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Review Open Access

A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review)

  • Authors:
    • Liming Zheng
    • Xingyue Chen
    • Li Zhang
    • Nannan Qin
    • Jiaxing An
    • Jiaxing Zhu
    • Hai Jin
    • Biguang Tuo
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China, Department of Critical Care Medicine of the First People's Hospital of Zunyi (The Third Affiliated Hospital), Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 106
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    Published online on: August 1, 2023
       https://doi.org/10.3892/ijo.2023.5554
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Abstract

Due to concealment, high invasiveness and a lack of indicators, malignant tumors have emerged as one of the deadliest diseases worldwide and their incidence is rising yearly. Research has revealed that the chaperonin family member, chaperonin containing TCP‑1 (CCT), serves a crucial role in malignant tumors. CCT is involved in the growth of numerous malignant tumors such as lung cancer, breast cancer, hepatocellular carcinoma and colorectal cancer and assists the folding of a number of proteins linked to cancer, such as KRAS, p53 and STAT3. According to clinical data, CCT is highly expressed in a range of tumor cells and is associated with poor patient prognosis. In addition, through controlling the cell cycle or interacting with other proteins (including YAP1, HoXB2 and SMAD2), CCT has an effect on the proliferation, invasion and migration of cancer cells. As a result, it is possible that CCT will become a new tumor marker or therapeutic target, which will provide some guidance for early tumor screening or late tumor prognosis. In the present review, the molecular properties of CCT are introduced, alongside a summary of its interactions with other cancer‑related proteins and a discussion of its function in common malignant tumors. It is expected that the present review will offer fresh approaches to the treatment of cancer.
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1 

Showalter AE, Martini AC, Nierenberg D, Hosang K, Fahmi NA, Gopalan P, Khaled AS, Zhang W and Khaled AR: Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis. Sci Rep. 10:7982020. View Article : Google Scholar : PubMed/NCBI

2 

Valpuesta JM, Martin-Benito J, Gomez-Puertas P, Carrascosa JL and Willison KR: Structure and function of a protein folding machine: The eukaryotic cytosolic chaperonin CCT. FEBS Lett. 529:11–16. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Huang X, Wang X, Cheng C, Cai J, He S, Wang H, Liu F, Zhu C, Ding Z, Huang X, et al: Chaperonin containing TCP1, subunit 8 (CCT8) is upregulated in hepatocellular carcinoma and promotes HCC proliferation. APMIS. 122:1070–1079. 2014.PubMed/NCBI

4 

Tracy CM, Gray AJ, Cuellar J, Shaw TS, Howlett AC, Taylor RM, Prince JT, Ahn NG, Valpuesta JM and Willardson BM: Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate beta-tubulin folding. J Biol Chem. 289:4490–4502. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Li W, Liu J and Zhao H: Prognostic power of a chaperonin containing TCP-1 subunit genes panel for hepatocellular carcinoma. Front Genet. 12:6688712021. View Article : Google Scholar : PubMed/NCBI

6 

Roh SH, Kasembeli M, Bakthavatsalam D, Chiu W and Tweardy DJ: Contribution of the type II chaperonin, TRiC/CCT, to oncogenesis. Int J Mol Sci. 16:26706–26720. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Brackley KI and Grantham J: Activities of the chaperonin containing TCP-1 (CCT): Implications for cell cycle progression and cytoskeletal organisation. Cell Stress Chaperones. 14:23–31. 2009. View Article : Google Scholar :

8 

Yam AY, Xia Y, Lin HT, Burlingame A, Gerstein M and Frydman J: Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies. Nat Struct Mol Biol. 15:1255–1262. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Wang Y, Liu P, Zhang Z, Wang J, Cheng Z and Fan C: Identification of CCT3 as a prognostic factor and correlates with cell survival and invasion of head and neck squamous cell carcinoma. Biosci Rep. 41:BSR202111372021. View Article : Google Scholar : PubMed/NCBI

10 

Xu G, Bu S, Wang X, Zhang H and Ge H: Suppression of CCT3 inhibits the proliferation and migration in breast cancer cells. Cancer Cell Int. 20:2182020. View Article : Google Scholar : PubMed/NCBI

11 

Lopez T, Dalton K and Frydman J: The mechanism and function of group II chaperonins. J Mol Biol. 427:2919–2930. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Weng H, Feng X, Lan Y and Zheng Z: TCP1 regulates PI3K/AKT/mTOR signaling pathway to promote proliferation of ovarian cancer cells. J Ovarian Res. 14:822021. View Article : Google Scholar : PubMed/NCBI

