Open Access

Roles of salt‑inducible kinases in cancer (Review)

  • Authors:
    • Shenghui Feng
    • Fangyi Wei
    • Haoran Shi
    • Shen Chen
    • Bangqi Wang
    • Deqiang Huang
    • Lingyu Luo
  • View Affiliations

  • Published online on: August 25, 2023     https://doi.org/10.3892/ijo.2023.5566
  • Article Number: 118
  • Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Salt inducible kinases (SIKs) with three subtypes SIK1, SIK2 and SIK3, belong to the AMP‑activated protein kinase family. They are expressed ubiquitously in humans. Under normal circumstances, SIK1 regulates adrenocortical function in response to high salt or adrenocorticotropic hormone stimulation, SIK2 is involved in cell metabolism, controlling insulin signaling and gluconeogenesis and SIK3 coordinates with the mTOR complex, promoting cancer. The dysregulation of SIKs has been widely detected in various types of cancers. Based on most of the existing studies, SIK1 is mostly considered a tumor inhibitor, SIK2 and SIK3 are usually associated with tumor promotion. However, the functions of SIKs have shown contradictory in certain tumors, suggesting that SIKs cannot be simply classified as oncogenes or tumor suppressor genes. The present review provided a comprehensive summary of the roles of SIKs in the initiation and progression of different cancers, aiming to elucidate their clinical value and discuss potential strategies for targeting SIKs in cancer therapy.
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November-2023
Volume 63 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Feng S, Wei F, Shi H, Chen S, Wang B, Huang D and Luo L: Roles of salt‑inducible kinases in cancer (Review). Int J Oncol 63: 118, 2023
APA
Feng, S., Wei, F., Shi, H., Chen, S., Wang, B., Huang, D., & Luo, L. (2023). Roles of salt‑inducible kinases in cancer (Review). International Journal of Oncology, 63, 118. https://doi.org/10.3892/ijo.2023.5566
MLA
Feng, S., Wei, F., Shi, H., Chen, S., Wang, B., Huang, D., Luo, L."Roles of salt‑inducible kinases in cancer (Review)". International Journal of Oncology 63.5 (2023): 118.
Chicago
Feng, S., Wei, F., Shi, H., Chen, S., Wang, B., Huang, D., Luo, L."Roles of salt‑inducible kinases in cancer (Review)". International Journal of Oncology 63, no. 5 (2023): 118. https://doi.org/10.3892/ijo.2023.5566