
Role of stress in the pathogenesis of cancer (Review)
- Authors:
- Ioannis G. Lempesis
- Vasiliki Epameinondas Georgakopoulou
- Petros Papalexis
- Georgios P. Chrousos
- Demetrios A. Spandidos
-
Affiliations: Department of Infectious Diseases-COVID-19 Unit, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, Unit of Endocrinology, First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, Clinical, Translational and Experimental Surgery Research Centre, Biomedical Research Foundation Academy of Athens, 11527 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece - Published online on: September 11, 2023 https://doi.org/10.3892/ijo.2023.5572
- Article Number: 124
-
Copyright: © Lempesis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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Chrousos GP: Stress and disorders of the stress system. Nat Rev Endocrinol. 5:374–381. 2009. View Article : Google Scholar : PubMed/NCBI | |
Agorastos A and Chrousos GP: The neuroendocrinology of stress: The stress-related continuum of chronic disease development. Mol Psychiatry. 27:502–513. 2022. View Article : Google Scholar | |
Tsigos C, Kyrou I, Kassi E and Chrousos GP: Stress: Endocrine Physiology and Pathophysiology. Endotext. Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, et al: MDTextcom, Inc; South Dartmouth, MA: 2000 | |
Chrousos GP: The glucocorticoid receptor gene, longevity, and the complex disorders of Western societies. Am J Med. 117:204–207. 2004. View Article : Google Scholar : PubMed/NCBI | |
Yan J, Chen Y, Luo M, Hu X, Li H, Liu Q and Zou Z: Chronic stress in solid tumor development: From mechanisms to interventions. J Biomed Sci. 30:82023. View Article : Google Scholar : PubMed/NCBI | |
Lempesis IG, Karlafti E, Papalexis P, Fotakopoulos G, Tarantinos K, Lekakis V, Papadakos SP, Cholongitas E and Georgakopoulou VE: COVID-19 and liver injury in individuals with obesity. World J Gastroenterol. 29:908–916. 2023. View Article : Google Scholar : PubMed/NCBI | |
Georgakopoulou VE, Lembessis P, Skarlis C, Gkoufa A, Sipsas NV and Mavragani CP: Hematological abnormalities in COVID-19 disease: Association with type I interferon pathway activation and disease outcomes. Front Med (Lausanne). 9:8504722022. View Article : Google Scholar : PubMed/NCBI | |
Tsamakis K, Gavriatopoulou M, Schizas D, Stravodimou A, Mougkou A, Tsiptsios D, Sioulas V, Spartalis E, Sioulas AD, Tsamakis C, et al: Oncology during the COVID-19 pandemic: Challenges, dilemmas and the psychosocial impact on cancer patients. Oncol Lett. 20:441–447. 2020. View Article : Google Scholar : PubMed/NCBI | |
Georgakopoulou VE, Makrodimitri S, Triantafyllou M, Samara S, Voutsinas PM, Anastasopoulou A, Papageorgiou CV, Spandidos DA, Gkoufa A, Papalexis P, et al: Immature granulocytes: Innovative biomarker for SARS-CoV-2 infection. Mol Med Rep. 26:2172022. View Article : Google Scholar : | |
Lempesis IG and Georgakopoulou VE: Implications of obesity and adiposopathy on respiratory infections; focus on emerging challenges. World J Clin Cases. 11:29252023. View Article : Google Scholar : PubMed/NCBI | |
Eckerling A, Ricon-Becker I, Sorski L, Sandbank E and Ben-Eliyahu S: Stress and cancer: Mechanisms, significance and future directions. Nat Rev Cancer. 21:767–785. 2021. View Article : Google Scholar : PubMed/NCBI | |
Mravec B, Tibensky M and Horvathova L: Stress and cancer. Part I: Mechanisms mediating the effect of stressors on cancer. J Neuroimmunol. 346:5773112020. View Article : Google Scholar : PubMed/NCBI | |
Deshaies-Gendron M: Enquiries Into the Nature, Knowledge, and Cure of Cancers. Mr Gendron Deshaies : Done out of French. Gale Ecco, Print Editions. April 22–2018. | |
Selye H: A syndrome produced by diverse nocuous agents. Nature. 138:32. 1936. View Article : Google Scholar | |
Antoni MH and Dhabhar FS: The impact of psychosocial stress and stress management on immune responses in patients with cancer. Cancer. 125:1417–1431. 2019. View Article : Google Scholar : PubMed/NCBI | |
Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial N, et al: Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 123:874–886. 2013.PubMed/NCBI | |
Inbar S, Neeman E, Avraham R, Benish M, Rosenne E and Ben-Eliyahu S: Do stress responses promote leukemia progression? An animal study suggesting a role for epinephrine and prostaglandin-E2 through reduced NK activity. PLoS One. 6:e192462011. View Article : Google Scholar : PubMed/NCBI | |
Thaker PH, Han LY, Kamat AA, Arevalo JM, Takahashi R, Lu C, Jennings NB, Armaiz-Pena G, Bankson JA, Ravoori M, et al: Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med. 12:939–944. 2006. View Article : Google Scholar : PubMed/NCBI | |
Wu Y, Zhou L, Zhang X, Yang X, Niedermann G and Xue J: Psychological distress and eustress in cancer and cancer treatment: Advances and perspectives. Sci Adv. 8:eabq79822022. View Article : Google Scholar : PubMed/NCBI | |
Heikkilä K, Nyberg ST, Theorell T, Fransson EI, Alfredsson L, Bjorner JB, Bonenfant S, Borritz M, Bouillon K, Burr H, et al: Work stress and risk of cancer: Meta-analysis of 5700 incident cancer events in 116 000 European men and women. BMJ. 346:f1652013. View Article : Google Scholar | |
Yang T, Qiao Y, Xiang S, Li W, Gan Y and Chen Y: Work stress and the risk of cancer: A meta-analysis of observational studies. Int J Cancer. 144:2390–2400. 2019. View Article : Google Scholar | |
Chida Y, Hamer M, Wardle J and Steptoe A: Do stress-related psychosocial factors contribute to cancer incidence and survival? Nat Clin Pract Oncol. 5:466–475. 2008. View Article : Google Scholar : PubMed/NCBI | |
Coyne JC, Ranchor AV and Palmer SC: Meta-analysis of stress-related factors in cancer. Nat Rev Clin Oncol. 72010. View Article : Google Scholar | |
Mravec B and Tibensky M: Increased cancer incidence in 'cold' countries: An (un) sympathetic connection? J Therm Biol. 89:1025382020. View Article : Google Scholar | |
Keinan-Boker L, Vin-Raviv N, Liphshitz I, Linn S and Barchana M: Cancer incidence in Israeli jewish survivors of World War II. J Natl Cancer Inst. 101:1489–1500. 2009. View Article : Google Scholar : PubMed/NCBI | |