13 

Dou L and Zhang X: Upregulation of CCT3 promotes cervical cancer progression through FN1. Mol Med Rep. 24:8562021. View Article : Google Scholar : PubMed/NCBI

14 

Li Y, Liu C, Zhang X, Huang X, Liang S, Xing F and Tian H: CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/β-catenin signalling pathway. Br J Cancer. 126:1684–1694. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Peng X, Chen G, Lv B and Lv J: MicroRNA-148a/152 cluster restrains tumor stem cell phenotype of colon cancer via modulating CCT6A. Anticancer Drugs. 33:e610–e621. 2022. View Article : Google Scholar

16 

Cox A, Nierenberg D, Camargo O, Lee E, Khaled AS, Mazar J, Boohaker RJ, Westmoreland TJ and Khaled AR: Chaperonin containing TCP-1 (CCT/TRiC) is a novel therapeutic and diagnostic target for neuroblastoma. Front Oncol. 12:9750882022. View Article : Google Scholar : PubMed/NCBI

17 

Wang Z: Regulation of cell cycle progression by growth factor-induced cell signaling. Cells. 10:33272021. View Article : Google Scholar : PubMed/NCBI

18 

Zatulovskiy E, Zhang S, Berenson DF, Topacio BR and Skotheim JM: Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division. Science. 369:466–471. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Hume S, Dianov GL and Ramadan K: A unified model for the G1/S cell cycle transition. Nucleic Acids Res. 48:12483–12501. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Temiz E, Koyuncu İ and Sahin E: CCT3 suppression prompts apoptotic machinery through oxidative stress and energy deprivation in breast and prostate cancers. Free Radic Biol Med. 165:88–99. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Chen S, Tian Y, Ju A, Li B, Fu Y and Luo Y: Suppression of CCT3 inhibits tumor progression by impairing ATP production and cytoplasmic translation in lung adenocarcinoma. Int J Mol Sci. 23:39832022. View Article : Google Scholar : PubMed/NCBI

22 

Huang W, Hu H, Zhang Q, Wu X, Wei F, Yang F, Gan L, Wang N, Yang X and Guo AY: Regulatory networks in mechanotransduction reveal key genes in promoting cancer cell stemness and proliferation. Oncogene. 38:6818–6834. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Zhang Y, Wang Y, Wei Y, Wu J, Zhang P, Shen S, Saiyin H, Wumaier R, Yang X, Wang C and Yu L: Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells. Cancer Lett. 372:101–109. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Chen X, Chen X, Huang Y, Lin J, Wu Y and Chen Y: TCP1 increases drug resistance in acute myeloid leukemia by suppressing autophagy via activating AKT/mTOR signaling. Cell Death Dis. 12:10582021. View Article : Google Scholar : PubMed/NCBI

25 

Wang K, He J, Tu C, Xu H, Zhang X, Lv Y and Song C: Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma. BMC Mol Cell Biol. 23:252022. View Article : Google Scholar : PubMed/NCBI

26 

Fu R, Jiang S, Guan Z, Li J, Zhang X and Chen H: Comprehensive analysis of the expression of chaperonin containing TCP1 subunits (CCTs) and their influence on prognosis in hepatocellular carcinoma. Transl Cancer Res. 9:1867–1883. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Meng Y, Yang L, Wei X, Luo H, Hu Y, Tao X, He J, Zheng X, Xu Q, Luo K, et al: CCT5 interacts with cyclin D1 promoting lung adenocarcinoma cell migration and invasion. Biochem Biophys Res Commun. 567:222–229. 2021. View Article : Google Scholar : PubMed/NCBI

28 

Guest ST, Kratche ZR, Bollig-Fischer A, Haddad R and Ethier SP: Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes. Exp Cell Res. 332:223–235. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Li H, Wang L, Cao F, Yu D, Yang J, Yu X, Dong J, Qin JJ and Guan X: Design, synthesis, and biological characterization of a potent STAT3 degrader for the treatment of gastric cancer. Front Pharmacol. 13:9444552022. View Article : Google Scholar : PubMed/NCBI

30 

Kasembeli M, Lau WC, Roh SH, Eckols TK, Frydman J, Chiu W and Tweardy DJ: Modulation of STAT3 folding and function by TRiC/CCT chaperonin. PLoS Biol. 12:e10018442014. View Article : Google Scholar : PubMed/NCBI

