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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October-2023 Volume 63 Issue 4

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Review

RNA binding proteins in extracellular vesicles and their potential value for cancer diagnosis and treatment (Review)

  • Authors:
    • Weichao Sun
    • Hanwei Cui
    • Tianhao Xu
    • Jiaji Yue
    • Jianhui Liang
    • Wei You
    • Wei Sun
    • Qian Yi
  • View Affiliations / Copyright

    Affiliations: Department of Bone Joint and Bone Oncology, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China, Central Laboratory, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China, Department of Physiology, School of Basic Medical Science, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
  • Article Number: 114
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    Published online on: August 14, 2023
       https://doi.org/10.3892/ijo.2023.5562
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Abstract

Extracellular vesicles (EVs) are spherical bilayer membrane vesicles released by cells into extracellular spaces and body fluids, including plasma and synovial fluid. EV cargo comprises various biomolecules, such as proteins, DNA, mRNAs, non‑coding RNAs, lipids and metabolites. By delivering these bioactive molecules to recipient cells, EVs mediate intercellular communications and play a critical role in maintaining cellular homeostasis and promoting pathological progression. Of note, cells can selectively sort these bioactive molecules (particularly RNAs) into EVs for secretion, as well as regulate cell‑cell communications. RNA‑binding proteins (RBPs) are a large class of proteins capable of binding to RNA molecules and function in regulating RNA metabolism. There is increasing evidence to indicate that RBPs can be delivered to receipt cells to influence their cell biology and play a significant role in the sorting of coding and non‑coding RNAs in EVs. The present review summarized the current knowledge on EV‑associated RBPs, their functions in tumorigenesis and RBP‑related exosome engineering. It is hoped that the present review may provide novel insight into RBPs and targeted cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Sun W, Cui H, Xu T, Yue J, Liang J, You W, Sun W and Yi Q: RNA binding proteins in extracellular vesicles and their potential value for cancer diagnosis and treatment (Review). Int J Oncol 63: 114, 2023.
APA
Sun, W., Cui, H., Xu, T., Yue, J., Liang, J., You, W. ... Yi, Q. (2023). RNA binding proteins in extracellular vesicles and their potential value for cancer diagnosis and treatment (Review). International Journal of Oncology, 63, 114. https://doi.org/10.3892/ijo.2023.5562
MLA
Sun, W., Cui, H., Xu, T., Yue, J., Liang, J., You, W., Sun, W., Yi, Q."RNA binding proteins in extracellular vesicles and their potential value for cancer diagnosis and treatment (Review)". International Journal of Oncology 63.4 (2023): 114.
Chicago
Sun, W., Cui, H., Xu, T., Yue, J., Liang, J., You, W., Sun, W., Yi, Q."RNA binding proteins in extracellular vesicles and their potential value for cancer diagnosis and treatment (Review)". International Journal of Oncology 63, no. 4 (2023): 114. https://doi.org/10.3892/ijo.2023.5562
Copy and paste a formatted citation
x
Spandidos Publications style
Sun W, Cui H, Xu T, Yue J, Liang J, You W, Sun W and Yi Q: RNA binding proteins in extracellular vesicles and their potential value for cancer diagnosis and treatment (Review). Int J Oncol 63: 114, 2023.
APA
Sun, W., Cui, H., Xu, T., Yue, J., Liang, J., You, W. ... Yi, Q. (2023). RNA binding proteins in extracellular vesicles and their potential value for cancer diagnosis and treatment (Review). International Journal of Oncology, 63, 114. https://doi.org/10.3892/ijo.2023.5562
MLA
Sun, W., Cui, H., Xu, T., Yue, J., Liang, J., You, W., Sun, W., Yi, Q."RNA binding proteins in extracellular vesicles and their potential value for cancer diagnosis and treatment (Review)". International Journal of Oncology 63.4 (2023): 114.
Chicago
Sun, W., Cui, H., Xu, T., Yue, J., Liang, J., You, W., Sun, W., Yi, Q."RNA binding proteins in extracellular vesicles and their potential value for cancer diagnosis and treatment (Review)". International Journal of Oncology 63, no. 4 (2023): 114. https://doi.org/10.3892/ijo.2023.5562
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