Open Access

A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review)

  • Authors:
    • Liming Zheng
    • Xingyue Chen
    • Li Zhang
    • Nannan Qin
    • Jiaxing An
    • Jiaxing Zhu
    • Hai Jin
    • Biguang Tuo
  • View Affiliations

  • Published online on: August 1, 2023     https://doi.org/10.3892/ijo.2023.5554
  • Article Number: 106
  • Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Due to concealment, high invasiveness and a lack of indicators, malignant tumors have emerged as one of the deadliest diseases worldwide and their incidence is rising yearly. Research has revealed that the chaperonin family member, chaperonin containing TCP‑1 (CCT), serves a crucial role in malignant tumors. CCT is involved in the growth of numerous malignant tumors such as lung cancer, breast cancer, hepatocellular carcinoma and colorectal cancer and assists the folding of a number of proteins linked to cancer, such as KRAS, p53 and STAT3. According to clinical data, CCT is highly expressed in a range of tumor cells and is associated with poor patient prognosis. In addition, through controlling the cell cycle or interacting with other proteins (including YAP1, HoXB2 and SMAD2), CCT has an effect on the proliferation, invasion and migration of cancer cells. As a result, it is possible that CCT will become a new tumor marker or therapeutic target, which will provide some guidance for early tumor screening or late tumor prognosis. In the present review, the molecular properties of CCT are introduced, alongside a summary of its interactions with other cancer‑related proteins and a discussion of its function in common malignant tumors. It is expected that the present review will offer fresh approaches to the treatment of cancer.
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September-2023
Volume 63 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Zheng L, Chen X, Zhang L, Qin N, An J, Zhu J, Jin H and Tuo B: A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review). Int J Oncol 63: 106, 2023
APA
Zheng, L., Chen, X., Zhang, L., Qin, N., An, J., Zhu, J. ... Tuo, B. (2023). A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review). International Journal of Oncology, 63, 106. https://doi.org/10.3892/ijo.2023.5554
MLA
Zheng, L., Chen, X., Zhang, L., Qin, N., An, J., Zhu, J., Jin, H., Tuo, B."A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review)". International Journal of Oncology 63.3 (2023): 106.
Chicago
Zheng, L., Chen, X., Zhang, L., Qin, N., An, J., Zhu, J., Jin, H., Tuo, B."A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review)". International Journal of Oncology 63, no. 3 (2023): 106. https://doi.org/10.3892/ijo.2023.5554