31 

Vallin J, Córdoba-Beldad CM and Grantham J: Sequestration of the transcription factor STAT3 by the molecular chaperone CCT: A potential mechanism for modulation of STAT3 phosphorylation. J Mol Biol. 433:1669582021. View Article : Google Scholar : PubMed/NCBI

32 

Bocchini CE, Nahmod K, Katsonis P, Kim S, Kasembeli MM, Freeman A, Lichtarge O, Makedonas G and Tweardy DJ: Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome. Blood. 128:3061–3072. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Carr AC, Khaled AS, Bassiouni R, Flores O, Nierenberg D, Bhatti H, Vishnubhotla P, Manuel JP, Santra S and Khaled AR: Targeting chaperonin containing TCP1 (CCT) as a molecular therapeutic for small cell lung cancer. Oncotarget. 8:110273–110288. 2017. View Article : Google Scholar

34 

Qian T, Cui L, Liu Y, Cheng Z, Quan L, Zeng T, Huang W, Dai Y, Chen J, Liu L, et al: High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma. Pharmacogenomics J. 20:563–573. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Danni X, Jiangzheng Z, Huamao S, Yinglian P, Changcheng Y and Yanda L: Chaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway. Bioengineered. 12:7335–7347. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Cui X, Hu ZP, Li Z, Gao PJ and Zhu JY: Overexpression of chaperonin containing TCP1, subunit 3 predicts poor prognosis in hepatocellular carcinoma. World J Gastroenterol. 21:8588–8604. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Morimoto E, Inagaki K, Komatsubara M, Terasaka T, Itoh Y, Fujisawa S, Sasaki E, Nishiyama Y, Hara T and Wada J: Effects of Wnt-β-Catenin signaling and sclerostin on the phenotypes of rat pheochromocytoma PC12 cells. J Endocr Soc. 6:bvac1212022. View Article : Google Scholar

38 

Li W, Xu Y, Wang X, Cao G, Bu W, Wang X, Fang Z, Xu Y, Dong M and Tao Q: circCCT3 modulates vascular endothelial growth factor A and Wnt signaling to enhance colorectal cancer metastasis through sponging miR-613. DNA Cell Biol. 39:118–125. 2020. View Article : Google Scholar

39 

Qu H, Zhu F, Dong H, Hu X and Han M: Upregulation of CCT-3 induces breast cancer cell proliferation through miR-223 competition and Wnt/β-Catenin signaling pathway activation. Front Oncol. 10:5331762020. View Article : Google Scholar

40 

Tang N, Cai X, Peng L, Liu H and Chen Y: TCP1 regulates Wnt7b/β-catenin pathway through P53 to influence the proliferation and migration of hepatocellular carcinoma cells. Signal Transduct Target Ther. 5:1692020. View Article : Google Scholar

41 

Wang Q, Huang WR, Chih WY, Chuang KP, Chang CD, Wu Y, Huang Y and Liu HJ: Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis. Vet Microbiol. 235:151–163. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Rivlin N, Katz S, Doody M, Sheffer M, Horesh S, Molchadsky A, Koifman G, Shetzer Y, Goldfinger N, Rotter V and Geiger T: Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation. Proc Natl Acad Sci USA. 111:7006–7011. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Trinidad AG, Muller PA, Cuellar J, Klejnot M, Nobis M, Valpuesta JM and Vousden KH: Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity. Mol Cell. 50:805–817. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Monteith J and McMahon SB: p53: The TRiC is knowing when to fold 'em. Mol Cell. 50:781–782. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Arsic N, Slatter T, Gadea G, Villain E, Fournet A, Kazantseva M, Allemand F, Sibille N, Seveno M, de Rossi S, et al: Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells. Nat Commun. 12:54632021. View Article : Google Scholar

46 

Lee SC and Chan J: Proteomic identification of chaperonin-containing tail-less complex polypeptide-1 gamma subunit as a p53-responsive protein in colon cancer cells. Cancer Genomics Proteomics. 9:101–108. 2012.PubMed/NCBI

47 

Ooe A, Kato K and Noguchi S: Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers. Breast Cancer Res Treat. 101:305–315. 2007. View Article : Google Scholar

48 

Liu Q, Liu J, He N, Zhang M, Wu L, Chen X, Zhu J, Ran F, Chen Q and Zhang H: CRISPR/Cas12a coupling with magnetic nanoparticles and cascaded strand displacement reaction for ultrasensitive fluorescence determination of exosomal miR-21. Molecules. 27:53382022. View Article : Google Scholar : PubMed/NCBI

