN, Yüksel Ş, Tokat F, Özbek P, Güllü Amuran G, Yakıcıer C and Akkiprik M: Next-generation sequencing identifies BRCA1 and/or BRCA2 mutations in Women at high hereditary risk for breast cancer with shorter telomere length. OMICS. 24:5–15. 2020. View Article : Google Scholar

178 

Badie S, Escandell JM, Bouwman P, Carlos AR, Thanasoula M, Gallardo MM, Suram A, Jaco I, Benitez J, Herbig U, et al: BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat Struct Mol Biol. 17:1461–1469. 2010. View Article : Google Scholar : PubMed/NCBI

179 

Thorvaldsdottir B, Aradottir M, Stefansson OA, Bodvarsdottir SK and Eyfjörd JE: Telomere length is predictive of breast cancer risk in BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev. 26:1248–1254. 2017. View Article : Google Scholar : PubMed/NCBI

180 

Ennour-Idrissi K, Maunsell E and Diorio C: Telomere length and breast cancer prognosis: A systematic review. Cancer Epidemiol Biomarkers Prev. 26:3–10. 2017. View Article : Google Scholar

181 

Garland SN, Johnson B, Palmer C, Speck RM, Donelson M, Xie SX, DeMichele A and Mao JJ: Physical activity and telomere length in early stage breast cancer survivors. Breast Cancer Res. 16:4132014. View Article : Google Scholar : PubMed/NCBI

182 

Alhareeri AA, Archer KJ, Fu H, Lyon DE, Elswick RK Jr, Kelly DL, Starkweather AR, Elmore LW, Bokhari YA and Jackson-Cook CK: Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: A longitudinal study. Breast Cancer Res. 22:1372020. View Article : Google Scholar : PubMed/NCBI

183 

Mirabello L, Garcia-Closas M, Cawthon R, Lissowska J, Brinton LA, Pepłońska B, Sherman ME and Savage SA: Leukocyte telomere length in a population-based case-control study of ovarian cancer: A pilot study. Cancer Causes Control. 21:77–82. 2010. View Article : Google Scholar

184 

Kuhn E, Meeker AK, Visvanathan K, Gross AL, Wang TL, Kurman RJ and Shih IeM: Telomere length in different histologic types of ovarian carcinoma with emphasis on clear cell carcinoma. Mod Pathol. 24:1139–1145. 2011. View Article : Google Scholar : PubMed/NCBI

185 

Vajpeyi R: WHO Classification of Tumours: Pathology and genetics of tumours of the breast and female genital organs. J Clin Pathol. 58:671–672. 2005.

186 

Martinez-Delgado B, Anowsky K, Inglada-Perez L, de la Hoya M, Caldes T, Vega A, Blanco A, Martin T, Gonzalez-Sarmiento R, Blasco M, et al: Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases. J Med Genet. 49:341–344. 2012. View Article : Google Scholar : PubMed/NCBI

187 

Falandry C, Horard B, Bruyas A, Legouffe E, Cretin J, Meunier J, Alexandre J, Delecroix V, Fabbro M, Certain MN, et al: Telomere length is a prognostic biomarker in elderly advanced ovarian cancer patients: A multicenter GINECO study. Aging (Albany NY). 7:1066–1076. 2015. View Article : Google Scholar : PubMed/NCBI

188 

Yang M, Prescott J, Poole EM, Rice MS, Kubzansky LD, Idahl A, Lundin E, De Vivo I and Tworoger SS: Prediagnosis leukocyte telomere length and risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 26:339–345. 2017. View Article : Google Scholar : PubMed/NCBI

189 

Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, et al: Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet. 45:371–384. 384e1–2. 2013. View Article : Google Scholar : PubMed/NCBI

190 

Terry KL, Tworoger SS, Vitonis AF, Wong J, Titus-Ernstoff L, De Vivo I and Cramer DW: Telomere length and genetic variation in telomere maintenance genes in relation to ovarian cancer risk. Cancer Epidemiol Biomarkers Prev. 21:504–512. 2012. View Article : Google Scholar : PubMed/NCBI

191 

Kotsopoulos J, Prescott J, De Vivo I, Fan I, Mclaughlin J, Rosen B, Risch H, Sun P and Narod SA: Telomere length and mortality following a diagnosis of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 23:2603–2606. 2014. View Article : Google Scholar : PubMed/NCBI

