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Targeting the mitochondrial calcium uniporter inhibits cancer progression and alleviates cisplatin resistance in esophageal squamous cell carcinoma

  • Authors:
    • Yu Miao
    • Xiaofei Wang
    • Yafang Lai
    • Ying Huang
    • Hua Yin
    • Xiangkun Meng
    • Hao Liu
    • Ruirui Hou
    • Wan Lin
    • Xiaoxu Zhang
    • Xu Zhang
    • Bei Cho Chai
    • Feixiong Zhang
    • Le Guo
    • Shaoqi Yang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China, Pathology Department, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebie 063000, P.R. China, Department of Gastroenterology, Ordos Central Hospital, Ordos, Inner Mongolia Autonomous Region 017000, P.R. China, Department of Medical Laboratory, School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China
    Copyright: © Miao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 82
    |
    Published online on: June 1, 2023
       https://doi.org/10.3892/ijo.2023.5530
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Abstract

Cisplatin is the standard chemotherapeutic drug used for the treatment of esophageal squamous cell carcinoma (ESCC). Acquired cisplatin resistance is the primary obstacle to prolonging patient survival time. Here, the therapeutic effects of mitochondrial calcium uniporter (MCU) inhibition on tumor growth and cisplatin resistance in ESCC were assessed. MCU was stably overexpressed or knocked down in three ESCC cell lines and three cisplatin‑resistant ESCC cell lines. Then, proliferation, migration, and mitochondrial membrane potential (MMP) were measured by colony formation, wound healing, Transwell, and JC‑1 staining assays. MCU, MICU2, MICU1, and PD‑L1 levels were detected through western blotting and immunofluorescence. ESCC and cisplatin‑resistant ESCC xenograft mouse models were established. After MCU knockdown, tumor volume was measured. The expression levels of proliferation markers (CyclinD1 and Ki‑67), MICU1/2, PD‑L1, epithelial–mesenchymal transition (EMT) markers (vimentin, β‑catenin, and E‑cadherin), and the angiogenesis marker CD34 were detected through western blotting, immunohistochemistry, or immunofluorescence. The results showed that MCU overexpression significantly promoted proliferation, migration, and MMP in ESCC cells and cisplatin‑resistant ESCC cells. However, proliferation, migration, and MMP were suppressed following MCU knockdown. In ESCC cells, MCU overexpression markedly increased MICU2, MICU1, and PD‑L1 levels, and the opposite results were observed when MCU was stably knocked down. Similarly, MCU inhibition decreased MICU2, MICU1, and PD‑L1 expression in cisplatin‑resistant ESCC cells. Moreover, MCU knockdown substantially decreased tumor growth, EMT, and angiogenesis in ESCC and cisplatin‑resistant ESCC xenograft mice. Collectively, targeting MCU may inhibit cancer progression and alleviate cisplatin resistance in ESCC.
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View References

1 

Arnold M, Ferlay J, van Berge Henegouwen MI and Soerjomataram I: Global burden of oesophageal and gastric cancer by histology and subsite in 2018. Gut. 69:1564–1571. 2020. View Article : Google Scholar : PubMed/NCBI

2 

GBD 2017 Oesophageal Cancer Collaborators: The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990-2017: A systematic analysis for the global burden of disease study 2017. Lancet Gastroenterol Hepatol. 5:582–597. 2020. View Article : Google Scholar : PubMed/NCBI

3 

van Laarhoven HW: Is chemotherapy for advanced or metastatic oesophageal squamous cell carcinoma no longer needed? Lancet Oncol. 21:743–745. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Hu Y, Xie C, Yang H, Ho JWK, Wen J, Han L, Lam KO, Wong IYH, Law SYK, Chiu KWH, et al: Computed tomography-based deep-learning prediction of neoadjuvant chemoradiotherapy treatment response in esophageal squamous cell carcinoma. Radiother Oncol. 154:6–13. 2021. View Article : Google Scholar

5 

Leng XF, Daiko H, Han YT and Mao YS: Optimal preoperative neoadjuvant therapy for resectable locally advanced esophageal squamous cell carcinoma. Ann N Y Acad Sci. 1482:213–224. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Hsu PK, Yeh YC, Chien LI, Huang CS and Hsu HS: Clinicopathological significance of pathologic complete lymph node regression after neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma. Ann Surg Oncol. 28:2048–2058. 2021. View Article : Google Scholar

7 

Chen S, Yang M, Wang C, Ouyang Y, Chen X, Bai J, Hu Y, Song M, Zhang S and Zhang Q: Forkhead box D1 promotes EMT and chemoresistance by upregulating lncRNA CYTOR in oral squamous cell carcinoma. Cancer Lett. 503:43–53. 2021. View Article : Google Scholar