49 

Ke L, Ma H, Zhang Q, Wang Y, Xia P, Yu L, Lv W and Hu J: The pattern of lymph node metastasis in peripheral pulmonary nodules patients and risk prediction models. Front Surg. 9:9813132022. View Article : Google Scholar : PubMed/NCBI

50 

Shao F, Chen Y, Xu H, Chen X, Zhou J, Wu Y, Tang Y, Wang Z, Zhang R, Lange T, et al: Metabolic obesity phenotypes and risk of lung cancer: A prospective cohort study of 450,482 UK biobank participants. Nutrients. 14:33702022. View Article : Google Scholar : PubMed/NCBI

51 

Villalobos-Manzo R, Ríos-Castro E, Hernández-Hernández JM, Oza G, Medina MA and Tapia-Ramírez J: Identification of transferrin receptor 1 (TfR1) overexpressed in lung cancer cells, and internalization of magnetic Au-CoFe(2)O(4) core-shell nanoparticles functionalized with its ligand in a cellular model of small cell lung cancer (SCLC). Pharmaceutics. 14:17152022. View Article : Google Scholar : PubMed/NCBI

52 

Xu M and Gong J: Prognostic signature, immune features, and therapeutic responses of a novel ubiquitination-related gene signature in lung adenocarcinoma. J Oncol. 2022:25246492022. View Article : Google Scholar : PubMed/NCBI

53 

Platini H, Ferdinand E, Kohar K, Prayogo SA, Amirah S, Komariah M and Maulana S: Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as prognostic markers for advanced non-small-cell lung cancer treated with immunotherapy: A systematic review and meta-analysis. Medicina (Kaunas). 58:10692022. View Article : Google Scholar : PubMed/NCBI

54 

Zhou F, Qian C, Chen T and Zang X: MiR-96-5p facilitates lung adenocarcinoma cell phenotypes by inhibiting FHL1. Comput Math Methods Med. 2022:78912222022. View Article : Google Scholar : PubMed/NCBI

55 

Hu S, Cao P, Kong K, Han P, Yue J, Deng Y, Li F and Zhao B: circCNN2 accelerates cell proliferation and invasion in lung squamous cell carcinoma via regulating miR-184/E2F1 and Activating MAPK signaling pathway. Dis Markers. 2022:63290972022. View Article : Google Scholar : PubMed/NCBI

56 

Barak D, Engelberg S, Assaraf YG and Livney YD: Selective targeting and eradication of various human non-small cell lung cancer cell lines using self-assembled aptamer-decorated nanoparticles. Pharmaceutics. 14:16502022. View Article : Google Scholar : PubMed/NCBI

57 

Skonieczna M, Kasprzycka A, Jelen M and Morak-Mlodawska B: Tri- and pentacyclic azaphenothiazine as pro-apoptotic agents in lung carcinoma with a protective potential to healthy cell lines. Molecules. 27:52552022. View Article : Google Scholar : PubMed/NCBI

58 

Cui XY, Park SH and Park WH: Anti-cancer effects of auranofin in human lung cancer cells by increasing intracellular ROS levels and depleting GSH levels. Molecules. 27:52072022. View Article : Google Scholar : PubMed/NCBI

59 

Shi H, Zhang Y, Wang Y, Fang P, Liu Y and Li W: Restraint of chaperonin containing T-complex protein-1 subunit 3 has antitumor roles in non-small cell lung cancer via affection of YAP1. Toxicol Appl Pharmacol. 439:1159262022. View Article : Google Scholar : PubMed/NCBI

60 

Liu YJ, Chang YJ, Kuo YT and Liang PH: Targeting β-tubulin/CCT-β complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma. Carcinogenesis. 41:699–710. 2020. View Article : Google Scholar

61 

Ying Z, Tian H, Li Y, Lian R, Li W, Wu S, Zhang HZ, Wu J, Liu L, Song J, et al: CCT6A suppresses SMAD2 and promotes prometastatic TGF-β signaling. J Clin Invest. 127:1725–1740. 2017. View Article : Google Scholar : PubMed/NCBI

62 

Wang H, Wang X, Xu L, Lin Y and Zhang J: CCT6A and CHCHD2 are coamplified with EGFR and associated with the unfavorable clinical outcomes of lung adenocarcinoma. Dis Markers. 2022:15601992022.PubMed/NCBI