192 

Antoun S, Atallah D, Tahtouh R, Assaf MD, Moubarak M, Ayoub EN, Chahine G and Hilal G: Glucose restriction combined with chemotherapy decreases telomere length and cancer antigen-125 secretion in ovarian carcinoma. Oncol Lett. 19:1338–1350. 2020.PubMed/NCBI

193 

Victorelli S and Passos JF: Telomeres and cell senescence-size matters not. EBioMedicine. 21:14–20. 2017. View Article : Google Scholar : PubMed/NCBI

194 

Kim B, Ryu KJ, Lee S and Kim T: Changes in telomere length and senescence markers during human ovarian tissue cryopreservation. Sci Rep. 11:22382021. View Article : Google Scholar : PubMed/NCBI

195 

Zhang DK, Ngan HY, Cheng RY, Cheung AN, Liu SS and Tsao SW: Clinical significance of telomerase activation and telomeric restriction fragment (TRF) in cervical cancer. Eur J Cancer. 35:154–160. 1999. View Article : Google Scholar : PubMed/NCBI

196 

Maida Y, Kyo S, Forsyth NR, Takakura M, Sakaguchi J, Mizumoto Y, Hashimoto M, Nakamura M, Nakao S and Inoue M: Distinct telomere length regulation in premalignant cervical and endometrial lesions: Implications for the roles of telomeres in uterine carcinogenesis. J Pathol. 210:214–223. 2006. View Article : Google Scholar : PubMed/NCBI

197 

Chen X, Wei S, Ma H, Jin G, Hu Z, Suping H, Li D, Hang D, Wu X and Li N: Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high-risk HPV-positive women. Cancer Me. 8:4845–4851. 2019. View Article : Google Scholar

198 

Azzalin CM, Reichenbach P, Khoriauli L, Giulotto E and Lingner J: Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science. 318:798–801. 2007. View Article : Google Scholar : PubMed/NCBI

199 

Deng Z, Wang Z, Xiang C, Molczan A, Baubet V, Conejo-Garcia J, Xu X, Lieberman PM and Dahmane N: Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma. J Cell Sci. 125:4383–4394. 2012.PubMed/NCBI

200 

Oh BK, Keo P, Bae J, Ko JH and Choi JS: Variable TERRA abundance and stability in cervical cancer cells. Int J Mol Med. 39:1597–1604. 2017. View Article : Google Scholar : PubMed/NCBI

201 

Déjardin J and Kingston RE: Purification of proteins associated with specific genomic Loci. Cell. 136:175–186. 2009. View Article : Google Scholar : PubMed/NCBI

202 

Kappei D, Butter F, Benda C, Scheibe M, Draškovič I, Stevense M, Novo CL, Basquin C, Araki M, Krastev DB, et al: HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. EMBO J. 32:1681–1701. 2013. View Article : Google Scholar : PubMed/NCBI

203 

Zhou S, Xiao Y, Zhuang Y, Liu Y, Zhao H, Yang H, Xie C, Zhou F and Zhou Y: Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening. Oncol Rep. 38:515–521. 2017. View Article : Google Scholar : PubMed/NCBI

204 

Du J, Xue W, Ji Y, Zhu X, Gu Y, Zhu M, Wang C, Gao Y, Dai J, Ma H, et al: U-shaped association between telomere length and esophageal squamous cell carcinoma risk: A case-control study in Chinese population. Front Med. 9:478–486. 2015. View Article : Google Scholar : PubMed/NCBI

205 

Xing J, Ajani JA, Chen M, Izzo J, Lin J, Chen Z, Gu J and Wu X: Constitutive short telomere length of chromosome 17p and 12q but not 11q and 2p is associated with an increased risk for esophageal cancer. Cancer Prev Res (Phila). 2:459–465. 2009. View Article : Google Scholar : PubMed/NCBI

206 

Zheng YL, Hu N, Sun Q, Wang C and Taylor PR: Telomere attrition in cancer cells and telomere length in tumor stroma cells predict chromosome instability in esophagealsquamous cell carcinoma: A genome-wide analysis. Cancer Res. 69:1604–1614. 2009. View Article : Google Scholar : PubMed/NCBI