8 

Chang WM, Chang YC, Yang YC, Lin SK, Chang PM and Hsiao M: AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway. J Exp Clin Cancer Res. 38:2452019. View Article : Google Scholar : PubMed/NCBI

9 

Oshimori N, Oristian D and Fuchs E: TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma. Cell. 160:963–976. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Mohapatra P, Shriwas O, Mohanty S, Ghosh A, Smita S, Kaushik SR, Arya R, Rath R, Das Majumdar SK, Muduly DK, et al: CMTM6 drives cisplatin resistance by regulating Wnt signaling through the ENO-1/AKT/GSK3β axis. JCI Insight. 6:e1436432021.

11 

Liu Z, Gu S, Lu T, Wu K, Li L, Dong C and Zhou Y: IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress. J Exp Clin Cancer Res. 39:1442020. View Article : Google Scholar : PubMed/NCBI

12 

Xu Y, Wang C, Su J, Xie Q, Ma L, Zeng L, Yu Y, Liu S, Li S, Li Z and Sun L: Tolerance to endoplasmic reticulum stress mediates cisplatin resistance in human ovarian cancer cells by maintaining endoplasmic reticulum and mitochondrial homeostasis. Oncol Rep. 34:3051–3060. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Ren T, Zhang H, Wang J, Zhu J, Jin M, Wu Y, Guo X, Ji L, Huang Q, Zhang H, et al: MCU-dependent mitochondrial Ca2+ inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells. Oncogene. 36:5897–5909. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Cui C, Yang J, Fu L, Wang M and Wang X: Progress in understanding mitochondrial calcium uniporter complex-mediated calcium signalling: A potential target for cancer treatment. Br J Pharmacol. 176:1190–1205. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Vultur A, Gibhardt CS, Stanisz H and Bogeski I: The role of the mitochondrial calcium uniporter (MCU) complex in cancer. Pflugers Arch. 470:1149–1163. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Liu Y, Jin M, Wang Y, Zhu J, Tan R, Zhao J, Ji X, Jin C, Jia Y, Ren T and Xing J: MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth. Signal Transduct Target Ther. 5:592020. View Article : Google Scholar : PubMed/NCBI

17 

Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, et al: The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α. EMBO Mol Med. 8:569–585. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Stoica SI, Onose G, Pitica IM, Neagu AI, Ion G, Matei L, Dragu LD, Radu LE, Chivu-Economescu M, Necula LG, et al: Molecular aspects of hypoxic stress effects in Chronic ethanol exposure of neuronal cells. Curr Issues Mol Biol. 45:1655–1680. 2023. View Article : Google Scholar : PubMed/NCBI

19 

Xue W, Shen Z, Li L, Zheng Y, Yan D, Kan Q and Zhao J: Long non-coding RNAs MACC1-AS1 and FOXD2-AS1 mediate NSD2-induced cisplatin resistance in esophageal squamous cell carcinoma. Mol Ther Nucleic Acids. 23:592–602. 2020. View Article : Google Scholar

20 

Cui W, Fang T, Duan Z, Xiang D, Wang Y, Zhang M, Zhai F, Cui X and Yang L: Dihydroartemisinin sensitizes esophageal squamous cell carcinoma to cisplatin by inhibiting sonic hedgehog signaling. Front Cell Dev Biol. 8:5967882020. View Article : Google Scholar : PubMed/NCBI

21 

Wang J, Ji H, Zhu Q, Yu X, Du J and Jiang Z: Co-inhibition of BMI1 and Mel18 enhances chemosensitivity of esophageal squamous cell carcinoma in vitro and in vivo. Oncol Lett. 17:5012–5022. 2019.PubMed/NCBI

22 

Barra GB, Santa Rita TH, Almeida ALSC, Jácomo RH and Nery LFA: Serum has higher proportion of Janus kinase 2 V617F mutation compared to paired EDTA-whole blood sample: A model for somatic mutation quantification using qPCR and the 2 method. Diagnostics (Basel). 10:1532020. View Article : Google Scholar

23 

Sugimura K, Yamasaki M, Yasuda T, Yano M, Hirao M, Fujitani K, Kimura Y, Miyata H, Motoori M, Takeno A, et al: Long-term results of a randomized controlled trial comparing neoadjuvant Adriamycin, cisplatin, and 5-fluorouracil vs docetaxel, cisplatin, and 5-fluorouracil followed by surgery for esophageal cancer (OGSG1003). Ann Gastroenterol Surg. 5:75–82. 2020. View Article : Google Scholar