63 

Zhang T, Shi W, Tian K and Kong Y: Chaperonin containing t-complex polypeptide 1 subunit 6A correlates with lymph node metastasis, abnormal carcinoembryonic antigen and poor survival profiles in non-small cell lung carcinoma. World J Surg Oncol. 18:1562020. View Article : Google Scholar : PubMed/NCBI

64 

Tewelde B, Tamire M and Kaba M: Breast self-examination practice and predictors among female secondary school teachers in Addis Ababa, Ethiopia: Using the health belief model. BMC Womens Health. 22:3172022. View Article : Google Scholar : PubMed/NCBI

65 

Liu N, Yang DW, Wu YX, Xue WQ, Li DH, Zhang JB, He YQ and Jia WH: Burden, trends, and risk factors for breast cancer in China from 1990 to 2019 and its predictions until 2034: An up-to-date overview and comparison with those in Japan and South Korea. BMC Cancer. 22:8262022. View Article : Google Scholar : PubMed/NCBI

66 

de Freitas GB, Penteado L, Miranda MM, Filassi JR, Baracat EC and Linhares IM: The circulating 70 kDa heat shock protein (HSPA1A) level is a potential biomarker for breast carcinoma and its progression. Sci Rep. 12:130122022. View Article : Google Scholar

67 

Tang M, O'Grady S, Crown J and Duffy MJ: MYC as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigations with the novel MYC inhibitor, MYCi975. Breast Cancer Res Treat. 195:105–115. 2022. View Article : Google Scholar : PubMed/NCBI

68 

Tam S, Al-Zubaidi Y, Rahman MK, Bourget K, Zhou F and Murray M: The ixabepilone and vandetanib combination shows synergistic activity in docetaxel-resistant MDA-MB-231 breast cancer cells. Pharmacol Rep. 74:998–1010. 2022. View Article : Google Scholar : PubMed/NCBI

69 

Kotani H, Masuda N, Yamashita T, Naito Y, Taira T, Inoue K, Takahashi M, Yonemori K, Toyoizumi S, Mori Y, et al: Efficacy and safety of talazoparib in Japanese patients with germline BRCA-mutated locally advanced or metastatic breast cancer: Results of the phase 1 dose-expansion study. Breast Cancer. 29:1088–1098. 2022. View Article : Google Scholar : PubMed/NCBI

70 

Xu WX, Song W, Jiang MP, Yang SJ, Zhang J, Wang DD and Tang JH: Systematic characterization of expression profiles and prognostic values of the eight subunits of the chaperonin TRiC in breast cancer. Front Genet. 12:6378872021. View Article : Google Scholar : PubMed/NCBI

71 

Huang K, Zeng Y, Xie Y, Huang L and Wu Y: Bioinformatics analysis of the prognostic value of CCT6A and associated signalling pathways in breast cancer. Mol Med Rep. 19:4344–4352. 2019.PubMed/NCBI

72 

Macario AJL and Conway de Macario E: Chaperonins in cancer: Expression, function, and migration in extracellular vesicles. Semin Cancer Biol. 86(Pt 1): 26–35. 2021. View Article : Google Scholar : PubMed/NCBI

73 

Liu Q, Qi Y, Kong X, Wang X, Zhang W, Zhai J, Yang Y, Fang Y and Wang J: Molecular and clinical characterization of CCT2 expression and prognosis via large-scale transcriptome profile of breast cancer. Front Oncol. 11:6144972021. View Article : Google Scholar : PubMed/NCBI

74 

Ghozlan H, Showalter A, Lee E, Zhu X and Khaled AR: Chaperonin-Containing TCP1 Complex (CCT) promotes breast cancer growth through correlations with key cell cycle regulators. Front Oncol. 11:6638772021. View Article : Google Scholar : PubMed/NCBI

75 

Bassiouni R, Nemec KN, Iketani A, Flores O, Showalter A, Khaled AS, Vishnubhotla P, Sprung RW Jr, Kaittanis C, Perez JM and Khaled AR: Chaperonin Containing TCP-1 protein level in breast cancer cells predicts therapeutic application of a cytotoxic peptide. Clin Cancer Res. 22:4366–4379. 2016. View Article : Google Scholar : PubMed/NCBI

76 

Satriano L, Lewinska M, Rodrigues PM, Banales JM and Andersen JB: Metabolic rearrangements in primary liver cancers: Cause and consequences. Nat Rev Gastroenterol Hepatol. 16:748–766. 2019. View Article : Google Scholar : PubMed/NCBI