Huang T, Poole EM, Okereke OI, Kubzansky LD, Eliassen AH, Sood AK, Wang M and Tworoger SS: Depression and risk of epithelial ovarian cancer: Results from two large prospective cohort studies. Gynecol Oncol. 139:481–486. 2015. View Article : Google Scholar : PubMed/NCBI | |
Fang F, Fall K, Sparén P, Adami HO, Valdimarsdóttir HB, Lambe M and Valdimarsdóttir U: Risk of infection-related cancers after the loss of a child: A follow-up study in Sweden. Cancer Res. 71:116–122. 2011. View Article : Google Scholar | |
Schoemaker MJ, Jones ME, Wright LB, Griffin J, McFadden E, Ashworth A and Swerdlow AJ: Psychological stress, adverse life events and breast cancer incidence: A cohort investigation in 106,000 Women in the United Kingdom. Breast Cancer Res. 18:722016. View Article : Google Scholar : PubMed/NCBI | |
Trudel-Fitzgerald C, Poole EM, Idahl A, Lundin E, Sood AK, Kawachi I, Kubzansky LD and Tworoger SS: The association of work characteristics with ovarian cancer risk and mortality. Psychosom Med. 79:1059–1067. 2017. View Article : Google Scholar : PubMed/NCBI | |
Carlson L, Angen M, Cullum J, Goodey E, Koopmans J, Lamont L, MacRae JH, Martin M, Pelletier G, Robinson J, et al: High levels of untreated distress and fatigue in cancer patients. Br J Cancer. 90:2297–2304. 2004. View Article : Google Scholar : PubMed/NCBI | |
Mitchell AJ, Chan M, Bhatti H, Halton M, Grassi L, Johansen C and Meader N: Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: A meta-analysis of 94 interview-based studies. Lancet Oncol. 12:160–174. 2011. View Article : Google Scholar : PubMed/NCBI | |
Lu D, Andersson TM, Fall K, Hultman CM, Czene K, Valdimarsdóttir U and Fang F: Clinical diagnosis of mental disorders immediately before and after cancer diagnosis: A nationwide matched cohort study in Sweden. JAMA Oncol. 2:1188–1196. 2016. View Article : Google Scholar : PubMed/NCBI | |
Batty GD, Russ TC, Stamatakis E and Kivimäki M: Psychological distress in relation to site specific cancer mortality: Pooling of unpublished data from 16 prospective cohort studies. BMJ. 356:1082017. View Article : Google Scholar | |
Wang X, Wang N, Zhong L, Wang S, Zheng Y, Yang B, Zhang J, Lin Y and Wang Z: Prognostic value of depression and anxiety on breast cancer recurrence and mortality: A systematic review and meta-analysis of 282,203 patients. Mol Psychiatry. 25:3186–3197. 2020. View Article : Google Scholar : PubMed/NCBI | |
Pinquart M and Duberstein P: Depression and cancer mortality: A meta-analysis. Psychol Med. 40:1797–1810. 2010. View Article : Google Scholar : PubMed/NCBI | |
Pinquart M and Duberstein PR: Associations of social networks with cancer mortality: A meta-analysis. Crit Rev Oncol Hematol. 75:122–137. 2010. View Article : Google Scholar : | |
Manjili MH: Tumor dormancy and relapse: From a natural byproduct of evolution to a disease state. Cancer Res. 77:2564–2569. 2017. View Article : Google Scholar : PubMed/NCBI | |
Cannon WB: The wisdom of the body. 2nd. Norton and Co; New York, NY: 1939 | |
Cannon WB: Bodily changes in pain, hunger, fear, and rage An account of recent researches into the function of emotional excitement. D. Appleton and Company; 1915, View Article : Google Scholar | |
Selye H: The stress of life. McGraw-Hill Education; New York, NY: 1956 | |
Chrousos GP: Hans Selye memorial lecture: Stressors, stress and neuroendocrine integration of the adaptive response. Ann NY Acad Sci. 851:311–335. 1997. View Article : Google Scholar | |
Lim CT and Khoo B: Normal Physiology of ACTH and GH Release in the Hypothalamus and Anterior Pituitary in Man. Endotext. Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, et al: MDTextcom, Inc; South Dartmouth, MA: 2000 | |
Gassen NC, Chrousos GP, Binder EB and Zannas AS: Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases. Neurosci Biobehav Rev. 74:356–365. 2017. View Article : Google Scholar | |
Nicolaides NC, Chrousos G and Kino T: Glucocorticoid Receptor. Endotext. Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, et al: MDText.com, Inc.; South Dartmouth MA: 2000 | |
Chrousos GP, McCarty R, Pacak K, Cizza G, Sternberg G, Gold P and Květňanský R: Stress: Basic mechanisms and clinical implications. 1995. | |
Chrousos GP and Gold PW: The concepts of stress and stress system disorders: Overview of physical and behavioral homeostasis. JAMA. 267:1244–1252. 1992. View Article : Google Scholar : PubMed/NCBI | |
Chrousos GP: Organization and integration of the endocrine system: The arousal and sleep perspective. Sleep Med Clin. 2:125–145. 2007. View Article : Google Scholar | |
Charmandari E, Tsigos C and Chrousos G: Neuroendocrinology of stress. Ann Rev Physiol. 67:259–284. 2005. View Article : Google Scholar | |
Gold PW, Goodwin FK and Chrousos GP: Clinical and biochemical manifestations of depression. N Engl J Med. 319:413–420. 1988. View Article : Google Scholar : PubMed/NCBI | |
Chrousos GP and Kino T: Glucocorticoid action networks and complex psychiatric and/or somatic disorders. Stress. 10:213–219. 2007. View Article : Google Scholar : PubMed/NCBI | |
Franchimont D, Kino T, Galon J, Meduri GU and Chrousos G: Glucocorticoids and Inflammation Revisited: The State of the ArtNIH clinical staff conference. Neuroimmunomodulation. 10:247–260. 2003. View Article : Google Scholar | |
Chrousos GP: The stress response and immune function: Clinical implications. Ann NY Acad Sci. 917:38–67. 2000. View Article : Google Scholar | |
Karalis K, Sano H, Redwine J, Listwak S, Wilder RL and Chrousos GP: Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone in vivo. Science. 254:421–423. 1991. View Article : Google Scholar : PubMed/NCBI | |
Sapolsky RM: Stress and the brain: Individual variability and the inverted-U. Nat Neurosci. 18:1344–1346. 2015. View Article : Google Scholar : PubMed/NCBI | |
McEwen BS: Neurobiological and systemic effects of chronic stress. Chronic Stress (Thousand Oaks). 1:24705470176923282017.PubMed/NCBI | |
McEwen BS and Gianaros PJ: Central role of the brain in stress and adaptation: Links to socioeconomic status, health, and disease. Ann N Y Acad Sci. 1186:190–222. 2010. View Article : Google Scholar : PubMed/NCBI | |
