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m6A‑mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR‑552‑5p

  • Authors:
    • Wenjun Liu
    • Zilang Zhang
    • Xitu Luo
    • Kai Qian
    • Baojun Huang
    • Jianmin Liang
    • Zhihao Ma
    • Jianzhong Deng
    • Chengyu Yang
  • View Affiliations / Copyright

    Affiliations: The First Department of General Surgery, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China, Department of AnoRectal Surgery, The First People's Hospital of Foshan, Foshan, Guangdong 528010, P.R. China, Division of Vascular and Interventional Radiology, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 81
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    Published online on: May 30, 2023
       https://doi.org/10.3892/ijo.2023.5529
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Abstract

Long noncoding RNAs (lncRNAs) are a type of regulatory molecule with potential roles in the development of several different malignancies. However, the underlying mechanisms of lncRNAs in colorectal cancer (CRC) are incompletely understood. The present study investigated the molecular mechanism of LINC02038 in CRC. LINC02038 expression was decreased in CRC tissues compared to the para‑cancerous tissues and LINC02038 overexpression markedly reduced the proliferation, vitality, migration and invasive ability and greatly accelerated apoptosis of colorectal cancer cells. Bioinformatics examination indicated that LINC02038 may have targeted microRNA (miR)‑552‑5p. RNA immunoprecipitation and luciferase reporter assays showed that LINC02038 served as a sponge for miR‑552‑5p, hindering target gene FAM172A of miR‑552‑5p degradation. Moreover, methylated RNA immunoprecipitation (MeRIP)‑qualitative PCR assays revealed that YTHDF2 could identify and regulate the METTL3‑mediated LINC02038 N6‑methyladenosine (m6A) modification and increase its degradation, thereby promoting CRC progression via the PI3K/AKT pathway. Based on the CRC clinical specimens, it was shown that LINC02038 was negatively associated with lymphatic metastasis and distant metastasis. These results revealed that m6A/LINC02038/miR‑552‑5p/FAM172A may be a novel anti‑tumor axis and LINC02038 may serve as a biomarker and treatment option for colorectal cancer.
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View References

1 

Kanth P and Inadomi JM: Screening and prevention of colorectal cancer. BMJ. 374:n18552021. View Article : Google Scholar : PubMed/NCBI

2 

Dekker E, Tanis PJ, Vleugels JLA, Kasi PM and Wallace MB: Colorectal cancer. Lancet. 394:1467–1480. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Biller LH and Schrag D: Diagnosis and treatment of metastatic colorectal cancer: A review. JAMA. 325:669–685. 2021. View Article : Google Scholar : PubMed/NCBI

4 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Li N, Lu B, Luo C, Cai J, Lu M, Zhang Y, Chen H and Dai M: Incidence, mortality, survival, risk factor and screening of colorectal cancer: A comparison among China, Europe, and northern America. Cancer Lett. 522:255–268. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Zhou L, Zhu Y, Sun D and Zhang Q: Emerging roles of long non-coding RNAs in the tumor microenvironment. Int J Biol Sci. 16:2094–2103. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Chi Y, Wang D, Wang J, Yu W and Yang J: Long non-coding RNA in the pathogenesis of cancers. Cells. 8:10152019. View Article : Google Scholar : PubMed/NCBI

8 

Zhao Z, Sun W, Guo Z, Zhang J, Yu H and Liu B: Mechanisms of lncRNA/microRNA interactions in angiogenesis. Life Sci. 254:1169002020. View Article : Google Scholar

9 

Winkle M, El-Daly SM, Fabbri M and Calin GA: Noncoding RNA therapeutics - challenges and potential solutions. Nat Rev Drug Discov. 20:629–651. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Chan JJ and Tay Y: Noncoding RNA: RNA regulatory networks in cancer. Int J Mol Sci. 19:13102018. View Article : Google Scholar

11 

Tang J, Yan T, Bao Y, Shen C, Yu C, Zhu X, Tian X, Guo F, Liang Q, Liu Q, et al: LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc. Nat Commun. 10:34992019. View Article : Google Scholar : PubMed/NCBI

12 

Lin X, Zhuang S, Chen X, Du J, Zhong L, Ding J, Wang L, Yi J, Hu G, Tang G, et al: lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling. Mol Ther. 30:688–702. 2022. View Article : Google Scholar :