77 

Trefts E, Gannon M and Wasserman DH: The liver. Curr Biol. 27:R1147–R1151. 2017. View Article : Google Scholar : PubMed/NCBI

78 

Cheng ML, Nakib D, Perciani CT and MacParland SA: The immune niche of the liver. Clin Sci (Lond). 135:2445–2466. 2021. View Article : Google Scholar : PubMed/NCBI

79 

Villanueva A: Hepatocellular carcinoma. N Engl J Med. 380:1450–1462. 2019. View Article : Google Scholar : PubMed/NCBI

80 

Gao YX, Yang TW, Yin JM, Yang PX, Kou BX, Chai MY, Liu XN and Chen DX: Progress and prospects of biomarkers in primary liver cancer (Review). Int J Oncol. 57:54–66. 2020.PubMed/NCBI

81 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

82 

Hepatocellular carcinoma. Nat Rev Dis Primers. 7:72021. View Article : Google Scholar : PubMed/NCBI

83 

Moon H, Park H, Chae MJ, Choi HJ, Kim DY and Ro SW: Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathways. BMC Cancer. 22:4232022. View Article : Google Scholar : PubMed/NCBI

84 

Keenan BP, Fong L and Kelley RK: Immunotherapy in hepatocellular carcinoma: The complex interface between inflammation, fibrosis, and the immune response. J Immunother Cancer. 7:2672019. View Article : Google Scholar : PubMed/NCBI

85 

Wang H, Lu Z and Zhao X: Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer. J Hematol Oncol. 12:1332019. View Article : Google Scholar : PubMed/NCBI

86 

Mintz KJ and Leblanc RM: The use of nanotechnology to combat liver cancer: Progress and perspectives. Biochim Biophys Acta Rev Cancer. 1876:1886212021. View Article : Google Scholar : PubMed/NCBI

87 

Anwanwan D, Singh SK, Singh S, Saikam V and Singh R: Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta Rev Cancer. 1873:1883142010. View Article : Google Scholar

88 

Rebouissou S and Nault JC: Advances in molecular classification and precision oncology in hepatocellular carcinoma. J Hepatol. 72:215–229. 2020. View Article : Google Scholar : PubMed/NCBI

89 

Qian EN, Han SY, Ding SZ and Lv X: Expression and diagnostic value of CCT3 and IQGAP3 in hepatocellular carcinoma. Cancer Cell Int. 16:552016. View Article : Google Scholar : PubMed/NCBI

90 

Wang F, Wang R, Li Q, Qu X, Hao Y, Yang J, Zhao H, Wang Q, Li G, Zhang F, et al: A transcriptome profile in hepatocellular carcinomas based on integrated analysis of microarray studies. Diagn Pathol. 12:42017. View Article : Google Scholar : PubMed/NCBI

91 

Yunna C, Mengru H, Lei W and Weidong C: Macrophage M1/M2 polarization. Eur J Pharmacol. 877:1730902020. View Article : Google Scholar : PubMed/NCBI

92 

Wong N, Chan A, Lee SW, Lam E, To KF, Lai PB, Li XN, Liew CT and Johnson PJ: Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression. J Hepatol. 38:298–306. 2003. View Article : Google Scholar : PubMed/NCBI

93 

Liu J, Huang L, Zhu Y, He Y, Zhang W, Lei T, Xuan J, Xiao B, Li L, Zhou Q and Sun Z: Exploring the expression and prognostic value of the TCP1 ring complex in hepatocellular carcinoma and overexpressing its subunit 5 Promotes HCC tumorigenesis. Front Oncol. 11:7396602021. View Article : Google Scholar : PubMed/NCBI

94 

Zeng G, Wang J and Huang Y, Lian Y, Chen D, Wei H, Lin C and Huang Y: Overexpressing CCT6A contributes to cancer cell growth by affecting the G1-To-S phase transition and predicts a negative prognosis in hepatocellular carcinoma. Onco Targets Ther. 12:10427–10439. 2019. View Article : Google Scholar : PubMed/NCBI

95 

Shaath H, Vishnubalaji R, Elango R, Kardousha A, Islam Z, Qureshi R, Alam T, Kolatkar PR and Alajez NM: Long non-coding RNA and RNA-binding protein interactions in cancer: Experimental and machine learning approaches. Semin Cancer Biol. 86(Pt 3): 325–345. 2022. View Article : Google Scholar : PubMed/NCBI