McEwen BS and Stellar E: Stress and the individual: Mechanisms leading to disease. Arch Intern Med. 153:2093–2101. 1993. View Article : Google Scholar : PubMed/NCBI | |
Stefanaki C, Pervanidou P, Boschiero D and Chrousos GP: Chronic stress and body composition disorders: Implications for health and disease. Hormones (Athens). 17:33–43. 2018. View Article : Google Scholar : PubMed/NCBI | |
Chrousos GP and Tsigos C: Stress, obesity, and metabolic syndrome. Blackwell Pub on behalf of the New York Academy of Sciences; 2006 | |
Chrousos G: The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: Neuro-endocrine and target tissue-related causes. Int J Obes Relat Metab Disord. 24(Suppl 2): S50–S55. 2000. View Article : Google Scholar : PubMed/NCBI | |
Lempesis IG, Hoebers N, Essers Y, Jocken JWE, Dineen R, Blaak EE, Manolopoulos KN and Goossens GH: Distinct inflammatory signatures of upper and lower body adipose tissue and adipocytes in women with normal weight or obesity. Front Endocrinol (Lausanne). 14:16002023. View Article : Google Scholar | |
Lempesis IG, Tsilingiris D, Liu J and Dalamaga M: Of mice and men: Considerations on adipose tissue physiology in animal models of obesity and human studies. Metabol Open. 15:1002082022. View Article : Google Scholar : PubMed/NCBI | |
Lempesis IG and Georgakopoulou VE: Physiopathological mechanisms related to inflammation in obesity and type 2 diabetes mellitus. World J Exp Med. 13:7–16. 2023. View Article : Google Scholar : PubMed/NCBI | |
Lempesis IG, Varrias D, Sagris M, Attaran RR, Altin ES, Bakoyiannis C, Palaiodimos L, Dalamaga M and Kokkinidis DG: Obesity and peripheral artery disease: Current evidence and controversies. Curr Obes Rep. May 27–2023.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI | |
Lempesis IG, van Meijel RLJ, Manolopoulos KN and Goossens GH: Oxygenation of adipose tissue: A human perspective. Acta Physiol (Oxf). 228:e132982020. View Article : Google Scholar | |
Spandidos DA: A unified theory for the development of cancer. Biosci Rep. 6:691–708. 1986. View Article : Google Scholar : PubMed/NCBI | |
Spandidos DA and Anderson ML: Oncogenes and onco-suppressor genes: Their involvement in cancer. J Pathol. 157:1–10. 1989. View Article : Google Scholar : PubMed/NCBI | |
Simatou A, Simatos G, Goulielmaki M, Spandidos DA, Baliou S and Zoumpourlis V: Historical retrospective of the SRC oncogene and new perspectives (Review). Mol Clin Oncol. 13:212020.PubMed/NCBI | |
Nitulescu GM, Van De Venter M, Nitulescu G, Ungurianu A, Juzenas P, Peng Q, Olaru OT, Grădinaru D, Tsatsakis A, Tsoukalas D, et al: The Akt pathway in oncology therapy and beyond (Review). Int J Oncol. 53:2319–2331. 2018.PubMed/NCBI | |
Fotakopoulos G, Georgakopoulou VE, Spandidos DA, Papalexis P, Angelopoulou E, Aravantinou-Fatorou A, Trakas N, Trakas I and Brotis AG: Role of miR-200 family in brain metastases: A systematic review. Mol Clin Oncol. 18:152023. View Article : Google Scholar | |
Damaskos C, Garmpis N, Dimitroulis D, Garmpi A, Diamantis E, Sarantis P, Georgakopoulou VE, Patsouras A, Despotidis M, Prevezanos D, et al: The Role of SNHG15 in the pathogenesis of hepatocellular carcinoma. J Pers Med. 12:7532022. View Article : Google Scholar : PubMed/NCBI | |
Garmpis N, Damaskos C, Garmpi A, Nonni A, Georgakopoulou VE, Antoniou E, Schizas D, Sarantis P, Patsouras A, Syllaios A, et al: Histone deacetylases and their inhibitors in colorectal cancer therapy: Current evidence and future considerations. Curr Med Chem. 29:2979–2994. 2022. View Article : Google Scholar | |
Garmpis N, Damaskos C, Angelou A, Garmpi A, Georgakopoulou VE, Valsami S, Schizas D, Voutyritsa E, Syllaios A, Diamantis E, et al: Animal models for the calculation of circulating tumor cells for experimental demonstration. Anticancer Res. 40:6599–6607. 2020. View Article : Google Scholar : PubMed/NCBI | |
Tsatsakis A, Oikonomopoulou T, Nikolouzakis TK, Vakonaki E, Tzatzarakis M, Flamourakis M, Renieri E, Fragkiadaki P, Iliaki E, Bachlitzanaki M, et al: Role of telomere length in human carcinogenesis (Review). Int J Oncol. 63:782023. View Article : Google Scholar : PubMed/NCBI | |
Anderson ML and Spandidos DA: Onco-suppressor genes and their involvement in cancer (review). Anticancer Res. 8:873–879. 1988.PubMed/NCBI | |
Lang JC and Spandidos DA: The structure and function of eukaryotic enhancer elements and their role in oncogenesis. Anticancer Res. 6:437–449. 1986.PubMed/NCBI | |
Field JK and Spandidos DA: Expression of oncogenes in human tumours with special reference to the head and neck region. J Oral Pathol. 16:97–107. 1987. View Article : Google Scholar : PubMed/NCBI | |
Spandidos DA and Anderson ML: A study of mechanisms of carcinogenesis by gene transfer of oncogenes into mammalian cells. Mutat Res. 185:271–291. 1987. View Article : Google Scholar : PubMed/NCBI | |
Hanahan D and Weinberg RA: The hallmarks of cancer. Cell. 100:57–70. 2000. View Article : Google Scholar : PubMed/NCBI | |
Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI | |
Fouad YA and Aanei C: Revisiting the hallmarks of cancer. Am J Cancer Res. 7:10162017.PubMed/NCBI | |
Spandidos DA and Anderson ML: A role of ras oncogenes in carcinogenesis and differentiation. Adv Exp Med Biol. 265:127–131. 1990. View Article : Google Scholar : PubMed/NCBI | |
Gonos ES and Spandidos DA: Oncogenes in cellular immortalisation and differentiation (review). Anticancer Res. 13:1117–1122. 1993.PubMed/NCBI | |
Neagu M, Constantin C, Popescu ID, Zipeto D, Tzanakakis G, Nikitovic D, Fenga C, Stratakis CA, Spandidos DA and Tsatsakis AM: Inflammation and metabolism in cancer cell-mitochondria key player. Front Oncol. 9:3482019. View Article : Google Scholar : PubMed/NCBI | |
Pierouli K, Papakonstantinou E, Papageorgiou L, Diakou I, Mitsis T, Dragoumani K, Spandidos DA, Bacopoulou F, Chrousos GP, Goulielmos GN, et al: Long non-coding RNAs and microRNAs as regulators of stress in cancer (Review). Mol Med Rep. 26:3612022. View Article : Google Scholar | |
Connerty P, Lock RB and De Bock CE: Long non-coding RNAs: Major regulators of cell stress in cancer. Front Oncol. 10:2852020. View Article : Google Scholar : PubMed/NCBI | |