207 

Lin SW, Abnet CC, Freedman ND, Murphy G, Risques R, Prunkard D, Rabinovitch P, Pan QJ, Roth MJ, Wang GQ, et al: Measuring telomere length for the early detection of precursor lesions of esophageal squamous cell carcinoma. BMC Cancer. 13:5782013. View Article : Google Scholar : PubMed/NCBI

208 

Li Z, Song Y, Xu Y, Shen Y, Zhang N, Yang M and Yu D: Identification of Leukocyte telomere length-related genetic variants contributing to predisposition of Esophageal Squamous Cell Carcinoma. J Cancer. 11:5025–5031. 2020. View Article : Google Scholar : PubMed/NCBI

209 

Lu Y, Yan C, Du J, Ji Y, Gao Y, Zhu X, Yu F, Huang T, Dai J, Ma H, et al: Genetic variants affecting telomere length are associated with the prognosis of esophageal squamous cell carcinoma in a Chinese population. Mol Carcinog. 56:1021–1029. 2017. View Article : Google Scholar

210 

Shi J, Sun F, Peng L, Li B, Liu L, Zhou C, Han J, Zhang L, Zhou L, Zhang X, et al: Leukocyte telomere length-related genetic variants in 1p34.2 and 14q21 loci contribute to the risk of esophageal squamous cell carcinoma. Int J Cancer. 132:2799–2807. 2013. View Article : Google Scholar

211 

Hao XD, Yang Y, Song X, Zhao XK, Wang LD, He JD, Kong QP, Tang NL and Zhang YP: Correlation of telomere length shortening with TP53 somatic mutations, polymorphisms and allelic loss in breast tumors and esophageal cancer. Oncol Rep. 29:226–236. 2013. View Article : Google Scholar

212 

Yu Q, Yang J, Liu B, Li W, Hu G, Qiu H, Huang L, Xiong H and Yuan X: Combined effects of leukocyte telomere length, p53 polymorphism and human papillomavirus infection on esophageal squamous cell carcinoma in a Han Chinese population. Cancer Epidemiol. 38:569–575. 2014. View Article : Google Scholar : PubMed/NCBI

213 

Wennerström EC, Risques RA, Prunkard D, Giffen C, Corley DA, Murray LJ, Whiteman DC, Wu AH, Bernstein L, Ye W, et al: Leukocyte telomere length in relation to the risk of Barrett's esophagus and esophageal adenocarcinoma. Cancer Med. 5:2657–2665. 2016. View Article : Google Scholar : PubMed/NCBI

214 

Pan W, Du J, Shi M, Jin G and Yang M: Short leukocyte telomere length, alone and in combination with smoking, contributes to increased risk of gastric cancer or esophageal squamous cell carcinoma. Carcinogenesis. 38:12–18. 2017. View Article : Google Scholar

215 

Tahara T, Tahara S, Horiguchi N, Kawamura T, Okubo M, Ishizuka T, Yamada H, Yoshida D, Ohmori T, Maeda K, et al: Telomere length in leukocyte DNA in gastric cancer patients and its association with Clinicopathological features and prognosis. Anticancer Res. 37:1997–2001. 2017. View Article : Google Scholar : PubMed/NCBI

216 

Hou L, Savage SA, Blaser MJ, Perez-Perez G, Hoxha M, Dioni L, Pegoraro V, Dong LM, Zatonski W, Lissowska J, et al: Telomere length in peripheral leukocyte DNA and gastric cancer risk. Cancer Epidemiol Biomarkers Prev. 18:3103–3109. 2009. View Article : Google Scholar : PubMed/NCBI

217 

Qu F, Li R, He X, Li Q, Xie S, Gong L, Ji G, Lu J and Bao G: Short telomere length in peripheral blood leukocytes predicts poor prognosis and indicates an immunosuppressive phenotypegastric cancer patients. Mol Oncol. 9:727–739. 2015. View Article : Google Scholar

218 

Wang Z, Koh WP, Jin A, Wang R and Yuan JM: Telomere length and risk of developing gastric adenocarcinoma: The Singapore Chinese Health Study. Gastric Cancer. 2:598–605. 2018. View Article : Google Scholar

219 

Weischer M, Nordestgaard BG, Cawthon RM, Freiberg JJ, Tybjærg-Hansen A and Bojesen SE: Short telomere length, cancer survival, and cancer risk in 47102 individuals. J Natl Cancer Inst. 105:459–468. 2013. View Article : Google Scholar : PubMed/NCBI