24 

Liu H, Zhang J, Luo X, Zeng M and Xu L, Zhang Q, Liu H, Guo J and Xu L: Overexpression of the long noncoding RNA FOXD2-AS1 promotes cisplatin resistance in esophageal squamous cell carcinoma through the miR-195/Akt/mTOR axis. Oncol Res. 28:65–73. 2020. View Article : Google Scholar

25 

Suo D, Wang L, Zeng T, Zhang H, Li L, Liu J, Yun J, Guan XY and Li Y: NRIP3 upregulation confers resistance to chemoradiotherapy in ESCC via RTF2 removal by accelerating ubiquitination and degradation of RTF2. Oncogenesis. 9:752020. View Article : Google Scholar : PubMed/NCBI

26 

Zhou T, Fu H, Dong B, Dai L, Yang Y, Yan W and Shen L: HOXB7 mediates cisplatin resistance in esophageal squamous cell carcinoma through involvement of DNA damage repair. Thorac Cancer. 11:3071–3085. 2020. View Article : Google Scholar :

27 

Ben-David U, Siranosian B, Ha G, Tang H, Oren Y, Hinohara K, Strathdee CA, Dempster J, Lyons NJ, Burns R, et al: Genetic and transcriptional evolution alters cancer cell line drug response. Nature. 560:325–330. 2018. View Article : Google Scholar : PubMed/NCBI

28 

PCAWG Transcriptome Core Group; Calabrese C, Davidson NR, Demircioğlu D, Fonseca NA, He Y, Kahles A, Lehmann KV, Liu F, Shiraishi Y, et al: Genomic basis for RNA alterations in cancer. Nature. 578:129–136. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Wang X, Song X, Cheng G, Zhang J, Dong L, Bai J, Luo D, Xiong Y, Li S, Liu F, et al: The regulatory mechanism and biological significance of mitochondrial calcium uniporter in the migration, invasion, angiogenesis and growth of gastric cancer. Onco Targets Ther. 13:11781–11794. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Xu P, Zhang X, Ni W, Fan H, Xu J, Chen Y, Zhu J, Gu X, Yang L, Ni R, et al: Upregulated HOXC8 expression is associated with poor prognosis and oxaliplatin resistance in hepatocellular carcinoma. Dig Dis Sci. 60:3351–3363. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Kamer KJ, Jiang W, Kaushik VK, Mootha VK and Grabarek Z: Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism. Proc Natl Acad Sci USA. 116:3546–3555. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Patron M, Checchetto V, Raffaello A, Teardo E, Vecellio Reane D, Mantoan M, Granatiero V, Szabò I, De Stefani D and Rizzuto R: MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity. Mol Cell. 53:726–737. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Wang C, Jacewicz A, Delgado BD, Baradaran R and Long SB: Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2. Elife. 9:e599912020. View Article : Google Scholar

34 

Lee J, Kim B, Jung HA, La Choi Y and Sun JM: Nivolumab for esophageal squamous cell carcinoma and the predictive role of PD-L1 or CD8 expression in its therapeutic effect. Cancer Immunol Immunother. 70:1203–1211. 2021. View Article : Google Scholar

35 

McBride S, Sherman E, Tsai CJ, Baxi S, Aghalar J, Eng J, Zhi WI, McFarland D, Michel LS, Young R, et al: Randomized phase II trial of nivolumab with stereotactic body radiotherapy versus nivolumab alone in metastatic head and neck squamous cell carcinoma. J Clin Oncol. 39:30–37. 2021. View Article : Google Scholar :

36 

Fukuoka E, Yamashita K, Tanaka T, Sawada R, Sugita Y, Arimoto A, Fujita M, Takiguchi G, Matsuda T, Oshikiri T, et al: Neoadjuvant chemotherapy increases PD-L1 expression and CD8+ tumor-infiltrating lymphocytes in esophageal squamous cell carcinoma. Anticancer Res. 39:4539–4548. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Tran L, Allen CT, Xiao R, Moore E, Davis R, Park SJ, Spielbauer K, Van Waes C and Schmitt NC: Cisplatin alters antitumor immunity and synergizes with PD-1/PD-L1 inhibition in head and neck squamous cell carcinoma. Cancer Immunol Res. 5:1141–1151. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Wu L, Cai S, Deng Y, Zhang Z, Zhou X, Su Y and Xu D: PD-1/PD-L1 enhanced cisplatin resistance in gastric cancer through PI3K/AKT mediated P-gp expression. Int Immunopharmacol. 94:1074432021. View Article : Google Scholar : PubMed/NCBI

39 

Zhu X, Chen L, Liu L and Niu X: EMT-mediated acquired EGFR-TKI resistance in NSCLC: Mechanisms and strategies. Front Oncol. 9:10442019. View Article : Google Scholar : PubMed/NCBI