Bergers G and Benjamin LE: Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 3:401–410. 2003. View Article : Google Scholar : PubMed/NCBI | |
Patidar A, Selvaraj S, Sarode A, Chauhan P, Chattopadhyay D and Saha B: DAMP-TLR-cytokine axis dictates the fate of tumor. Cytokine. 104:114–123. 2018. View Article : Google Scholar | |
Melamed R, Rosenne E, Shakhar K, Schwartz Y, Abudarham N and Ben-Eliyahu S: Marginating pulmonary-NK activity and resistance to experimental tumor metastasis: Suppression by surgery and the prophylactic use of a beta-adrenergic antagonist and a prostaglandin synthesis inhibitor. Brain Behav Immun. 19:114–126. 2005. View Article : Google Scholar : PubMed/NCBI | |
Melamed R, Rosenne E, Benish M, Goldfarb Y, Levi B and Ben-Eliyahu S: The marginating-pulmonary immune compartment in rats: Characteristics of continuous inflammation and activated NK cells. J Immunother. 33:16–29. 2010. View Article : Google Scholar | |
Sorski L, Melamed R, Levi B, Matzner P, Lavon H, Rosenne E, Shaashua L, Ricon I, Sandbank E, Benbenishty A and Ben-Eliyahu S: Prevention of liver metastases through perioperative acute CpG-C immune stimulation. Cancer Immunol Immunother. 69:2021–2031. 2020. View Article : Google Scholar : PubMed/NCBI | |
Strilic B and Offermanns S: Intravascular survival and extravasation of tumor cells. Cancer Cell. 32:282–293. 2017. View Article : Google Scholar : PubMed/NCBI | |
Gonzalez H, Hagerling C and Werb Z: Roles of the immune system in cancer: From tumor initiation to metastatic progression. Genes Dev. 32:1267–1284. 2018. View Article : Google Scholar : PubMed/NCBI | |
Neeman E and Ben-Eliyahu S: Surgery and stress promote cancer metastasis: New outlooks on perioperative mediating mechanisms and immune involvement. Brain Behav Immun. 30(Suppl): S32–S40. 2013. View Article : Google Scholar | |
Agorastos A, Nicolaides NC, Bozikas VP, Chrousos GP and Pervanidou P: Multilevel interactions of stress and circadian system: Implications for traumatic stress. Front Psychiatry. 10:10032020. View Article : Google Scholar : PubMed/NCBI | |
Chrousos GP: The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med. 332:1351–1363. 1995. View Article : Google Scholar : PubMed/NCBI | |
Rosenne E, Shakhar G, Melamed R, Schwartz Y, Erdreich-Epstein A and Ben-Eliyahu S: Inducing a mode of NK-resistance to suppression by stress and surgery: A potential approach based on low dose of poly I-C to reduce postoperative cancer metastasis. Brain Behav Immun. 21:395–408. 2007. View Article : Google Scholar : PubMed/NCBI | |
Ben-Eliyahu S, Shakhar G, Page GG, Stefanski V and Shakhar K: Suppression of NK cell activity and of resistance to metastasis by stress: A role for adrenal catecholamines and β-adrenoceptors. Neuroimmunomodulation. 8:154–164. 2000. View Article : Google Scholar | |
Sloan EK, Priceman SJ, Cox BF, Yu S, Pimentel MA, Tangkanangnukul V, Arevalo JM, Morizono K, Karanikolas BD, Wu L, et al: The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Res. 70:7042–7052. 2010. View Article : Google Scholar : PubMed/NCBI | |
Du P, Zeng H, Xiao Y, Zhao Y, Zheng B, Deng Y, Liu J, Huang B, Zhang X, Yang K, et al: Chronic stress promotes EMT-mediated metastasis through activation of STAT3 signaling pathway by miR-337-3p in breast cancer. Cell Death Dis. 11:7612020. View Article : Google Scholar : PubMed/NCBI | |
Madden KS, Szpunar MJ and Brown EB: Early impact of social isolation and breast tumor progression in mice. Brain Behav Immun. 30(Suppl): S135–S141. 2013. View Article : Google Scholar | |
Cole SW and Sood AK: Molecular pathways: Beta-adrenergic signaling in cancer. Clin Cancer Res. 18:1201–1206. 2012. View Article : Google Scholar : | |
Eng JWL, Kokolus KM, Reed CB, Hylander BL, Ma WW and Repasky EA: A nervous tumor microenvironment: The impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response. Cancer Immunol Immunother. 63:1115–1128. 2014. View Article : Google Scholar : PubMed/NCBI | |
Cole SW, Nagaraja AS, Lutgendorf SK, Green PA and Sood AK: Sympathetic nervous system regulation of the tumour microenvironment. Nat Rev Cancer. 15:563–572. 2015. View Article : Google Scholar : PubMed/NCBI | |
Volden PA and Conzen SD: The influence of glucocorticoid signaling on tumor progression. Brain Behav Immun. 30(Suppl): S26–S31. 2013. View Article : Google Scholar | |
Slominski RM, Raman C, Chen JY and Slominski AT: How cancer hijacks the Body's homeostasis through the neuroendocrine system. Trends Neurosci. 46:263–275. 2023. View Article : Google Scholar : PubMed/NCBI | |
Rosch PJ: Stress and cancer: Disorders of communication, control, and civilization. Handbook of stress, medicine, and health. Cooper CL: CRC Press/Routledge/Taylor and Francis Group; Oxfordshire: pp. 27–60. 1996 | |
Slawikowski GJ: Tumor development in adrenalectomized rats given inoculations of aged tumor cells after surgical stress. Cancer Res. 20:316–320. 1960.PubMed/NCBI | |
Helgesson Ö, Cabrera C, Lapidus L, Bengtsson C and Lissner L: Self-reported stress levels predict subsequent breast cancer in a cohort of Swedish women. Eur J Cancer Prev. 377–381. 2003. View Article : Google Scholar : PubMed/NCBI | |
Nielsen NR, Zhang ZF, Kristensen TS, Netterstr B, Schnohr P and Gr M: Self reported stress and risk of breast cancer: Prospective cohort study. BMJ. 331:5482005. View Article : Google Scholar : PubMed/NCBI | |
Cui B, Peng F, Lu J, He B, Su Q, Luo H, Deng Z, Jiang T, Su K, Huang Y, et al: Cancer and stress: NextGen strategies. Brain Behav Immun. 93:368–383. 2021. View Article : Google Scholar | |
Yasuda MT, Sakakibara H and Shimoi K: Estrogen-and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoid. Genes Environ. 39:102017. View Article : Google Scholar | |
Jenkins FJ, Van Houten B and Bovbjerg DH: Effects on DNA damage and/or repair processes as biological mechanisms linking psychological stress to cancer risk. J Appl Biobehav Res. 19:3–23. 2014. View Article : Google Scholar : PubMed/NCBI | |
Tomasetti C and Vogelstein B: Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 347:78–81. 2015. View Article : Google Scholar : PubMed/NCBI | |