13 

Hu XT, Xing W, Zhao RS, Tan Y, Wu XF, Ao LQ, Li Z, Yao MW, Yuan M, Guo W, et al: HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer. J Exp Clin Cancer Res. 39:2702020. View Article : Google Scholar : PubMed/NCBI

14 

Chen J, Song Y, Li M, Zhang Y, Lin T, Sun J, Wang D, Liu Y, Guo J and Yu W: Comprehensive analysis of ceRNA networks reveals prognostic lncRNAs related to immune infiltration in colorectal cancer. BMC Cancer. 21:2552021. View Article : Google Scholar : PubMed/NCBI

15 

Karreth FA and Pandolfi PP: ceRNA cross-talk in cancer: When ce-bling rivalries go awry. Cancer Discov. 3:1113–1121. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Xu AM, He CJ, Tuerxun Z and Anikezi A: FAM172A affects cell proliferation and apoptosis not by targeting β-tubulin in HepG2 cells. Transl Cancer Res. 9:5637–5644. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Narayanankutty A: PI3K/Akt/mTOR pathway as a therapeutic target for colorectal cancer: A review of preclinical and clinical evidence. Curr Drug Targets. 20:1217–1226. 2019. View Article : Google Scholar

18 

Vu LP, Cheng Y and Kharas MG: The biology of m6A RNA methylation in normal and malignant hematopoiesis. Cancer Discov. 9:25–33. 2019. View Article : Google Scholar

19 

Ianniello Z, Paiardini A and Fatica A: N6-Methyladenosine (m6A): A promising new molecular target in acute myeloid leukemia. Front Oncol. 9:2512019. View Article : Google Scholar

20 

Xiang S, Liang X, Yin S, Liu J and Xiang Z: N6-methyladenosine methyltransferase METTL3 promotes colorectal cancer cell proliferation through enhancing MYC expression. Am J Transl Res. 12:1789–1806. 2020.PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

22 

Li HB, Tong J, Zhu S, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, et al: m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. Nature. 548:338–342. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Pfaff J, Hennig J, Herzog F, Aebersold R, Sattler M, Niessing D and Meister G: Structural features of Argonaute-GW182 protein interactions. Proc Natl Acad Sci USA. 110:E3770–E3779. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Hicks JA, Li L, Matsui M, Chu Y, Volkov O, Johnson KC and Corey DR: Human GW182 paralogs are the central organizers for RNA-mediated control of transcription. Cell Rep. 20:1543–1552. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Smolarz B, Zadrożna-Nowak A and Romanowicz H: The Role of lncRNA in the development of tumors, including breast cancer. Int J Mol Sci. 22:84272021. View Article : Google Scholar : PubMed/NCBI

26 

Ghafouri-Fard S, Abak A, Tondro Anamag F, Shoorei H, Majidpoor J and Taheri M: The emerging role of non-coding RNAs in the regulation of PI3K/AKT pathway in the carcinogenesis process. Biomed Pharmacother. 137:1112792021. View Article : Google Scholar : PubMed/NCBI

27 

He Q, Long J, Yin Y, Li Y, Lei X, Li Z and Zhu W: Emerging roles of lncRNAs in the formation and progression of colorectal cancer. Front Oncol. 9:15422019. View Article : Google Scholar

28 

Statello L, Guo CJ, Chen LL and Huarte M: Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol. 22:96–118. 2021. View Article : Google Scholar

29 

Smillie CL, Sirey T and Ponting CP: Complexities of post-transcriptional regulation and the modeling of ceRNA crosstalk. Crit Rev Biochem Mol Biol. 53:231–245. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Yang XZ, Cheng TT, He QJ, Lei ZY, Chi J, Tang Z, Liao QX, Zhang H, Zeng LS and Cui SZ: LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway. Mol Cancer. 17:1262018. View Article : Google Scholar

31 

Xu M, Chen X, Lin K, Zeng K, Liu X, Xu X, Pan B, Xu T, Sun L, He B, et al: lncRNA SNHG6 regulates EZH2 expression by sponging miR-26a/b and miR-214 in colorectal cancer. J Hematol Oncol. 12:32019. View Article : Google Scholar : PubMed/NCBI

32 

Chen T, Lei S, Zeng Z, Zhang J, Xue Y, Sun Y, Lan J, Xu S, Mao D and Guo B: Linc00261 inhibits metastasis and the WNT signaling pathway of pancreatic cancer by regulating a miR-552-5p/FOXO3 axis. Oncol Rep. 43:930–942. 2020.PubMed/NCBI