220 

Liu X, Bao G, Huo T, Wang Z, He X and Dong G: Constitutive telomere length and gastric cancer risk: Case-control analysis in Chinese Han population. Cancer Sci. 100:1300–1305. 2009. View Article : Google Scholar : PubMed/NCBI

221 

Liu Y, Lei T, Zhang N, Zheng Y, Kou P, Shang S and Yang M: Leukocyte telomere length and risk of gastric cardia adenocarcinoma. Sci Rep. 8:145842018. View Article : Google Scholar : PubMed/NCBI

222 

Tahara T, Shibata T, Kawamura T, Horiguchi N, Okubo M, Nakano N, Ishizuka T, Nagasaka M, Nakagawa Y and Ohmiya N: Telomere length shortening in gastric mucosa is a field effect associated with increased risk of gastric cancer. Virchows Arch. 469:19–24. 2016. View Article : Google Scholar : PubMed/NCBI

223 

Heo YR and Lee JH: Association between telomere length and PIK3CA amplification in gastric cancer. Clin Exp Med. 18:133–134. 2018. View Article : Google Scholar

224 

Lili M, Yuxiang F, Zhongcheng H, Ying S, Ru C, Rong X and Jiang L: Genetic variations associated with telomere length affect the risk of gastric carcinoma. Medicine (Baltimore). 99:e205512020. View Article : Google Scholar : PubMed/NCBI

225 

Du J, Zhu X, Xie C, Dai N, Gu Y, Zhu M, Wang C, Gao Y, Pan F, Ren C, et al: Telomere length, genetic variants and gastric cancer risk in a Chinese population. Carcinogenesis. 36:963–970. 2015. View Article : Google Scholar : PubMed/NCBI

226 

Choi BJ, Yoon JH, Kim O, Choi WS, Nam SW, Lee JY and Park WS: Influence of the hTERT rs2736100 polymorphism on telomere length in gastric cancer. World J Gastroenterol. 21:9328–9336. 2015. View Article : Google Scholar : PubMed/NCBI

227 

Campa D, Matarazzi M, Greenhalf W, Bijlsma M, Saum KU, Pasquali C, van Laarhoven H, Szentesi A, Federici F, Vodicka P, et al: Genetic determinants of telomere length and risk of pancreatic cancer: A PANDoRA study. Int J Cancer. 144:1275–1283. 2019. View Article : Google Scholar

228 

Duell EJ: Telomere length and pancreatic cancer risk: Breaking down the evidence. Gut. 66:12017. View Article : Google Scholar

229 

Luu HN, Huang JY, Wang R, Adams-Haduch J, Jin A, Koh WP and Yuan JM: Association between leukocyte telomere length and the risk of pancreatic cancer: Findings from a prospective study. PLoS One. 14:e02216972019. View Article : Google Scholar : PubMed/NCBI

230 

Campa D, Mergarten B, De Vivo I, Boutron-Ruault MC, Racine A, Severi G, Nieters A, Katzke VA, Trichopoulou A, Yiannakouris N, et al: Leukocyte telomere length in relation to pancreatic cancer risk: A prospective study. Cancer Epidemiol Biomarkers Prev. 23:2447–2454. 2014. View Article : Google Scholar : PubMed/NCBI

231 

Mormile R: Telomere length and pancreatic cancer risk-letter. Cancer Epidemiol Biomarkers Prev. 26:11572017. View Article : Google Scholar : PubMed/NCBI

232 

Skinner HG, Gangnon RE, Litzelman K, Johnson RA, Chari ST, Petersen GM and Boardman LA: Telomere length and pancreatic cancer: A case-control study. Cancer Epidemiol Biomarkers Prev. 21:2095–2100. 2012. View Article : Google Scholar : PubMed/NCBI

233 

Zhang R, Zhao J, Xu J and Liu F: Association of peripheral leukocyte telomere length and its variation with pancreatic cancer and colorectal cancer risk in Chinese population. Oncotarget. 7:38579–38585. 2016. View Article : Google Scholar : PubMed/NCBI

234 

Antwi SO, Bamlet WR, Broderick BT, Chaffee KG, Oberg A, Jatoi A, Boardman LA and Petersen GM: Genetically predicted telomere length is not associated with pancreatic cancer risk. Cancer Epidemiol Biomarkers Prev. 26:971–974. 2017. View Article : Google Scholar : PubMed/NCBI