Chalkia AK, Spandidos DA and Detorakis ET: Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium. Int J Mol Med. 32:539–543. 2013. View Article : Google Scholar : PubMed/NCBI | |
Filippakis H, Spandidos DA and Sourvinos G: Herpesviruses: Hijacking the Ras signaling pathway. Biochim Biophys Acta. 1803:777–785. 2010. View Article : Google Scholar : PubMed/NCBI | |
Plummer M, de Martel C, Vignat J, Ferlay J, Bray F and Franceschi S: Global burden of cancers attributable to infections in 2012: A synthetic analysis. Lancet Glob Health. 4:e609–e616. 2016. View Article : Google Scholar : PubMed/NCBI | |
de Martel C, Georges D, Bray F, Ferlay J and Clifford GM: Global burden of cancer attributable to infections in 2018: A worldwide incidence analysis. Lancet Glob Health. 8:e180–e190. 2020. View Article : Google Scholar | |
Cacioppo JT, Kiecolt-Glaser JK, Malarkey WB, Laskowski BF, Rozlog LA, Poehlmann KM, Burleson MH and Glaser R: Autonomic and glucocorticoid associations with the steady-state expression of latent Epstein-Barr virus. Horm Behav. 42:32–41. 2002. View Article : Google Scholar : PubMed/NCBI | |
Glaser R, Friedman SB, Smyth J, Ader R, Bijur P, Brunell P, Cohen N, Krilov LR, Lifrak ST, Stone A and Toffler P: The differential impact of training stress and final examination stress on herpesvirus latency at the United States Military Academy at West Point. Brain Behav Immun. 13:240–251. 1999. View Article : Google Scholar : PubMed/NCBI | |
Stamatiou DP, Derdas SP, Zoras OL and Spandidos DA: Herpes and polyoma family viruses in thyroid cancer. Oncol Lett. 11:1635–1644. 2016. View Article : Google Scholar : PubMed/NCBI | |
Mammas IN, Sourvinos G, Giannoudis A and Spandidos DA: Human papilloma virus (HPV) and host cellular interactions. Pathol Oncol Res. 14:345–354. 2008. View Article : Google Scholar : PubMed/NCBI | |
Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, McDonald PG, Stefanek M and Sood AK: The influence of bio-behavioural factors on tumour biology: Pathways and mechanisms. Nat Rev Cancer. 6:240–248. 2006. View Article : Google Scholar : PubMed/NCBI | |
Irwin MR and Cole SW: Reciprocal regulation of the neural and innate immune systems. Nat Rev Immunol. 11:625–632. 2011. View Article : Google Scholar : PubMed/NCBI | |
Collado-Hidalgo A, Sung C and Cole S: Adrenergic inhibition of innate anti-viral response: PKA blockade of Type I interferon gene transcription mediates catecholamine support for HIV-1 replication. Brain Behav Immun. 20:552–563. 2006. View Article : Google Scholar : PubMed/NCBI | |
Fang CY, Miller SM, Bovbjerg DH, Bergman C, Edelson MI, Rosenblum NG, Bove BA, Godwin AK, Campbell DE and Douglas SD: Perceived stress is associated with impaired T-cell response to HPV16 in women with cervical dysplasia. Ann Behav Med. 35:87–96. 2008. View Article : Google Scholar : PubMed/NCBI | |
Fischman HK, Pero RW and Kelly DD: Psychogenic stress induces chromosomal and DNA damage. Int J Neuroscience. 84:219–227. 1996. View Article : Google Scholar | |
Irie M, Asami S, Nagata S, Ikeda M, Miyata M and Kasai H: Psychosocial factors as a potential trigger of oxidative DNA damage in human leukocytes. Japanese J Cancer Res. 92:367–376. 2001. View Article : Google Scholar | |
Kiecolt-Glaser JK, Stephens RE, Lipetz PD, Speicher CE and Glaser R: Distress and DNA repair in human lymphocytes. J Behavioral Med. 8:311–320. 1985. View Article : Google Scholar | |
Dimitroglou E, Zafiropoulou M, Messini-Nikolaki N, Doudounakis S, Tsilimigaki S and Piperakis SM: DNA damage in a human population affected by chronic psychogenic stress. Int J Hyg Environ Health. 206:39–44. 2003. View Article : Google Scholar : PubMed/NCBI | |
Flint MS, Baum A, Chambers WH and Jenkins FJ: Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormones. Psychoneuroendocrinology. 32:470–479. 2007. View Article : Google Scholar : PubMed/NCBI | |
Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, et al: A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature. 477:349–353. 2011. View Article : Google Scholar : PubMed/NCBI | |
Hara MR, Sachs BD, Caron MG and Lefkowitz RJ: Pharmacological blockade of a β2AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. Cell Cycle. 12:219–224. 2013. View Article : Google Scholar : PubMed/NCBI | |
Feng Z, Liu L, Zhang C, Zheng T, Wang J, Lin M, Zhao Y, Wang X, Levine AJ and Hu W: Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci USA. 109:7013–7018. 2012. View Article : Google Scholar : PubMed/NCBI | |
Magnon C, Hall SJ, Lin J, Xue X, Gerber L, Freedland SJ and Frenette PS: Autonomic nerve development contributes to prostate cancer progression. Science. 341:12363612013. View Article : Google Scholar : PubMed/NCBI | |
Zachos G, Varras M, Koffa M, Ergazaki M and Spandidos DA: The association of the H-ras oncogene and steroid hormone receptors in gynecological cancer. J Exp Ther Oncol. 1:335–341. 1996.PubMed/NCBI | |
Wrobel LJ and Le Gal FA: Inhibition of human melanoma growth by a non-cardioselective β-blocker. J Investigative Dermatol. 135:525–531. 2015. View Article : Google Scholar | |
Armaiz-Pena GN, Allen JK, Cruz A, Stone RL, Nick AM, Lin YG, Han LY, Mangala LS, Villares GJ, Vivas-Mejia P, et al: Src activation by β-adrenoreceptors is a key switch for tumour metastasis. Nat Commun. 4:14032013. View Article : Google Scholar | |
Shi M, Liu D, Duan H, Qian L, Wang L, Niu L, Zhang H, Yong Z, Gong Z, Song L, et al: The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells. Br Cancer Res Treat. 125:351–362. 2011. View Article : Google Scholar | |
Saul AN, Oberyszyn TM, Daugherty C, Kusewitt D, Jones S, Jewell S, Malarkey WB, Lehman A, Lemeshow S and Dhabhar FS: Chronic stress and susceptibility to skin cancer. J Natl Cancer Inst. 97:1760–1767. 2005. View Article : Google Scholar : PubMed/NCBI | |
Sumis A, Cook KL, Andrade FO, Hu R, Kidney E, Zhang X, Kim D, Carney E, Nguyen N, Yu W, et al: Social isolation induces autophagy in the mouse mammary gland: Link to increased mammary cancer risk. Endocr Relat Cancer. 23:839–856. 2016. View Article : Google Scholar : PubMed/NCBI | |