40 

Ashrafizadeh M, Zarrabi A, Hushmandi K, Kalantari M, Mohammadinejad R, Javaheri T and Sethi G: Association of the epithelial-mesenchymal transition (EMT) with cisplatin resistance. Int J Mol Sci. 21:40022020. View Article : Google Scholar : PubMed/NCBI

41 

Shen M, Xu Z, Xu W, Jiang K, Zhang F, Ding Q, Xu Z and Chen Y: Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway. J Exp Clin Cancer Res. 38:1492019. View Article : Google Scholar : PubMed/NCBI

42 

Chen Y, Wang D, Peng H, Chen X, Han X, Yu J, Wang W, Liang L, Liu Z, Zheng Y, et al: Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/Bcl-2 expression. Mol Cancer. 18:12019. View Article : Google Scholar

43 

Mao Y, Wang Y, Dong L, Zhang Y, Zhang Y, Wang C, Zhang Q, Yang S, Cao L, Zhang X, et al: Hypoxic exosomes facilitate angiogenesis and metastasis in esophageal squamous cell carcinoma through altering the phenotype and transcriptome of endothelial cells. J Exp Clin Cancer Res. 38:3892019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Miao Y, Wang X, Lai Y, Huang Y, Yin H, Meng X, Liu H, Hou R, Lin W, Zhang X, Zhang X, et al: Targeting the mitochondrial calcium uniporter inhibits cancer progression and alleviates cisplatin resistance in esophageal squamous cell carcinoma. Int J Oncol 63: 82, 2023.
APA
Miao, Y., Wang, X., Lai, Y., Huang, Y., Yin, H., Meng, X. ... Yang, S. (2023). Targeting the mitochondrial calcium uniporter inhibits cancer progression and alleviates cisplatin resistance in esophageal squamous cell carcinoma. International Journal of Oncology, 63, 82. https://doi.org/10.3892/ijo.2023.5530
MLA
Miao, Y., Wang, X., Lai, Y., Huang, Y., Yin, H., Meng, X., Liu, H., Hou, R., Lin, W., Zhang, X., Zhang, X., Chai, B. C., Zhang, F., Guo, L., Yang, S."Targeting the mitochondrial calcium uniporter inhibits cancer progression and alleviates cisplatin resistance in esophageal squamous cell carcinoma". International Journal of Oncology 63.1 (2023): 82.
Chicago
Miao, Y., Wang, X., Lai, Y., Huang, Y., Yin, H., Meng, X., Liu, H., Hou, R., Lin, W., Zhang, X., Zhang, X., Chai, B. C., Zhang, F., Guo, L., Yang, S."Targeting the mitochondrial calcium uniporter inhibits cancer progression and alleviates cisplatin resistance in esophageal squamous cell carcinoma". International Journal of Oncology 63, no. 1 (2023): 82. https://doi.org/10.3892/ijo.2023.5530
Copy and paste a formatted citation
x
Spandidos Publications style
Miao Y, Wang X, Lai Y, Huang Y, Yin H, Meng X, Liu H, Hou R, Lin W, Zhang X, Zhang X, et al: Targeting the mitochondrial calcium uniporter inhibits cancer progression and alleviates cisplatin resistance in esophageal squamous cell carcinoma. Int J Oncol 63: 82, 2023.
APA
Miao, Y., Wang, X., Lai, Y., Huang, Y., Yin, H., Meng, X. ... Yang, S. (2023). Targeting the mitochondrial calcium uniporter inhibits cancer progression and alleviates cisplatin resistance in esophageal squamous cell carcinoma. International Journal of Oncology, 63, 82. https://doi.org/10.3892/ijo.2023.5530
MLA
Miao, Y., Wang, X., Lai, Y., Huang, Y., Yin, H., Meng, X., Liu, H., Hou, R., Lin, W., Zhang, X., Zhang, X., Chai, B. C., Zhang, F., Guo, L., Yang, S."Targeting the mitochondrial calcium uniporter inhibits cancer progression and alleviates cisplatin resistance in esophageal squamous cell carcinoma". International Journal of Oncology 63.1 (2023): 82.
Chicago
Miao, Y., Wang, X., Lai, Y., Huang, Y., Yin, H., Meng, X., Liu, H., Hou, R., Lin, W., Zhang, X., Zhang, X., Chai, B. C., Zhang, F., Guo, L., Yang, S."Targeting the mitochondrial calcium uniporter inhibits cancer progression and alleviates cisplatin resistance in esophageal squamous cell carcinoma". International Journal of Oncology 63, no. 1 (2023): 82. https://doi.org/10.3892/ijo.2023.5530
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