235 

Antwi SO, Bamlet WR, Rabe KG, Cawthon RM, Umudi I, Druliner BR, Sicotte H, Oberg AL, Jatoi A, Boardman LA and Petersen GM: Leukocyte telomere length and its interaction with germline variation in Telomere-Related genes in relation to pancreatic adenocarcinoma risk. Cancer Epidemiol Biomarkers Prev. 29:1492–1500. 2020. View Article : Google Scholar : PubMed/NCBI

236 

Hamada T, Yuan C, Bao Y, Zhang M, Khalaf N, Babic A, Morales-Oyarvide V, Cochrane BB, Gaziano JM, Giovannucci EL, et al: Prediagnostic leukocyte telomere length and pancreatic cancer survival. Cancer Epidemiol Biomarkers Prev. 28:1868–1875. 2019. View Article : Google Scholar : PubMed/NCBI

237 

Bao Y, Prescott J, Yuan C, Zhang M, Kraft P, Babic A, Morales-Oyarvide V, Qian ZR, Buring JE, Cochrane BB, et al: Leucocyte telomere length genetic variants at the TERT gene region and risk of pancreatic cancer. Gut. 66:1116–1122. 2017. View Article : Google Scholar

238 

Posch A, Hofer-Zeni S, Klieser E, Primavesi F, Naderlinger E, Brandstetter A, Filipits M, Urbas R, Swiercynski S, Jäger T, et al: Hot Spot TERT promoter mutations are rare in sporadic pancreatic neuroendocrine Neoplasms and associated with telomere length and epigenetic expression patterns. Cancers (Basel). 12:16252020. View Article : Google Scholar : PubMed/NCBI

239 

Mormile R: Leukocyte telomere length and pancreatic cancer survival: A consequence of activation of IL-6 signaling pathway in the carcinogenic process? J Gastrointest Cancer. 51:720–721. 2020. View Article : Google Scholar : PubMed/NCBI

240 

Kroupa M, Rachakonda SK, Liska V, Srinivas N, Urbanova M, Jiraskova K, Schneiderova M, Vycital O, Vymetalkova V, Vodickova L, et al: Relationship of telomere length in colorectal cancer patients with cancer phenotype and patient prognosis Relationship of telomere length in colorectal cancer patients with cancer phenotype and patient prognosis. Br J Cance. 121:344–350. 2019. View Article : Google Scholar

241 

Lopez-Doriga A, Valle L, Alonso MH, Aussó S, Closa A, Sanjuan X, Barquero D, Rodríguez-Moranta F, Sanz-Pamplona R and Moreno V: Telomere length alterations in microsatellite stable colorectal cancer and association with the immune response. Biochim Biophys Acta Mol Basis Dis. 1864:2992–3000. 2018. View Article : Google Scholar : PubMed/NCBI

242 

Piñol-Felis C, Fernández-Marcelo T, Viñas-Salas J and Valls-Bautista C: Telomeres and telomerase in the clinical management of colorectal cancer. Clin Transl Oncol. 19:399–408. 2017. View Article : Google Scholar

243 

Balc'h EL, Grandin N, Demattei MV, Guyétant S, Tallet A, Pagès JC, Ouaissi M, Lecomte and Charbonneau M: Measurement of telomere length in colorectal cancers for improved molecular diagnosis. Int J Mol Sci. 18:18712017. View Article : Google Scholar : PubMed/NCBI

244 

Luu HN, Qi M, Wang R, Adams-Haduch J, Miljkovic I, Opresko PL, Jin A, Koh WP and Yuan JM: Association between leukocyte telomere length and colorectal cancer risk in the Singapore Chinese Health Study. Clin Transl Gastroenterol. 10:1–9. 2019. View Article : Google Scholar : PubMed/NCBI

245 

Peacock SD, Massey TE, Vanner SJ and King WD: Telomere length in the colon is related to colorectal adenoma prevalence. PLoS One. 13:e02056972018. View Article : Google Scholar : PubMed/NCBI

246 

Naing C, Aung K, Lai PK and Mak JW: Association between telomere length and the risk of colorectal cancer: A meta-analysis of observational studies. BMC Cancer. 17:242017. View Article : Google Scholar : PubMed/NCBI

247 

Aljarbou F, Almobarak A, Binrayes A and Alamri HM: The expression of telomere-related proteins and DNA damage response and their association with telomere length in colorectal cancer in Saudi patients. PLoS One. 13:e01971542018. View Article : Google Scholar : PubMed/NCBI

