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Review Open Access

Role of gasdermin family proteins in cancers (Review)

  • Authors:
    • Xin Yang
    • Zhe Tang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Thoracic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 100
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    Published online on: July 18, 2023
       https://doi.org/10.3892/ijo.2023.5548
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Abstract

The gasdermin (GSDM) family comprises six proteins, including GSDMA‑GSDME and Pejvakin. Most of these proteins have a crucial role in inducing pyroptosis; in particular, GSDMD and GSDME are the most extensively studied proteins as the executioners of the pyroptosis process. Pyroptosis is a highly pro‑inflammatory form of programmed cell death and is closely associated with the incidence, development and prognosis of multiple cancer types. The present review focused on the current knowledge of the molecular mechanism of GSDM‑mediated pyroptosis, its intricate role in cancer and the potential therapeutic value of its anti‑tumor effects.
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Yang X and Tang Z: Role of gasdermin family proteins in cancers (Review). Int J Oncol 63: 100, 2023.
APA
Yang, X., & Tang, Z. (2023). Role of gasdermin family proteins in cancers (Review). International Journal of Oncology, 63, 100. https://doi.org/10.3892/ijo.2023.5548
MLA
Yang, X., Tang, Z."Role of gasdermin family proteins in cancers (Review)". International Journal of Oncology 63.3 (2023): 100.
Chicago
Yang, X., Tang, Z."Role of gasdermin family proteins in cancers (Review)". International Journal of Oncology 63, no. 3 (2023): 100. https://doi.org/10.3892/ijo.2023.5548
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X and Tang Z: Role of gasdermin family proteins in cancers (Review). Int J Oncol 63: 100, 2023.
APA
Yang, X., & Tang, Z. (2023). Role of gasdermin family proteins in cancers (Review). International Journal of Oncology, 63, 100. https://doi.org/10.3892/ijo.2023.5548
MLA
Yang, X., Tang, Z."Role of gasdermin family proteins in cancers (Review)". International Journal of Oncology 63.3 (2023): 100.
Chicago
Yang, X., Tang, Z."Role of gasdermin family proteins in cancers (Review)". International Journal of Oncology 63, no. 3 (2023): 100. https://doi.org/10.3892/ijo.2023.5548
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