Kokolus KM, Capitano ML, Lee CT, Eng JW, Waight JD, Hylander BL, Sexton S, Hong CC, Gordon CJ, Abrams SI and Repasky EA: Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature. Proc Natl Acad Sci USA. 110:20176–20181. 2013. View Article : Google Scholar : PubMed/NCBI | |
Renz BW, Takahashi R, Tanaka T, Macchini M, Hayakawa Y, Dantes Z, Maurer HC, Chen X, Jiang Z, Westphalen CB, et al: β2 adrenergic-neurotrophin feedforward loop promotes pancreatic cancer. Cancer Cell. 33:75–90.e7. 2018. View Article : Google Scholar | |
Hermes GL, Delgado B, Tretiakova M, Cavigelli SA, Krausz T, Conzen SD and McClintock MK: Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors. Proc Natl Acad Sci USA. 106:22393–22398. 2009. View Article : Google Scholar : PubMed/NCBI | |
Hasen NS, O'Leary KA, Auger AP and Schuler LA: Social isolation reduces mammary development, tumor incidence, and expression of epigenetic regulators in wild-type and p53-heterozygotic mice. Cancer Prev Res. 3:620–629. 2010. View Article : Google Scholar | |
Riley V: Psychoneuroendocrine influences on immunocompetence and neoplasia. Science. 212:1100–1109. 1981. View Article : Google Scholar : PubMed/NCBI | |
Leonardi GC, Candido S, Cervello M, Nicolosi D, Raiti F, Travali S, Spandidos DA and Libra M: The tumor microenvironment in hepatocellular carcinoma (review). Int J Oncol. 40:1733–1747. 2012.PubMed/NCBI | |
Wu T and Dai Y: Tumor microenvironment and therapeutic response. Cancer Lett. 387:61–68. 2017. View Article : Google Scholar | |
Gysler SM and Drapkin R: Tumor innervation: Peripheral nerves take control of the tumor microenvironment. J Clin Invest. 131:e1472762021. View Article : Google Scholar : PubMed/NCBI | |
Monje M, Borniger JC, D'Silva NJ, Deneen B, Dirks PB, Fattahi F, Frenette PS, Garzia L, Gutmann DH, Hanahan D, et al: Roadmap for the emerging field of cancer neuroscience. Cell. 181:219–222. 2020. View Article : Google Scholar : PubMed/NCBI | |
Yang EV, Kim SJ, Donovan EL, Chen M, Gross AC, Webster Marketon JI, Barsky SH and Glaser R: Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: Implications for stress-related enhancement of tumor progression. Brain Behav Immun. 23:267–275. 2009. View Article : Google Scholar : | |
Moretti S, Massi D, Farini V, Baroni G, Parri M, Innocenti S, Cecchi R and Chiarugi P: β-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines. Lab Invest. 93:279–290. 2013. View Article : Google Scholar : PubMed/NCBI | |
Madden KS, Szpunar MJ and Brown EB: β-Adrenergic receptors (β-AR) regulate VEGF and IL-6 production by divergent pathways in high β-AR-expressing breast cancer cell lines. Br Cancer Res Treat. 130:747–758. 2011. View Article : Google Scholar | |
Lutgendorf SK, Cole S, Costanzo E, Bradley S, Coffin J, Jabbari S, Rainwater K, Ritchie JM, Yang M and Sood AK: Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res. 9:4514–4521. 2003.PubMed/NCBI | |
Chen H, Liu D, Yang Z, Sun L, Deng Q, Yang S, Qian L, Guo L, Yu M, Hu M, et al: Adrenergic signaling promotes angiogenesis through endothelial cell-tumor cell crosstalk. Endocr Relat Cancer. 21:783–795. 2014. View Article : Google Scholar : PubMed/NCBI | |
Medeiros PJ and Jackson DN: Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis. Peptides. 48:106–113. 2013. View Article : Google Scholar : PubMed/NCBI | |
Shan T, Ma J, Ma Q, Guo K, Guo J, Li X, Li W, Liu J, Huang C, Wang F and Wu E: β2-AR-HIF-1α: A novel regulatory axis for stress-induced pancreatic tumor growth and angiogenesis. Curr Mol Med. 13:1023–1034. 2013. View Article : Google Scholar : PubMed/NCBI | |
Xu P, He H, Gu Y, Wang Y, Sun Z, Yang L and Miao C: Surgical trauma contributes to progression of colon cancer by downregulating CXCL4 and recruiting MDSCs. Exp Cell Res. 370:692–698. 2018. View Article : Google Scholar : PubMed/NCBI | |
Budiu RA, Vlad AM, Nazario L, Bathula C, Cooper KL, Edmed J, Thaker PH, Urban J, Kalinski P, Lee AV, et al: Restraint and social isolation stressors differentially regulate adaptive immunity and tumor angiogenesis in a breast cancer mouse model. Cancer Clin Oncol. 6:12–24. 2017. View Article : Google Scholar : PubMed/NCBI | |
Hulsurkar M, Li Z, Zhang Y, Li X, Zheng D and Li W: Beta-adrenergic signaling promotes tumor angiogenesis and prostate cancer progression through HDAC2-mediated suppression of thrombospondin-1. Oncogene. 36:1525–1536. 2017. View Article : Google Scholar | |
Le CP, Nowell CJ, Kim‑Fuchs C, Botteri E, Hiller JG, Ismail H, Pimentel MA, Chai MG, Karnezis T, Rotmensz N, et al: Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination. Nat Commun. 7:106342016. View Article : Google Scholar : PubMed/NCBI | |
Colon-Echevarria CB, Lamboy-Caraballo R, Aquino-Acevedo AN and Armaiz-Pena GN: Neuroendocrine regulation of tumor-associated immune cells. Front Oncol. 9:10772019. View Article : Google Scholar : PubMed/NCBI | |
Qiao G, Chen M, Bucsek MJ, Repasky EA and Hylander BL: Adrenergic signaling: A targetable checkpoint limiting development of the antitumor immune response. Front Immunol. 9:1642018. View Article : Google Scholar : PubMed/NCBI | |
Grivennikov SI, Greten FR and Karin M: Immunity, inflammation, and cancer. Cell. 140:883–899. 2010. View Article : Google Scholar : PubMed/NCBI | |
Huan HB, Wen XD, Chen XJ, Wu L, Wu LL, Zhang L, Yang DP, Zhang X, Bie P, Qian C and Xia F: Sympathetic nervous system promotes hepatocarcinogenesis by modulating inflammation through activation of alpha1-adrenergic receptors of Kupffer cells. Brain Behav Immun. 59:118–134. 2017. View Article : Google Scholar | |
Nagaraja AS, Dorniak PL, Sadaoui NC, Kang Y, Lin T, Armaiz-Pena G, Wu SY, Rupaimoole R, Allen JK, Gharpure KM, et al: Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis. Oncogene. 35:2390–2397. 2016. View Article : Google Scholar : | |
Qin JF, Jin FJ, Li N, Guan HT, Lan L, Ni H and Wang Y: Adrenergic receptor β2 activation by stress promotes breast cancer progression through macrophages M2 polarization in tumor microenvironment. BMB Rep. 48:2952015. View Article : Google Scholar : PubMed/NCBI | |