248 

Park WJ, Bae SU, Heo YR, Jung SJ and Lee JH: Telomere shortening in non-tumorous and tumor mucosa is independently related to colorectal carcinogenesis in precancerous lesions. Int J Mol Epidemiol Genet. 8:53–58. 2017.PubMed/NCBI

249 

Li J, Chang J, Tian J, Ke J, Zhu Y, Yang Y, Gong Y, Zou D, Peng X, Yang N, et al: A Rare Variant P507L in TPP1 interrupts TPP1-TIN2 interaction, influences telomere length, and confers colorectal cancer risk in Chinese population. Cancer Epidemiol Biomarkers Prev. 27:1029–1035. 2018. View Article : Google Scholar : PubMed/NCBI

250 

Ridout KK, Ridout SJ, Price LH, Sen S and Tyrka AR: Depression and telomere length: A meta-analysis. J Affect Disord. 191:237–247. 2016. View Article : Google Scholar :

251 

AlAhwal MS, Zaben FA, Sehlo MG, Khalifa DA, Al-Aama JY, Edris S, Ashy JA and Koenig HG: Depression and telomere length in colorectal cancer patients in Saudi Arabia. Asian J Psychiatr. 40:130–131. 2019. View Article : Google Scholar

252 

Ko E, Seo HW and Jung G: Telomere length and reactive oxygen species levels are positively associated with a high risk of mortality and recurrence in hepatocellular carcinoma. Hepatology. 67:1378–1391. 2018. View Article : Google Scholar

253 

Ma LJ, Wang XY, Duan M, Liu LZ, Shi JY, Dong LQ, Yang LX, Wang ZC, Ding ZB and Ke AW: Telomere length variation in tumor cells and cancer-associated fibroblasts: Potential biomarker for hepatocellular carcinoma. J Pathol. 243:407–417. 2017. View Article : Google Scholar : PubMed/NCBI

254 

Lee HW, Park TI, Jang SY, Park SY, Park WJ, Jung SJ and Lee JH: Clinicopathological characteristics of TERT promoter mutation and telomere length in hepatocellular carcinoma. Medicine (Baltimore). 96:e57662017. View Article : Google Scholar : PubMed/NCBI

255 

Ningarhari M, Caruso S, Hirsch TZ, Bayard Q, Franconi A, Védie AL, Noblet B, Blanc JF, Amaddeo G, Ganne N, et al: Telomere length is key to hepatocellular carcinoma diversity and telomerase addiction is an actionable therapeutic target. J Hepatol. 74:1155–1166. 2021. View Article : Google Scholar

256 

Zeng H, Wu HC, Wang Q, Yang HI, Chen CJ, Santella RM and Shen J: Telomere length and risk of hepatocellular carcinoma: A nested Case-control study in Taiwan cancer screening program cohort. Anticancer Res. 37:637–644. 2017. View Article : Google Scholar : PubMed/NCBI

257 

Cheng Y, Yu C, Huang M, Du F, Song C, Ma Z, Zhai X, Yang Y, Liu J, Bei JX, et al: Genetic association of telomere length with hepatocellular carcinoma risk: A Mendelian randomization analysis. Cancer Epidemiol. 50:39–45. 2017. View Article : Google Scholar : PubMed/NCBI

258 

Feng W, Yu D, Li B, Luo OY, Xu T, Cao Y and Ding Y: Paired assessment of liver telomere lengths in hepatocellular cancer is a reliable predictor of disease persistence. Biosci Rep. 37:BSR201606212017. View Article : Google Scholar : PubMed/NCBI

259 

Nikolouzakis TK, Stivaktakis PD, Apalaki P, Kalliantasi K, Sapsakos TM, Spandidos DA, Tsatsakis A, Souglakos J and Tsiaoussis J: Effect of systemic treatment on the micronuclei frequency in the peripheral blood of patients with metastatic colorectal cancer. Oncol Lett. 17:2703–2712. 2019.PubMed/NCBI

260 

Nikolouzakis TK, Vakonaki E, Stivaktakis PD, Alegakis A, Berdiaki A, Razos N, Souglakos J, Tsatsakis A and Tsiaoussis J: Novel prognostic biomarkers in metastatic and locally advanced colorectal cancer: Micronuclei frequency and telomerase activity in peripheral blood lymphocytes. Front Oncol. 11:6836052021. View Article : Google Scholar : PubMed/NCBI