96 

Pereira B, Billaud M and Almeida R: RNA-Binding proteins in cancer: Old players and new actors. Trends Cancer. 3:506–528. 2017. View Article : Google Scholar : PubMed/NCBI

97 

Iino K, Mitobe Y, Ikeda K, Takayama KI, Suzuki T, Kawabata H, Suzuki Y, Horie-Inoue K and Inoue S: RNA-binding protein NONO promotes breast cancer proliferation by post-transcriptional regulation of SKP2 and E2F8. Cancer Sci. 111:148–159. 2020. View Article : Google Scholar

98 

Sondergaard JN, Sommerauer C, Atanasoai I, Hinte LC, Geng K, Guiducci G, Brautigam L, Aouadi M, Stojic L, Barragan I and Kutter C: CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism. Gut. 71:2081–2092. 2022. View Article : Google Scholar : PubMed/NCBI

99 

Zhang Z, Xu L and Sun C: Comprehensive characterization of cancer genes in hepatocellular carcinoma genomes. Oncol Lett. 15:1503–1510. 2018.PubMed/NCBI

100 

Xu J, Zhang Y, Liu C, Yan P and Yang Z: Roles of the miR-139-5p/CCT5 axis in hepatocellular carcinoma: A bioinformatic analysis. Int J Med Sci. 18:3556–3564. 2021. View Article : Google Scholar : PubMed/NCBI

101 

Zayegh O, Hmidi ZS, Nawlo AA, Al-Mouakeh A, Amin B, Banjah B, Chammout A and Alsayid M: Awareness and knowledge of colorectal cancer screening among medical students at the university of aleppo: A cross-sectional study. Avicenna J Med. 12:54–60. 2022. View Article : Google Scholar : PubMed/NCBI

102 

Cummings A, Foster R, Calman L, Permyakova NV, Bridges J, Wiseman T, Corbett T, Smith PWF and Foster C: Quality of life and health status in older adults (>/=65 years) up to five years following colorectal cancer treatment: Findings from the ColoREctal Wellbeing (CREW) cohort study. PLoS One. 17:e02700332022. View Article : Google Scholar

103 

La Vecchia S and Sebastián C: Metabolic pathways regulating colorectal cancer initiation and progression. Semin Cell Dev Biol. 98:63–70. 2020. View Article : Google Scholar

104 

Liu X, Yang K, Li Z and Liu J: MMP2 polymorphisms and colorectal cancer susceptibility in a Chinese Han Population. Int J Gen Med. 15:6009–6019. 2022. View Article : Google Scholar : PubMed/NCBI

105 

Pan S, Mei W, Huang L, Tao Y, Xu J and Ruan Y: Prediction of postoperative survival in young colorectal cancer patients: A cohort study based on the SEER database. J Immunol Res. 2022:27366762022. View Article : Google Scholar : PubMed/NCBI

106 

Li J, Ma X, Chakravarti D, Shalapour S and DePinho RA: Genetic and biological hallmarks of colorectal cancer. Genes Dev. 35:787–820. 2021. View Article : Google Scholar : PubMed/NCBI

107 

Dienstmann R, Vermeulen L, Guinney J, Kopetz S, Tejpar S and Tabernero J: Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer. Nat Rev Cancer. 17:79–92. 2017. View Article : Google Scholar : PubMed/NCBI

108 

Watson AJ and Collins PD: Colon cancer: A civilization disorder. Dig Dis. 29:222–228. 2011. View Article : Google Scholar : PubMed/NCBI

109 

Goldstein DA, Zeichner SB, Bartnik CM, Neustadter E and Flowers CR: Metastatic colorectal cancer: A systematic review of the value of current therapies. Clin Colorectal Cancer. 15:1–6. 2016. View Article : Google Scholar :

110 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

111 

Qian-Lin Z, Ting-Feng W, Qi-Feng C, Min-Hua Z and Ai-Guo L: Inhibition of cytosolic chaperonin CCTζ-1 expression depletes proliferation of colorectal carcinoma in vitro. J Surg Oncol. 102:419–423. 2010. View Article : Google Scholar : PubMed/NCBI

112 

Coghlin C, Carpenter B, Dundas SR, Lawrie LC, Telfer C and Murray GI: Characterization and over-expression of chaperonin t-complex proteins in colorectal cancer. J Pathol. 210:351–357. 2006. View Article : Google Scholar : PubMed/NCBI