Armaiz-Pena GN, Gonzalez-Villasana V, Nagaraja AS, Rodriguez-Aguayo C, Sadaoui NC, Stone RL, Matsuo K, Dalton HJ, Previs RA, Jennings NB, et al: Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. Oncotarget. 6:4266–4273. 2015. View Article : Google Scholar : PubMed/NCBI | |
Lamkin DM, Ho H-Y, Ong TH, Kawanishi CK, Stoffers VL, Ahlawat N, Ma JCY, Arevalo JMG, Cole SW and Sloan EK: β-Adrenergic-stimulated macrophages: Comprehensive localization in the M1-M2 spectrum. Brain Behav Immun. 57:338–346. 2016. View Article : Google Scholar : PubMed/NCBI | |
Bower JE, Shiao SL, Sullivan P, Lamkin DM, Atienza R, Mercado F, Arevalo J, Asher A, Ganz PA and Cole SW: Prometastatic molecular profiles in breast tumors from socially isolated women. JNCI Cancer Spectr. 2:pky0292018. View Article : Google Scholar : PubMed/NCBI | |
Shakhar G and Ben-Eliyahu S: In vivo β-adrenergic stimulation suppresses natural killer activity and compromises resistance to tumor metastasis in rats. J Immunol. 160:3251–3258. 1998. View Article : Google Scholar : PubMed/NCBI | |
Rosenne E, Sorski L, Shaashua L, Neeman E, Matzner P, Levi B and Ben-Eliyahu S: In vivo suppression of NK cell cytotoxicity by stress and surgery: Glucocorticoids have a minor role compared to catecholamines and prostaglandins. Brain Behav Immun. 37:207–219. 2014. View Article : Google Scholar | |
Lutgendorf SK, Sood AK, Anderson B, McGinn S, Maiseri H, Dao M, Sorosky JI, De Geest K, Ritchie J and Lubaroff DM: Social support, psychological distress, and natural killer cell activity in ovarian cancer. J Clin Oncol. 23:7105–7113. 2005. View Article : Google Scholar : PubMed/NCBI | |
Hou N, Zhang X, Zhao L, Zhao X, Li Z, Song T and Huang C: A novel chronic stress-induced shift in the Th1 to Th2 response promotes colon cancer growth. Biochem Biophys Res Commun. 439:471–476. 2013. View Article : Google Scholar : PubMed/NCBI | |
Bucsek MJ, Qiao G, MacDonald CR, Giridharan T, Evans L, Niedzwecki B, Liu H, Kokolus KM, Eng JW, Messmer MN, et al: β-Adrenergic signaling in mice housed at standard temperatures suppresses an effector phenotype in CD8+ T cells and undermines checkpoint inhibitor therapy. Cancer Res. 77:5639–5651. 2017. View Article : Google Scholar : PubMed/NCBI | |
Lutgendorf SK, Lamkin DM, DeGeest K, Anderson B, Dao M, McGinn S, Zimmerman B, Maiseri H, Sood AK and Lubaroff DM: Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients. Brain Behav Immun. 22:890–900. 2008. View Article : Google Scholar : PubMed/NCBI | |
Mohammadpour H, MacDonald CR, Qiao G, Chen M, Dong B, Hylander BL, McCarthy PL, Abrams SI and Repasky EA: β2 adrenergic receptor-mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells. J Clin Invest. 129:5537–5552. 2019. View Article : Google Scholar : PubMed/NCBI | |
Mundy-Bosse BL, Thornton LM, Yang HC, Andersen BL and Carson WE: Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients. Cell Immunol. 270:80–87. 2011. View Article : Google Scholar : PubMed/NCBI | |
Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM and Chawla A: Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature. 480:104–108. 2011. View Article : Google Scholar : PubMed/NCBI | |
Flierl MA, Rittirsch D, Nadeau BA, Chen AJ, Sarma JV, Zetoune FS, McGuire SR, List RP, Day DE, Hoesel LM, et al: Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature. 449:721–725. 2007. View Article : Google Scholar : PubMed/NCBI | |
Wong HPS, Yu L, Lam EKY, Tai EKK, Wu WKK and Cho CH: Nicotine promotes cell proliferation via α7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells. Toxicol Appl Pharmacol. 221:261–267. 2007. View Article : Google Scholar : PubMed/NCBI | |
Amaro F, Silva D, Reguengo H, Oliveira JC, Quintas C, Vale N, Gonçalves J and Fresco P: β-adrenoceptor activation in breast MCF-10A cells induces a pattern of catecholamine production similar to that of tumorigenic MCF-7 cells. Int J Mol Sci. 21:79682020. View Article : Google Scholar | |
Zhang X, Zhang Y, He Z, Yin K, Li B, Zhang L and Xu Z: Chronic stress promotes gastric cancer progression and metastasis: An essential role for ADRB2. Cell Death Dis. 10:7882019. View Article : Google Scholar : PubMed/NCBI | |
Zhi X, Li B, Li Z, Zhang J, Yu J, Zhang L and Xu Z: Adrenergic modulation of AMPK-dependent autophagy by chronic stress enhances cell proliferation and survival in gastric cancer. Int J Oncol. 54:1625–1638. 2019.PubMed/NCBI | |
Wong HP, Ho JW, Koo MW, Yu L, Wu WK, Lam EK, Tai EK, Ko JK, Shin VY, Chu KM and Cho CH: Effects of adrenaline in human colon adenocarcinoma HT-29 cells. Life Sci. 88:1108–1112. 2011. View Article : Google Scholar : PubMed/NCBI | |
Sood AK, Armaiz-Pena GN, Halder J, Nick AM, Stone RL, Hu W, Carroll AR, Spannuth WA, Deavers MT, Allen JK, et al: Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest. 120:1515–1523. 2010. View Article : Google Scholar : PubMed/NCBI | |
Liu H, Wang C, Xie N, Zhuang Z, Liu X, Hou J and Huang H: Activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma. Int J Mol Med. 41:147–154. 2018. | |
Kim-Fuchs C, Le CP, Pimentel MA, Shackleford D, Ferrari D, Angst E, Hollande F and Sloan EK: Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment. Brain Behav Immun. 40:40–47. 2014. View Article : Google Scholar : PubMed/NCBI | |
Pu J, Zhang X, Luo H, Xu L, Lu X and Lu J: Adrenaline promotes epithelial-to-mesenchymal transition via HuR-TGFβ regulatory axis in pancreatic cancer cells and the implication in cancer prognosis. Biochem Biophys Res Commun. 493:1273–1279. 2017. View Article : Google Scholar : PubMed/NCBI | |
Liu J, Qu L, Wan C, Xiao M, Ni W, Jiang F, Fan Y, Lu C and Ni R: A novel β2-AR/YB-1/β-catenin axis mediates chronic stress-associated metastasis in hepatocellular carcinoma. Oncogenesis. 9:842020. View Article : Google Scholar | |
Chen H, Liu D, Guo L, Cheng X, Guo N and Shi M: Chronic psychological stress promotes lung metastatic colonization of circulating breast cancer cells by decorating a pre-metastatic niche through activating β-adrenergic signaling. J Pathol. 244:49–60. 2018. View Article : Google Scholar | |
Lamkin DM, Sloan EK, Patel AJ, Chiang BS, Pimentel MA, Ma JC, Arevalo JM, Morizono K and Cole SW: Chronic stress enhances progression of acute lymphoblastic leukemia via β-adrenergic signaling. Brain Behav Immun. 26:635–641. 2012. View Article : Google Scholar : PubMed/NCBI | |