261 

Guterres AN and Villanueva J: Targeting telomerase for cancer therapy. Oncogene. 39:5811–5824. 2020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tsatsakis A, Oikonomopoulou T, Nikolouzakis TK, Vakonaki E, Tzatzarakis M, Flamourakis M, Renieri E, Fragkiadaki P, Iliaki E, Bachlitzanaki M, Bachlitzanaki M, et al: Role of telomere length in human carcinogenesis (Review). Int J Oncol 63: 78, 2023.
APA
Tsatsakis, A., Oikonomopoulou, T., Nikolouzakis, T.K., Vakonaki, E., Tzatzarakis, M., Flamourakis, M. ... Berdiaki, A. (2023). Role of telomere length in human carcinogenesis (Review). International Journal of Oncology, 63, 78. https://doi.org/10.3892/ijo.2023.5526
MLA
Tsatsakis, A., Oikonomopoulou, T., Nikolouzakis, T. K., Vakonaki, E., Tzatzarakis, M., Flamourakis, M., Renieri, E., Fragkiadaki, P., Iliaki, E., Bachlitzanaki, M., Karzi, V., Katsikantami, I., Kakridonis, F., Hatzidaki, E., Tolia, M., Svistunov, A. A., Spandidos, D. A., Nikitovic, D., Tsiaoussis, J., Berdiaki, A."Role of telomere length in human carcinogenesis (Review)". International Journal of Oncology 63.1 (2023): 78.
Chicago
Tsatsakis, A., Oikonomopoulou, T., Nikolouzakis, T. K., Vakonaki, E., Tzatzarakis, M., Flamourakis, M., Renieri, E., Fragkiadaki, P., Iliaki, E., Bachlitzanaki, M., Karzi, V., Katsikantami, I., Kakridonis, F., Hatzidaki, E., Tolia, M., Svistunov, A. A., Spandidos, D. A., Nikitovic, D., Tsiaoussis, J., Berdiaki, A."Role of telomere length in human carcinogenesis (Review)". International Journal of Oncology 63, no. 1 (2023): 78. https://doi.org/10.3892/ijo.2023.5526
Copy and paste a formatted citation
x
Spandidos Publications style
Tsatsakis A, Oikonomopoulou T, Nikolouzakis TK, Vakonaki E, Tzatzarakis M, Flamourakis M, Renieri E, Fragkiadaki P, Iliaki E, Bachlitzanaki M, Bachlitzanaki M, et al: Role of telomere length in human carcinogenesis (Review). Int J Oncol 63: 78, 2023.
APA
Tsatsakis, A., Oikonomopoulou, T., Nikolouzakis, T.K., Vakonaki, E., Tzatzarakis, M., Flamourakis, M. ... Berdiaki, A. (2023). Role of telomere length in human carcinogenesis (Review). International Journal of Oncology, 63, 78. https://doi.org/10.3892/ijo.2023.5526
MLA
Tsatsakis, A., Oikonomopoulou, T., Nikolouzakis, T. K., Vakonaki, E., Tzatzarakis, M., Flamourakis, M., Renieri, E., Fragkiadaki, P., Iliaki, E., Bachlitzanaki, M., Karzi, V., Katsikantami, I., Kakridonis, F., Hatzidaki, E., Tolia, M., Svistunov, A. A., Spandidos, D. A., Nikitovic, D., Tsiaoussis, J., Berdiaki, A."Role of telomere length in human carcinogenesis (Review)". International Journal of Oncology 63.1 (2023): 78.
Chicago
Tsatsakis, A., Oikonomopoulou, T., Nikolouzakis, T. K., Vakonaki, E., Tzatzarakis, M., Flamourakis, M., Renieri, E., Fragkiadaki, P., Iliaki, E., Bachlitzanaki, M., Karzi, V., Katsikantami, I., Kakridonis, F., Hatzidaki, E., Tolia, M., Svistunov, A. A., Spandidos, D. A., Nikitovic, D., Tsiaoussis, J., Berdiaki, A."Role of telomere length in human carcinogenesis (Review)". International Journal of Oncology 63, no. 1 (2023): 78. https://doi.org/10.3892/ijo.2023.5526
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team