Open Access

Role of gasdermin family proteins in cancers (Review)

  • Authors:
    • Xin Yang
    • Zhe Tang
  • View Affiliations

  • Published online on: July 18, 2023     https://doi.org/10.3892/ijo.2023.5548
  • Article Number: 100
  • Copyright : © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

The gasdermin (GSDM) family comprises six proteins, including GSDMA‑GSDME and Pejvakin. Most of these proteins have a crucial role in inducing pyroptosis; in particular, GSDMD and GSDME are the most extensively studied proteins as the executioners of the pyroptosis process. Pyroptosis is a highly pro‑inflammatory form of programmed cell death and is closely associated with the incidence, development and prognosis of multiple cancer types. The present review focused on the current knowledge of the molecular mechanism of GSDM‑mediated pyroptosis, its intricate role in cancer and the potential therapeutic value of its anti‑tumor effects.
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September-2023
Volume 63 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Yang X and Yang X: Role of gasdermin family proteins in cancers (Review). Int J Oncol 63: 100, 2023
APA
Yang, X., & Yang, X. (2023). Role of gasdermin family proteins in cancers (Review). International Journal of Oncology, 63, 100. https://doi.org/10.3892/ijo.2023.5548
MLA
Yang, X., Tang, Z."Role of gasdermin family proteins in cancers (Review)". International Journal of Oncology 63.3 (2023): 100.
Chicago
Yang, X., Tang, Z."Role of gasdermin family proteins in cancers (Review)". International Journal of Oncology 63, no. 3 (2023): 100. https://doi.org/10.3892/ijo.2023.5548