Chang A, Le CP, Walker AK, Creed SJ, Pon CK, Albold S, Carroll D, Halls ML, Lane JR, Riedel B, et al: β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer. Brain Behav Immun. 57:106–115. 2016. View Article : Google Scholar : PubMed/NCBI | |
Zahalka AH and Frenette PS: Nerves in cancer. Nat Rev Cancer. 20:143–157. 2020. View Article : Google Scholar : PubMed/NCBI | |
Lutgendorf SK, DeGeest K, Dahmoush L, Farley D, Penedo F, Bender D, Goodheart M, Buekers TE, Mendez L, Krueger G, et al: Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. Brain Behav Immun. 25:250–255. 2011. View Article : Google Scholar : | |
Schuller HM and Cole B: Regulation of cell proliferation by β-adrenergjc receptors in a human lung adenocarcinoma cell line. Carcinogenesis. 10:1753–1755. 1989. View Article : Google Scholar : PubMed/NCBI | |
Huang XY, Wang HC, Yuan Z, Huang J and Zheng Q: Norepinephrine stimulates pancreatic cancer cell proliferation, migration and invasion via β-adrenergic receptor-dependent activation of P38/MAPK pathway. Hepatogastroenterology. 59:889–893. 2012. | |
Lackovicova L, Banovska L, Bundzikova J, Janega P, Bizik J, Kiss A and Mravec B: Chemical sympathectomy suppresses fibrosarcoma development and improves survival of tumor-bearing rats. Neoplasma. 58:424–429. 2011. View Article : Google Scholar : PubMed/NCBI | |
Simon WE, Albrecht M, Trams G, Dietel M and Hölzel F: In vitro growth promotion of human mammary carcinoma cells by steroid hormones, tamoxifen, and prolactin. J Natl Cancer Inst. 73:313–321. 1984. View Article : Google Scholar : PubMed/NCBI | |
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM and Feldman D: Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat Med. 6:703–706. 2000. View Article : Google Scholar : PubMed/NCBI | |
Horvathova L, Padova A, Tillinger A, Osacka J, Bizik J and Mravec B: Sympathectomy reduces tumor weight and affects expression of tumor-related genes in melanoma tissue in the mouse. Stress. 19:528–534. 2016. View Article : Google Scholar : PubMed/NCBI | |
Chin CC, Li JM, Lee KF, Huang YC, Wang KC, Lai HC, Cheng CC, Kuo YH and Shi CS: Selective β2-AR blockage suppresses colorectal cancer growth through regulation of EGFR-Akt/ERK1/2 signaling, G1-phase arrest, and apoptosis. J Cell Physiol. 231:459–472. 2016. View Article : Google Scholar | |
Masur K, Niggemann B, Zanker KS and Entschladen F: Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by β-blockers. Cancer Res. 61:2866–2869. 2001.PubMed/NCBI | |
Yang EV, Sood AK, Chen M, Li Y, Eubank TD, Marsh CB, Jewell S, Flavahan NA, Morrison C, Yeh PE, et al: Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res. 66:10357–10364. 2006. View Article : Google Scholar : PubMed/NCBI | |
Sood AK, Bhatty R, Kamat AA, Landen CN, Han L, Thaker PH, Li Y, Gershenson DM, Lutgendorf S and Cole SW: Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res. 12:369–375. 2006. View Article : Google Scholar : PubMed/NCBI | |
Lutgendorf SK, Lamkin DM, Jennings NB, Arevalo JM, Penedo F, DeGeest K, Langley RR, Lucci JA III, Cole SW, Lubaroff DM and Sood AK: Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma. Clin Cancer Res. 14:6839–6846. 2008. View Article : Google Scholar : PubMed/NCBI | |
Campbell JP, Karolak MR, Ma Y, Per rien DS, Masood-Campbell SK, Penner NL, Munoz SA, Zijlstra A, Yang X, Sterling JA and Elefteriou F: Stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice. PLoS Biol. 10:e10013632012. View Article : Google Scholar : PubMed/NCBI | |
Simpson CD, Anyiwe K and Schimmer AD: Anoikis resistance and tumor metastasis. Cancer Lett. 272:177–185. 2008. View Article : Google Scholar : PubMed/NCBI | |
Benish M, Bartal I, Goldfarb Y, Levi B, Avraham R, Raz A and Ben-Eliyahu S: Perioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis. Ann Surg Oncol. 15:2042–2052. 2008. View Article : Google Scholar : PubMed/NCBI | |
Kaira K, Kamiyoshihara M, Kawashima O, Endoh H, Imaizumi K, Sugano M, Tanaka S, Fujita A, Kogure Y, Shimizu A, et al: Prognostic impact of β2 adrenergic receptor expression in surgically resected pulmonary pleomorphic carcinoma. Anticancer Res. 39:395–403. 2019. View Article : Google Scholar | |
Choy C, Raytis JL, Smith DD, Duenas M, Neman J, Jandial R and Lew MW: Inhibition of β2-adrenergic receptor reduces triple-negative breast cancer brain metastases: The potential benefit of perioperative β-blockade. Oncol Rep. 35:3135–3142. 2016. View Article : Google Scholar : PubMed/NCBI | |
Al-Niaimi A, Dickson EL, Albertin C, Karnowski J, Niemi C, Spencer R, Shahzad MM, Uppal S, Saha S, Rice L and Nally AM: The impact of perioperative β blocker use on patient outcomes after primary cytoreductive surgery in high-grade epithelial ovarian carcinoma. Gynecol Oncol. 143:521–525. 2016. View Article : Google Scholar : PubMed/NCBI | |
Barron TI, Connolly RM, Sharp L, Bennett K and Visvanathan K: Beta blockers and breast cancer mortality: A population-based study. J Clin Oncol. 29:2635–2644. 2011. View Article : Google Scholar : PubMed/NCBI | |
Lemeshow S, Sørensen HT, Phillips G, Yang EV, Antonsen S, Riis AH, Lesinski GB, Jackson R and Glaser R: β-Blockers and survival among Danish patients with malignant melanoma: A population-based cohort study. Cancer Epidemiol Biomarkers Prev. 20:2273–2279. 2011. View Article : Google Scholar : PubMed/NCBI | |
Cata JP, Villarreal J, Keerty D, Thakar DR, Liu DD, Sood AK and Gottumukkala V: Perioperative beta-blocker use and survival in lung cancer patients. J Clin Anesth. 26:106–117. 2014. View Article : Google Scholar : PubMed/NCBI | |
Heitz F, Hengsbach A, Harter P, Traut A, Ataseven B, Schneider S, Prader S, Kurzeder C, Sporkmann M and du Bois A: Intake of selective beta blockers has no impact on survival in patients with epithelial ovarian cancer. Gynecol Oncol. 144:181–186. 2017. View Article : Google Scholar | |
Kim TH, Gill NK, Nyberg KD, Nguyen AV, Hohlbauch SV, Geisse NA, Nowell CJ, Sloan EK and Rowat AC: Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling. J Cell Sci. 129:4563–4575. 2016.PubMed/NCBI |