33 

Cai W, Xu Y, Yin J, Zuo W and Su Z: miR-552-5p facilitates osteosarcoma cell proliferation and metastasis by targeting WIF1. Exp Ther Med. 17:3781–3788. 2019.PubMed/NCBI

34 

Liu W, Qian K, Wei X, Deng H, Zhao B, Chen Q, Zhang J and Liu H: miR-27a promotes proliferation, migration, and invasion of colorectal cancer by targeting FAM172A and acts as a diagnostic and prognostic biomarker. Oncol Rep. 37:3554–3564. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Chen Y, Liu P, Shen D, Liu H, Xu L, Wang J, Shen D, Sun H and Wu H: FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling. Biol Open. 9:bio0484622020. View Article : Google Scholar : PubMed/NCBI

36 

Liu HT, Zou YX, Zhu WJ, Sen-Liu, Zhang GH, Ma RR, Guo XY and Gao P: lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus. Cell Death Differ. 29:627–641. 2022. View Article : Google Scholar :

37 

Deng X, Su R, Weng H, Huang H, Li Z and Chen J: RNA N6-methyladenosine modification in cancers: Current status and perspectives. Cell Res. 28:507–517. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Roundtree IA, Evans ME, Pan T and He C: Dynamic RNA modifications in gene expression regulation. Cell. 169:1187–1200. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Peng W, Li J, Chen R, Gu Q, Yang P, Qian W, Ji D, Wang Q, Zhang Z, Tang J and Sun Y: Upregulated METTL3 promotes metastasis of colorectal cancer via miR-1246/SPRED2/MAPK signaling pathway. J Exp Clin Cancer Res. 38:3932019. View Article : Google Scholar : PubMed/NCBI

40 

Zhou D, Tang W, Xu Y, Xu Y, Xu B, Fu S, Wang Y, Chen F, Chen Y, Han Y and Wang G: METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5. Mol Oncol. 15:2172–2184. 2021. View Article : Google Scholar : PubMed/NCBI

41 

Liu W, Liu C, You J, Chen Z, Qian C, Lin W, Yu L, Ye L, Zhao L and Zhou R: Pan-cancer analysis identifies YTHDF2 as an immunotherapeutic and prognostic biomarker. Front Cell Dev Biol. 10:9542142022. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Zhang Z, Luo X, Qian K, Huang B, Liang J, Ma Z, Deng J and Yang C: m<sup>6</sup>A‑mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR‑552‑5p. Int J Oncol 63: 81, 2023.
APA
Liu, W., Zhang, Z., Luo, X., Qian, K., Huang, B., Liang, J. ... Yang, C. (2023). m<sup>6</sup>A‑mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR‑552‑5p. International Journal of Oncology, 63, 81. https://doi.org/10.3892/ijo.2023.5529
MLA
Liu, W., Zhang, Z., Luo, X., Qian, K., Huang, B., Liang, J., Ma, Z., Deng, J., Yang, C."m<sup>6</sup>A‑mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR‑552‑5p". International Journal of Oncology 63.1 (2023): 81.
Chicago
Liu, W., Zhang, Z., Luo, X., Qian, K., Huang, B., Liang, J., Ma, Z., Deng, J., Yang, C."m<sup>6</sup>A‑mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR‑552‑5p". International Journal of Oncology 63, no. 1 (2023): 81. https://doi.org/10.3892/ijo.2023.5529
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Zhang Z, Luo X, Qian K, Huang B, Liang J, Ma Z, Deng J and Yang C: m<sup>6</sup>A‑mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR‑552‑5p. Int J Oncol 63: 81, 2023.
APA
Liu, W., Zhang, Z., Luo, X., Qian, K., Huang, B., Liang, J. ... Yang, C. (2023). m<sup>6</sup>A‑mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR‑552‑5p. International Journal of Oncology, 63, 81. https://doi.org/10.3892/ijo.2023.5529
MLA
Liu, W., Zhang, Z., Luo, X., Qian, K., Huang, B., Liang, J., Ma, Z., Deng, J., Yang, C."m<sup>6</sup>A‑mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR‑552‑5p". International Journal of Oncology 63.1 (2023): 81.
Chicago
Liu, W., Zhang, Z., Luo, X., Qian, K., Huang, B., Liang, J., Ma, Z., Deng, J., Yang, C."m<sup>6</sup>A‑mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR‑552‑5p". International Journal of Oncology 63, no. 1 (2023): 81. https://doi.org/10.3892/ijo.2023.5529
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