113 

Yokota S, Yamamoto Y, Shimizu K, Momoi H, Kamikawa T, Yamaoka Y, Yanagi H, Yura T and Kubota H: Increased expression of cytosolic chaperonin CCT in human hepatocellular and colonic carcinoma. Cell Stress Chaperones. 6:345–350. 2001. View Article : Google Scholar

114 

Yang X, Tong Y, Ye W and Chen L: HOXB2 increases the proliferation and invasiveness of colon cancer cells through the upregulation of CCT6A. Mol Med Rep. 25:1742022. View Article : Google Scholar : PubMed/NCBI

115 

Liu YJ, Kumar V, Lin YF and Liang PH: Disrupting CCT-β : β-tubulin selectively kills CCT-β overexpressed cancer cells through MAPKs activation. Cell Death Dis. 8:e30522017. View Article : Google Scholar

116 

Park SH, Jeong S, Kim BR, Jeong YA, Kim JL, Na YJ, Jo MJ, Yun HK, Kim DY, Kim BG, et al: Activating CCT2 triggers Gli-1 activation during hypoxic condition in colorectal cancer. Oncogene. 39:136–150. 2020. View Article : Google Scholar

117 

Sun H, Wang Y, Jing HY, Yang XY, Shi XX, Zhang JH, Yu YX, Gao L, Wang XY, Li WH and Yu L: Chaperonin-Containing TCP1 Subunit 6A Is a prognostic potential biomarker that correlates with the presence of immune infiltrates in colorectal cancer. Front Genet. 12:6298562021. View Article : Google Scholar : PubMed/NCBI

118 

Hu J, Han C, Zhong J, Liu H, Liu R, Luo W, Chen P and Ling F: Dynamic network biomarker of pre-exhausted CD8(+) T cells contributed to T cell exhaustion in colorectal cancer. Front Immunol. 12:6911422021. View Article : Google Scholar : PubMed/NCBI

119 

Lu L, Li ZJ, Li LF, Wu WK, Shen J, Zhang L, Chan RL, Yu L, Liu YW, Ren SX, et al: Vascular-targeted TNFα improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer. J Control Release. 210:134–146. 2015. View Article : Google Scholar : PubMed/NCBI

120 

Lu L, Li ZJ, Li LF, Shen J, Zhang L, Li MX, Xiao ZG, Wang JH and Cho CH: A novel vascular-targeting peptide for gastric cancer delivers low-dose TNFα to normalize the blood vessels and improve the anti-cancer efficiency of 5-fluorouracil. Peptides. 97:54–63. 2017. View Article : Google Scholar : PubMed/NCBI

121 

Liao Q, Ren Y, Yang Y, Zhu X, Zhi Y, Zhang Y, Chen Y, Ding Y and Zhao L: CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression. Oncogenesis. 10:842021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zheng L, Chen X, Zhang L, Qin N, An J, Zhu J, Jin H and Tuo B: A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review). Int J Oncol 63: 106, 2023.
APA
Zheng, L., Chen, X., Zhang, L., Qin, N., An, J., Zhu, J. ... Tuo, B. (2023). A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review). International Journal of Oncology, 63, 106. https://doi.org/10.3892/ijo.2023.5554
MLA
Zheng, L., Chen, X., Zhang, L., Qin, N., An, J., Zhu, J., Jin, H., Tuo, B."A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review)". International Journal of Oncology 63.3 (2023): 106.
Chicago
Zheng, L., Chen, X., Zhang, L., Qin, N., An, J., Zhu, J., Jin, H., Tuo, B."A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review)". International Journal of Oncology 63, no. 3 (2023): 106. https://doi.org/10.3892/ijo.2023.5554
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng L, Chen X, Zhang L, Qin N, An J, Zhu J, Jin H and Tuo B: A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review). Int J Oncol 63: 106, 2023.
APA
Zheng, L., Chen, X., Zhang, L., Qin, N., An, J., Zhu, J. ... Tuo, B. (2023). A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review). International Journal of Oncology, 63, 106. https://doi.org/10.3892/ijo.2023.5554
MLA
Zheng, L., Chen, X., Zhang, L., Qin, N., An, J., Zhu, J., Jin, H., Tuo, B."A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review)". International Journal of Oncology 63.3 (2023): 106.
Chicago
Zheng, L., Chen, X., Zhang, L., Qin, N., An, J., Zhu, J., Jin, H., Tuo, B."A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review)". International Journal of Oncology 63, no. 3 (2023): 106. https://doi.org/10.3892/ijo.2023.5554
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