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Review Open Access

Exosome as a crucial communicator between tumor microenvironment and gastric cancer (Review)

  • Authors:
    • Menghui Wang
    • Hongxin Shu
    • Xifu Cheng
    • Hong Xiao
    • Zhenhua Jin
    • Nan Yao
    • Shengxun Mao
    • Zhen Zong
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China, School of Ophthalmology and Optometry, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Queen Marry College, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 28
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    Published online on: January 19, 2024
       https://doi.org/10.3892/ijo.2024.5616
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Abstract

Gastric cancer is one of the most common malignancies and has relatively high morbidity and mortality rates. Exosomes are nanoscale extracellular vesicles that originate from a diverse array of cells and may be found throughout various bodily fluids. These vesicles are endogenous nanocarriers in their natural state with the unique ability to transport lipids, proteins, DNA and RNA. Exosomes contain DNA, RNA, proteins, lipids and other bioactive components that have crucial roles in the transmission of information and regulation of cell activities in gastric cancer. This paper begins with an exploration of the composition, formation and release mechanisms of exosomes. Subsequently, the role of exosomes in the tumor microenvironment is reviewed in terms of the immune cell population, nonimmune cell population and other factors. Finally, the current status and challenges of exosome‑based research on the progression, diagnosis and therapeutic methods of gastric cancer are summarized. This holistic review offers insight that may guide future research directions for exosomes and potentially pave the way for novel therapeutic interventions in the management of gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang M, Shu H, Cheng X, Xiao H, Jin Z, Yao N, Mao S and Zong Z: Exosome as a crucial communicator between tumor microenvironment and gastric cancer (Review). Int J Oncol 64: 28, 2024.
APA
Wang, M., Shu, H., Cheng, X., Xiao, H., Jin, Z., Yao, N. ... Zong, Z. (2024). Exosome as a crucial communicator between tumor microenvironment and gastric cancer (Review). International Journal of Oncology, 64, 28. https://doi.org/10.3892/ijo.2024.5616
MLA
Wang, M., Shu, H., Cheng, X., Xiao, H., Jin, Z., Yao, N., Mao, S., Zong, Z."Exosome as a crucial communicator between tumor microenvironment and gastric cancer (Review)". International Journal of Oncology 64.3 (2024): 28.
Chicago
Wang, M., Shu, H., Cheng, X., Xiao, H., Jin, Z., Yao, N., Mao, S., Zong, Z."Exosome as a crucial communicator between tumor microenvironment and gastric cancer (Review)". International Journal of Oncology 64, no. 3 (2024): 28. https://doi.org/10.3892/ijo.2024.5616
Copy and paste a formatted citation
x
Spandidos Publications style
Wang M, Shu H, Cheng X, Xiao H, Jin Z, Yao N, Mao S and Zong Z: Exosome as a crucial communicator between tumor microenvironment and gastric cancer (Review). Int J Oncol 64: 28, 2024.
APA
Wang, M., Shu, H., Cheng, X., Xiao, H., Jin, Z., Yao, N. ... Zong, Z. (2024). Exosome as a crucial communicator between tumor microenvironment and gastric cancer (Review). International Journal of Oncology, 64, 28. https://doi.org/10.3892/ijo.2024.5616
MLA
Wang, M., Shu, H., Cheng, X., Xiao, H., Jin, Z., Yao, N., Mao, S., Zong, Z."Exosome as a crucial communicator between tumor microenvironment and gastric cancer (Review)". International Journal of Oncology 64.3 (2024): 28.
Chicago
Wang, M., Shu, H., Cheng, X., Xiao, H., Jin, Z., Yao, N., Mao, S., Zong, Z."Exosome as a crucial communicator between tumor microenvironment and gastric cancer (Review)". International Journal of Oncology 64, no. 3 (2024): 28. https://doi.org/10.3892/ijo.2024.5616
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